Title:
BRAIN SPECIFIC EXOSOME BASED DIAGNOSTICS AND EXTRACORPOREAL THERAPIES
Document Type and Number:
WIPO Patent Application WO/2015/130956
Kind Code:
A3
Abstract:
Disclosed are methods, compositions, devices, and kits for the isolation of brain-specific exosomes. Specifically, methods, compositions, devices, and kits comprising an isolated brain- specific extracellular vesicle or exosome joined to a first binding agent that is specific for tau, β- amyloid, SlOO β, neuron-specific enolase, glycoprotein A2B5, CD133, NQ01, synaptophysin, neuronal nuclei, MAB 1569, polysialic acid-neural cell adhesion molecule (PSA-NCAM), or neurogenic differentiation 1 (NeuroD or Beta2), or glycosylated or phosphorylated forms of these molecules, are provided.
Inventors:
JOYCE JAMES (US)
TAYLOR DOUGLAS (US)
TAYLOR CICEK (US)
TAYLOR DOUGLAS (US)
TAYLOR CICEK (US)
Application Number:
PCT/US2015/017800
Publication Date:
December 10, 2015
Filing Date:
February 26, 2015
Export Citation:
Assignee:
EXOSOME SCIENCES INC (US)
International Classes:
C12Q1/68; G01N33/50; G01N33/53
Domestic Patent References:
| WO2011066589A1 | 2011-06-03 | |||
| WO2010065765A2 | 2010-06-10 | |||
| WO2008030546A2 | 2008-03-13 |
Foreign References:
| US20090208975A1 | 2009-08-20 | |||
| US20060040408A1 | 2006-02-23 | |||
| US20100184049A1 | 2010-07-22 |
Other References:
See also references of EP 3110977A4
Attorney, Agent or Firm:
HART, Daniel (2040 Main Street 14th Floo, Irvine CA, US)
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