Title:
BORONO-PHENYLALANINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2022/270143
Kind Code:
A1
Abstract:
The present invention provides a novel compound which can have the property of being specifically taken into cancer cells. Produced in the present invention is a novel 4-borono-phenylalanine derivative, a borono-phenylalanine derivative having a heterocyclic skeleton, a borono-phenylalanine derivative having a condensed ring structure, or a pharmaceutically acceptable salt of any of these. In an evaluation of LAT1- and LAT2-specific intake, these compounds are LAT1-specifically taken in, and thus have the property of being easily specifically taken into cancer cells and can be used favorably in neutron capture therapy and the like. Representatively, provided is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
Inventors:
MURATA YUSUKE (JP)
TAKENAKA HIROSHI (JP)
OHTA YOICHIRO (JP)
SUDANI AYA (JP)
ISHIMURA MIKI (JP)
SUZUKI KENSUKE (JP)
KAI HIROYUKI (JP)
TAKENAKA HIROSHI (JP)
OHTA YOICHIRO (JP)
SUDANI AYA (JP)
ISHIMURA MIKI (JP)
SUZUKI KENSUKE (JP)
KAI HIROYUKI (JP)
Application Number:
PCT/JP2022/018258
Publication Date:
December 29, 2022
Filing Date:
April 20, 2022
Export Citation:
Assignee:
STELLA PHARMA CORP (JP)
International Classes:
C07F5/02; A61K31/69; A61K41/00; A61K51/00; A61K51/04; A61P35/00
Foreign References:
| JP2018024668A | 2018-02-15 | |||
| PL227525B1 | 2017-12-29 | |||
| PL215215B1 | 2013-11-29 | |||
| JP2008214319A | 2008-09-18 |
Other References:
HARADA SHINGO, KAJIHARA RYOTA, MURAMOTO RISA, JUTABHA PROMSUK, ANZAI NAOHIKO, NEMOTO TETSUHIRO: "Catalytic asymmetric synthesis of α-methyl-p-boronophenylalanine", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 28, no. 10, 1 June 2018 (2018-06-01), Amsterdam NL , pages 1915 - 1918, XP093017501, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2018.03.075
ZAIDLEWICZ MAREK, CYTARSKA JOANNA, DZIELENDZIAK ADAM, ZIEGLER-BOROWSKA MARTA: "Synthesis of boronated phenylalanine analogues with a quaternary center for boron neutron capture therapy", ARKIVOC, 2 October 2003 (2003-10-02), pages 11 - 21, XP093017504, Retrieved from the Internet [retrieved on 20230125]
KHUNWEERAPHONG, N ET AL., JOURNAL OF PHARMACOLOGY SCIENCE, vol. 119, 2012, pages 368 - 380
HATTORI, Y ET AL., SENSORS, vol. 17, 2017, pages 2436
ZAIDLEWICZ MAREK, CYTARSKA JOANNA, DZIELENDZIAK ADAM, ZIEGLER-BOROWSKA MARTA: "Synthesis of boronated phenylalanine analogues with a quaternary center for boron neutron capture therapy", ARKIVOC, 2 October 2003 (2003-10-02), pages 11 - 21, XP093017504, Retrieved from the Internet
KHUNWEERAPHONG, N ET AL., JOURNAL OF PHARMACOLOGY SCIENCE, vol. 119, 2012, pages 368 - 380
HATTORI, Y ET AL., SENSORS, vol. 17, 2017, pages 2436
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
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