Title:
BRAIN FUNCTION-IMPROVING AGENT, FOOD, AND MEDICINE USING LIPOPOLYSACCHARIDE
Document Type and Number:
WIPO Patent Application WO/2018/220886
Kind Code:
A1
Abstract:
A readily-available brain function-improving agent or food composition having a suppressive effect on Aβ brain deposition or the effect of improving learning function is provided based on the discovery that, as a result of orally administering Pantoea LPS to Alzheimer's disease model mice and studying the effects, oral administration of Pantoea LPS significantly decreased Aβ peptide accumulation in the brain and improved learning function.
Inventors:
SOMA GEN-ICHIRO (JP)
INAGAWA HIROYUKI (JP)
KOHCHI CHIE (JP)
KOBAYASHI YUTARO (JP)
INAGAWA HIROYUKI (JP)
KOHCHI CHIE (JP)
KOBAYASHI YUTARO (JP)
Application Number:
PCT/JP2017/043429
Publication Date:
December 06, 2018
Filing Date:
December 04, 2017
Export Citation:
Assignee:
CONTROL OF INNATE IMMUNITY TECH RESEARCH ASSOCIATION (JP)
UNIV KAGAWA NAT UNIV CORP (JP)
UNIV KAGAWA NAT UNIV CORP (JP)
International Classes:
A61K31/739; A23L33/135; A61K35/74; A61K35/741; A61P25/28
Foreign References:
| JP2016193865A | 2016-11-17 | |||
| JP2011193877A | 2011-10-06 | |||
| JP2017105133A | 2017-06-15 |
Other References:
KOBAYASHI, Y. ET AL.: "Effect of Lipopolysaccharide derived from Pantoea agglomerans on the Phagocytic activity of Amyloid beta by primary marine microglial cells", ANTICANCER RESEARCH, vol. 36, no. 7, 2016, pages 3693 - 3698, XP055634553, ISSN: 0250-7005
HIROYUKI INAGAWA, YUTARO KOBAYASHI, CHIE KOHCHI, RAN ZHANG, YASUHIRO SHIBASAKI, AND GEN-ICHIRO SOMA: "Primed Activation of Macrophages by Oral Administration of Lipopolysaccharide Derived from Pantoea agglomerans", IN VIVO, vol. 30, no. 3, May 2016 (2016-05-01), pages 205 - 211, XP055634562, ISSN: 0258-851X
IKEDA, SATSUYA ET AL.: "Discussion of phagocytosis function activated of pantoea agglomerans-derived LPS in macrophge cell line RAW 264.7", 20TH ANNUAL MEETING OF THE BIOTHERAPY RESEARCH SOCIETY, PROGRAM/ABSTRACTS; 10/12/2016, 2016, JAPAN, pages 42, XP009518527
J. HARDY ET AL., SCIENCE, vol. 297, 2002, pages 353 - 356
M. FUKASAKA ET AL., PLOS ONE, vol. 10, 2015, pages e0126849
0. WESTPAL ET AL., ANGEWANDTE CHEMIE, vol. 66, 1954, pages 407 - 417
D. L. HERBER ET AL., JOURNAL OF NEUROIMMUNE PHARMACOLOGY, vol. 2, 2007, pages 222 - 231
J. P. MICHAUD ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, 1941
C. KOHCHI ET AL., JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 102, 2006, pages 485 - 496
Y. KOBAYASHI ET AL., ANTICANCER RESEARCH, vol. 36, 2016, pages 3693 - 3698
J. E. MORLEY ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1822, 2012, pages 650 - 656
J. MEHLA ET AL., JOURNAL OF ALZHEIMER'S DISEASE, vol. 39, 2014, pages 145 - 162
K. NAKATA ET AL., NUTRITION RESEARCH AND PRACTICE, vol. 5, 2011, pages 435 - 442
NEUROINFORMATICS, vol. 14, 2016, pages 479 - 481
See also references of EP 3643314A4
HIROYUKI INAGAWA, YUTARO KOBAYASHI, CHIE KOHCHI, RAN ZHANG, YASUHIRO SHIBASAKI, AND GEN-ICHIRO SOMA: "Primed Activation of Macrophages by Oral Administration of Lipopolysaccharide Derived from Pantoea agglomerans", IN VIVO, vol. 30, no. 3, May 2016 (2016-05-01), pages 205 - 211, XP055634562, ISSN: 0258-851X
IKEDA, SATSUYA ET AL.: "Discussion of phagocytosis function activated of pantoea agglomerans-derived LPS in macrophge cell line RAW 264.7", 20TH ANNUAL MEETING OF THE BIOTHERAPY RESEARCH SOCIETY, PROGRAM/ABSTRACTS; 10/12/2016, 2016, JAPAN, pages 42, XP009518527
J. HARDY ET AL., SCIENCE, vol. 297, 2002, pages 353 - 356
M. FUKASAKA ET AL., PLOS ONE, vol. 10, 2015, pages e0126849
0. WESTPAL ET AL., ANGEWANDTE CHEMIE, vol. 66, 1954, pages 407 - 417
D. L. HERBER ET AL., JOURNAL OF NEUROIMMUNE PHARMACOLOGY, vol. 2, 2007, pages 222 - 231
J. P. MICHAUD ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, 1941
C. KOHCHI ET AL., JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 102, 2006, pages 485 - 496
Y. KOBAYASHI ET AL., ANTICANCER RESEARCH, vol. 36, 2016, pages 3693 - 3698
J. E. MORLEY ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1822, 2012, pages 650 - 656
J. MEHLA ET AL., JOURNAL OF ALZHEIMER'S DISEASE, vol. 39, 2014, pages 145 - 162
K. NAKATA ET AL., NUTRITION RESEARCH AND PRACTICE, vol. 5, 2011, pages 435 - 442
NEUROINFORMATICS, vol. 14, 2016, pages 479 - 481
See also references of EP 3643314A4
Attorney, Agent or Firm:
NAKAMURA Kazuo (JP)
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