Title:
BOTANICAL EXTRACT COMPOSITIONS WITH ANTI-CANCER OR PHYTOESTROGENIC ACTIVITY COMPRISING WOGONIN, ISOLIQUIRITIGENIN AND/OR COUMESTROL
Document Type and Number:
WIPO Patent Application WO2003075943
Kind Code:
A3
Abstract:
A composition having phytoestrogenic and anti-cancer activity is described. The composition comprises wogonin, isoliquiritigenin, coumestrol, their pharmaceutically acceptable salts or esters, their selectively substituted analogs, or combinations thereof. The compositions may also include an anti-cancer agent and/or an immune stimulant. A method for treating or preventing cancer or an estrogen related disorder includes administering a therapeutically effective amount of the compositions is described. The compositions are particularly useful in the treatment of hormone-related cancers.
Inventors:
CHEN SOPHIE PH D (US)
Application Number:
PCT/US2003/006979
Publication Date:
April 22, 2004
Filing Date:
March 06, 2003
Export Citation:
Assignee:
CHEN SOPHIE PH D (US)
International Classes:
A61K31/122; A61K31/352; A61K31/37; A61K36/07; A61K36/258; A61K36/28; A61K36/288; A61K36/31; A61K36/48; A61K36/484; A61K36/53; A61K36/539; A61K36/9066; A61K45/06; (IPC1-7): A61K31/352; A61K31/122; A61K31/37; A61K35/78; A61K45/06
Domestic Patent References:
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| WO2000003706A1 | 2000-01-27 | |||
| WO1998048790A1 | 1998-11-05 | |||
| WO2002034073A2 | 2002-05-02 | |||
| WO1998009615A1 | 1998-03-12 | |||
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Other References:
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DATABASE WPI Week 199737, 8 July 1997 Derwent World Patents Index; AN 1997-399429, XP002257002, MORINO MASAYOSHI ET AL.: "Flavonoid-containing agent for suppressing synthesis of protein of HSP27 family"
MIAO-JING LAI ET AL.: "Relative flavone bioavailability of Scutellariae Radix between traditional decoction and commercial powder preparation in humans", J. FOOD AND DRUG ANALYSIS, vol. 10, no. 2, June 2002 (2002-06-01), pages 75 - 80, XP001170316
DATABASE WPI Week 199047, Derwent World Patents Index; AN 1990-352780, XP002268303, IKEGAWA TETSUDO ET AL.: "Carcinostatic assistant"
DATABASE WPI Week 199429, 21 June 1994 Derwent World Patents Index; AN 1994-238658, XP002268304, KAMATAKI TETSUYA: "UDP-glucuronyl transferase inhibitor"
DATABASE WPI Week 198543, 12 September 1985 Derwent World Patents Index; AN 1985-266688, XP002268305, TAKAHASHI NOBUTAKA ET AL.: "Carcinostatic agent"
MA JING ET AL: "Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells", PLANTA MEDICA, vol. 67, no. 8, November 2001 (2001-11-01), pages 754 - 757, XP008026919, ISSN: 0032-0943
DATABASE WPI Week 199409, 1 February 1994 Derwent World Patents Index; AN 1994-071834, XP002268306, AOKI YASUO ET AL.: "Enhancer for carcinostatic activity"
DATABASE WPI Week 198701, 21 November 1986 Derwent World Patents Index; AN 1987-003722, XP002268307, KINOSHITA MASAHIKO: "Carcinostatic adjuvant"
KUBO M ET AL: "SCUTELLARIAE RADIX 7. ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIONS OF METHANOLIC EXTRACT AND FLAVONOID COMPONENTS FROM SCUTELLARIAE RADIX", CHEMICAL AND PHARMACEUTICAL BULLETIN (TOKYO), vol. 32, no. 7, 1984, pages 2724 - 2729, XP008026902, ISSN: 0009-2363
DATABASE WPI Week 199626, 23 April 1996 Derwent World Patents Index; AN 1996-255073, XP002268308, KUMAGAI KAZUO ET AL.: "Inhibitor of matrixmetalloprotease"
DATABASE WPI Week 200066, 5 September 2000 Derwent World Patents Index; AN 2000-675074, XP002268309, OKADA TADASHI ET AL.: "Oral antibacterial agent"
DATABASE WPI Week 199247, 8 October 1992 Derwent World Patents Index; AN 1992-385398, XP002268310, MATSUURA MASARU: "Agents for alleviating periodontitis"
DATABASE WPI Week 200145, 24 April 2001 Derwent World Patents Index; AN 2001-421066, XP002268311
KUTTAN R ET AL: "POTENTIAL ANTICANCER ACTIVITY OF TURMERIC (CURCUMA LONGA)", CANCER LETTERS, NEW YORK, NY, US, vol. 29, no. 2, November 1985 (1985-11-01), pages 197 - 202, XP001120343, ISSN: 0304-3835
DATABASE WPI Week 197803, 3 December 1977 Derwent World Patents Index; AN 1978-05666A, XP002268312, MATSUI TOKUTAROU: "antitumor agent"
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, OHNO NAOHITO ET AL: "Resistance of highly branched (1 fwdarw 3)-beta-D-glucans to formolysis", XP002268301, Database accession no. PREV199598411947
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1978, HAMURO J ET AL: "SOLID PHASE ACTIVATION OF ALTERNATIVE PATHWAY OF COMPLEMENT BY BETA-1 3 GLUCANS AND ITS POSSIBLE ROLE FOR TUMOR REGRESSING ACTIVITY", XP002268302, Database accession no. PREV197866028521
LEE WOAN-ROUH ET AL: "Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca2+-dependent endonuclease", BIOCHEMICAL PHARMACOLOGY, vol. 63, no. 2, 15 January 2002 (2002-01-15), pages 225 - 236, XP001162761, ISSN: 0006-2952
DATABASE WPI Week 199737, 8 July 1997 Derwent World Patents Index; AN 1997-399429, XP002257002, MORINO MASAYOSHI ET AL.: "Flavonoid-containing agent for suppressing synthesis of protein of HSP27 family"
MIAO-JING LAI ET AL.: "Relative flavone bioavailability of Scutellariae Radix between traditional decoction and commercial powder preparation in humans", J. FOOD AND DRUG ANALYSIS, vol. 10, no. 2, June 2002 (2002-06-01), pages 75 - 80, XP001170316
DATABASE WPI Week 199047, Derwent World Patents Index; AN 1990-352780, XP002268303, IKEGAWA TETSUDO ET AL.: "Carcinostatic assistant"
DATABASE WPI Week 199429, 21 June 1994 Derwent World Patents Index; AN 1994-238658, XP002268304, KAMATAKI TETSUYA: "UDP-glucuronyl transferase inhibitor"
DATABASE WPI Week 198543, 12 September 1985 Derwent World Patents Index; AN 1985-266688, XP002268305, TAKAHASHI NOBUTAKA ET AL.: "Carcinostatic agent"
MA JING ET AL: "Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells", PLANTA MEDICA, vol. 67, no. 8, November 2001 (2001-11-01), pages 754 - 757, XP008026919, ISSN: 0032-0943
DATABASE WPI Week 199409, 1 February 1994 Derwent World Patents Index; AN 1994-071834, XP002268306, AOKI YASUO ET AL.: "Enhancer for carcinostatic activity"
DATABASE WPI Week 198701, 21 November 1986 Derwent World Patents Index; AN 1987-003722, XP002268307, KINOSHITA MASAHIKO: "Carcinostatic adjuvant"
KUBO M ET AL: "SCUTELLARIAE RADIX 7. ANTI-ARTHRITIC AND ANTI-INFLAMMATORY ACTIONS OF METHANOLIC EXTRACT AND FLAVONOID COMPONENTS FROM SCUTELLARIAE RADIX", CHEMICAL AND PHARMACEUTICAL BULLETIN (TOKYO), vol. 32, no. 7, 1984, pages 2724 - 2729, XP008026902, ISSN: 0009-2363
DATABASE WPI Week 199626, 23 April 1996 Derwent World Patents Index; AN 1996-255073, XP002268308, KUMAGAI KAZUO ET AL.: "Inhibitor of matrixmetalloprotease"
DATABASE WPI Week 200066, 5 September 2000 Derwent World Patents Index; AN 2000-675074, XP002268309, OKADA TADASHI ET AL.: "Oral antibacterial agent"
DATABASE WPI Week 199247, 8 October 1992 Derwent World Patents Index; AN 1992-385398, XP002268310, MATSUURA MASARU: "Agents for alleviating periodontitis"
DATABASE WPI Week 200145, 24 April 2001 Derwent World Patents Index; AN 2001-421066, XP002268311
KUTTAN R ET AL: "POTENTIAL ANTICANCER ACTIVITY OF TURMERIC (CURCUMA LONGA)", CANCER LETTERS, NEW YORK, NY, US, vol. 29, no. 2, November 1985 (1985-11-01), pages 197 - 202, XP001120343, ISSN: 0304-3835
DATABASE WPI Week 197803, 3 December 1977 Derwent World Patents Index; AN 1978-05666A, XP002268312, MATSUI TOKUTAROU: "antitumor agent"
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, OHNO NAOHITO ET AL: "Resistance of highly branched (1 fwdarw 3)-beta-D-glucans to formolysis", XP002268301, Database accession no. PREV199598411947
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1978, HAMURO J ET AL: "SOLID PHASE ACTIVATION OF ALTERNATIVE PATHWAY OF COMPLEMENT BY BETA-1 3 GLUCANS AND ITS POSSIBLE ROLE FOR TUMOR REGRESSING ACTIVITY", XP002268302, Database accession no. PREV197866028521
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