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Title:
BRD4 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/052519
Kind Code:
A1
Abstract:
Disclosed is a BRD4 inhibitor as shown in formula I, belonging to the field of compound drugs. The compound provided has a good inhibitory effect on prostate cancer cell proliferation, and can be used for preparing a drug combatting tumours, autoimmune or inflammatory diseases and viral infection, and in particular an anti-prostate cancer drug.

Inventors:
FAN LEI (CN)
XU KEXIN (CN)
CHEN KE (CN)
WANG FEI (CN)
WU XIAOQUAN (CN)
LUO TONGCHUAN (CN)
ZHANG SHAOHUA (CN)
LI XINGHAI (CN)
CHEN YUANWEI (CN)
Application Number:
PCT/CN2018/105620
Publication Date:
March 21, 2019
Filing Date:
September 14, 2018
Export Citation:
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Assignee:
HINOVA PHARMACEUTICALS INC (CN)
International Classes:
C07D401/14; A61K31/517; A61K31/553; A61K31/555; A61P29/00; A61P35/00; C07D239/91
Domestic Patent References:
WO2017027571A12017-02-16
WO2015018520A12015-02-12
WO2018144789A12018-08-09
Foreign References:
CN103037865A2013-04-10
EP0638560A11995-02-15
Other References:
ENDO, J. ET AL.: "A Phenotypic Drug Discovery Study on Thienodiazepine Derivatives as Inhibitors of T Cell Proliferation Induced by CD 28 Co-Stimulation Leads to the Discovery of a First Bromodomain Inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 5, 2 February 2016 (2016-02-02), pages 1365 - 1370, XP029418009, DOI: doi:10.1016/j.bmcl.2016.01.084
WANG, LE ET AL.: "Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 9, 3 April 2017 (2017-04-03), pages 3828 - 3850, XP055582786
TYLER, D.S. ET AL.: "Click Chemistry Enables Preclinical Evaluation of Targeted Epigenetic Therapies", SCIENCE, vol. 356, no. 6345, 30 June 2017 (2017-06-30), pages 1397 - 1401, XP055582788
JANG ET AL., MOL. CELL, vol. 19, 2005, pages 523 - 534
DEVAIAH ET AL., RROC. NAT. ACAD. SCI., vol. 109, 2012, pages 6927 - 6932
CHEN CHONG: "The effect and possible mechanism of BRD4 inhibitor GSK525762A on the proliferation and apoptosis of acute B lymphocytic leukemia cells", NATIONAL SYMPOSIUM ON THE PROGRESS OF LYMPHOMA DIAGNOSIS AND TREATMENT, 2014
NI PING ET AL.: "A preliminary study of BRD4 inhibitor JQ1 effects on non-small cell lung cancer cells", JOURNAL OF NANJING MEDICAL UNIVERSITY, 2015
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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