Title:
BRAIN CELL OR NERVE CELL PROTECTING AGENTS COMPRISING GINSENG
Document Type and Number:
WIPO Patent Application WO/2001/015717
Kind Code:
A1
Abstract:
Medicinal compositions and preparations for administration comprising ginseng, which is useful as a cell protecting agent and a remedy for nerve trauma, its extract, ginseng components, metabolites thereof or salts thereof (for example, red ginseng powder or components thereof). More particularly, medicinal compositions for inhibiting apoptosis or apoptosis-like cell death, medicinal compositions for promoting the expression of a cell death inhibitory gene product Bcl-XL, or preparations for oral or intravenous administration which comprise ginseng, its extract, ginseng components, metabolites thereof or salts thereof preferably at a low concentration. These medicinal compositions and preparations for administration are characterized by containing as the active ingredient ginseng, its extract, ginseng components, metabolites thereof or salts thereof at a low concentration. These drugs are useful in treating, preventing or managing brain and nerve diseases, heart diseases, etc.
Inventors:
SAKANAKA MASAHIRO (JP)
MAEDA NOBUJI (JP)
TANAKA JUNYA (JP)
NAKATA KIMIHIKO (JP)
MAEDA NOBUJI (JP)
TANAKA JUNYA (JP)
NAKATA KIMIHIKO (JP)
Application Number:
PCT/JP2000/004102
Publication Date:
March 08, 2001
Filing Date:
June 22, 2000
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
SAKANAKA MASAHIRO (JP)
MAEDA NOBUJI (JP)
TANAKA JUNYA (JP)
NAKATA KIMIHIKO (JP)
SAKANAKA MASAHIRO (JP)
MAEDA NOBUJI (JP)
TANAKA JUNYA (JP)
NAKATA KIMIHIKO (JP)
International Classes:
A61K31/00; A61K31/704; A61K36/00; A61K36/258; A61P9/08; A61P25/00; A61P43/00; C07J9/00; C07J17/00; C07J53/00; C07J63/00; (IPC1-7): A61K35/78; A61K31/704; C07J17/00; A61P9/08; A61P25/00; A61P43/00; G01N33/15; G01N33/50
Domestic Patent References:
| WO1990008315A1 | 1990-07-26 |
Foreign References:
| JP2000159793A | 2000-06-13 | |||
| JPH06316527A | 1994-11-15 |
Other References:
J.Q. LI ET AL.: "Study on the anti-apoptptic mecvhanism of ginsenoside Rg1 in cultured cortical neurons", ACTA PHARMACEUTICA SINICA, vol. 32, no. 6, 1997, pages 406 - 410, XP002933191
SUNG-HO KIM ET AL.: "Radioprotectiv effect of red ginseng in irradiated mice with high and low dose of radiation", KOREAN J. GINSENG SCI., vol. 22, no. 1, 1998, pages 66 - 72, XP002933192
ZHANG YING-GE ET AL.: "Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats", ACTA PHARM. SINICA, vol. 17, no. 1, 1996, pages 44 - 48, XP002933193
NEUROSCIENCE RESEARCH, vol. 28, 1997, pages 191 - 200, XP002933194
ACTA PHARMACEUTICA SINICA, vol. 30, no. 9, 1995, XP002933195
ZHANG YING-GE ET AL.: "Protective effects of total saponins of panax ginseng on ischemia-reperfusion injury in rat brains", ZHONGGUO YAOLIXUE YU DULIXUE ZAZHI, vol. 8, no. 1, 1994, pages 7 - 12, XP002933196
CHU GUOXIANG ET AL.: "Protective effect of ginsenoside on acute cerebral ischemia/reperfusion injury of rats", ZHONGGUO YAOLIXUE YU DULIXUE ZAZHI, vol. 3, no. 1, 1989, pages 18 - 21, XP002933197
JIANG YAN ET AL.: "Influences of ginsenosides Rb1, Rb2 and Rb3 on electric and contractile activities of normal and damaged cultured myocardiocytes", ACTA PHARMACOLOGICA SINICA, vol. 13, no. 5, 1992, pages 403 - 406, XP002933198
FANG YUN-XIANG ET AL.: "Benefical changes in prostacyclin and thromboxane A2 by ginsenosides in myocardial infarction and reperfusion injury of dogs", ACTA PHARMACOLOGICA SINICA, vol. 7, no. 3, 1986, pages 222 - 226, XP002933199
XIU CHEN: "cardiovascular protection by ginsenosides and their nitric oxide releasing action", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 23, no. 8, 1996, pages 728 - 732, XP002933200
LI YUAN-JIAN: "The protective effect of ginsenosides and its components onmyocytes anoxia/reoxygenation and myocardial reperfusion injury", ACTA PHARMACEUTICA SINICA, vol. 22, no. 1, 1987, pages 1 - 5, XP002933316
MATAO KANAOKA ET AL.: "Studieson the enzyme immunoassay of bio-active constituents in oriental medicinal drugs. VI. Enzyme immunoassay of ginsenoside Rb1 from panax ginseng", CHEM. PHARM. BULL., vol. 40, no. 2, 1992, pages 314 - 317, XP002933317
NORIKO KONDO ET AL.: "Studies on the constituents of himalayan ginseng, panax pseudoginseng. I. The structure of the saponins", CHEM. PHARM. BULL., vol. 21, no. 13, 1973, pages 2702 - 2711, XP002933318
See also references of EP 1213026A4
SUNG-HO KIM ET AL.: "Radioprotectiv effect of red ginseng in irradiated mice with high and low dose of radiation", KOREAN J. GINSENG SCI., vol. 22, no. 1, 1998, pages 66 - 72, XP002933192
ZHANG YING-GE ET AL.: "Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats", ACTA PHARM. SINICA, vol. 17, no. 1, 1996, pages 44 - 48, XP002933193
NEUROSCIENCE RESEARCH, vol. 28, 1997, pages 191 - 200, XP002933194
ACTA PHARMACEUTICA SINICA, vol. 30, no. 9, 1995, XP002933195
ZHANG YING-GE ET AL.: "Protective effects of total saponins of panax ginseng on ischemia-reperfusion injury in rat brains", ZHONGGUO YAOLIXUE YU DULIXUE ZAZHI, vol. 8, no. 1, 1994, pages 7 - 12, XP002933196
CHU GUOXIANG ET AL.: "Protective effect of ginsenoside on acute cerebral ischemia/reperfusion injury of rats", ZHONGGUO YAOLIXUE YU DULIXUE ZAZHI, vol. 3, no. 1, 1989, pages 18 - 21, XP002933197
JIANG YAN ET AL.: "Influences of ginsenosides Rb1, Rb2 and Rb3 on electric and contractile activities of normal and damaged cultured myocardiocytes", ACTA PHARMACOLOGICA SINICA, vol. 13, no. 5, 1992, pages 403 - 406, XP002933198
FANG YUN-XIANG ET AL.: "Benefical changes in prostacyclin and thromboxane A2 by ginsenosides in myocardial infarction and reperfusion injury of dogs", ACTA PHARMACOLOGICA SINICA, vol. 7, no. 3, 1986, pages 222 - 226, XP002933199
XIU CHEN: "cardiovascular protection by ginsenosides and their nitric oxide releasing action", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 23, no. 8, 1996, pages 728 - 732, XP002933200
LI YUAN-JIAN: "The protective effect of ginsenosides and its components onmyocytes anoxia/reoxygenation and myocardial reperfusion injury", ACTA PHARMACEUTICA SINICA, vol. 22, no. 1, 1987, pages 1 - 5, XP002933316
MATAO KANAOKA ET AL.: "Studieson the enzyme immunoassay of bio-active constituents in oriental medicinal drugs. VI. Enzyme immunoassay of ginsenoside Rb1 from panax ginseng", CHEM. PHARM. BULL., vol. 40, no. 2, 1992, pages 314 - 317, XP002933317
NORIKO KONDO ET AL.: "Studies on the constituents of himalayan ginseng, panax pseudoginseng. I. The structure of the saponins", CHEM. PHARM. BULL., vol. 21, no. 13, 1973, pages 2702 - 2711, XP002933318
See also references of EP 1213026A4
Attorney, Agent or Firm:
Saeki, Norio (Taka-ai Building 15-2 Nihonbashi 3-chome Chuo-ku, Tokyo, JP)
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