Title:
BRD4 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/052519
Kind Code:
A1
Abstract:
Disclosed is a BRD4 inhibitor as shown in formula I, belonging to the field of compound drugs. The compound provided has a good inhibitory effect on prostate cancer cell proliferation, and can be used for preparing a drug combatting tumours, autoimmune or inflammatory diseases and viral infection, and in particular an anti-prostate cancer drug.
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Inventors:
FAN LEI (CN)
XU KEXIN (CN)
CHEN KE (CN)
WANG FEI (CN)
WU XIAOQUAN (CN)
LUO TONGCHUAN (CN)
ZHANG SHAOHUA (CN)
LI XINGHAI (CN)
CHEN YUANWEI (CN)
XU KEXIN (CN)
CHEN KE (CN)
WANG FEI (CN)
WU XIAOQUAN (CN)
LUO TONGCHUAN (CN)
ZHANG SHAOHUA (CN)
LI XINGHAI (CN)
CHEN YUANWEI (CN)
Application Number:
PCT/CN2018/105620
Publication Date:
March 21, 2019
Filing Date:
September 14, 2018
Export Citation:
Assignee:
HINOVA PHARMACEUTICALS INC (CN)
International Classes:
C07D401/14; A61K31/517; A61K31/553; A61K31/555; A61P29/00; A61P35/00; C07D239/91
Domestic Patent References:
WO2017027571A1 | 2017-02-16 | |||
WO2015018520A1 | 2015-02-12 | |||
WO2018144789A1 | 2018-08-09 |
Foreign References:
CN103037865A | 2013-04-10 | |||
EP0638560A1 | 1995-02-15 |
Other References:
ENDO, J. ET AL.: "A Phenotypic Drug Discovery Study on Thienodiazepine Derivatives as Inhibitors of T Cell Proliferation Induced by CD 28 Co-Stimulation Leads to the Discovery of a First Bromodomain Inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 5, 2 February 2016 (2016-02-02), pages 1365 - 1370, XP029418009, DOI: doi:10.1016/j.bmcl.2016.01.084
WANG, LE ET AL.: "Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 9, 3 April 2017 (2017-04-03), pages 3828 - 3850, XP055582786
TYLER, D.S. ET AL.: "Click Chemistry Enables Preclinical Evaluation of Targeted Epigenetic Therapies", SCIENCE, vol. 356, no. 6345, 30 June 2017 (2017-06-30), pages 1397 - 1401, XP055582788
JANG ET AL., MOL. CELL, vol. 19, 2005, pages 523 - 534
DEVAIAH ET AL., RROC. NAT. ACAD. SCI., vol. 109, 2012, pages 6927 - 6932
CHEN CHONG: "The effect and possible mechanism of BRD4 inhibitor GSK525762A on the proliferation and apoptosis of acute B lymphocytic leukemia cells", NATIONAL SYMPOSIUM ON THE PROGRESS OF LYMPHOMA DIAGNOSIS AND TREATMENT, 2014
NI PING ET AL.: "A preliminary study of BRD4 inhibitor JQ1 effects on non-small cell lung cancer cells", JOURNAL OF NANJING MEDICAL UNIVERSITY, 2015
WANG, LE ET AL.: "Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 9, 3 April 2017 (2017-04-03), pages 3828 - 3850, XP055582786
TYLER, D.S. ET AL.: "Click Chemistry Enables Preclinical Evaluation of Targeted Epigenetic Therapies", SCIENCE, vol. 356, no. 6345, 30 June 2017 (2017-06-30), pages 1397 - 1401, XP055582788
JANG ET AL., MOL. CELL, vol. 19, 2005, pages 523 - 534
DEVAIAH ET AL., RROC. NAT. ACAD. SCI., vol. 109, 2012, pages 6927 - 6932
CHEN CHONG: "The effect and possible mechanism of BRD4 inhibitor GSK525762A on the proliferation and apoptosis of acute B lymphocytic leukemia cells", NATIONAL SYMPOSIUM ON THE PROGRESS OF LYMPHOMA DIAGNOSIS AND TREATMENT, 2014
NI PING ET AL.: "A preliminary study of BRD4 inhibitor JQ1 effects on non-small cell lung cancer cells", JOURNAL OF NANJING MEDICAL UNIVERSITY, 2015
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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