Title:
BRANCHED ADAMANTYL AND NORADAMANTYL ARYL- AND ARALKYLPIPERAZINES WITH SEROTONIN 5-HT1A ACTIVITY
Document Type and Number:
WIPO Patent Application WO2001034586
Kind Code:
A3
Abstract:
This invention provides compounds and methods using them to provide neuroprotection and prevent or limit processes of neurodegeneration in mammals, including Alzeimer's Disease, Huntington's Disease, Parkinson's Disease, AIDS dementia, retinal disease, diabetic peripheral neuropathy, multiple sclerosis, stroke, acute thromboembolic stroke, focal ischemia, global ischemia, transient ischemic attack, ischemia resulting from surgery, head trauma, spinal trauma, hypoxia, fetal hypoxia, and neuroprotection; the compounds having the structure (I), wherein X is -CH2- or a bond; Y is -(CH2)m- or -(CH2)-O-(CH2)-; m is 0 or 1; n is 0 or 1; R1 and R2 are independently selected from optionally substituted aryl or heteroaryl, the optical isomers and the pharmaceutically acceptable salts thereof.
Inventors:
CHILDERS WAYNE EVERETT JR
FLETCHER HORACE III
ABOU-GHARBIA MAGID ABDEL-MEGID
YARDLEY JOHN PATRICK
FLETCHER HORACE III
ABOU-GHARBIA MAGID ABDEL-MEGID
YARDLEY JOHN PATRICK
Application Number:
PCT/US2000/030529
Publication Date:
November 07, 2002
Filing Date:
November 06, 2000
Export Citation:
Assignee:
WYETH CORP (US)
International Classes:
A61K31/495; A61K31/496; A61P3/10; A61P9/00; C07D295/12; A61P9/10; A61P19/00; A61P21/00; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P31/18; C07D239/42; C07D295/13; (IPC1-7): C07D295/12; C07D403/06; A61K31/506; A61K31/495
Domestic Patent References:
| WO2000051999A1 | 2000-09-08 | |||
| WO2000052002A1 | 2000-09-08 |
Foreign References:
| EP0900792A1 | 1999-03-10 | |||
| EP0343961A2 | 1989-11-29 | |||
| EP0395312A2 | 1990-10-31 | |||
| EP0395313A2 | 1990-10-31 |
Other References:
ABOU-GHARBIA, MAGID A. ET AL: "Synthesis and SAR of Adatanserin: Novel Adamantyl Aryl- and Heteroarylpiperazines with Dual Serotonin 5-HT1A and 5-HT2 Activity as Potential Anxiolytic and Antidepressant Agents", J. MED. CHEM. (1999), 42(25), 5077-5094, XP000973607
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