Title:
BRAIN TUMOR-TARGETING POLYPEPTIDE, DERIVATIVE THEREOF AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/104048
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedicine. Disclosed are a brain tumor-targeting polypeptide, a derivative thereof and an application thereof. Specifically disclosed is use of the polypeptide in the preparation of a brain tumor-targeting drug or a detection reagent. The polypeptide is selected from metabolitin or osteocalcin. Also disclosed is a derivative of the polypeptide. The derivative is a product obtained by modifying the polypeptide by a terminus or a side chain. The polypeptide molecules can enter brain tissue across the blood-brain barrier to be combined with a brain tumor area, and the polypeptide provides a specific targeted delivery means for diagnosis and treatment of brain tumor diseases.
Inventors:
ZHAO HUASHAN (CN)
ZHU WEN (CN)
ZHANG JIAN (CN)
ZHANG PENGFEI (CN)
ZHU WEN (CN)
ZHANG JIAN (CN)
ZHANG PENGFEI (CN)
Application Number:
PCT/CN2022/137005
Publication Date:
June 15, 2023
Filing Date:
December 06, 2022
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
SHENZHEN INST OF ADV TECH CAS (CN)
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
A61K47/64; A61K45/00; A61K49/00; A61K51/08; A61P35/00; C07K14/47; C07K14/575
Foreign References:
| CN114306630A | 2022-04-12 | |||
| CN108324927A | 2018-07-27 |
Other References:
ZHAO HUASHAN, ZHU WEN, LI JINGWEI, LIN JINJU, LEI XIAOHUA, ZHANG PENGFEI, ZHANG JIAN V.: "Metabolitin-based molecular drug delivery by targeting GPR158 in glioblastoma", BIORXIV, 13 December 2021 (2021-12-13), XP093070704, [retrieved on 20230804], DOI: 10.1101/2021.12.13.472376
TENG BIN; HUANG CHEN; CHENG CHUAN-LI; UDDUTTULA ANJANEYULU; YU XIANG-FANG; LIU CHANG; LI JIAN; YAO ZHEN-YU; LONG JING; MIAO LI-FU;: "Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A", JOURNAL OF HEPATOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 73, no. 2, 6 March 2020 (2020-03-06), AMSTERDAM, NL , pages 383 - 393, XP086215621, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2020.02.026
LI NINGNING; ZHANG YING; SIDLAUSKAS KASTYTIS; ELLIS MATTHEW; EVANS IAN; FRANKEL PAUL; LAU JOANNE; EL-HASSAN TEDANI; GUGLIELMI LORE: "Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 37, no. 31, 3 May 2018 (2018-05-03), London , pages 4313 - 4333, XP036557708, ISSN: 0950-9232, DOI: 10.1038/s41388-018-0277-1
OURY FRANCK; KHRIMIAN LORI; DENNY CHRISTINE A.; GARDIN ANTOINE; CHAMOUNI ALEXANDRE; GOEDEN NICK; HUANG YUNG-YU; LEE HOJOON; SRINIV: "Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions", CELL, ELSEVIER, AMSTERDAM NL, vol. 155, no. 1, 26 September 2013 (2013-09-26), Amsterdam NL , pages 228 - 241, XP028729734, ISSN: 0092-8674, DOI: 10.1016/j.cell.2013.08.042
TENG BIN; HUANG CHEN; CHENG CHUAN-LI; UDDUTTULA ANJANEYULU; YU XIANG-FANG; LIU CHANG; LI JIAN; YAO ZHEN-YU; LONG JING; MIAO LI-FU;: "Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A", JOURNAL OF HEPATOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 73, no. 2, 6 March 2020 (2020-03-06), AMSTERDAM, NL , pages 383 - 393, XP086215621, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2020.02.026
LI NINGNING; ZHANG YING; SIDLAUSKAS KASTYTIS; ELLIS MATTHEW; EVANS IAN; FRANKEL PAUL; LAU JOANNE; EL-HASSAN TEDANI; GUGLIELMI LORE: "Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 37, no. 31, 3 May 2018 (2018-05-03), London , pages 4313 - 4333, XP036557708, ISSN: 0950-9232, DOI: 10.1038/s41388-018-0277-1
OURY FRANCK; KHRIMIAN LORI; DENNY CHRISTINE A.; GARDIN ANTOINE; CHAMOUNI ALEXANDRE; GOEDEN NICK; HUANG YUNG-YU; LEE HOJOON; SRINIV: "Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions", CELL, ELSEVIER, AMSTERDAM NL, vol. 155, no. 1, 26 September 2013 (2013-09-26), Amsterdam NL , pages 228 - 241, XP028729734, ISSN: 0092-8674, DOI: 10.1016/j.cell.2013.08.042
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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