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Title:
BORIC ACID AND BORATE ESTER COMPOUND, AND PREPARATION METHOD AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/196812
Kind Code:
A1
Abstract:
Disclosed are a boric acid and borate ester compound, and a preparation method and use therefor. Specifically disclosed are a borate ester compound of formula I, a crystal form, and pharmaceutically acceptable salts, hydrates or solvates thereof, and a borate ester compound of formula II, a crystal form, and pharmaceutically acceptable salts, hydrates or solvates thereof. The boric acid and borate ester compound of the present invention have the function of inhibiting proteasome and can be used for treating multiple myeloma.

Inventors:
ZHANG, Fuyao (4th Floor, Building 1 No.230 Cailun Road, Shanghai Free Trade Zone, Shanghai 3, 201203, CN)
LI, Huoming (4th Floor, Building 1 No.230 Cailun Road, Shanghai Free Trade Zone, Shanghai 3, 201203, CN)
Application Number:
CN2018/084623
Publication Date:
November 01, 2018
Filing Date:
April 26, 2018
Export Citation:
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Assignee:
SELECTION BIOSCIENCE LLC (4th Floor, Building 1 No.230 Cailun Road, Shanghai Free Trade Zone, Shanghai 3, 201203, CN)
International Classes:
C07F5/02; A61K31/69; A61P35/00; C07C47/02; C07C231/12; C07C233/81; C07C321/12
Domestic Patent References:
WO2018019196A12018-02-01
WO2017007689A12017-01-12
Foreign References:
CN106916177A2017-07-04
CN102066386A2011-05-18
CN101772507A2010-07-07
Other References:
PREVOST, MICHEL: "Investigation of diastereoselective acyclic alpha-alko- xydithioacetal substitutions involving thiacarbenium intermediates", JOURNAL OF ORGANIC CHEMISTRY, vol. 79, no. 21, 3 October 2014 (2014-10-03), pages 10504 - 10525, XP055527144
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (21st Floor SFECO Mansion 681 Xiaomuqiao Road, Shanghai 2, 200032, CN)
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