Title:
BOSUTINIB 1,3-PROPANEDIETHER DIMER IMPURITY AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/127327
Kind Code:
A1
Abstract:
Disclosed in the present invention are a bosutinib 1,3-propanediether dimer impurity and a synthesis process thereof. The synthesis process is simple, the purity is high, raw materials are simple and easy to obtain, the purity of a prepared finished product can reach 99% or above, and a qualified impurity reference substance can be provided for quality control of bosutinib.
Inventors:
YAO JIMING (CN)
XU YI (CN)
WANG RONGRONG (CN)
HUANG HUI (CN)
LIU HONG (CN)
XU YI (CN)
WANG RONGRONG (CN)
HUANG HUI (CN)
LIU HONG (CN)
Application Number:
PCT/CN2021/123807
Publication Date:
June 23, 2022
Filing Date:
October 14, 2021
Export Citation:
Assignee:
NANJING HUAWE MEDICINE TECH GROUP CO LTD (CN)
International Classes:
C07D215/54
Domestic Patent References:
| WO2019186429A1 | 2019-10-03 |
Foreign References:
| CN112552236A | 2021-03-26 | |||
| IN201403287I3 |
Other References:
GREGORY J. WITHBROE, CHRIS SEADEEK, KEVIN P. GIRARD, STEVEN M. GUINNESS, BRIAN C. VANDERPLAS, RAJAPPA VAIDYANATHAN: "A Robust, Streamlined Approach to Bosutinib Monohydrate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 17, no. 3, 15 March 2013 (2013-03-15), pages 500 - 504, XP055133427, ISSN: 10836160, DOI: 10.1021/op300087r
CHEN HONG , WANG YINGLI , LIU TONGBIN: "Synthesis of Bosutinib", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 44, no. 11, 10 November 2013 (2013-11-10), pages 1086 - 1088, XP055944392, ISSN: 1001-8255, DOI: 10.16522/j.cnki.cjph.2013.11.022
CHEN HONG , WANG YINGLI , LIU TONGBIN: "Synthesis of Bosutinib", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 44, no. 11, 10 November 2013 (2013-11-10), pages 1086 - 1088, XP055944392, ISSN: 1001-8255, DOI: 10.16522/j.cnki.cjph.2013.11.022
Attorney, Agent or Firm:
NANJING QINGTIAN INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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