Title:
BORONIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/061445
Kind Code:
A1
Abstract:
Disclosed is a boronic acid derivative. Provided are a compound of formula (I) or a pharmaceutically acceptable salt, solvate, polymorph or isomer thereof, a pharmaceutical composition containing same, and the use thereof in the treatment of lmp7-related diseases.
Inventors:
WANG YELIU (CN)
LU CHANG (CN)
ZHAO SHENG (CN)
LI JIJUN (CN)
HE WEINAN (CN)
LI HONGJUAN (CN)
LU CHANG (CN)
ZHAO SHENG (CN)
LI JIJUN (CN)
HE WEINAN (CN)
LI HONGJUAN (CN)
Application Number:
PCT/CN2022/125099
Publication Date:
April 20, 2023
Filing Date:
October 13, 2022
Export Citation:
Assignee:
SHOUYAO HOLDINGS BEIJING CO LTD (CN)
International Classes:
C07F5/04; A61K31/69; A61P17/06; A61P25/28; A61P35/00; A61P37/00; C07F5/02
Domestic Patent References:
WO2019099582A1 | 2019-05-23 | |||
WO2019038250A1 | 2019-02-28 | |||
WO2018140809A1 | 2018-08-02 |
Foreign References:
CN107001391A | 2017-08-01 | |||
CN112469480A | 2021-03-09 | |||
CN113135943A | 2021-07-20 | |||
CN104321060A | 2015-01-28 | |||
CN111183142A | 2020-05-19 | |||
CN107001390A | 2017-08-01 | |||
CN107074885A | 2017-08-18 | |||
CN113135944A | 2021-07-20 | |||
CN110156820A | 2019-08-23 |
Other References:
MICHAEL BASLER ET AL., EMBO REPORTS, 2018
A . ARKHJAMI ET AL.: "Immune and non-immune functions of the immunoproteasome", FRONTIERS IN BIOSCIENCE, vol. 17, no. 1, 2012, pages 1904
T. MUCHAMUEL ET AL.: "A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis", NAT MED, vol. 15, no. 7, 2009, pages 781 - 7, XP037922221, DOI: 10.1038/nm.1978
C. M. CAUDILL ET AL.: "T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens", J. IMMUNOL, vol. 176, no. 7, 2006, pages 4075 - 82
U. SEIFERT ET AL.: "Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress", CELL, vol. 142, no. 4, 2010, pages 613 - 24, XP028931176, DOI: 10.1016/j.cell.2010.07.036
M. LEE ET AL.: "Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers", CANCER RESEARCH AND TREATMENT, vol. 51, no. 1, 2018
J. KOERNER ET AL.: "Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice", ONCOTARGET, vol. 8, no. 31, 2017, pages 50873 - 50888, XP055876312, DOI: 10.18632/oncotarget.15141
T. EGERER ET AL.: "Tissue-specific up-regulation of theproteasome subunit β5i (LMP7) in Sjogren's syndrome", ARTHRITIS RHEUM, vol. 54, no. 5, 2006, pages 1501 - 8
M. DÍAZHERNÁNDEZ ET AL.: "Neuronal Induction of the Immunoproteasome in Huntington's Disease", JOURNAL OF NEUROSCIENCE, vol. 23, no. 37, 2003, pages 11653 - 11661
A . ARKHJAMI ET AL.: "Immune and non-immune functions of the immunoproteasome", FRONTIERS IN BIOSCIENCE, vol. 17, no. 1, 2012, pages 1904
T. MUCHAMUEL ET AL.: "A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis", NAT MED, vol. 15, no. 7, 2009, pages 781 - 7, XP037922221, DOI: 10.1038/nm.1978
C. M. CAUDILL ET AL.: "T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens", J. IMMUNOL, vol. 176, no. 7, 2006, pages 4075 - 82
U. SEIFERT ET AL.: "Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress", CELL, vol. 142, no. 4, 2010, pages 613 - 24, XP028931176, DOI: 10.1016/j.cell.2010.07.036
M. LEE ET AL.: "Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers", CANCER RESEARCH AND TREATMENT, vol. 51, no. 1, 2018
J. KOERNER ET AL.: "Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice", ONCOTARGET, vol. 8, no. 31, 2017, pages 50873 - 50888, XP055876312, DOI: 10.18632/oncotarget.15141
T. EGERER ET AL.: "Tissue-specific up-regulation of theproteasome subunit β5i (LMP7) in Sjogren's syndrome", ARTHRITIS RHEUM, vol. 54, no. 5, 2006, pages 1501 - 8
M. DÍAZHERNÁNDEZ ET AL.: "Neuronal Induction of the Immunoproteasome in Huntington's Disease", JOURNAL OF NEUROSCIENCE, vol. 23, no. 37, 2003, pages 11653 - 11661
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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