Title:
BRANCHED CHAIN ALKYL HETEROAROMATIC RING DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/187466
Kind Code:
A1
Abstract:
A branched chain alkyl heteroaromatic ring derivative represented by formula (Ia) or a pharmaceutically acceptable salt thereof is useful for treatment or prophylaxis of diseases such as sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's disease, eating disorder, cephalalgia, hemicrania, pain, digestive diseases, epilepsy, inflammation, immune-related diseases, endocrine-related diseases and hypertension, on the basis of an orexin (OX) receptor antagonist activity.
Inventors:
ARAKI YUKO (JP)
NOZAWA DAI (JP)
SUZUKI RYO (JP)
OHTA HIROSHI (JP)
FUTAMURA AYA (JP)
ABE MASAHITO (JP)
AMADA HIDEAKI (JP)
KONISHI KAZUHIDE (JP)
OGATA YUYA (JP)
NOZAWA DAI (JP)
SUZUKI RYO (JP)
OHTA HIROSHI (JP)
FUTAMURA AYA (JP)
ABE MASAHITO (JP)
AMADA HIDEAKI (JP)
KONISHI KAZUHIDE (JP)
OGATA YUYA (JP)
Application Number:
PCT/JP2013/066314
Publication Date:
December 19, 2013
Filing Date:
June 13, 2013
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D249/06; A61K31/4439; A61K31/506; A61P1/00; A61P5/00; A61P9/12; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P37/02; C07D401/14; C07D403/12; C07D413/12; C07D413/14
Domestic Patent References:
| WO2008062878A1 | 2008-05-29 | |||
| WO2012153729A1 | 2012-11-15 | |||
| WO2012081692A1 | 2012-06-21 | |||
| WO2003002559A2 | 2003-01-09 | |||
| WO2008062878A1 | 2008-05-29 | |||
| WO2011051540A1 | 2011-05-05 |
Foreign References:
| JP2012507539A | 2012-03-29 | |||
| JP2012507538A | 2012-03-29 | |||
| JP2012506376A | 2012-03-15 | |||
| JP2012505263A | 2012-03-01 | |||
| JP2010520206A | 2010-06-10 | |||
| JP2010535769A | 2010-11-25 |
Other References:
JOHN GATFIELD ET AL.: "Orexin Receptor Antagonists: A New Concept In CNS Disorders", CHEMMEDCHEM, vol. 5, 2010, pages 1197 - 1214, XP009145815
ZHU Y ET AL., J. PHARMACOL. SCI., vol. 92, 2003, pages 259 - 266
ZEITZER JM ET AL., TRENDS PHARMACOL. SCI., vol. 27, 2006, pages 368 - 374
MARCUS JN ET AL., J. COMP. NEUROL., vol. 435, 2001, pages 6 - 25
TRIVEDI JP ET AL., FEBS LETT., vol. 438, 1998, pages 71 - 75
YAMANAKA A ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 290, 2002, pages 1237 - 1245
HAGAN JJ ET AL., PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 10911 - 10916
NAKAMURA T ET AL., BRAIN RES., vol. 873, 2000, pages 181 - 187
SMITH MI ET AL., NEUROSCI. LETT., vol. 341, 2003, pages 256 - 258
BRISBARE-ROCH C ET AL., NAT. MED., vol. 13, 2007, pages 150 - 155
COX CD ET AL., J. MED. CHEM., vol. 53, 2010, pages 5320 - 5332
JOHN G ET AL., CHEMMEDCHEM., vol. 5, 2010, pages 1197 - 1214
"The Japanese Pharmacopoeia"
J. F.W. MCOMIE, PROTECTIVE GROUPS IN ORGANIC CHEMISTRY
T. W. GREENE; P. G. M. WUTS, PROTECTIVE GROUPS IN ORGANIC SYNTHESIS
SYNLETT, vol. 15, 2003, pages 2428 - 2439
J. F. W. MCOMIE, PROTECTIVE GROUPS IN ORGANIC CHEMISTRY
TOSHIKATSU OKUMURA ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 280, 2001, pages 976 - 981
See also references of EP 2862855A4
ZHU Y ET AL., J. PHARMACOL. SCI., vol. 92, 2003, pages 259 - 266
ZEITZER JM ET AL., TRENDS PHARMACOL. SCI., vol. 27, 2006, pages 368 - 374
MARCUS JN ET AL., J. COMP. NEUROL., vol. 435, 2001, pages 6 - 25
TRIVEDI JP ET AL., FEBS LETT., vol. 438, 1998, pages 71 - 75
YAMANAKA A ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 290, 2002, pages 1237 - 1245
HAGAN JJ ET AL., PROC. NATL. ACAD. SCI. USA, vol. 96, 1999, pages 10911 - 10916
NAKAMURA T ET AL., BRAIN RES., vol. 873, 2000, pages 181 - 187
SMITH MI ET AL., NEUROSCI. LETT., vol. 341, 2003, pages 256 - 258
BRISBARE-ROCH C ET AL., NAT. MED., vol. 13, 2007, pages 150 - 155
COX CD ET AL., J. MED. CHEM., vol. 53, 2010, pages 5320 - 5332
JOHN G ET AL., CHEMMEDCHEM., vol. 5, 2010, pages 1197 - 1214
"The Japanese Pharmacopoeia"
J. F.W. MCOMIE, PROTECTIVE GROUPS IN ORGANIC CHEMISTRY
T. W. GREENE; P. G. M. WUTS, PROTECTIVE GROUPS IN ORGANIC SYNTHESIS
SYNLETT, vol. 15, 2003, pages 2428 - 2439
J. F. W. MCOMIE, PROTECTIVE GROUPS IN ORGANIC CHEMISTRY
TOSHIKATSU OKUMURA ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 280, 2001, pages 976 - 981
See also references of EP 2862855A4
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, p. c. (JP)
Patent business corporation Asamura patent firm (JP)
Patent business corporation Asamura patent firm (JP)
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