Title:
BRAIN ACTIVITY ANALYSIS DEVICE, BRAIN ACTIVITY ANALYSIS METHOD, AND BIOMARKER DEVICE
Document Type and Number:
WIPO Patent Application WO/2014/178323
Kind Code:
A1
Abstract:
Provided is a brain activity analysis method for identifying functional neuroimaging biomarkers for neurological and psychiatric disorders. A correlation matrix (80) for the degree of activity between given brain regions is derived for subjects from data from resting-state functional connectivity MRI measured in a healthy group and a patient group. Feature extraction (84) is performed by means of regularized canonical correlation analysis (82) of the subject attributes including the sick/healthy label of the subject and the correlation matrix (80). A classifier (88) is constructed by means of classification analysis (86) using sparse logistic regression on the basis of the results of the regularized canonical correlation analysis.
Inventors:
MORIMOTO JUN (JP)
KAWATO MITSUO (JP)
YAHATA NORIAKI (JP)
HASHIMOTO RYUICHIRO (JP)
SHIBATA KAZUHISA (JP)
WATANABE TAKEO (JP)
SASAKI YUKA (JP)
KATO NOBUMASA (JP)
KASAI KIYOTO (JP)
KAWATO MITSUO (JP)
YAHATA NORIAKI (JP)
HASHIMOTO RYUICHIRO (JP)
SHIBATA KAZUHISA (JP)
WATANABE TAKEO (JP)
SASAKI YUKA (JP)
KATO NOBUMASA (JP)
KASAI KIYOTO (JP)
Application Number:
PCT/JP2014/061544
Publication Date:
November 06, 2014
Filing Date:
April 24, 2014
Export Citation:
Assignee:
ATR ADVANCED TELECOMM RES INST (JP)
International Classes:
G06T1/00; A61B5/055; G16H30/40
Domestic Patent References:
| WO2012165602A1 | 2012-12-06 |
Foreign References:
| JP2006513742A | 2006-04-27 | |||
| JP2008178546A | 2008-08-07 | |||
| JP2012165370A | 2012-08-30 | |||
| JP2006132313A | 2006-05-25 | |||
| JP2011000184A | 2011-01-06 |
Other References:
VINZENZ H. SCHÖNFELDER: "Sparse regularized regression identifies behaviorally-relevant stimulus features from psychophysical data", THE JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, vol. 131, no. 5, May 2012 (2012-05-01), pages 3953 - 3969, XP012160197
NIKOLAUS WEISKOPF: "Real-time fMRI and its application to neurofeedback", NEUROIMAGE, vol. 62, 2012, pages 682 - 692
DECHARMS RC; MAEDA F; GLOVER GH ET AL.: "Control over brain activation and pain learned by using real-time functional MRI", PROC NATL ACAD SCI USA, vol. 102, no. 51, 2005, pages 18626 - 18631
RAICHLE ME; MACLEOD AM; SNYDER AZ ET AL.: "A default mode of brain function", PROC NATL ACAD SCI USA, vol. 98, no. 2, 2001, pages 676 - 682
KAZUHISA SHIBATA; TAKEO WATANABE; YUKA SASAKI; MITSUO KAWATO: "Perceptual Learning Incepted by Decoded fMRI Neurofeedback Without Stimulus Presentation", SCIENCE, vol. 334, 9 December 2011 (2011-12-09)
T. WATANABE; J. E. NANEZ SR; S. KOYAMA; 1. MUKAI; J. LIEDERMAN; Y. SASAKI: "Greater plasticity in lower-level than higher-level visual motion processing in a passive perceptual learning task", NATURE NEUROSCIENCE, vol. 5, 2002, pages 1003 - 1009
KAMITANI Y; TONG F.: "Decoding the visual and subjective contents of the human brain", NAT NEUROSCI, vol. 8, 2005, pages 679 - 85
WITTEN DM; TIBSHIRANI R; T HASTIE: "A penalized matrix decomposition, with applications to sparse principal components and canonical correlation analysis", BIOSTATISTICS, vol. 10, no. 3, 2009, pages 515 - 534
OKITO YAMASHITA; MASAAKI SATO; TAKU YOSHIOKA; FRANK TONG; YUKIYASU KAMITANI: "Sparse Estimation automatically selects voxels relevant for the decoding offMRI activity patterns", NEUROIMAGE, vol. 42, no. 4, 2008, pages 1414 - 1429
NIKOLAUS WEISKOPF: "Real-time fMRI and its application to neurofeedback", NEUROIMAGE, vol. 62, 2012, pages 682 - 692
DECHARMS RC; MAEDA F; GLOVER GH ET AL.: "Control over brain activation and pain learned by using real-time functional MRI", PROC NATL ACAD SCI USA, vol. 102, no. 51, 2005, pages 18626 - 18631
RAICHLE ME; MACLEOD AM; SNYDER AZ ET AL.: "A default mode of brain function", PROC NATL ACAD SCI USA, vol. 98, no. 2, 2001, pages 676 - 682
KAZUHISA SHIBATA; TAKEO WATANABE; YUKA SASAKI; MITSUO KAWATO: "Perceptual Learning Incepted by Decoded fMRI Neurofeedback Without Stimulus Presentation", SCIENCE, vol. 334, 9 December 2011 (2011-12-09)
T. WATANABE; J. E. NANEZ SR; S. KOYAMA; 1. MUKAI; J. LIEDERMAN; Y. SASAKI: "Greater plasticity in lower-level than higher-level visual motion processing in a passive perceptual learning task", NATURE NEUROSCIENCE, vol. 5, 2002, pages 1003 - 1009
KAMITANI Y; TONG F.: "Decoding the visual and subjective contents of the human brain", NAT NEUROSCI, vol. 8, 2005, pages 679 - 85
WITTEN DM; TIBSHIRANI R; T HASTIE: "A penalized matrix decomposition, with applications to sparse principal components and canonical correlation analysis", BIOSTATISTICS, vol. 10, no. 3, 2009, pages 515 - 534
OKITO YAMASHITA; MASAAKI SATO; TAKU YOSHIOKA; FRANK TONG; YUKIYASU KAMITANI: "Sparse Estimation automatically selects voxels relevant for the decoding offMRI activity patterns", NEUROIMAGE, vol. 42, no. 4, 2008, pages 1414 - 1429
Attorney, Agent or Firm:
SHIMIZU, SATOSHI (JP)
Spring water 敏 (JP)
Spring water 敏 (JP)
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