BREAST CANCER TREATMENT WITH TAXANE THERAPY

CROSS-REFERENCE TO RELATED APPLICATIONS

[01] This application claims the benefit of U.S. Provisional Application No. 62/089,579, filed December 9, 2014. The contents of the aforementioned patent application are incorporated herein by reference in their entireties.

SEQUENCE LISTING

[02] The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on December 7, 2015, is named ATE-026_ST25.txt and is 274,591 bytes in size.

FIELD OF THE INVENTION

[03] This disclosure relates generally to the field of cancer biology, and specifically, to the fields of detection and identification of specific cancer cell phenotypes and correlation with appropriate therapies.

BACKGROUND OF THE INVENTION

[04] Human breast cancers are classifiable into five molecular distinct intrinsic subtypes, Her2-enriched, Basal-like, Luminal A, Luminal B and normal-like (Perou et al. Nature,

406(6797):747-52 (2000); Sorlie et al. PNAS, 98(19):10869-74 (2001)). Although differences in prognosis and molecular biology have been established, to date, there exists less evidence demonstrating a variation in chemosensitivity among the intrinsic subtypes.

[05] Taxane therapy has proven to be effective against many types of tumors. However, side effects are associated with taxane therapy, including nausea and vomiting, loss of appetite, change in taste, thinned or brittle hair, pain in the joints of the arms or legs lasting two to three days, changes in the color of the nails, and tingling in the hands or toes. More serious side effects such include bruising or bleeding, pain/redness/swelling at the injection site, change in normal bowel habits for more than two days, fever, chills, cough, sore throat, difficulty swallowing, dizziness, shortness of breath, severe exhaustion, skin rash, facial flushing, female infertility by ovarian damage and chest pain. Based on these side-effects of taxane based therapy, there is a need in the art to determine types of cancer that respond best to taxane based therapy and which types of cancer would be better to treat with non-taxane based therapy. SUMMARY OF THE INVENTION

[06] The present invention provides methods of predicting local-regional relapse free, or breast cancer specific survival in a subject having a breast cancer including assaying a biological sample from the subject to determine whether the biological sample is classified as a Luminal A subtype, Luminal B subtype, Basal-like subtype, or HER2-enriched subtype, wherein the subtypes are determined using a measurement of at least 10, at least 15, at least 20, at least 25, at least 40, 41 , 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1 , and providing a prediction, wherein if the biological sample is classified as a non-Basal-like subtype, a breast cancer treatment including a taxane or taxane derivative is more likely to prolong local-regional relapse free survival or breast cancer specific survival of the subject.

[07] The present invention also provides methods of predicting the likelihood of the effectiveness of a breast cancer treatment including a taxane or taxane derivative in a subject in need thereof including assaying a biological sample from the subject to determine whether the biological sample is classified as a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype, wherein the subtype is determined using a measurement of at least 10, at least 15, at least 20, at least 25, at least 40, 41 , 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1 , and providing a prediction, wherein if the biological sample is classified as a non-Basal- like subtype, the breast cancer treatment including a taxane or taxane derivative is more likely to be effective in the subject.

[08] The present invention also provides a method of treating breast cancer in a subject in need thereof including assaying a biological sample from the subject to determine whether the biological sample is classified as a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype, wherein the subtype is determined using a measurement of at least 10, at least 15, at least 20, at least 25, at least 40, 41 , 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1 , and administering a breast cancer treatment including a taxane or taxane derivative to the subject, if the biological sample is classified as a non-Basal-like subtype.

[09] In any of the above methods, preferably, the subtypes are determined using expression levels (e.g., RNA expression levels) of at least 40 of the genes listed in Table 1 , e.g., 46 or 50 of the genes listed in Table 1. The step of assaying may include detecting expression levels of at the least the following 23 genes from the at least 40 of the genes listed in Table 1 , i.e., FOXA1, MLPH, ESR1, FOXC1, CDC20, ANLN, MAPT, ORC6L, CEP55, MKI67, UBE2C, KNTC2, EXOl, PTTG1, MELK, GPR160, RRM2, SRFP1, NAT1, KIF2C, CXXC5, MIA and BCL2.

Expression levels of CCNE1, CDC6, CDCA1, CENPF, TYMS, and UBE2T may additionally be detected. In embodiments, expression level of each gene in the NAN046 gene set (which is all 50 genes in Table 1 with the exception of MYBL2, BIRC5, GRB7 and CCNB1) is detected.

Additionally, expression levels of housekeeping genes may be detected. Expression levels of the at least 40 genes as well as a plurality of (e.g., eight or more) housekeeping genes can be detected in a single hybridization reaction. Expression levels of the at least 40 genes may be normalized to expression levels of the plurality of housekeeping genes. To control for any differences in the intact R A amount in the reference sample, the levels of the at least 40 genes are normalized against the mean of the level of plurality of housekeeping genes.

[10] Measurement of gene expression can be performed using any method known in the art. Non-limiting examples include detecting the presence of at least 40 complexes with each complex comprising at least one fiuorescently labeled probe and an expression product of at least one gene (e.g., mRNA or cDNA); detecting the presence of expression products via at least 40 nucleic acid probes arrayed on and attached to a solid substrate (e.g., a microarray); and detecting a complementary DNA molecule (cDNA) for each of the at least 40 genes. cDNA molecules are obtained by performing reverse-transcriptase polymerase chain reaction (RT-PCR) with primers specific to each gene.

[11] A synthetic RNA reference sample, comprising in vitro transcribed RNA targets from the at least 40 genes and the plurality of housekeeping genes, may be assayed and used as a control. Further, to control for any variation in the assay procedure, the above normalized expression levels for each of the at least 40 genes from a biological sample are then further normalized to the normalized levels from each of the at least 40 genes of the synthetic reference sample. The normalized gene expression levels are then log transformed and scaled using two scaling factors.

[12] The step of assaying may include one or more steps of generating a gene expression profile based on expression of the genes in the biological sample, comparing the gene expression profile for the biological sample to centroids constructed from gene expression data for the at least 40 of the genes listed in Table 1 for the Luminal A, Luminal B, HER2 -enriched or Basal- like subtypes, utilizing a supervised algorithm and calculating the distance of the gene expression profile for the biological sample to each of the centroids, and classifying the biological sample as a Luminal A, Luminal B, HER2-enriched or Basal-like subtype based upon the nearest centroid. More specifically, a computational algorithm based on a Pearson's correlation compares the normalized and scaled gene expression profile of the entirety of the at least 40 genes from the biological sample to prototypical expression signatures (termed "centroids") which define each of the four breast cancer intrinsic subtypes, e.g., derived from gene expression data deposited with the National Center for Biotechnology Information Gene Expression Omnibus (GEO) (as examples, with accession number GSE2845 or GSE 10886). The Pearson's correlation calculation assigns the patient breast tumor sample to the intrinsic subtype with the most similar expression profile or centroid score across the at least 40 genes. The Pearson's correlation of the totality of the at least 40 genes to the four centroids results in four numerical values that each range from -1 to +1 where a value of +1 is a perfectly correlated expression profile, -1 is a perfectly anti-correlated profile and 0 is completely uncorrelated. Features of the above- mentioned steps are included in the "PAM50 classification model" or the "NAN046

classification model", as described below.

[13] At least one of the above described steps is performed on a computer or electronic computational device.

[14] The expression of the genes from Table 1 can be determined using the nanoreporter code system (nCounter® Analysis system).

[15] The taxane or taxane derivative can be paclitaxel (Taxol®) or docetaxel (Taxotere®). Preferably, the taxane or taxane derivative is docetaxel. The taxane or taxane derivative can be administered daily (once every 24 hours), weekly (once every 5-7 days), every two weeks (every 10-14 days) or monthly (once every 30 days). Preferably, the taxane or taxane derivative is administered weekly.

[16] The breast cancer can be primary breast cancer, locally advanced breast cancer or metastatic breast cancer. The subject can be a mammal. Preferably, the subject is human. The subject may be a male or a female. The subject has been diagnosed by a skilled artisan as having a breast cancer and is included in a subpopulation of humans who currently have breast cancer or had breast cancer. The subject that has breast cancer can be pre-mastectomy or post-mastectomy. The subject that has breast cancer can be estrogen receptor (ER) negative, progesterone receptor (PgR) negative or HER2 negative. The subject that has breast cancer can be ER-. PgR- and HER2- ("triple negative"). The subject that has breast cancer can have a mutation in the BRCAl gene or the BRCA2 gene. The subject that has breast cancer can have a mutation in the BRCAl and BRCA2 genes.

[17] The breast cancer treatment that includes a taxanes or taxanes derivative can also include one or more anti-cancer or chemotherapeutic agents. Classes of anti-cancer or chemotherapeutic agents can include anthracycline agents, alkylating agents, nucleoside analogs, platinum agents, vinca agents, anti-estrogen drugs, aromatase inhibitors, ovarian suppression agents,

endocrine/hormonal agents, bisphophonate therapy agents and targeted biological therapy agents. Specific anti-cancer or chemotherapeutic agents include cyclophosphamide, fluorouracil (or 5- fluorouracil or 5-FU), methotrexate, thiotepa, carboplatin, cisplatin, gemcitabine, anthracycline, taxanes, paclitaxel, protein-bound paclitaxel, docetaxel, vinorelbine, tamoxifen, raloxifene, toremifene, fulvestrant, irinotecan, ixabepilone, temozolmide, topotecan, vincristine, vinblastine, eribulin, mutamycin, capecitabine, capecitabine, anastrozole, exemestane, letrozole, leuprolide, abarelix, buserlin, goserelin, megestrol acetate, risedronate, pamidronate, ibandronate, alendronate, denosumab, zoledronate, trastuzumab, tykerb or bevacizumab, or combinations thereof. Preferably, the treatment that includes radiation also includes cyclophosphamide, fluorouracil (or 5 -fluorouracil or 5-FU), methotrexate, or combinations thereof; one such combination is CMF which includes cyclophosphamide, methotrexate, and fluorouracil.

[18] The assaying of the biological sample to determine whether the biological sample is classified as either a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype cancer is performed using RNA expression profiling, immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH). Preferably, the assay is RNA expression profiling. The expression of the members of the gene list of Table 1 can be determined using a nanoreporter and the nanoreporter code system (nCounter® Analysis system; NanoString Technologies, Seattle, WA). Preferably, expression of the members of the gene list of Table 1 can be determined using a reporter probe and capture probe for the detection of at least 10, at least 15, at least 20, at least 25, at least 40, 41 , 42, 43, 44, 45, 46, 47, 48, 49 or all 50 of the genes listed in Table 1. In particular, expression of the "NAN046" set of genes is determined (which is by determining the expression of all 50 genes in Table 1 with the exception of determining the expression of MYBL2, BIRC5, GRB7 and CCNB1). Preferably, there is only one reporter probe/capture probe pair for any one gene of Table 1 to be detected.

[19] The biological sample can be a cell, a tissue or a bodily fluid. The tissue can be sampled from a biopsy or smear. The biological sample can be a tumor. The tumor can be an estrogen receptor positive tumor or an estrogen receptor negative tumor. The sample can also be a sampling of bodily fluids. The bodily fluid can include blood, lymph, urine, saliva, nipple aspirates and gynecological fluids. The biological sample can be a formalin fixed paraffin embedded tissues (FFPE) sample.

[20] The methods of the present invention can include determining at least one of, a combination of, or each of, the following: tumor size, tumor grade, nodal status, intrinsic subtype, estrogen receptor expression, progesterone receptor expression, HER2/ERBB2 expression and/or ROR score.

[21] When a biological sample is classified as either a Luminal A, Luminal B, HER2- enriched, or Basal-like subtype cancer, the subject from which the biological sample is obtained is classified as having, respectively, a Luminal A, Luminal B, HER2-enriched, or Basal-like subtype cancer. A subject is assigned to a recommended treatment group based on his/her classified cancer subtype. Finally, a recommend treatment to be provided to a subject depends on the group to which the subject is assigned.

[22] In embodiments, a computational algorithm then calculates a Risk of Recurrence (ROR) score. In embodiments, the ROR score is calculated using coefficients from a Cox model that includes (1) Pearson's correlation of the expression profiles of the at least 40 genes (e.g., the NAN046 gene set) in the biological sample with the expected profiles for the four intrinsic subtypes (as described above), (2) a proliferation score (determined from the mean gene expression of a subset of 18 proliferation genes of the at least 40 genes (as described below) and (3) gross tumor size of the subject's tumor. The variables are multiplied by the corresponding coefficients from the Cox Model to generate the score, which is then adjusted to a 0-100 scale. The 0- 100 ROR score is correlated with the probability of distant recurrence at ten years (Distant Recurrence-Free Survival (DRFS) at 10 years). Risk categories (low, intermediate, or high) are also calculated based on cut-offs for risk of recurrence score determined in a clinical validation study.

[23] In embodiments, a risk of recurrence (ROR) score of 0 to 40 is a low risk of recurrence for a node -negative cancer, a ROR score of 0 to 15 is a low risk of recurrence for a node -positive cancer, a ROR score of 61 to 100 is a high risk of recurrence for a node -negative cancer, and a ROR score of 41 to 100 is a high risk of recurrence for a node -positive cancer.

[24] As used herein a ROR score can be calculated using any method or formula known in the art. Exemplary formulae include Equations 1 to 6, s described herein.

[25] The at least 40 genes set contains many genes that are known markers for proliferation. The methods and kits of the present invention provide for the determination of subsets of genes that provide a proliferation signature. The methods and kits of the present invention can include steps and reagents for determining the expression of at least one of, a combination of, or each of, a 18-gene subset of the intrinsic genes of Table 1 selected from ^NLN, CCNE1, CDC20, CDC6, CDCA1, CENPF, CEP55, EXOl, KIF2C, KNTC2, MELK, MKI67, ORC6L, PTTG1, RRM2, TYMS, UBE2C and/or UBE2T. Preferably, the expression of each of the 18-gene subset of the gene set of Table 1 is determined to provide a proliferation score. The expression of one or more of these genes may be determined and a proliferation signature index can be generated by averaging the normalized expression estimates of one or more of these genes in a sample. The sample can be assigned a high proliferation signature, a moderate/intermediate proliferation signature, a low proliferation signature or an ultra-low proliferation signature. Methods of determining a proliferation signature from a biological sample are as described in Nielsen et al. Clin. Cancer Res., 16(21):5222-5232 (2009) and supplemental online material.

[26] The term "likely" as used herein has the meaning commonly understood by a person skilled in the art to which this invention belongs. For example, if a subject is "more likely" to benefit from a therapy, it would be recommended for a health care provider to select the therapy for the subject.

[27] The term "measurement" as used herein includes obtaining, measuring, or detecting a numeric value of a quantifiable property, e.g., expression level of a gene, and also includes calculations using the value, e.g., the deviation of a gene's expression level in a test sample relative to a control sample, a correlation, and a statistic.

[28] Any of the above aspects and embodiments can be combined with any other aspect or embodiment.

[29] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In the specification, the singular forms also include the plural unless the context clearly dictates otherwise; as examples, the terms "a," "an," and "the" are understood to be singular or plural and the term "or" is understood to be inclusive. By way of example, "an element" means one or more element. Throughout the specification the word "comprising," or variations such as "comprises" or "comprising," will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps. About can be understood as within 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, 0.1%, 0.05%, or 0.01% of the stated value. Unless otherwise clear from the context, all numerical values provided herein are modified by the term "about."

[30] While the disclosure has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the disclosure, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.

[31] The patent and scientific literature referred to herein establishes the knowledge that is available to those with skill in the art. All United States patents and published or unpublished United States patent applications cited herein are incorporated by reference. All published foreign patents and patent applications cited herein are hereby incorporated by reference. Genbank and NCBI submissions indicated by accession number cited herein are hereby incorporated by reference. All other published references, documents, manuscripts and scientific literature cited herein are hereby incorporated by reference.

BRIEF DESCRIPTION OF THE DRAWINGS

[32] The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawings will be provided by the Office upon request and payment of the necessary fee.

[33] Figure 1 is an illustration of the Example's trial design.

[34] Figure 2 is an illustration of intrinsic subtype by PAM50 or NAN046 for subjects with triple negative breast cancer (TNBC) in the trial of the Example.

[35] Figure 3 is an illustration of the objective response rate observed in the trial of the Example.

[36] Figure 4 is an illustration of response of patients in the trial of the Example with Basal- like subtype as determined by IHC.

[37] Figure 5 is an illustration of response of patients in the trial of the Example with Basal- like subtype as determined by PAM50 or NAN046.

[38] Figure 6 is an illustration of waterfall plots of response of patients in the trial of the Example with Basal-like subtype as determined by PAM50 or NAN046.

[39] Figure 7 is a schematic of the Breast Cancer Intrinsic Subtyping test.

[40] Figure 8 is a schematic of an algorithm process.

DETAILED DESCRIPTION OF THE INVENTION

[41] The present invention provides a method of determining whether a breast cancer treatment comprising a taxane or taxane derivative is optimal for administration to a patient suffering from breast cancer. Determining whether a breast cancer patient should receive a treatment including a taxane or taxane derivative includes determining the intrinsic subtype of the breast cancer using an intrinsic gene expression set. The disclosure also provides a method of treating breast cancer by determining whether a breast cancer patient should receive a treatment including a taxane or taxane derivative and then administering the optimal breast cancer treatment to the patient based on that determination.

[42] As used herein, the terms "treat," treating," "treatment," and the like refer to reducing or ameliorating a disorder and/or a symptom associated therewith. It will be appreciated that, although not precluded, treating a disorder or condition does not require that the disorder, condition or symptoms associated therewith be completely eliminated. Treating may include a health care professional or diagnostic scientist making a recommendation to a subject for a desired course of action or treatment regimen, e.g., a prescription.

[43] As used herein, the term "predict", "prediction", "predicting" and the like is intended to mean assessing the likelihood that a patient will experience a positive or negative outcome with a particular treatment or will experience a positive or negative outcome absent a particular treatment.

[44] Intrinsic genes are statistically selected to have low variation in expression between biological sample replicates from the same individual and high variation in expression across samples from different individuals. Thus, intrinsic genes are used as classifier genes for breast cancer classification. Although clinical information was not used to derive the breast cancer intrinsic subtypes, this classification has proved to have prognostic significance. Intrinsic gene screening can be used to classify breast cancers into various subtypes. The major intrinsic subtypes of breast cancer are referred to as Luminal A (LumA), Luminal B (LumB), HER2- enriched (Her-2-E), Basal-like, and Normal-like (Perou et al. Nature, 406(6797):747-52 (2000); Sorlie et al. PNAS, 98(19): 10869-74 (2001)). [45] The PAM50 gene expression assay, as described herein, is able to identify intrinsic subtype from standard formalin fixed paraffin embedded tumor tissue (also see, Parker et al. J Clin Oncol, 27(8):1 160-7 (2009) and U.S. Patent Application Publication No. 201 1/0145176). The methods utilize a supervised algorithm to classify subject samples according to breast cancer intrinsic subtype. This algorithm, referred to herein as the "PAM50 classification model", is based on the gene expression profile of a defined subset of intrinsic genes that has been identified herein as superior for classifying breast cancer intrinsic subtypes. See, U.S. Patent Application Publication No. 2011/0145176. The subset of genes, along with exemplary primers specific for their detection, is provided in Table 1. The subset of genes, along with exemplary probes specific for their detection, is provided in Table 2. The exemplary primers and target specific probe sequences are merely representative and not meant to limit the invention. The skilled artisan can utilize any primer and/or target sequence-specific probe for detecting any of (or each of) the genes in Table 1.

[46] Table 1. PAM50 Intrinsic Gene List

[47] Table 1

GTAAATCACCTTCT 10 ACTTGGGATATGTGA 60

CDC6 NM 001254 GAGCCT ATAAGACC

GGAGGCGGAAGAA 11 GGGGAAAGACAAAG 61

CDCA1 NM 031423 ACCAG TTTCCA

GACAAGGAGAATCA 12 ACTGTCTGGGTCCAT 62

CDH3 BC041846 AAAGATCAGC GGCTA

GTGGCAGCAGATCA 13 GGATTTCGTGGTGGG 63

CENPF NM 016343 CAA TTC

CCTCACGAATTGCT 14 CCACAGTCTGTGATA 64

CEP55 AB091343 GAACTT AACGG

CATGAAATAGTGCA 15 CCATCAACATTCTCT 65

CXXC5 BC006428 TAGTTTGCC TTATGAACG

ACACAGAATCTATA 16 ATCAACTCCCAAAC 66

EGFR NM 005228 CCCACCAGAGT GGTCAC

GCTGGCTCTCACAC 17 GCCCTTACACATCGG 67

ERBB2 NM 001005862 TGATAG AGAAC

GCAGGGAGAGGAGT 18 GACTTCAGGGTGCTG 68

ESR1 NM 001 122742 TTGT GAC

CCCATCCATGTGAG 19 TGTGAAGCCAGCAA 69

EXOl NM 130398 GAAGTATAA TATGTATC

CTTCTTGGACCTTGG 20 TATTGGGAGGCAGG 70

FGFR4 AB209631 CG AGGTTTA

GCTACTACGCAGAC 21 CTGAGTTCATGTTGC 71

FOXA1 NM 004496 ACG TGACC

GATGTTCGAGTCAC 22 GACAGCTACTATTCC 72

FOXC1 NM 001453 AGAGG CGTT

TTCGGCTGGAAGGA 23 TATGTGAGTAAGCTC 73

GPR160 AJ249248 ACC GGAGAC

CGTGGCAGATGTGA 24 AGTGGGCATCCCGT 74

GRB7 NM 005310 ACGA AGA

HSPC150 GGAGATCCGTCAAC 25 AGTGGACATGCGAG 75 (UBE2T) NM 014176 TCCAAA TGGAG

TGGGTCGTGTCAGG 26 CACCGCTGGAAACT 76

KIF2C NM 006845 AAAC GAAC

CGCAGTCATCCAGA 27 CGTGCACATCCATGA 77

KNTC2 NM 006101 GATGTG CCTT

ACTCAGTACAAGAA 28 GAGGAGATGACCTT 78

KRT14 BC042437 AGAACCG GCC

GTTGGACCAGTCAA 29 GCCATAGCCACTGCC 79

KRT17 A 095281 CATCTCTG ACT

TGTGGCTCATTAGG 30 CTTCGACTGGACTCT 80

KRT5 M21389 CAAC GT

GACTCCAAGCGCGA 31 CAGACATGTTGGTAT 81

MAPT NM 001 123066 AAAC TGCACATT

CCACAAAATATTCA 32 AGGCGATCCTGGGA 82

MDM2 M92424 TGGTTCTTG AATTAT

CCAGTAGCATTGTC 33 CCCATTTGTCTGTCT 83

MELK NM 014791 CGAG TCAC GTCTCTGGTAATGC 34 CTGATGGTTGAGGCT 84

MIA BG765502 ACACT GTT

GTGGAATGCCTGCT 35 CGCACTCCAGCACCT 85

MKI67 NM 002417 GACC AGAC

AGGGGTGCCCTCTG 36 TCACAGGGTCAAAC 86

MLPH NM 024101 AGAT TTCCAGT

CGAGATCGCCAAGA

37 GATGGTAGAGTTCC 87

MMP11 NM 005940 TGTT AGTGATT

AGGCGAACACACAA 38 TCTGGTCACGCAGG 88

MYBL2 BX647151 CGTC GCAA

AGCCTCGAACAATT ACACAGATGATGGA

39 89

MYC NM 002467 GAAGA GATGTC

ATCGACTGTGTAAA 40 AGTAGCTACATCTCC 90

NAT1 BC013732 CAACTAGAGAAGA AGGTTCTCTG

TTTAAGAGGGCAAA 41 CGGATTTTATCAACG 91

ORC6L NM 014321 TGGAAGG ATGCAG

TGCCGCAGAACTCA 42 CATTTGCCGTCCTTC 92

PGR NM 000926 CTTG ATCG

CCTCAGATGATGCC 43 GCAGGTCAAAACTC 93

PHGDH A 093306 TATCCA TCAAAG

CAGCAAGCGATGGC 44 AGCGGGCTTCTGTAA 94

PTTG1 BE904476 ATAGT TCTGA

AATGCCACCGAAGC 45 GCCTCAGATTTCAAC 95

RRM2 A 123010 CTC TCGT

TCGAACTGAAGGCT 46 CTGCTGAGAATCAA 96

SFRP1 BC036503 ATTTACGAG AGTGGGA

GTCGAAGCCGCAAT

47 GGAACAAACTGCTC 97

SLC39A6 NM 012319 TAGG TGCCA

CAAACGTGTGTTCT 48 ACAGCTCTTTAGCAT 98

TMEM45B A 098106 GGAGG TTGTGGA

TGCCCTGTATGATGT GGGACTATCAATGTT

49 99

TYMS BQ56428 CAGGA GGGTTCTC

GTGAGGGGTGTCAG 50 CACACAGTTCACTGC 100

UBE2C BC032677 CTCAGT TCCACA

Table 2. Exemplary Probes for detecting NAN046 g

[49] Table 2

BAG1 NM_004323.3 CTTCATGTTACCTCCCAGCAGGGCAGCAGTGAAC

CAGTTGTCCAAGACCTGGCCCAGGTTGTTGAAGA 103 GGTCATAGGGGTTCCACAGTCTTTTCAGAAAC

BCL2 NM_000633.2 CCAAGCACCGCTTCGTGTGGCTCCACCTGGATGTT

CTGTGCCTGTAAACATAGATTCGCTTTCCATGTTG 104 TTGGCCGGATCACCATCTGAAGAGCAGACG

BLVRA NM_000712.3 TTCCTGAAAAAAGAAGTGGTGGGGAAAGACCTGC

TGAAAGGGTCGCTCCTCTTCACAGCTGGCCCGTTG 105 GAAGAAGAGCGGTTTGGCTTCCCTGCATTCA

CCNE1 NM_001238.1 GAGAACTGTGTCAAGTGGATGGTTCCATTTGCCA

TGGTTATAAGGGAGACGGGGAGCTCAAAACTGAA 106

GCACTTCAGGGGCGTCGCTGATGAAGATGCAC

CDC20 NM_001255.1 CCCGAGTGGGCTCCCTAAGCTGGAACAGCTATAT

CCTGTCCAGTGGTTCACGTTCTGGCCACATCCACC 107

ACCATGATGTTCGGGTAGCAGAACACCATGT

CDC6 NM_001254.3 GGGGAAGTTATATGAAGCCTACAGTAAAGTCTGT

CGCAAACAGCAGGTGGCGGCTGTGGACCAGTCAG 108

AGTGTTTGTCACTTTCAGGGCTCTTGGAAGCC

CDCA1 NMJ45697.1 GCCTGGCGGTGTTTTCGTCGTGCTCAGCGGTGGG

AGGAGGCGGAAGAAACCAGAGCCTGGGAGATTA 109 ACAGGAAACTTCCAAGATGGAAACTTTGTCTTT

CDH3 NM_001793.3 CCCTCGACCGTGAGGATGAGCAGTTTGTGAGGAA

CAACATCTATGAAGTCATGGTCTTGGCCATGGAC 110

AATGGAAGCCCTCCCACCACTGGCACGGGAAC

CENPF NM_016343.3 AGAAAATCTTGCAGAGTCCTCCAAACCAACAGCT

GGTGGCAGCAGATCACAAAAGGTCAAAGTTGCTC 111 AGCGGAGCCCAGTAGATTCAGGCACCATCCTC

CEP55 NM_018131.3 GTACTACCGCATTGCTTGAACAGCTGGAAGAGAC

AACGAGAGAAGGAGAAAGGAGGGAGCAGGTGTT 112 GAAAGCCTTATCTGAAGAGAAAGACGTATTGAA

CXXC5 NM_016463.5 AGCTGCCCTCTCCGTGCAATGTCACTGCTCGTGTG

GTCTCCAGCAAGGGATTCGGGCGAAGACAAACGG 113 ATGCACCCGTCTTTAGAACCAAAAATATTCT

EGFR NM_005228.3 GCAGCCAGGAACGTACTGGTGAAAACACCGCAGC

ATGTCAAGATCACAGATTTTGGGCTGGCCAAACT 114

GCTGGGTGCGGAAGAGAAAGAATACCATGCAG

ERBB2 NM_004448.2 TGAAGGTGCTTGGATCTGGCGCTTTTGGCACAGTC

TACAAGGGCATCTGGATCCCTGATGGGGAGAATG 115 TGAAAATTCCAGTGGCCATCAAAGTGTTGAG

ESR1 NM_000125.2 AGGAACCAGGGAAAATGTGTAGAGGGCATGGTG

GAGATCTTCGACATGCTGCTGGCTACATCATCTCG 116

GTTCCGCATGATGAATCTGCAGGGAGAGGAGT

EXOl NM_006027.3 TGGCCCACAAAGTAATTAAAGCTGCCCGGTCTCA

GGGGGTAGATTGCCTCGTGGCTCCCTATGAAGCT 117 GATGCGCAGTTGGCCTATCTTAACAAAGCGGG

FGFR4 NM_00201 1.3 CCCACATCCAGTGGCTGAAGCACATCGTCATCAA

CGGCAGCAGCTTCGGAGCCGACGGTTTCCCCTAT 118 GTGCAAGTCCTAAAGACTGCAGACATCAATAG

FOXA1 NM_004496.2 TGGATGGTTGTATTGGGCAGGGTGGCTCCAGGAT

GTTAGGAACTGTGAAGATGGAAGGGCATGAAACC 119

AGCGACTGGAACAGCTACTACGCAGACACGCA

FOXC1 NM_001453.1 TTCGAGTCACAGAGGATCGGCTTGAACAACTCTC

CAGTGAACGGGAATAGTAGCTGTCAAATGGCCTT 120 CCCTTCCAGCCAGTCTCTGTACCGCACGTCCG GPR160 NM_014373.1 GGATTTCAGTCCTTGCTTATGTTTTGGGAGACCCA

GCCATCTACCAAAGCCTGAAGGCACAGAATGCTT 121 ATTCTCGTCACTGTCCTTTCTATGTCAGCAT

UBE2T NM_014176.1 GTGTCAGCTCAGTGCATCCCAGGCAGCTCTTAGT

GTGGAGCAGTGAACTGTGTGTGGTTCCTTCTACTT 122

GGGGATCATGCAGAGAGCTTCACGTCTGAAG

KIF2C NM_006845.2 GTTGTCTACAGGTTCACAGCAAGGCCACTGGTAC

AGACAATCTTTGAAGGTGGAAAAGCAACTTGTTT 123 TGCATATGGCCAGACAGGAAGTGGCAAGACAC

KNTC2 NM_006101.1 AAAAGGTCATAAGCATGAAGCGCAGTTCAGTTTC

CAGCGGTGGTGCTGGCCGCCTCTCCATGCAGGAG 124 TTAAGATCCCAGGATGTAAATAAACAAGGCCT

KRT14 NM_000526.3 GCAGTCATCCAGAGATGTGACCTCCTCCAGCCGC

CAAATCCGCACCAAGGTCATGGATGTGCACGATG 125 GCAAGGTGGTGTCCACCCACGAGCAGGTCCTT

KRT17 NM_000422.1 CTGACTCAGTACAAGAAAGAACCGGTGACCACCC

GTCAGGTGCGTACCATTGTGGAAGAGGTCCAGGA 126 TGGCAAGGTCATCTCCTCCCGCGAGCAGGTCC

KRT5 NM_000424.2 CTGGTTCTCTTGCTCCACCAGGAACAAGCCACCAT

GTCTCGCCAGTCAAGTGTGTCCTTCCGGAGCGGG 127

GGCAGTCGTAGCTTCAGCACCGCCTCTGCCA

MAPT NM_016835.3 GCCGGGTCCCTCAACTCAAAGCTCGCATGGTCAG

TAAAAGCAAAGACGGGACTGGAAGCGATGACAA 128 AAAAGCCAAGACATCCACACGTTCCTCTGCTAA

MDM2 NM_006878.2 GGTGAGGAGCAGGCAAATGTGCAATACCAACATG

TCTGTACCTACTGATGGTGCTGTAACCACCTCACA 129 GATTCCAGCTTCGGAACAAGAGACCCTGGTT

MELK NM_014791.2 AGAGACAGCCAACAAAATATTCATGGTTCTTGAG

TACTGCCCTGGAGGAGAGCTGTTTGACTATATAA 130 TTTCCCAGGATCGCCTGTCAGAAGAGGAGACC

MIA NM_006533.1 CCGGGGCCAAGTGGTGTATGTCTTCTCCAAGCTG

AAGGGCCGTGGGCGGCTCTTCTGGGGAGGCAGCG 131

TTCAGGGAGATTACTATGGAGATCTGGCTGCT

MKI67 NM_002417.2 GCTTCCAGCAGCAAATCTCAGACAGAGGTTCCTA

AGAGAGGAGGAGAAAGAGTGGCAACCTGCCTTC 132 AAAAGAGAGTGTCTATCAGCCGAAGTCAACATG

MLPH NM_024101.4 GAGGAAGTCAAACCTCCCGATATTTCTCCCTCGA

GTGGCTGGGAAACTTGGCAAGAGACCAGAGGAC 133 CCAAATGCAGACCCTTCAAGTGAGGCCAAGGCA

MMP11 NM_005940.3 AGCAGCCAAGGCCCTGATGTCCGCCTTCTACACC

TTTCGCTACCCACTGAGTCTCAGCCCAGATGACTG 134

CAGGGGCGTTCAACACCTATATGGCCAGCCC

MYC NM_002467.3 CACCGAGGAGAATGTCAAGAGGCGAACACACAA

CGTCTTGGAGCGCCAGAGGAGGAACGAGCTAAA 135 ACGGAGCTTTTTTGCCCTGCGTGACCAGATCCCG

NAT1 NM_000662.4 AGCACTTCCTCATAGACCTTGGATGTGGGAGGAT

TGCATTCAGTCTAGTTCCTGGTTGCCGGCTGAAAT 136

AACCTGAATTCAAGCCAGGAAGAAGCAGCAA

ORC6L NM_014321.2 GACTGTGTAAACAACTAGAGAAGATTGGACAGCA

GGTCGACAGAGAACCTGGAGATGTAGCTACTCCA 137 CCACGGAAGAGAAAGAAGATAGTGGTTGAAGC

PGR NM_000926.2 GGGATGAAGCATCAGGCTGTCATTATGGTGTCCT

TACCTGTGGGAGCTGTAAGGTCTTCTTTAAGAGG 138 GCAATGGAAGGGCAGCACAACTACTTATGTGC PHGDH NM_006623.2 GCGACGGCTTCGATGAAGGACGGCAAATGGGAG

CGGAAGAAGTTCATGGGAACAGAGCTGAATGGA 139 AAGACCCTGGGAATTCTTGGCCTGGGCAGGATTG

PTTG1 NM_004219.2 CACCAGCCTTACCTAAAGCTACTAGAAAGGCTTT

GGGAACTGTCAACAGAGCTACAGAAAAGTCTGTA 140

AAGACCAAGGGACCCCTCAAACAAAAACAGCC

RRM2 NM_001034.1 TTCCTTTTGGACCGCCGAGGAGGTTGACCTCTCCA

AGGACATTCAGCACTGGGAATCCCTGAAACCCGA 141 GGAGAGATATTTTATATCCCATGTTCTGGCT

SFRP1 NM_003012.3 GTGGGTCACACACACGCACTGCGCCTGTCAGTAG

TGGACATTGTAATCCAGTCGGCTTGTTCTTGCAGC 142 ATTCCCGCTCCCTTCCCTCCATAGCCACGCT

SLC39A6 NM_012319.2 GATCGAACTGAAGGCTATTTACGAGCAGACTCAC

AAGAGCCCTCCCACTTTGATTCTCAGCAGCCTGCA 143

GTCTTGGAAGAAGAAGAGGTCATGATAGCTC

TMEM45B NM_138788.3 CTGGCTGCCCTCAGCATTGTGGCCGTCAACTATTC

TCTTGTTTACTGCCTTTTGACTCGGATGAAGAGAC 144 ACGGAAGGGGAGAAATCATTGGAATTCAGA

TYMS NM_001071.1 TGCTAAAGAGCTGTCTTCCAAGGGAGTGAAAATC

TGGGATGCCAATGGATCCCGAGACTTTTTGGACA 145 GCCTGGGATTCTCCACCAGAGAAGAAGGGGAC

UBE2C NM_007019.2 GTCTGCCCTGTATGATGTCAGGACCATTCTGCTCT

CCATCCAGAGCCTTCTAGGAGAACCCAACATTGA 146 TAGTCCCTTGAACACACATGCTGCCGAGCTC

[50] Table 3 provides select sequences for the PAM50 genes of Table 1.

[51] Table 3

ATAGACGTTGGTTACGAAAGATTCCTGGGACCTGAAATATTCTTTCACC

CGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGA

TGAAGTAATACAGAACTGCCCCATCGATGTGCGGCGCCCGCTGTATAAG

AATGTCGTACTCTCAGGAGGCTCCACCATGTTCAGGGATTTCGGACGCC

GACTGCAGAGGGATTTGAAGAGAGTGGTGGATGCTAGGCTGAGGCTCA

GCGAGGAGCTCAGCGGCGGGAGGATCAAGCCGAAGCCTGTGGAGGTCC

AGGTGGTCACGCATCACATGCAGCGCTACGCCGTGTGGTTCGGAGGCTC

CATGCTGGCCTCGACTCCCGAGTTCTTTCAGGTCTGCCACACCAAGAAG

GACTATGAAGAGTACGGGCCCAGCATCTGCCGCCACAACCCCGTCTTTG

GAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGATGGTGTCACGT

TGGGGAACAAGTGTCCTTCAGAACCCAGAGAAGGCCGCCGTTCTGTAA

ATAGCGACGTCGGTGTTGCTGCCCAGCAGCGTGCTTGCATTGCCGGTGC

ATGAGGCGCGGCGCGGGCCCTTCAGTAAAAGCCATTTATCCGTGTGCCG

ACCGCTGTCTGCCAGCCTCCTCCTTCTCCCGCCCTCCTCACCCTCGCTCT

CCCTCCTCCTCCTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAG

GAATCCAAATGTGACTTTGAAAATTGTTAGAGAAAACAACATTAGAAA

ATGGCGCAAAATCGTTAGGTCCCAGGAGAGAATGTGGGGGCGCAAACC

CTTTTCCTCCCAGCCTATTTTTGTAAATAAAATGTTTAAACTTGAAATAC

AAATCGATGTTTATATTTCCTATCATTTTGTATTTTATGGTATTTGGTAC

AACTGGCTGATACTAAGCACGAATAGATATTGATGTTATGGAGTGCTGT

AATCCAAAGTTTTTAATTGTGAGGCATGTTCTGATATGTTTATAGGCAA

ACAAATAAAACAGCAAACTTTTTTGCCACATGTTTGCTAGAAAATGATT

ATACTTTATTGGAGTGACATGAAGTTTGAACACTAAACAGTAATGTATG

AGAATTACTACAGATACATGTATCTTTTAGTTTTTTTTGTTTGAACTTTC

TGGAGCTGTTTTATAGAAGATGATGGTTTGTTGTCGGTGAGTGTTGGAT

GAAATACTTCCTTGCACCATTGTAATAAAAGCTGTTAGAATATTTGTAA

ATATC

ΝΜ_001040135 CAGCGGCGCTGCGGCGGCTCGCGGGAGACGCTGCGCGCGGGGCTAGCG 148

GGCGGCGGAGCGGACGGCGACGGGGCGCTCTCGGGCTGCCGGCGGGGC

CGAGCGCCGCGCGTCCCGAGCATGGCAGGCTCCCTGCCTCCCTGCGTGG

TGGACTGTGGCACCGGGTATACCAAGCTTGGCTACGCAGGCAACACTG

AGCCCCAGTTCATTATTCCTTCATGTATTGCCATCAGAGAGTCAGCAAA

GGTAGTTGACCAAGCTCAAAGGAGAGTGTTGAGGGGAGTTGATGACCT

TGACTTTTTCATAGGAGATGAAGCCATCGATAAACCTACATATGCTACA

AAGTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAA

AGGTTCATGGAGCAAGTGGTTTTTAAATATCTTCGAGCTGAACCTGAGG

ACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAG

AGAGTATCTTGCAGAAATTATGTTTGAATCATTTAACGTACCAGGACTC

TACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTC

GACAAGTGGGTGAACGTACGTTAACGGGGATAGTCATTGACAGCGGAG

ATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGAAG

CTGCATCAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATT

CAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCTGAGCAGTCA

CTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCC

GATATAGTCAAGGAATTTGCCAAGTATGATGTGGATCCCCGGAAGTGG

ATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTT

ATAGACGTTGGTTACGAAAGATTCCTGGGACCTGAAATATTCTTTCACC

CGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGA

TGAAGTAATACAGAACTGCCCCATCGATGTGCGGCGCCCGCTGTATAAG

CCCGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTATGAAGAGTACG

GGCCCAGCATCTGCCGCCACAACCCCGTCTTTGGAGTCATGTCCTAGTG

TCTGCCTGAACGCGTCGTTCGATGGTGTCACGTTGGGGAACAAGTGTCC

TTCAGAACCCAGAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTT

GCTGCCCAGCAGCGTGCTTGCATTGCCGGTGCATGAGGCGCGGCGCGG

GCCCTTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGC

CTCCTCCTTCTCCCGCCCTCCTCACCCTCGCTCTCCCTCCTCCTCCTCCTC CGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGACTT

TGAAAATTGTTAGAGAAAACAACATTAGAAAATGGCGCAAAATCGTTA

GGTCCCAGGAGAGAATGTGGGGGCGCAAACCCTTTTCCTCCCAGCCTAT

TTTTGTAAATAAAATGTTTAAACTTGAAATACAAATCGATGTTTATATTT

CCTATCATTTTGTATTTTATGGTATTTGGTACAACTGGCTGATACTAAGC

ACGAATAGATATTGATGTTATGGAGTGCTGTAATCCAAAGTTTTTAATT

GTGAGGCATGTTCTGATATGTTTATAGGCAAACAAATAAAACAGCAAA

CTTTTTTGCCACATGTTTGCTAGAAAATGATTATACTTTATTGGAGTGAC

ATGAAGTTTGAACACTAAACAGTAATGTATGAGAATTACTACAGATAC

ATGTATCTTTTAGTTTTTTTTGTTTGAACTTTCTGGAGCTGTTTTATAGAA

GATGATGGTTTGTTGTCGGTGAGTGTTGGATGAAATACTTCCTTGCACC

ATTGTAATAAAAGCTGTTAGAATATTTGTAAATATC

ΝΜ_018685 CTCGGCGCTGAAATTCAAATTTGAACGGCTGCAGAGGCCGAGTCCGTCA 149

CTGGAAGCCGAGAGGAGAGGACAGCTGGTTGTGGGAGAGTTCCCCCGC

CTCAGACTCCTGGTTTTTTCCAGGAGACACACTGAGCTGAGACTCACTT

TTCTCTTCCTGAATTTGAACCACCGTTTCCATCGTCTCGTAGTCCGACGC

CTGGGGCGATGGATCCGTTTACGGAGAAACTGCTGGAGCGAACCCGTG

CCAGGCGAGAGAATCTTCAGAGAAAAATGGCTGAGAGGCCCACAGCAG

CTCCAAGGTCTATGACTCATGCTAAGCGAGCTAGACAGCCACTTTCAGA

AGCAAGTAACCAGCAGCCCCTCTCTGGTGGTGAAGAGAAATCTTGTAC

AAAACCATCGCCATCAAAAAAACGCTGTTCTGACAACACTGAAGTAGA

AGTTTCTAACTTGGAAAATAAACAACCAGTTGAGTCGACATCTGCAAAA

TCTTGTTCTCCAAGTCCTGTGTCTCCTCAGGTGCAGCCACAAGCAGCAG

ATACCATCAGTGATTCTGTTGCTGTCCCGGCATCACTGCTGGGCATGAG

GAGAGGGCTGAACTCAAGATTGGAAGCAACTGCAGCCTCCTCAGTTAA

AACACGTATGCAAAAACTTGCAGAGCAACGGCGCCGTTGGGATAATGA

TGATATGACAGATGACATTCCTGAAAGCTCACTCTTCTCACCAATGCCA

TCAGAGGAAAAGGCTGCTTCCCCTCCCAGACCTCTGCTTTCAAATGCCT

CGGCAACTCCAGTTGGCAGAAGGGGCCGTCTGGCCAATCTTGCTGCAAC

TATTTGCTCCTGGGAAGATGATGTAAATCACTCATTTGCAAAACAAAAC

AGTGTACAAGAACAGCCTGGTACCGCTTGTTTATCCAAATTTTCCTCTG

CAAGTGGAGCATCTGCTAGGATCAATAGCAGCAGTGTTAAGCAGGAAG

CTACATTCTGTTCCCAAAGGGATGGCGATGCCTCTTTGAATAAAGCCCT

ATCCTCAAGTGCTGATGATGCGTCTTTGGTTAATGCCTCAATTTCCAGCT

CTGTGAAAGCTACTTCTCCAGTGAAATCTACTACATCTATCACTGATGC

TAAAAGTTGTGAGGGACAAAATCCTGAGCTACTTCCAAAAACTCCTATT

AGTCCTCTGAAAACGGGGGTATCGAAACCAATTGTGAAGTCAACTTTAT

CCCAGACAGTTCCATCCAAGGGAGAATTAAGTAGAGAAATTTGTCTGC

AATCTCAATCTAAAGACAAATCTACGACACCAGGAGGAACAGGAATTA

AGCCTTTCCTGGAACGCTTTGGAGAGCGTTGTCAAGAACATAGCAAAG

AAAGTCCAGCTCGTAGCACACCCCACAGAACCCCCATTATTACTCCAAA

TACAAAGGCCATCCAAGAAAGATTATTCAAGCAAGACACATCTTCATCT

ACTACCCATTTAGCACAACAGCTCAAGCAGGAACGTCAAAAAGAACTA

GCATGTCTTCGTGGCCGATTTGACAAGGGCAATATATGGAGTGCAGAA

AAAGGCGGAAACTCAAAAAGCAAACAACTAGAAACCAAACAGGAAAC

TCACTGTCAGAGCACTCCCCTCAAAAAACACCAAGGTGTTTCAAAAACT

CAGTCACTTCCAGTAACAGAAAAGGTGACCGAAAACCAGATACCAGCC

AAAAATTCTAGTACAGAACCTAAAGGTTTCACTGAATGCGAAATGACG

AAATCTAGCCCTTTGAAAATAACATTGTTTTTAGAAGAGGACAAATCCT

TAAAAGTAACATCAGACCCAAAGGTTGAGCAGAAAATTGAAGTGATAC

GTGAAATTGAGATGAGTGTGGATGATGATGATATCAATAGTTCGAAAG

TAATTAATGACCTCTTCAGTGATGTCCTAGAGGAAGGTGAACTAGATAT

GGAGAAGAGCCAAGAGGAGATGGATCAAGCATTAGCAGAAAGCAGCG

AAGAACAGGAAGATGCACTGAATATCTCCTCAATGTCTTTACTTGCACC

ATTGGCACAAACAGTTGGTGTGGTAAGTCCAGAGAGTTTAGTGTCCACA

CCTAGACTGGAATTGAAAGACACCAGCAGAAGTGATGAAAGTCCAAAA CCAGGAAAATTCCAAAGAACTCGTGTCCCTCGAGCTGAATCTGGTGATA

GCCTTGGTTCTGAAGATCGTGATCTTCTTTACAGCATTGATGCATATAG

ATCTCAAAGATTCAAAGAAACAGAACGTCCATCAATAAAGCAGGTGAT

TGTTCGGAAGGAAGATGTTACTTCAAAACTGGATGAAAAAAATAATGC

CTTTCCTTGTCAAGTTAATATCAAACAGAAAATGCAGGAACTCAATAAC

GAAATAAATATGCAACAGACAGTGATCTATCAAGCTAGCCAGGCTCTT

AACTGCTGTGTTGATGAAGAACATGGAAAAGGGTCCCTAGAAGAAGCT

GAAGCAGAAAGACTTCTTCTAATTGCAACTGGGAAGAGAACACTTTTG

ATTGATGAATTGAATAAATTGAAGAACGAAGGACCTCAGAGGAAGAAT

AAGGCTAGTCCCCAAAGTGAATTTATGCCATCCAAAGGATCAGTTACTT

TGTCAGAAATCCGCTTGCCTCTAAAAGCAGATTTTGTCTGCAGTACGGT

TCAGAAACCAGATGCAGCAAATTACTATTACTTAATTATACTAAAAGCA

GGAGCTGAAAATATGGTAGCCACACCATTAGCAAGTACTTCAAACTCTC

TTAACGGTGATGCTCTGACATTCACTACTACATTTACTCTGCAAGATGT

ATCCAATGACTTTGAAATAAATATTGAAGTTTACAGCTTGGTGCAAAAG

AAAGATCCCTCAGGCCTTGATAAGAAGAAAAAAACATCCAAGTCCAAG

GCTATTACTCCAAAGCGACTCCTCACATCTATAACCACAAAAAGCAACA

TTCATTCTTCAGTCATGGCCAGTCCAGGAGGTCTTAGTGCTGTGCGAAC

CAGCAACTTCGCCCTTGTTGGATCTTACACATTATCATTGTCTTCAGTAG

GAAATACTAAGTTTGTTCTGGACAAGGTCCCCTTTTTATCTTCTTTGGAA

GGTCATATTTATTTAAAAATAAAATGTCAAGTGAATTCCAGTGTTGAAG

AAAGAGGTTTTCTAACCATATTTGAAGATGTTAGTGGTTTTGGTGCCTG

GCATCGAAGATGGTGTGTTCTTTCTGGAAACTGTATATCTTATTGGACTT

ATCCAGATGATGAGAAACGCAAGAATCCCATAGGAAGGATAAATCTGG

CTAATTGTACCAGTCGTCAGATAGAACCAGCCAACAGAGAATTTTGTGC

AAGACGCAACACTTTTGAATTAATTACTGTCCGACCACAAAGAGAAGA

TGACCGAGAGACTCTTGTCAGCCAATGCAGGGACACACTCTGTGTTACC

AAGAACTGGCTGTCTGCAGATACTAAAGAAGAGCGGGATCTCTGGATG

CAAAAACTCAATCAAGTTCTTGTTGATATTCGCCTCTGGCAACCTGATG

CTTGCTACAAACCTATTGGAAAGCCTTAAACCGGGAAATTTCCATGCTA

TCTAGAGGTTTTTGATGTCATCTTAAGAAACACACTTAAGAGCATCAGA

TTTACTGATTGCATTTTATGCTTTAAGTACGAAAGGGTTTGTGCCAATAT

TCACTACGTATTATGCAGTATTTATATCTTTTGTATGTAAAACTTTAACT

GATTTCTGTCATTCATCAATGAGTAGAAGTAAATACATTATAGTTGATT

TTGCTAAATCTTAATTTAAAAGCCTCATTTTCCTAGAAATCTAATTATTC

AGTTATTCATGACAATATTTTTTTAAAAGTAAGAAATTCTGAGTTGTCTT

CTTGGAGCTGTAGGTCTTGAAGCAGCAACGTCTTTCAGGGGTTGGAGAC

AGAAACCCATTCTCCAATCTCAGTAGTTTTTTCGAAAGGCTGTGATCAT

TTATTGATCGTGATATGACTTGTTACTAGGGTACTGAAAAAAATGTCTA

AGGCCTTTACAGAAACATTTTTAGTAATGAGGATGAGAACTTTTTCAAA

TAGCAAATATATATTGGCTTAAAGCATGAGGCTGTCTTCAGAAAAGTGA

TGTGGACATAGGAGGCAATGTGTGAGACTTGGGGGTTCAATATTTTATA

TAGAAGAGTTAATAAGCACATGGTTTACATTTACTCAGCTACTATATAT

GCAGTGTGGTGCACATTTTCACAGAATTCTGGCTTCATTAAGATCATTA

TTTTTGCTGCGTAGCTTACAGACTTAGCATATTAGTTTTTTCTACTCCTA

CAAGTGTAAATTGAAAAATCTTTATATTAAAAAAGTAAACTGTTATGAA

GCTGCTATGTACTAATAATACTTTGCTTGCCAAAGTGTTTGGGTTTTGTT

GTTGTTTGTTTGTTTGTTTGTTTTTGGTTCATGAACAACAGTGTCTAGAA

ACCCATTTTGAAAGTGGAAAATTATTAAGTCACCTATCACCTTTAAACG

CCTTTTTTTAAAATTATAAAATATTGTAAAGCAGGGTCTCAACTTTTAAA

TACACTTTGAACTTCTTCTCTGAATTATTAAAGTTCTTTATGACCTCATT

TATAAACACTAAATTCTGTCACCTCCTGTCATTTTATTTTTTATTCATTCA

AATGTATTTTTTCTTGTGCATATTATAAAAATATATTTTATGAGCTCTTA

CTCAAATAAATACCTGTAAATGTCTAAAGGAAAAAAAAAAAAAAAAAA

NM_004323 AGGCCGGGGCGGGGCTGGGAAGTAGTCGGGCGGGGTTGTGAGACGCCG 150

CGCTCAGCTTCCATCGCTGGGCGGTCAACAAGTGCGGGCCTGGCTCAGC GCGGGGGGGCGCGGAGACCGCGAGGCGACCGGGAGCGGCTGGGTTCCC

GGCTGCGCGCCCTTCGGCCAGGCCGGGAGCCGCGCCAGTCGGAGCCCC

CGGCCCAGCGTGGTCCGCCTCCCTCTCGGCGTCCACCTGCCCGGAGTAC

TGCCAGCGGGCATGACCGACCCACCAGGGGCGCCGCCGCCGGCGCTCG

CAGGCCGCGGATGAAGAAGAAAACCCGGCGCCGCTCGACCCGGAGCGA

GGAGTTGACCCGGAGCGAGGAGTTGACCCTGAGTGAGGAAGCGACCTG

GAGTGAAGAGGCGACCCAGAGTGAGGAGGCGACCCAGGGCGAAGAGA

TGAATCGGAGCCAGGAGGTGACCCGGGACGAGGAGTCGACCCGGAGCG

AGGAGGTGACCAGGGAGGAAATGGCGGCAGCTGGGCTCACCGTGACTG

TCACCCACAGCAATGAGAAGCACGACCTTCATGTTACCTCCCAGCAGGG

CAGCAGTGAACCAGTTGTCCAAGACCTGGCCCAGGTTGTTGAAGAGGT

CATAGGGGTTCCACAGTCTTTTCAGAAACTCATATTTAAGGGAAAATCT

CTGAAGGAAATGGAAACACCGTTGTCAGCACTTGGAATACAAGATGGT

TGCCGGGTCATGTTAATTGGGAAAAAGAACAGTCCACAGGAAGAGGTT

GAACTAAAGAAGTTGAAACATTTGGAGAAGTCTGTGGAGAAGATAGCT

GACCAGCTGGAAGAGTTGAATAAAGAGCTTACTGGAATCCAGCAGGGT

TTTCTGCCCAAGGATTTGCAAGCTGAAGCTCTCTGCAAACTTGATAGGA

GAGTAAAAGCCACAATAGAGCAGTTTATGAAGATCTTGGAGGAGATTG

ACACACTGATCCTGCCAGAAAATTTCAAAGACAGTAGATTGAAAAGGA

AAGGCTTGGTAAAAAAGGTTCAGGCATTCCTAGCCGAGTGTGACACAG

TGGAGCAGAACATCTGCCAGGAGACTGAGCGGCTGCAGTCTACAAACT

TTGCCCTGGCCGAGTGAGGTGTAGCAGAAAAAGGCTGTGCTGCCCTGA

AGAATGGCGCCACCAGCTCTGCCGTCTCTGGAGCGGAATTTACCTGATT

TCTTCAGGGCTGCTGGGGGCAACTGGCCATTTGCCAATTTTCCTACTCTC

ACACTGGTTCTCAATGAAAAATAGTGTCTTTGTGATTTTGAGTAAAGCT

CCTATCTGTTTTCTCCTTCTGTCTCTGTGGTTGTACTGTCCAGCAATCCA

CCTTTTCTGGAGAGGGCCACCTCTGCCCAAATTTTCCCAGCTGTTTGGAC

CTCTGGGTGCTTTCTTTGGGCTGGTGAGAGCTCTAATTTGCCTTGGGCCA

GTTTCAGGTTTATAGGCCCCCTCAGTCTTCAGATACATGAGGGCTTCTTT

GCTCTTGTGATCGTGTAGTCCCATAGCTGTAAAACCAGAATCACCAGGA

GGTTGCACCTAGTCAGGAATATTGGGAATGGCCTAGAACAAGGTGTTTG

GCACATAAGTAGACCACTTATCCCTCATTGTGACCTAATTCCAGAGCAT

CTGGCTGGGTTGTTGGGTTCTAGACTTTGTCCTCACCTCCCAGTGACCCT

GACTAGCCACAGGCCATGAGATACCAGGGGGCCGTTCCTTGGATGGAG

CCTGTGGTTGATGCAAGGCTTCCTTGTCCCCAAGCAAGTCTTCAGAAGG

TTAGAACCCAGTGTTGACTGAGTCTGTGCTTGAAACCAGGCCAGAGCCA

TGGATTAGGAAGGGCAAAGAGAAGGCACCAGAATGAGTAAAGCAGGC

AGGTGGTGAAGCCAACCATAAACTTCTCAGGAGTGACATGTGCTTCCTT

CAAAGGCATTTTTGTTAACCATATCCTTCTGAGTTCTATGTTTCCTTCAC

AGCTGTTCTATCCATTTTGTGGACTGTCCCCCACCCCCACCCCATCATTG

TTTTTAAAAAATTAAGGCCTGGCGCAGCAGCTCATGCCTATAATCCCAG

CACTTTGGGAGGCTGAGGCGGGCGGATCACTTGAGGCCAGGAGTTTGA

GACCAGCCCAGGCAACATAGCAAAACCCCATTCTGCTTTAAAAAAAAA

AAAAAAAAAAATTAGCTTGGCGTAGTGGCATGTGCCTATAATCCCAGCT

ACTGGGGAGGCTGAGGCACAAGAATCATTTGAACCTGGGAGGTAGAGG

TTGCTGTGAGCCGAGATTACGCCCCTGCACTCCAGCCTGGGTCACAGAG

TGAGACTCCATCTCAGAAAAAAAAAAAATTGAGTCAGGTGCAGTAGCT

CCTTCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCTAGAGGATCACTT

GAGCCCAGGAGTTTGAGTCTAGTCTGGGCAACATAGCAAGACCCCATCT

CTAAAATTTAAGTAAGTAAAAGTAGATAAATAAAAAGAAAAAAAAACT

GTTTATGTGCTCATCATAAAGTAGAAGAGTGGTTTGCTTTTTTTTTTTTT

TTTGGATTAATGAGGAAATCATTCTGTGGCTCTAGTCATAATTTATGCTT

AATAACATTGATAGTAGCCCTTTGCGCTATAACTCTACCTAAAGACTCA

CATCATTTGGCAGAGAGAGAGTCGTTGAAGTCCCAGGAATTCAGGACT

GGGCAGGTTAAGACCTCAGACAAGGTAGTAGAGGTAGACTTGTGGACA

AGGCTCGGGTCCCAGCCCACCGCACCCCAACTTTAATCAGAGTGGTTCA CTATTGATCTATTTTTGTGTGATAGCTGTGTGGCGTGGGCCACAACATTT

AATGAGAAGTTACTGTGCACCAAACTGCCGAACACCATTCTAAACTATT

CATATATATTAGTCATTTAATTCTTACATAACTTGAGAGGTAGACAGAT

ATCCTTATTTTAGAGATGAGGAAACCAAGAGAACTTAGGTCATTAGCGC

AAGGTTGTAGAGTAAGCGGCAAAGCCAAGACACAAAGCTGGGTGGTTT

GGTTTCAGAGCCAGTGCTTTTCCCCTCTACTGTACTGCCTCTCAACCAAC

ACAGGGTTGCACAGGCCCATTCTCTGATTTTTTTCCTCTTGTCCTCTGCC

TCTCCCTCTAGCTCCCACTTCCTCTCTGCTCTAGTTCATTTTCTTTAGAGC

AGCCCGAGTGATCATGAAGTGCAAATCTTGCCATGTCAGTCCCCTGCTT

AGAACCCTCCAATGGCTCACTTTCTCTTTAGGCAAAAGTCTTTACCCCAT

GCCTTCTCCCATCTCATCTCAACCCCCTCATTTGTTGGCTGTCTGCTGTC

AGCCACTCTTCTTTCAGGTCCTCAGATGCACTGCACCCTCTCCTGCCTGG

GGGTCTTTGCTCCTGCTACTACCTCTGCTTGAACAGCTCCTCACCTTCCT

TCCTCCAACCCTACCCTTGTATAGGTGACTTTTGTTCATCCTTCAGAATT

CAACTCACATGTCTCTTGCATGGAGAACCCTCACCTACTGTGTTGAGAC

CCTGTCCAGCCCCCAGGTGGGATCCTCTCTCGACTTCCCATACATTTCTT

TCACAGCATTTACATAGTCCATGATAGTTTACTTGTGGGATTATTTGGTT

AATCTTTGCCTTTAACACCAGGGTTCCTTGGGTGAAGGAGCTTCTTTATC

TTGGTAACAGCATTATTTCAAGCATAACTTGTAATATAGTTATATTACAT

ATATAACATATATATATATAACATAACATATATAACATATATAACAAGC

ATAACTTGTTATATAGTCTTGTATATAGTAAGACCTCAATAAATATTTG

GAGAACAAAAAAAAAAAAAAA

NM_000633 TTTCTGTGAAGCAGAAGTCTGGGAATCGATCTGGAAATCCTCCTAATTT 151

TTACTCCCTCTCCCCGCGACTCCTGATTCATTGGGAAGTTTCAAATCAGC

TATAACTGGAGAGTGCTGAAGATTGATGGGATCGTTGCCTTATGCATTT

GTTTTGGTTTTACAAAAAGGAAACTTGACAGAGGATCATGCTGTACTTA

AAAAATACAACATCACAGAGGAAGTAGACTGATATTAACAATACTTAC

TAATAATAACGTGCCTCATGAAATAAAGATCCGAAAGGAATTGGAATA

AAAATTTCCTGCATCTCATGCCAAGGGGGAAACACCAGAATCAAGTGTT

CCGCGTGATTGAAGACACCCCCTCGTCCAAGAATGCAAAGCACATCCA

ATAAAATAGCTGGATTATAACTCCTCTTCTTTCTCTGGGGGCCGTGGGG

TGGGAGCTGGGGCGAGAGGTGCCGTTGGCCCCCGTTGCTTTTCCTCTGG

GAAGGATGGCGCACGCTGGGAGAACAGGGTACGATAACCGGGAGATA

GTGATGAAGTACATCCATTATAAGCTGTCGCAGAGGGGCTACGAGTGG

GATGCGGGAGATGTGGGCGCCGCGCCCCCGGGGGCCGCCCCCGCACCG

GGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCCGCATCCC

GGGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCG

GCGCCGCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCT

GACCCTCCGCCAGGCCGGCGACGACTTCTCCCGCCGCTACCGCCGCGAC

TTCGCCGAGATGTCCAGCCAGCTGCACCTGACGCCCTTCACCGCGCGGG

GACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGACGGGGTGAACT

GGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGA

GAGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTG

GATGACTGAGTACCTGAACCGGCACCTGCACACCTGGATCCAGGATAA

CGGAGGCTGGGATGCCTTTGTGGAACTGTACGGCCCCAGCATGCGGCCT

CTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTGCTCAGTTTGGCCCT

GGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGAAGT

CAACATGCCTGCCCCAAACAAATATGCAAAAGGTTCACTAAAGCAGTA

GAAATAATATGCATTGTCAGTGATGTACCATGAAACAAAGCTGCAGGC

TGTTTAAGAAAAAATAACACACATATAAACATCACACACACAGACAGA

CACACACACACACAACAATTAACAGTCTTCAGGCAAAACGTCGAATCA

GCTATTTACTGCCAAAGGGAAATATCATTTATTTTTTACATTATTAAGAA

AAAAAGATTTATTTATTTAAGACAGTCCCATCAAAACTCCTGTCTTTGG

AAATCCGACCACTAATTGCCAAGCACCGCTTCGTGTGGCTCCACCTGGA

TGTTCTGTGCCTGTAAACATAGATTCGCTTTCCATGTTGTTGGCCGGATC

ACCATCTGAAGAGCAGACGGATGGAAAAAGGACCTGATCATTGGGGAA GCTGGCTTTCTGGCTGCTGGAGGCTGGGGAGAAGGTGTTCATTCACTTG

CATTTCTTTGCCCTGGGGGCTGTGATATTAACAGAGGGAGGGTTCCTGT

GGGGGGAAGTCCATGCCTCCCTGGCCTGAAGAAGAGACTCTTTGCATAT

GACTCACATGATGCATACCTGGTGGGAGGAAAAGAGTTGGGAACTTCA

GATGGACCTAGTACCCACTGAGATTTCCACGCCGAAGGACAGCGATGG

GAAAAATGCCCTTAAATCATAGGAAAGTATTTTTTTAAGCTACCAATTG

TGCCGAGAAAAGCATTTTAGCAATTTATACAATATCATCCAGTACCTTA

AGCCCTGATTGTGTATATTCATATATTTTGGATACGCACCCCCCAACTCC

CAATACTGGCTCTGTCTGAGTAAGAAACAGAATCCTCTGGAACTTGAGG

AAGTGAACATTTCGGTGACTTCCGCATCAGGAAGGCTAGAGTTACCCAG

AGCATCAGGCCGCCACAAGTGCCTGCTTTTAGGAGACCGAAGTCCGCA

GAACCTGCCTGTGTCCCAGCTTGGAGGCCTGGTCCTGGAACTGAGCCGG

GGCCCTCACTGGCCTCCTCCAGGGATGATCAACAGGGCAGTGTGGTCTC

CGAATGTCTGGAAGCTGATGGAGCTCAGAATTCCACTGTCAAGAAAGA

GCAGTAGAGGGGTGTGGCTGGGCCTGTCACCCTGGGGCCCTCCAGGTA

GGCCCGTTTTCACGTGGAGCATGGGAGCCACGACCCTTCTTAAGACATG

TATCACTGTAGAGGGAAGGAACAGAGGCCCTGGGCCCTTCCTATCAGA

AGGACATGGTGAAGGCTGGGAACGTGAGGAGAGGCAATGGCCACGGC

CCATTTTGGCTGTAGCACATGGCACGTTGGCTGTGTGGCCTTGGCCCAC

CTGTGAGTTTAAAGCAAGGCTTTAAATGACTTTGGAGAGGGTCACAAAT

CCTAAAAGAAGCATTGAAGTGAGGTGTCATGGATTAATTGACCCCTGTC

TATGGAATTACATGTAAAACATTATCTTGTCACTGTAGTTTGGTTTTATT

TGAAAACCTGACAAAAAAAAAGTTCCAGGTGTGGAATATGGGGGTTAT

CTGTACATCCTGGGGCATTAAAAAAAAAATCAATGGTGGGGAACTATA

AAGAAGTAACAAAAGAAGTGACATCTTCAGCAAATAAACTAGGAAATT

TTTTTTTCTTCCAGTTTAGAATCAGCCTTGAAACATTGATGGAATAACTC

TGTGGCATTATTGCATTATATACCATTTATCTGTATTAACTTTGGAATGT

ACTCTGTTCAATGTTTAATGCTGTGGTTGATATTTCGAAAGCTGCTTTAA

AAAAATACATGCATCTCAGCGTTTTTTTGTTTTTAATTGTATTTAGTTAT

GGCCTATACACTATTTGTGAGCAAAGGTGATCGTTTTCTGTTTGAGATTT

TTATCTCTTGATTCTTCAAAAGCATTCTGAGAAGGTGAGATAAGCCCTG

AGTCTCAGCTACCTAAGAAAAACCTGGATGTCACTGGCCACTGAGGAG

CTTTGTTTCAACCAAGTCATGTGCATTTCCACGTCAACAGAATTGTTTAT

TGTGACAGTTATATCTGTTGTCCCTTTGACCTTGTTTCTTGAAGGTTTCC

TCGTCCCTGGGCAATTCCGCATTTAATTCATGGTATTCAGGATTACATGC

ATGTTTGGTTAAACCCATGAGATTCATTCAGTTAAAAATCCAGATGGCA

AATGACCAGCAGATTCAAATCTATGGTGGTTTGACCTTTAGAGAGTTGC

TTTACGTGGCCTGTTTCAACACAGACCCACCCAGAGCCCTCCTGCCCTC

CTTCCGCGGGGGCTTTCTCATGGCTGTCCTTCAGGGTCTTCCTGAAATGC

AGTGGTGCTTACGCTCCACCAAGAAAGCAGGAAACCTGTGGTATGAAG

CCAGACCTCCCCGGCGGGCCTCAGGGAACAGAATGATCAGACCTTTGA

ATGATTCTAATTTTTAAGCAAAATATTATTTTATGAAAGGTTTACATTGT

CAAAGTGATGAATATGGAATATCCAATCCTGTGCTGCTATCCTGCCAAA

ATCATTTTAATGGAGTCAGTTTGCAGTATGCTCCACGTGGTAAGATCCT

CCAAGCTGCTTTAGAAGTAACAATGAAGAACGTGGACGTTTTTAATATA

AAGCCTGTTTTGTCTTTTGTTGTTGTTCAAACGGGATTCACAGAGTATTT

GAAAAATGTATATATATTAAGAGGTCACGGGGGCTAATTGCTGGCTGG

CTGCCTTTTGCTGTGGGGTTTTGTTACCTGGTTTTAATAACAGTAAATGT

GCCCAGCCTCTTGGCCCCAGAACTGTACAGTATTGTGGCTGCACTTGCT

CTAAGAGTAGTTGATGTTGCATTTTCCTTATTGTTAAAAACATGTTAGA

AGCAATGAATGTATATAAAAGCCTCAACTAGTCATTTTTTTCTCCTCTTC

TTTTTTTTCATTATATCTAATTATTTTGCAGTTGGGCAACAGAGAACCAT

CCCTATTTTGTATTGAAGAGGGATTCACATCTGCATCTTAACTGCTCTTT

ATGAATGAAAAAACAGTCCTCTGTATGTACTCCTCTTTACACTGGCCAG

GGTCAGAGTTAAATAGAGTATATGCACTTTCCAAATTGGGGACAAGGG

CTCTAAAAAAAGCCCCAAAAGGAGAAGAACATCTGAGAACCTCCTCGG CCCTCCCAGTCCCTCGCTGCACAAATACTCCGCAAGAGAGGCCAGAATG

ACAGCTGACAGGGTCTATGGCCATCGGGTCGTCTCCGAAGATTTGGCAG

GGGCAGAAAACTCTGGCAGGCTTAAGATTTGGAATAAAGTCACAGAAT

TAAGGAAGCACCTCAATTTAGTTCAAACAAGACGCCAACATTCTCTCCA

CAGCTCACTTACCTCTCTGTGTTCAGATGTGGCCTTCCATTTATATGTGA

TCTTTGTTTTATTAGTAAATGCTTATCATCTAAAGATGTAGCTCTGGCCC

AGTGGGAAAAATTAGGAAGTGATTATAAATCGAGAGGAGTTATAATAA

TCAAGATTAAATGTAAATAATCAGGGCAATCCCAACACATGTCTAGCTT

TCACCTCCAGGATCTATTGAGTGAACAGAATTGCAAATAGTCTCTATTT

GTAATTGAACTTATCCTAAAACAAATAGTTTATAAATGTGAACTTAAAC

TCTAATTAATTCCAACTGTACTTTTAAGGCAGTGGCTGTTTTTAGACTTT

CTTATCACTTATAGTTAGTAATGTACACCTACTCTATCAGAGAAAAACA

GGAAAGGCTCGAAATACAAGCCATTCTAAGGAAATTAGGGAGTCAGTT

GAAATTCTATTCTGATCTTATTCTGTGGTGTCTTTTGCAGCCCAGACAAA

TGTGGTTACACACTTTTTAAGAAATACAATTCTACATTGTCAAGCTTATG

AAGGTTCCAATCAGATCTTTATTGTTATTCAATTTGGATCTTTCAGGGAT

TTTTTTTTTAAATTATTATGGGACAAAGGACATTTGTTGGAGGGGTGGG

AGGGAGGAAGAATTTTTAAATGTAAAACATTCCCAAGTTTGGATCAGG

GAGTTGGAAGTTTTCAGAATAACCAGAACTAAGGGTATGAAGGACCTG

TATTGGGGTCGATGTGATGCCTCTGCGAAGAACCTTGTGTGACAAATGA

GAAACATTTTGAAGTTTGTGGTACGACCTTTAGATTCCAGAGACATCAG

CATGGCTCAAAGTGCAGCTCCGTTTGGCAGTGCAATGGTATAAATTTCA

AGCTGGATATGTCTAATGGGTATTTAAACAATAAATGTGCAGTTTTAAC

TAACAGGATATTTAATGACAACCTTCTGGTTGGTAGGGACATCTGTTTC

TAAATGTTTATTATGTACAATACAGAAAAAAATTTTATAAAATTAAGCA

ATGTGAAACTGAATTGGAGAGTGATAATACAAGTCCTTTAGTCTTACCC

AGTGAATCATTCTGTTCCATGTCTTTGGACAACCATGACCTTGGACAAT

CATGAAATATGCATCTCACTGGATGCAAAGAAAATCAGATGGAGCATG

AATGGTACTGTACCGGTTCATCTGGACTGCCCCAGAAAAATAACTTCAA

GCAAACATCCTATCAACAACAAGGTTGTTCTGCATACCAAGCTGAGCAC

AGAAGATGGGAACACTGGTGGAGGATGGAAAGGCTCGCTCAATCAAGA

AAATTCTGAGACTATTAATAAATAAGACTGTAGTGTAGATACTGAGTAA

ATCCATGCACCTAAACCTTTTGGAAAATCTGCCGTGGGCCCTCCAGATA

GCTCATTTCATTAAGTTTTTCCCTCCAAGGTAGAATTTGCAAGAGTGAC

AGTGGATTGCATTTCTTTTGGGGAAGCTTTCTTTTGGTGGTTTTGTTTAT

TATACCTTCTTAAGTTTTCAACCAAGGTTTGCTTTTGTTTTGAGTTACTG

GGGTTATTTTTGTTTTAAATAAAAATAAGTGTACAATAAGTGTTTTTGTA

TTGAAAGCTTTTGTTATCAAGATTTTCATACTTTTACCTTCCATGGCTCT

TTTTAAGATTGATACTTTTAAGAGGTGGCTGATATTCTGCAACACTGTA

CACATAAAAAATACGGTAAGGATACTTTACATGGTTAAGGTAAAGTAA

GTCTCCAGTTGGCCACCATTAGCTATAATGGCACTTTGTTTGTGTTGTTG

GAAAAAGTCACATTGCCATTAAACTTTCCTTGTCTGTCTAGTTAATATTG

TGAAGAAAAATAAAGTACAGTGTGAGATACTG

NM_001012271 CCCAGAAGGCCGCGGGGGGTGGACCGCCTAAGAGGGCGTGCGCTCCCG 152

ACATGCCCCGCGGCGCGCCATTAACCGCCAGATTTGAATCGCGGGACCC

GTTGGCAGAGGTGGCGGCGGCGGCATGGGTGCCCCGACGTTGCCCCCT

GCCTGGCAGCCCTTTCTCAAGGACCACCGCATCTCTACATTCAAGAACT

GGCCCTTCTTGGAGGGCTGCGCCTGCACCCCGGAGCGGATGGCCGAGG

CTGGCTTCATCCACTGCCCCACTGAGAACGAGCCAGACTTGGCCCAGTG

TTTCTTCTGCTTCAAGGAGCTGGAAGGCTGGGAGCCAGATGACGACCCC

ATTGGGCCGGGCACGGTGGCTTACGCCTGTAATACCAGCACTTTGGGAG

GCCGAGGCGGGCGGATCACGAGAGAGGAACATAAAAAGCATTCGTCCG

GTTGCGCTTTCCTTTCTGTCAAGAAGCAGTTTGAAGAATTAACCCTTGGT

GAATTTTTGAAACTGGACAGAGAAAGAGCCAAGAACAAAATTGCAAAG

GAAACCAACAATAAGAAGAAAGAATTTGAGGAAACTGCGGAGAAAGT

GCGCCGTGCCATCGAGCAGCTGGCTGCCATGGATTGAGGCCTCTGGCCG GAGCTGCCTGGTCCCAGAGTGGCTGCACCACTTCCAGGGTTTATTCCCT

GGTGCCACCAGCCTTCCTGTGGGCCCCTTAGCAATGTCTTAGGAAAGGA

GATCAACATTTTCAAATTAGATGTTTCAACTGTGCTCTTGTTTTGTCTTG

AAAGTGGCACCAGAGGTGCTTCTGCCTGTGCAGCGGGTGCTGCTGGTAA

CAGTGGCTGCTTCTCTCTCTCTCTCTCTTTTTTGGGGGCTCATTTTTGCTG

TTTTGATTCCCGGGCTTACCAGGTGAGAAGTGAGGGAGGAAGAAGGCA

GTGTCCCTTTTGCTAGAGCTGACAGCTTTGTTCGCGTGGGCAGAGCCTT

CCACAGTGAATGTGTCTGGACCTCATGTTGTTGAGGCTGTCACAGTCCT

GAGTGTGGACTTGGCAGGTGCCTGTTGAATCTGAGCTGCAGGTTCCTTA

TCTGTCACACCTGTGCCTCCTCAGAGGACAGTTTTTTTGTTGTTGTGTTT

TTTTGTTTTTTTTTTTTTGGTAGATGCATGACTTGTGTGTGATGAGAGAA

TGGAGACAGAGTCCCTGGCTCCTCTACTGTTTAACAACATGGCTTTCTT

ATTTTGTTTGAATTGTTAATTCACAGAATAGCACAAACTACAATTAAAA

CTAAGCACAAAGCCATTCTAAGTCATTGGGGAAACGGGGTGAACTTCA

GGTGGATGAGGAGACAGAATAGAGTGATAGGAAGCGTCTGGCAGATAC

TCCTTTTGCCACTGCTGTGTGATTAGACAGGCCCAGTGAGCCGCGGGGC

ACATGCTGGCCGCTCCTCCCTCAGAAAAAGGCAGTGGCCTAAATCCTTT

TTAAATGACTTGGCTCGATGCTGTGGGGGACTGGCTGGGCTGCTGCAGG

CCGTGTGTCTGTCAGCCCAACCTTCACATCTGTCACGTTCTCCACACGG

GGGAGAGACGCAGTCCGCCCAGGTCCCCGCTTTCTTTGGAGGCAGCAG

CTCCCGCAGGGCTGAAGTCTGGCGTAAGATGATGGATTTGATTCGCCCT

CCTCCCTGTCATAGAGCTGCAGGGTGGATTGTTACAGCTTCGCTGGAAA

CCTCTGGAGGTCATCTCGGCTGTTCCTGAGAAATAAAAAGCCTGTCATT

TCAAACACTGCTGTGGACCCTACTGGGTTTTTAAAATATTGTCAGTTTTT

CATCGTCGTCCCTAGCCTGCCAACAGCCATCTGCCCAGACAGCCGCAGT

GAGGATGAGCGTCCTGGCAGAGACGCAGTTGTCTCTGGGCGCTTGCCA

GAGCCACGAACCCCAGACCTGTTTGTATCATCCGGGCTCCTTCCGGGCA

GAAACAACTGAAAATGCACTTCAGACCCACTTATTTCTGCCACATCTGA

GTCGGCCTGAGATAGACTTTTCCCTCTAAACTGGGAGAATATCACAGTG

GTTTTTGTTAGCAGAAAATGCACTCCAGCCTCTGTACTCATCTAAGCTG

CTTATTTTTGATATTTGTGTCAGTCTGTAAATGGATACTTCACTTTAATA

ACTGTTGCTTAGTAATTGGCTTTGTAGAGAAGCTGGAAAAAAATGGTTT

TGTCTTCAACTCCTTTGCATGCCAGGCGGTGATGTGGATCTCGGCTTCTG

TGAGCCTGTGCTGTGGGCAGGGCTGAGCTGGAGCCGCCCCTCTCAGCCC

GCCTGCCACGGCCTTTCCTTAAAGGCCATCCTTAAAACCAGACCCTCAT

GGCTACCAGCACCTGAAAGCTTCCTCGACATCTGTTAATAAAGCCGTAG

GCCCTTGTCTAAGTGCAACCGCCTAGACTTTCTTTCAGATACATGTCCAC

ATGTCCATTTTTCAGGTTCTCTAAGTTGGAGTGGAGTCTGGGAAGGGTT

GTGAATGAGGCTTCTGGGCTATGGGTGAGGTTCCAATGGCAGGTTAGA

GCCCCTCGGGCCAACTGCCATCCTGGAAAGTAGAGACAGCAGTGCCCG

CTGCCCAGAAGAGACCAGCAAGCCAAACTGGAGCCCCCATTGCAGGCT

GTCGCCATGTGGAAAGAGTAACTCACAATTGCCAATAAAGTCTCATGTG

GTTTTATCTAAAAAAAAAAAAAAAAAAAAAAAAA

AATGAGGGTATTTATAAACTACTTAAATTATAAAAAGAATGAGACATC 153

AGACTTACAGTTTTGGATACTAATTTTTTTCACTTAACGTTCATTATGTG

ATAGGAGTTTTCCATCCTATTATACCGCTGTGCGATCTGATCTTGGGCAC

GTTAACCAACCTCTTGTTGCCTCGATTTTCTCACCTGTAAAAGTGGGGGT

AATCATAATGCTTACTTAGTAGGATAGCCCTGAAGAATAAGTGACTTAG

CGAACATAAATAGCTTACAATAGGGTTTTCAGCATGGGAAGGATTCAGT

AAATGTTAGCTGTCATCATCACCACCTACAAAGGAAGCAATACTGTGCT

GAAAGTTTTTCCATCATTAATGTAATTTCTATAGTACGATTCCCAAGAA

GATATTAAAATTATGGAAATAAAGGTATTGGTATATTCCTAATTATTTC

CTAAAAGATTGTATTGATAAATATGCTCATCCTTCCCTTAACGGGATGC

ATTCCAGAAAAACAAGTCAAATGTTAGACAAAGTATCAGAAGGGAAAT

TCTGTAGCCAGAGAGCTAAAAATTACAATAGGGTCTCTAATTATACTTC

AACTTTTTTAGGAATAATTCTCAGTGTGTTTTCCCACATTTCATATGTAA TTTTTTTTTTTTTTTTTTTTTGAGACAGAGCCTCGCCCTGTCACCAGGCTG

GAGTACAGTGGCGCGATCTCGGCTCACTGCAACTTCCACCTGCTGGGTT

CAAGCAATTCTTCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAA

GTGCTGGGATTATAACAGGCGTGGCATGAGTCACCGCGCCCGGCCGAT

CTTTACTTTTTTATTCTTTGTACCCCCTGCCTATCCAGTTAGCATGTGATT

AAAGTCAAAGATTTGCCACTTTGGGCCACATCTATTAATTTTCATCTTTG

TTATAATTGTATTTAGTTTTTGATCTACACTGCTTATTACTCCCAGTCATT

TTTTATAGAACTGAAAATCTGGTAAAATACTCAAAATTGCACTGACTTC

TATGTAGAGGCGACACTCCATCAGAACCGTGGGCTGACAGGGAATCCC

ACTGTGCAGGAGCTGCGCGCATTTTCATTTCTGATTCTCTTTGGCGTATC

CAGGACTCTGATGACATGATCATATATTTATCAGTAGTAACAGGTTGGG

CCATTTGTTTTTTGTGGTAAATCATATATTTAAGATTTTAGAAATAAGTT

GATAGCCATGTATTTTGGAATTTGAAAAAGACATTGCATTACTCAGCTT

CAAATTAAGCTTTAATCAAATAGTGAAACTTTCCATTAATGGACAGTGT

ATACCTTTTTGTGTATTTAAAAAAAAAAACACTGAATATAGTGCCTTTG

TGACAGGGGAGCTTGGTTCCTGACAATGTCCTCTTGAGCCTTTTTTTTTT

TTTTGAGATGGAGTCTCACTGTGTCACCCAGGCTGGAGTGCAGTGGCGC

CATCTTGGCTCACTGCAACCTCCGCCCCCTGGGTTCAAGTGATTCTCATT

CCTCAGCTTCCTAAGTAGCTGGGATTACAGGCACGCACCACCATGACCA

GCTAATTTTTATACTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCTAGG

TTGGTCTCGAACTCCTGACCTCAAGTAATCCACCCACCATGGCCTCCCC

AAAGTGCTGGGATTACAGGCGTGAGCCATTTCACCCGGCCTCTCTTCCG

TCTTTGAGCTGTGAGGAAATAGCTACATTACATGAGCTGCTAGATCTGC

CTTATGGTCAGAAATGAAGGTTGAACTCTCAGGAACAGTGACATATATA

CACACTGATATTTCCAAAGTACAATGCCCCAAATTGATCCACAAAGGAA

TTAAGGTCATTTGCAACAAAATCACAGAATAGTAACAAATAAATAGAA

GATAAATATGGCCAGGGATGCTGCAAACTGATATACTGCCAAGTTTATC

AGTTGGGAATCCCAACAGTGAAAAGCATAAAAATGAAAGGAATTTTAA

GGAGACTTTTTATAGAAGAGTGGGAAGGATTGGAGGAGCCAACAAGTG

ATGGTGAGGCACACAGGGAAGAGCTTCAGTGGGCACCATCCCCTCTCT

GGTTTGAAGGGGTAGGGAGGGGACCAGAGCTGGGAGGAGGGGGCTGG

AATACTGCTGGAGGAGCCACTCCCTTCCAGACCTGCTGTGGCCATCACA

GAATGCAGCCACTGCCAGAGCAGCAGCCCGAGGAACCAGGCAGGGGG

AGCACAAGTACCCTAGCCTCTCTCTTTCTGTTTCTTGCCTGCCGATCTCC

TCCACTGGCTAAACCCAGCTGGATGCTAAGAGTACAGTCAGCCTGCCTG

CTGAGGAGGGACCACCAGGGACCACCATCAGCAAGGGATCCAATGTCT

TTCTGCCTCTGCAGAATGAAGGTTGGGGCGCGGGGGGCGCTCTACTTCT

TAGGGATATTGTGGGAATAAAAGGAAATAGGCAAAAAATGTTTTTGAA

AAACAAAGCACATACTGCGCACCCGTGGGCCACTACTGCTTTTGACCCC

TGGCTCTGTTTCATGAAGTAATGTCGTGTCATTCTCTTTTTAGGTGCTAC

AGGATTTCTTTAGGTTTGTTTTCTGTCCACCATATTTCAACTCATGTGTG

CTGTTTGTTGTGCTAAAACAAATATTTGCTGATGCCTGAGTGAATAGTT

GAATATTTTATATAAGTCAAATTTATACGTAATGATTTTTCTTGTAACTT

AGCCGTTTCTCTTTTACAAACTCAGAAAACCTCAGACTTTGAAAAGGCC

TTGAAGTTCCTCACCTGAAATCTGAGAACTTGGAGCGCCTTAAAAAATC

TAAAGGAAAACAAAACAGTGAAAGAACATGATATAGTCAGTGTAGAGA

ATAAAATTATTTATGTAATTAATATTGAGGATGCAGATAACACATTGTG

AAATCTTGCTTGTAAAAAATCTCGATCTGCTGAAGAAAGATGTTCTCTC

TAGAGATCTTTGAAAGCATAATTATTGAGCTTTTAAAATGTTAGAAACA

AAAGTTAGACCCACACATATTCTGGCGTGTGGAAGATTTGCATTCCTTC

CCCTGCCCGCCCCGCCCCCACACTTGTGAGTTGTGCCTGTGTACGCAGT

TCCTGTAGCACTCGGCTGGGCAGAAATCATCTTTCAGCACTAAGGGAAC

ATAGTTATGATCTGGACCTTCTGGGAGTGGTCAGTGCCCAAGAACAGGT

ATGGGACTCCAGAAAGTTCTGCTCTCAACCCTATTTTGAAATAGAGTTA

CACATTGTTCTACAATTATTTGAGTTAATAAGCAGCTCTTTTCAAACGTG

ATTATGCCCTTCCAAGTTTAAATACACTAGACTTTAGTGAAAGTAATTG ACCTCATCTCATTTCTCTCCTGTTATATTAAGATCACTTTCAGTAAAAGG

TAGAAGCTTTTGAAGTGGTGAGGAGGAGGTAGAGGAGGGACATAGAGC

AGATAGGGGCTGGAAAGTGGGGTGAGGAAGAGAGTGGCTTCTCTTTGG

CAGAGTACCAAGGAAAAGCCCTATCTGTACAGAACCTTTGTGCCTGGG

AACTTGATGGCTGCAACCTGAGCCTCAACCTAGTTTGCTTGCGGAGCCA

GAAGAGAAGCTAAAAACCTTCAGTTAACCAAGCCAGACACCAAGAAAG

TTAAACCGAAAGAGAACCCCCCACCCCCCGCAAAAAAAAGAAGTAAAG

TGGGTTAAAGTGATATCATGTTAGCACAGAAAGAGAACATAAGGGTCA

TCTAAGTTCATCTGCCCCCTCTTCTATTTCAAGGTGCAGAAACTAAGGC

ACAAGGGACCCCGTGTCCTGCTCTTGATCACATAGCTAGTGGGTGCCAA

GCCAGGTCTAGAACTCTGTTCTCTGGGGTCACAGGCTGGCTCTTCATCC

CTCTAGAGAGATAGCTCATCTGTGTGCACCTGAGCCCGTTGTGTTTCGG

AGTCAAAGCAAATAAAGGCTCAAACTCCAAGACTGTTTTGCAGACCGG

CTGCAGTAGATATGGGGGGAGGAGAAACCTGCTTTAAATTGCTTCAAG

CAAGTTGTTTCTGCAAAGGTGTTGACTTTTTTCTTTCAACTTTCTAGTGA

GTCACTGCAGCCTGAGCTGTTATTTGTCATTATGCAATAATTCAGGAAC

TAACTCAAGATTCTTCTTTTTAAATTATTTGTTTATTTAGAGACAGAGTC

TTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCGGCTCACTG

CAGCCTCTGCCTCCTGGGTTCAAGCAATTCTCATGTCTCAGCCTCCCGA

ATAGCTGGTATTGCAGGCTCGTGCCACCACCCCCTGCTAATTTTTGTAAT

TTTAGTGGAGACACGGTTTCGCCATGTTGGCCGGGCTCGTCTTGAGCTC

CTGGCCTCAGGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTG

CAGCCGTGAGCCTCCACACCCGGCCTATTTATTTATTTTTAAATTGGCTG

CTCTTAGAAAGGCATACCATGTTTCTGGATGGGAAGGCTTATTAATTCA

CCCTAATTTAATGTATAAATTTGATGCAATCATAGTCACAGTCCCAGTG

GAATTTTTTAACTTGGTAAGATGTTCTAAAATTAATGAGAGAACTTGAA

TTACCAGGTATTGAAACACTGTAAAGCCACAATCATGTAAACAGTATGT

TATAACCATGGGAATAGAGGTCTGTGATACAGCAGAAAAAAGTGAAAA

AAAGAATAACTGTATTCATAAAAATTTAAATGTGGAGTCACTGGGGGA

AAGGATTAAATATTCGATAATGTAGAAACAACTCAACTATTTGGAGAA

ATGTAAATTTAGAGCCTTATCTCATGCCATATACCAAAATACTATTTAG

ATTTGATTAAAAAATAAAAAAAAAAAAAAAAAAA

NM_031966 CGAACGCCTTCGCGCGATCGCCCTGGAAACGCATTCTCTGCGACCGGCA 154

GCCGCCAATGGGAAGGGAGTGAGTGCCACGAACAGGCCAATAAGGAG

GGAGCAGTGCGGGGTTTAAATCTGAGGCTAGGCTGGCTCTTCTCGGCGT

GCTGCGGCGGAACGGCTGTTGGTTTCTGCTGGGTGTAGGTCCTTGGCTG

GTCGGGCCTCCGGTGTTCTGCTTCTCCCCGCTGAGCTGCTGCCTGGTGA

AGAGGAAGCCATGGCGCTCCGAGTCACCAGGAACTCGAAAATTAATGC

TGAAAATAAGGCGAAGATCAACATGGCAGGCGCAAAGCGCGTTCCTAC

GGCCCCTGCTGCAACCTCCAAGCCCGGACTGAGGCCAAGAACAGCTCTT

GGGGACATTGGTAACAAAGTCAGTGAACAACTGCAGGCCAAAATGCCT

ATGAAGAAGGAAGCAAAACCTTCAGCTACTGGAAAAGTCATTGATAAA

AAACTACCAAAACCTCTTGAAAAGGTACCTATGCTGGTGCCAGTGCCAG

TGTCTGAGCCAGTGCCAGAGCCAGAACCTGAGCCAGAACCTGAGCCTG

TTAAAGAAGAAAAACTTTCGCCTGAGCCTATTTTGGTTGATACTGCCTC

TCCAAGCCCAATGGAAACATCTGGATGTGCCCCTGCAGAAGAAGACCT

GTGTCAGGCTTTCTCTGATGTAATTCTTGCAGTAAATGATGTGGATGCA

GAAGATGGAGCTGATCCAAACCTTTGTAGTGAATATGTGAAAGATATTT

ATGCTTATCTGAGACAACTTGAGGAAGAGCAAGCAGTCAGACCAAAAT

ACCTACTGGGTCGGGAAGTCACTGGAAACATGAGAGCCATCCTAATTG

ACTGGCTAGTACAGGTTCAAATGAAATTCAGGTTGTTGCAGGAGACCAT

GTACATGACTGTCTCCATTATTGATCGGTTCATGCAGAATAATTGTGTG

CCCAAGAAGATGCTGCAGCTGGTTGGTGTCACTGCCATGTTTATTGCAA

GCAAATATGAAGAAATGTACCCTCCAGAAATTGGTGACTTTGCTTTTGT

GACTGACAACACTTATACTAAGCACCAAATCAGACAGATGGAAATGAA

GATTCTAAGAGCTTTAAACTTTGGTCTGGGTCGGCCTCTACCTTTGCACT TCCTTCGGAGAGCATCTAAGATTGGAGAGGTTGATGTCGAGCAACATAC

TTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATGACATGGTG

CACTTTCCTCCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAA

AATTCTGGATAATGGTGAATGGACACCAACTCTACAACATTACCTGTCA

TATACTGAAGAATCTCTTCTTCCAGTTATGCAGCACCTGGCTAAGAATG

TAGTCATGGTAAATCAAGGACTTACAAAGCACATGACTGTCAAGAACA

AGTATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGA

ATTCTGCACTAGTTCAAGATTTAGCCAAGGCTGTGGCAAAGGTGTAACT

TGTAAACTTGAGTTGGAGTACTATATTTACAAATAAAATTGGCACCATG

TGCCATCTGTACATATTACTGTTGCATTTACTTTTAATAAAGCTTGTGGC

CCCTTTTACTTTTTTATAGCTTAACTAATTTGAATGTGGTTACTTCCTACT

GTAGGGTAGCGGAAAAGTTGTCTTAAAAGGTATGGTGGGGATATTTTTA

AAAACTCCTTTTGGTTTACCTGGGGATCCAATTGATGTATATGTTTATAT

ACTGGGTTCTTGTTTTATATACCTGGCTTTTACTTTATTAATATGAGTTA

CTGAAGGTGATGGAGGTATTTGAAAATTTTACTTCCATAGGACATACTG

CATGTAAGCCAAGTCATGGAGAATCTGCTGCATAGCTCTATTTTAAAGT

AAAAGTCTACCACCGAATCCCTAGTCCCCCTGTTTTCTGTTTCTTCTTGT

GATTGCTGCCATAATTCTAAGTTATTTACTTTTACCACTATTTAAGTTAT

CAACTTTAGCTAGTATCTTCAAACTTTCACTTTGAAAAATGAGAATTTTA

TATTCTAAGCCAGTTTTCATTTTGGTTTTGTGTTTTGGTTAATAAAACAA

TACTCAAATACAAAAAAAAAAAA

GCGGCCGCCAGCGCGGTGTAGGGGGCAGGCGCGGATCCCGCCACCGCC 155

GCGCGCTCGGCCCGCCGACTCCCGGCGCCGCCGCCGCCACTGCCGTCGC

CGCCGCCGCCTGCCGGGACTGGAGCGCGCCGTCCGCCGCGGACAAGAC

CCTGGCCTCAGGCCGGAGCAGCCCCATCATGCCGAGGGAGCGCAGGGA

GCGGGATGCGAAGGAGCGGGACACCATGAAGGAGGACGGCGGCGCGG

AGTTCTCGGCTCGCTCCAGGAAGAGGAAGGCAAACGTGACCGTTTTTTT

GCAGGATCCAGATGAAGAAATGGCCAAAATCGACAGGACGGCGAGGG

ACCAGTGTGGGAGCCAGCCTTGGGACAATAATGCAGTCTGTGCAGACC

CCTGCTCCCTGATCCCCACACCTGACAAAGAAGATGATGACCGGGTTTA

CCCAAACTCAACGTGCAAGCCTCGGATTATTGCACCATCCAGAGGCTCC

CCGCTGCCTGTACTGAGCTGGGCAAATAGAGAGGAAGTCTGGAAAATC

ATGTTAAACAAGGAAAAGACATACTTAAGGGATCAGCACTTTCTTGAG

CAACACCCTCTTCTGCAGCCAAAAATGCGAGCAATTCTTCTGGATTGGT

TAATGGAGGTGTGTGAAGTCTATAAACTTCACAGGGAGACCTTTTACTT

GGCACAAGATTTCTTTGACCGGTATATGGCGACACAAGAAAATGTTGTA

AAAACTCTTTTACAGCTTATTGGGATTTCATCTTTATTTATTGCAGCCAA

ACTTGAGGAAATCTATCCTCCAAAGTTGCACCAGTTTGCGTATGTGACA

GATGGAGCTTGTTCAGGAGATGAAATTCTCACCATGGAATTAATGATTA

TGAAGGCCCTTAAGTGGCGTTTAAGTCCCCTGACTATTGTGTCCTGGCT

GAATGTATACATGCAGGTTGCATATCTAAATGACTTACATGAAGTGCTA

CTGCCGCAGTATCCCCAGCAAATCTTTATACAGATTGCAGAGCTGTTGG

ATCTCTGTGTCCTGGATGTTGACTGCCTTGAATTTCCTTATGGTATACTT

GCTGCTTCGGCCTTGTATCATTTCTCGTCATCTGAATTGATGCAAAAGGT

TTCAGGGTATCAGTGGTGCGACATAGAGAACTGTGTCAAGTGGATGGTT

CCATTTGCCATGGTTATAAGGGAGACGGGGAGCTCAAAACTGAAGCAC

TTCAGGGGCGTCGCTGATGAAGATGCACACAACATACAGACCCACAGA

GACAGCTTGGATTTGCTGGACAAAGCCCGAGCAAAGAAAGCCATGTTG

TCTGAACAAAATAGGGCTTCTCCTCTCCCCAGTGGGCTCCTCACCCCGC

CACAGAGCGGTAAGAAGCAGAGCAGCGGGCCGGAAATGGCGTGACCA

CCCCATCCTTCTCCACCAAAGACAGTTGCGCGCCTGCTCCACGTTCTCTT

CTGTCTGTTGCAGCGGAGGCGTGCGTTTGCTTTTACAGATATCTGAATG

GAAGAGTGTTTCTTCCACAACAGAAGTATTTCTGTGGATGGCATCAAAC

AGGGCAAAGTGTTTTTTATTGAATGCTTATAGGTTTTTTTTAAATAAGTG

GGTCAAGTACACCAGCCACCTCCAGACACCAGTGCGTGCTCCCGATGCT

GCTATGGAAGGTGCTACTTGACCTAAGGGACTCCCACAACAACAAAAG CTTGAAGCTGTGGAGGGCCACGGTGGCGTGGCTCTCCTCGCAGGTGTTC

TGGGCTCCGTTGTACCAAGTGGAGCAGGTGGTTGCGGGCAAGCGTTGTG

CAGAGCCCATAGCCAGCTGGGCAGGGGGCTGCCCTCTCCACATTATCAG

TTGACAGTGTACAATGCCTTTGATGAACTGTTTTGTAAGTGCTGCTATAT

CTATCCATTTTTTAATAAAGATAATACTGTTTTTGAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAA

BG256659 GAGGGCACGGGCTCCGTAGGCACCAACTGCAAGGACCCCTCCCCCTGC 156

GGGCGCTCCCATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTG

CTTCAGCTGGATGCACCCATCCCCAATGCACCCCCTGCGCGCTGGCAGC

GCAAAGCCAAGGAAGCCGCAGGCCCGGCCCCCTCACCCATGCGGGCCG

CCAACCGATCCCACAGCGCCGGCAGGACTCCGGGCCGAACTCCTGGCA

AATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCG

CTATATCCCCCATCGCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCCTC

CTGAGCAAGGAGAACCAGCCTGAAAACAGCCAGACGCCCACCAAGAA

GGAACATCAGAAAGCCTGGGCTTTGAACCTGAACGGTTTTGATGTAGA

GGAAGCCAAGATCCTTCGGCTCAGTGGAAAAACCACAAAAATGCGCCA

GAGGGTTATCACGAACAGACTGAAAGTACTCTACAGCCAAAAGGCCAC

TCCTGGCTCCAGCCGGAAGACCTGCCGTTTACATTCCTTCCCTGCCAAG

ACCGTATCCTGGATGCGCCTGAAATCGAATGACTATTAACTGAACCTGT

GGGACTGGCAGTCCGGGGAATGTCCGGGCCGGGCCACGGCCACGAGGT

GTTCCGTGTGGAGTGCAAGCTGGGACACACCGTGCCGCTTGTGCACAGG

GCCACGCGGGGAAATAATCCCGGGGCGCGCAAAGCGGCACTGGCGAGA

GCCGCACGGGCCGGTGCTGGGGGTGGTACAACAGGCCAAAACAACACA

CAAGGCCAACAAGACATACGCGCGCTGACACCACGGTGCAAAGCGCTC

AGACGAGTAGTAACCGGCACTGTGGTTGCTGCCTCCCCACCTCTCCCGC

TCTCAGCGTAAGATAAAAGAAAGAAGAGCAAAAAGCAAAGAAAGAAG

ACGAGACGAGACACACAGGAACGAACAGTAAAGCAAGCTAAAGCAAA

CGCAAGACCAGACAACAGAAATAGAAAGAACCAACAGAGAGGAGACA

GAACAGGACGCCAGCAACATAGCAACAAACGAACAGAAGAGAGCACT

AAACAAAAGCAGCAGCAAGACGAGACAGGAGAGAAGGAGGAAGGAG

GGCCGAGCGAGCAGGGAGCGCGAGCAGCGAGGCGAAGCAGCAGACAA

GGGCAGGCGAAGGGCAACGAGAGGAGGCACCACACAAAAAGGAGAGG

GGACAGGAGAAGCAGCGAGAGAAGCGGAGGAGCAACAAGAGGAAGA

AAAGGAGAGGGAGAGGAGGGAGAGAGCGGAAGGAGGAAGAAACAGC

ACGAGGCGACGAAGGGGGGAGACGCGGGGGCAGGAAAAGACACAGGA

AGGCAGCGCGGAGGAGGAGAAGGGGAAGCAGGAAGGAGACGGAAGG

AGAAGAGGGAGAGGACAGCGCAAGAGAGCGCGCGCGGCGACAGCGAG

GGACGGAGCGAGAGAGAGGAAACGGAAAGCGAGAGGGAAGAGGAGA

GGCAACGCAGCGAACCAACCGAAAACAGCAGAAAGAGAGGAGAAGGA

CGCGCAAAGAGGCAAGCGCAAGACGACAGGAAACGAAGCGAGAGACG

AGAAGCCGGTGACGAGCAGGAGAAAGGGAAGGCAGGAGACAGGACAG

GCGGAAGAGAGACACGCGAGACGCAAAGAGTGAGCAGAACGAAGCGA

AGAGCAACGCACGAGAGAAACGAC

NM_001254 GAGCGCGGCTGGAGTTTGCTGCTGCCGCTGTGCAGTTTGTTCAGGGGCT 157

TGTGGTGGTGAGTCCGAGAGGCTGCGTGTGAGAGACGTGAGAAGGATC

CTGCACTGAGGAGGTGGAAAGAAGAGGATTGCTCGAGGAGGCCTGGGG

TCTGTGAGGCAGCGGAGCTGGGTGAAGGCTGCGGGTTCCGGCGAGGCC

TGAGCTGTGCTGTCGTCATGCCTCAAACCCGATCCCAGGCACAGGCTAC

AATCAGTTTTCCAAAAAGGAAGCTGTCTCGGGCATTGAACAAAGCTAA

AAACTCCAGTGATGCCAAACTAGAACCAACAAATGTCCAAACCGTAAC

CTGTTCTCCTCGTGTAAAAGCCCTGCCTCTCAGCCCCAGGAAACGTCTG

GGCGATGACAACCTATGCAACACTCCCCATTTACCTCCTTGTTCTCCACC

AAAGCAAGGCAAGAAAGAGAATGGTCCCCCTCACTCACATACACTTAA

GGGACGAAGATTGGTATTTGACAATCAGCTGACAATTAAGTCTCCTAGC

AAAAGAGAACTAGCCAAAGTTCACCAAAACAAAATACTTTCTTCAGTT AGAAAAAGTCAAGAGATCACAACAAATTCTGAGCAGAGATGTCCACTG

AAGAAAGAATCTGCATGTGTGAGACTATTCAAGCAAGAAGGCACTTGC

TACCAGCAAGCAAAGCTGGTCCTGAACACAGCTGTCCCAGATCGGCTG

CCTGCCAGGGAAAGGGAGATGGATGTCATCAGGAATTTCTTGAGGGAA

CACATCTGTGGGAAAAAAGCTGGAAGCCTTTACCTTTCTGGTGCTCCTG

GAACTGGAAAAACTGCCTGCTTAAGCCGGATTCTGCAAGACCTCAAGA

AGGAACTGAAAGGCTTTAAAACTATCATGCTGAATTGCATGTCCTTGAG

GACTGCCCAGGCTGTATTCCCAGCTATTGCTCAGGAGATTTGTCAGGAA

GAGGTATCCAGGCCAGCTGGGAAGGACATGATGAGGAAATTGGAAAAA

CATATGACTGCAGAGAAGGGCCCCATGATTGTGTTGGTATTGGACGAG

ATGGATCAACTGGACAGCAAAGGCCAGGATGTATTGTACACGCTATTTG

AATGGCCATGGCTAAGCAATTCTCACTTGGTGCTGATTGGTATTGCTAA

TACCCTGGATCTCACAGATAGAATTCTACCTAGGCTTCAAGCTAGAGAA

AAATGTAAGCCACAGCTGTTGAACTTCCCACCTTATACCAGAAATCAGA

TAGTCACTATTTTGCAAGATCGACTTAATCAGGTATCTAGAGATCAGGT

TCTGGACAATGCTGCAGTTCAATTCTGTGCCCGCAAAGTCTCTGCTGTTT

CAGGAGATGTTCGCAAAGCACTGGATGTTTGCAGGAGAGCTATTGAAA

TTGTAGAGTCAGATGTCAAAAGCCAGACTATTCTCAAACCACTGTCTGA

ATGTAAATCACCTTCTGAGCCTCTGATTCCCAAGAGGGTTGGTCTTATTC

ACATATCCCAAGTCATCTCAGAAGTTGATGGTAACAGGATGACCTTGAG

CCAAGAAGGAGCACAAGATTCCTTCCCTCTTCAGCAGAAGATCTTGGTT

TGCTCTTTGATGCTCTTGATCAGGCAGTTGAAAATCAAAGAGGTCACTC

TGGGGAAGTTATATGAAGCCTACAGTAAAGTCTGTCGCAAACAGCAGG

TGGCGGCTGTGGACCAGTCAGAGTGTTTGTCACTTTCAGGGCTCTTGGA

AGCCAGGGGCATTTTAGGATTAAAGAGAAACAAGGAAACCCGTTTGAC

AAAGGTGTTTTTCAAGATTGAAGAGAAAGAAATAGAACATGCTCTGAA

AGATAAAGCTTTAATTGGAAATATCTTAGCTACTGGATTGCCTTAAATT

CTTCTCTTACACCCCACCCGAAAGTATTCAGCTGGCATTTAGAGAGCTA

CAGTCTTCATTTTAGTGCTTTACACATTCGGGCCTGAAAACAAATATGA

CCTTTTTTACTTGAAGCCAATGAATTTTAATCTATAGATTCTTTAATATT

AGCACAGAATAATATCTTTGGGTCTTACTATTTTTACCCATAAAAGTGA

CCAGGTAGACCCTTTTTAATTACATTCACTACTTCTACCACTTGTGTATC

TCTAGCCAATGTGCTTGCAAGTGTACAGATCTGTGTAGAGGAATGTGTG

TATATTTACCTCTTCGTTTGCTCAAACATGAGTGGGTATTTTTTTGTTTGT

TTTTTTTGTTGTTGTTGTTTTTGAGGCGCGTCTCACCCTGTTGCCCAGGCT

GGAGTGCAATGGCGCGTTCTCTGCTCACTACAGCACCCGCTTCCCAGGT

TGAAGTGATTCTCTTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTG

CCCACCACCGCGCCCAGCTAATTTTTTAATTTTTAGTAGAGACAGGGTT

TTACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCCTCAAGTGATCT

GCCCACCTTGGCCTCCCTAAGTGCTGGGATTATAGGCGTGAGCCACCAT

GCTCAGCCATTAAGGTATTTTGTTAAGAACTTTAAGTTTAGGGTAAGAA

GAATGAAAATGATCCAGAAAAATGCAAGCAAGTCCACATGGAGATTTG

GAGGACACTGGTTAAAGAATTTATTTCTTTGTATAGTATACTATGTTCAT

GGTGCAGATACTACAACATTGTGGCATTTTAGACTCGTTGAGTTTCTTG

GGCACTCCCAAGGGCGTTGGGGTCATAAGGAGACTATAACTCTACAGA

TTGTGAATATATTTATTTTCAAGTTGCATTCTTTGTCTTTTTAAGCAATC

AGATTTCAAGAGAGCTCAAGCTTTCAGAAGTCAATGTGAAAATTCCTTC

CTAGGCTGTCCCACAGTCTTTGCTGCCCTTAGATGAAGCCACTTGTTTCA

AGATGACTACTTTGGGGTTGGGTTTTCATCTAAACACATTTTTCCAGTCT

TATTAGATAAATTAGTCCATATGGTTGGTTAATCAAGAGCCTTCTGGGT

TTGGTTTGGTGGCATTAAATGG

NM_031423 GCGGAATGGGGCGGGACTTCCAGTAGGAGGCGGCAAGTTTGAAAAGTG 158

ATGACGGTTGACGTTTGCTGATTTTTGACTTTGCTTGTAGCTGCTCCCCG

AACTCGCCGTCTTCCTGTCGGCGGCCGGCACTGTAGATTAACAGGAAAC

TTCCAAGATGGAAACTTTGTCTTTCCCCAGATATAATGTAGCTGAGATT

GTGATTCATATTCGCAATAAGATCTTAACAGGAGCTGATGGTAAAAACC TCACCAAGAATGATCTTTATCCAAATCCAAAGCCTGAAGTCTTGCACAT

GATCTACATGAGAGCCTTACAAATAGTATATGGAATTCGACTGGAACAT

TTTTACATGATGCCAGTGAACTCTGAAGTCATGTATCCACATTTAATGG

AAGGCTTCTTACCATTCAGCAATTTAGTTACTCATCTGGACTCATTTTTG

CCTATCTGCCGGGTGAATGACTTTGAGACTGCTGATATTCTATGTCCAA

AAGCAAAACGGACAAGTCGGTTTTTAAGTGGCATTATCAACTTTATTCA

CTTCAGAGAAGCATGCCGTGAAACGTATATGGAATTTCTTTGGCAATAT

AAATCCTCTGCGGACAAAATGCAACAGTTAAACGCCGCACACCAGGAG

GCATTAATGAAACTGGAGAGACTTGATTCTGTTCCAGTTGAAGAGCAAG

AAGAGTTCAAGCAGCTTTCAGATGGAATTCAGGAGCTACAACAATCAC

TAAATCAGGATTTTCATCAAAAAACGATAGTGCTGCAAGAGGGAAATT

CCCAAAAGAAGTCAAATATTTCAGAGAAAACCAAGCGTTTGAATGAAC

TAAAATTGTCGGTGGTTTCTTTGAAAGAAATACAAGAGAGTTTGAAAAC

AAAAATTGTGGATTCTCCAGAGAAGTTAAAGAATTATAAAGAAAAAAT

GAAAGATACGGTCCAGAAGCTTAAAAATGCCAGACAAGAAGTGGTGGA

GAAATATGAAATCTATGGAGACTCAGTTGACTGCCTGCCTTCATGTCAG

TTGGAAGTGCAGTTATATCAAAAGAAAATACAGGACCTTTCAGATAAT

AGGGAAAAATTAGCCAGTATCTTAAAGGAGAGCCTGAACTTGGAGGAC

CAAATTGAGAGTGATGAGTCAGAACTGAAGAAATTGAAGACTGAAGAA

AATTCGTTCAAAAGACTGATGATTGTGAAGAAGGAAAAACTTGCCACA

GCACAATTCAAAATAAATAAGAAGCATGAAGATGTTAAGCAATACAAA

CGCACAGTAATTGAGGATTGCAATAAAGTTCAAGAAAAAAGAGGTGCT

GTCTATGAACGAGTAACCACAATTAATCAAGAAATCCAAAAAATTAAA

CTTGGAATTCAACAACTAAAAGATGCTGCTGAAAGGGAGAAACTGAAG

TCCCAGGAAATATTTCTAAACTTGAAAACTGCTTTGGAGAAATACCACG

ACGGTATTGAAAAGGCAGCAGAGGACTCCTATGCTAAGATAGATGAGA

AGACAGCTGAACTGAAGAGGAAGATGTTCAAAATGTCAACCTGATTAA

CAAAATTACATGTCTTTTTGTAAATGGCTTGCCATCTTTTAATTTTCTAT

TTAGAAAGAAAAGTTGAAGCGAATGGAAGTATCAGAAGTACCAAATAA

TGTTGGCTTCATCAGTTTTTATACACTCTCATAAGTAGTTAATAAGATGA

ATTTAATGTAGGCTTTTATTAATTTATAATTAAAATAACTTGTGCAGCTA

TTCATGTCTCTACTCTGCCCCTTGTTGTAAATAGTTTGAGTAAAACAAAA

CTAGTTACCTTTGAAATATATATATTTTTTTCTGTTACTATC

GGCTAGCGCGGGAGGTGGAGAAAGAGGCTTGGGCGGCCCCGCTGTAGC 159

CGCGTGTGGGAGGACGCACGGGCCTGCTTCAAAGCTTTGGGATAACAG

CGCCTCCGGGGGATAATGAATGCGGAGCCTCCGTTTTCAGTCGACTTCA

GATGTGTCTCCACTTTTTTCCGCTGTAGCCGCAAGGCAAGGAAACATTT

CTCTTCCCGTACTGAGGAGGCTGAGGAGTGCACTGGGTGTTCTTTTCTC

CTCTAACCCAGAACTGCGAGACAGAGGCTGAGTCCCTGTAAAGAACAG

CTCCAGAAAAGCCAGGAGAGCGCAGGAGGGCATCCGGGAGGCCAGGA

GGGGTTCGCTGGGGCCTCAACCGCACCCACATCGGTCCCACCTGCGAGG

GGGCGGGACCTCGTGGCGCTGGACCAATCAGCACCCACCTGCGCTCAC

CTGGCCTCCTCCCGCTGGCTCCCGGGGGCTGCGGTGCTCAAAGGGGCAA

GAGCTGAGCGGAACACCGGCCCGCCGTCGCGGCAGCTGCTTCACCCCTC

TCTCTGCAGCCATGGGGCTCCCTCGTGGACCTCTCGCGTCTCTCCTCCTT

CTCCAGGTTTGCTGGCTGCAGTGCGCGGCCTCCGAGCCGTGCCGGGCGG

TCTTCAGGGAGGCTGAAGTGACCTTGGAGGCGGGAGGCGCGGAGCAGG

AGCCCGGCCAGGCGCTGGGGAAAGTATTCATGGGCTGCCCTGGGCAAG

AGCCAGCTCTGTTTAGCACTGATAATGATGACTTCACTGTGCGGAATGG

CGAGACAGTCCAGGAAAGAAGGTCACTGAAGGAAAGGAATCCATTGAA

GATCTTCCCATCCAAACGTATCTTACGAAGACACAAGAGAGATTGGGTG

GTTGCTCCAATATCTGTCCCTGAAAATGGCAAGGGTCCCTTCCCCCAGA

GACTGAATCAGCTCAAGTCTAATAAAGATAGAGACACCAAGATTTTCTA

CAGCATCACGGGGCCGGGGGCAGACAGCCCCCCTGAGGGTGTCTTCGC

TGTAGAGAAGGAGACAGGCTGGTTGTTGTTGAATAAGCCACTGGACCG

GGAGGAGATTGCCAAGTATGAGCTCTTTGGCCACGCTGTGTCAGAGAAT GGTGCCTCAGTGGAGGACCCCATGAACATCTCCATCATAGTGACCGACC

AGAATGACCACAAGCCCAAGTTTACCCAGGACACCTTCCGAGGGAGTG

TCTTAGAGGGAGTCCTACCAGGTACTTCTGTGATGCAGATGACAGCCAC

AGATGAGGATGATGCCATCTACACCTACAATGGGGTGGTTGCTTACTCC

ATCCATAGCCAAGAACCAAAGGACCCACACGACCTCATGTTCACAATTC

ACCGGAGCACAGGCACCATCAGCGTCATCTCCAGTGGCCTGGACCGGG

AAAAAGTCCCTGAGTACACACTGACCATCCAGGCCACAGACATGGATG

GGGACGGCTCCACCACCACGGCAGTGGCAGTAGTGGAGATCCTTGATG

CCAATGACAATGCTCCCATGTTTGACCCCCAGAAGTACGAGGCCCATGT

GCCTGAGAATGCAGTGGGCCATGAGGTGCAGAGGCTGACGGTCACTGA

TCTGGACGCCCCCAACTCACCAGCGTGGCGTGCCACCTACCTTATCATG

GGCGGTGACGACGGGGACCATTTTACCATCACCACCCACCCTGAGAGC

AACCAGGGCATCCTGACAACCAGGAAGGGTTTGGATTTTGAGGCCAAA

AACCAGCACACCCTGTACGTTGAAGTGACCAACGAGGCCCCTTTTGTGC

TGAAGCTCCCAACCTCCACAGCCACCATAGTGGTCCACGTGGAGGATGT

GAATGAGGCACCTGTGTTTGTCCCACCCTCCAAAGTCGTTGAGGTCCAG

GAGGGCATCCCCACTGGGGAGCCTGTGTGTGTCTACACTGCAGAAGAC

CCTGACAAGGAGAATCAAAAGATCAGCTACCGCATCCTGAGAGACCCA

GCAGGGTGGCTAGCCATGGACCCAGACAGTGGGCAGGTCACAGCTGTG

GGCACCCTCGACCGTGAGGATGAGCAGTTTGTGAGGAACAACATCTAT

GAAGTCATGGTCTTGGCCATGGACAATGGAAGCCCTCCCACCACTGGCA

CGGGAACCCTTCTGCTAACACTGATTGATGTCAACGACCATGGCCCAGT

CCCTGAGCCCCGTCAGATCACCATCTGCAACCAAAGCCCTGTGCGCCAG

GTGCTGAACATCACGGACAAGGACCTGTCTCCCCACACCTCCCCTTTCC

AGGCCCAGCTCACAGATGACTCAGACATCTACTGGACGGCAGAGGTCA

ACGAGGAAGGTGACACAGTGGTCTTGTCCCTGAAGAAGTTCCTGAAGC

AGGATACATATGACGTGCACCTTTCTCTGTCTGACCATGGCAACAAAGA

GCAGCTGACGGTGATCAGGGCCACTGTGTGCGACTGCCATGGCCATGTC

GAAACCTGCCCTGGACCCTGGAAAGGAGGTTTCATCCTCCCTGTGCTGG

GGGCTGTCCTGGCTCTGCTGTTCCTCCTGCTGGTGCTGCTTTTGTTGGTG

AGAAAGAAGCGGAAGATCAAGGAGCCCCTCCTACTCCCAGAAGATGAC

ACCCGTGACAACGTCTTCTACTATGGCGAAGAGGGGGGTGGCGAAGAG

GACCAGGACTATGACATCACCCAGCTCCACCGAGGTCTGGAGGCCAGG

CCGGAGGTGGTTCTCCGCAATGACGTGGCACCAACCATCATCCCGACAC

CCATGTACCGTCCTAGGCCAGCCAACCCAGATGAAATCGGCAACTTTAT

AATTGAGAACCTGAAGGCGGCTAACACAGACCCCACAGCCCCGCCCTA

CGACACCCTCTTGGTGTTCGACTATGAGGGCAGCGGCTCCGACGCCGCG

TCCCTGAGCTCCCTCACCTCCTCCGCCTCCGACCAAGACCAAGATTACG

ATTATCTGAACGAGTGGGGCAGCCGCTTCAAGAAGCTGGCAGACATGT

ACGGTGGCGGGGAGGACGACTAGGCGGCCTGCCTGCAGGGCTGGGGAC

CAAACGTCAGGCCACAGAGCATCTCCAAGGGGTCTCAGTTCCCCCTTCA

GCTGAGGACTTCGGAGCTTGTCAGGAAGTGGCCGTAGCAACTTGGCGG

AGACAGGCTATGAGTCTGACGTTAGAGTGGTTGCTTCCTTAGCCTTTCA

GGATGGAGGAATGTGGGCAGTTTGACTTCAGCACTGAAAACCTCTCCAC

CTGGGCCAGGGTTGCCTCAGAGGCCAAGTTTCCAGAAGCCTCTTACCTG

CCGTAAAATGCTCAACCCTGTGTCCTGGGCCTGGGCCTGCTGTGACTGA

CCTACAGTGGACTTTCTCTCTGGAATGGAACCTTCTTAGGCCTCCTGGTG

CAACTTAATTTTTTTTTTTAATGCTATCTTCAAAACGTTAGAGAAAGTTC

TTCAAAAGTGCAGCCCAGAGCTGCTGGGCCCACTGGCCGTCCTGCATTT

CTGGTTTCCAGACCCCAATGCCTCCCATTCGGATGGATCTCTGCGTTTTT

ATACTGAGTGTGCCTAGGTTGCCCCTTATTTTTTATTTTCCCTGTTGCGTT

GCTATAGATGAAGGGTGAGGACAATCGTGTATATGTACTAGAACTTTTT

TATTAAAGAAACTTTTCCCAAAAAAAAAAAAAAAA

ΝΜ_016343 GAGACCAGAAGCGGGCGAATTGGGCACCGGTGGCGGCTGCGGGCAGTT 160

TGAATTAGACTCTGGGCTCCAGCCCGCCGAAGCCGCGCCAGAACTGTAC TCTCCGAGAGGTCGTTTTCCCGTCCCCGAGAGCAAGTTTATTTACAAAT GTTGGAGTAATAAAGAAGGCAGAACAAAATGAGCTGGGCTTTGGAAGA

ATGGAAAGAAGGGCTGCCTACAAGAGCTCTTCAGAAAATTCAAGAGCT

TGAAGGACAGCTTGACAAACTGAAGAAGGAAAAGCAGCAAAGGCAGT

TTCAGCTTGACAGTCTCGAGGCTGCGCTGCAGAAGCAAAAACAGAAGG

TTGAAAATGAAAAAACCGAGGGTACAAACCTGAAAAGGGAGAATCAA

AGATTGATGGAAATATGTGAAAGTCTGGAGAAAACTAAGCAGAAGATT

TCTCATGAACTTCAAGTCAAGGAGTCACAAGTGAATTTCCAGGAAGGA

CAACTGAATTCAGGCAAAAAACAAATAGAAAAACTGGAACAGGAACTT

AAAAGGTGTAAATCTGAGCTTGAAAGAAGCCAACAAGCTGCGCAGTCT

GCAGATGTCTCTCTGAATCCATGCAATACACCACAAAAAATTTTTACAA

CTCCACTAACACCAAGTCAATATTATAGTGGTTCCAAGTATGAAGATCT

AAAAGAAAAATATAATAAAGAGGTTGAAGAACGAAAAAGATTAGAGG

CAGAGGTTAAAGCCTTGCAGGCTAAAAAAGCAAGCCAGACTCTTCCAC

AAGCCACCATGAATCACCGCGACATTGCCCGGCATCAGGCTTCATCATC

TGTGTTCTCATGGCAGCAAGAGAAGACCCCAAGTCATCTTTCATCTAAT

TCTCAAAGAACTCCAATTAGGAGAGATTTCTCTGCATCTTACTTTTCTGG

GGAACAAGAGGTGACTCCAAGTCGATCAACTTTGCAAATAGGGAAAAG

AGATGCTAATAGCAGTTTCTTTGACAATTCTAGCAGTCCTCATCTTTTGG

ATCAATTAAAAGCGCAGAATCAAGAGCTAAGAAACAAGATTAATGAGT

TGGAACTACGCCTGCAAGGACATGAAAAAGAAATGAAAGGCCAAGTGA

ATAAGTTTCAAGAACTCCAACTCCAACTGGAGAAAGCAAAAGTGGAAT

TAATTGAAAAAGAGAAAGTTTTGAACAAATGTAGGGATGAACTAGTGA

GAACAACAGCACAATACGACCAGGCGTCAACCAAGTATACTGCATTGG

AACAAAAACTGAAAAAATTGACGGAAGATTTGAGTTGTCAGCGACAAA

ATGCAGAAAGTGCCAGATGTTCTCTGGAACAGAAAATTAAGGAAAAAG

AAAAGGAGTTTCAAGAGGAGCTCTCCCGTCAACAGCGTTCTTTCCAAAC

ACTGGACCAGGAGTGCATCCAGATGAAGGCCAGACTCACCCAGGAGTT

ACAGCAAGCCAAGAATATGCACAACGTCCTGCAGGCTGAACTGGATAA

ACTCACATCAGTAAAGCAACAGCTAGAAAACAATTTGGAAGAGTTTAA

GCAAAAGTTGTGCAGAGCTGAACAGGCGTTCCAGGCGAGTCAGATCAA

GGAGAATGAGCTGAGGAGAAGCATGGAGGAAATGAAGAAGGAAAACA

ACCTCCTTAAGAGTCACTCTGAGCAAAAGGCCAGAGAAGTCTGCCACCT

GGAGGCAGAACTCAAGAACATCAAACAGTGTTTAAATCAGAGCCAGAA

TTTTGCAGAAGAAATGAAAGCGAAGAATACCTCTCAGGAAACCATGTT

AAGAGATCTTCAAGAAAAAATAAATCAGCAAGAAAACTCCTTGACTTT

AGAAAAACTGAAGCTTGCTGTGGCTGATCTGGAAAAGCAGCGAGATTG

TTCTCAAGACCTTTTGAAGAAAAGAGAACATCACATTGAACAACTTAAT

GATAAGTTAAGCAAGACAGAGAAAGAGTCCAAAGCCTTGCTGAGTGCT

TTAGAGTTAAAAAAGAAAGAATATGAAGAATTGAAAGAAGAGAAAAC

TCTGTTTTCTTGTTGGAAAAGTGAAAACGAAAAACTTTTAACTCAGATG

GAATCAGAAAAGGAAAACTTGCAGAGTAAAATTAATCACTTGGAAACT

TGTCTGAAGACACAGCAAATAAAAAGTCATGAATACAACGAGAGAGTA

AGAACGCTGGAGATGGACAGAGAAAACCTAAGTGTCGAGATCAGAAAC

CTTCACAACGTGTTAGACAGTAAGTCAGTGGAGGTAGAGACCCAGAAA

CTAGCTTATATGGAGCTACAGCAGAAAGCTGAGTTCTCAGATCAGAAA

CATCAGAAGGAAATAGAAAATATGTGTTTGAAGACTTCTCAGCTTACTG

GGCAAGTTGAAGATCTAGAACACAAGCTTCAGTTACTGTCAAATGAAA

TAATGGACAAAGACCGGTGTTACCAAGACTTGCATGCCGAATATGAGA

GCCTCAGGGATCTGCTAAAATCCAAAGATGCTTCTCTGGTGACAAATGA

AGATCATCAGAGAAGTCTTTTGGCTTTTGATCAGCAGCCTGCCATGCAT

CATTCCTTTGCAAATATAATTGGAGAACAAGGAAGCATGCCTTCAGAGA

GGAGTGAATGTCGTTTAGAAGCAGACCAAAGTCCGAAAAATTCTGCCA

TCCTACAAAATAGAGTTGATTCACTTGAATTTTCATTAGAGTCTCAAAA

ACAGATGAACTCAGACCTGCAAAAGCAGTGTGAAGAGTTGGTGCAAAT

CAAAGGAGAAATAGAAGAAAATCTCATGAAAGCAGAACAGATGCATC

AAAGTTTTGTGGCTGAAACAAGTCAGCGCATTAGTAAGTTACAGGAAG ACACTTCTGCTCACCAGAATGTTGTTGCTGAAACCTTAAGTGCCCTTGA

GAACAAGGAAAAAGAGCTGCAACTTTTAAATGATAAGGTAGAAACTGA

GCAGGCAGAGATTCAAGAATTAAAAAAGAGCAACCATCTACTTGAAGA

CTCTCTAAAGGAGCTACAACTTTTATCCGAAACCCTAAGCTTGGAGAAG

AAAGAAATGAGTTCCATCATTTCTCTAAATAAAAGGGAAATTGAAGAG

CTGACCCAAGAGAATGGGACTCTTAAGGAAATTAATGCATCCTTAAATC

AAGAGAAGATGAACTTAATCCAGAAAAGTGAGAGTTTTGCAAACTATA

TAGATGAAAGGGAGAAAAGCATTTCAGAGTTATCTGATCAGTACAAGC

AAGAAAAACTTATTTTACTACAAAGATGTGAAGAAACCGGAAATGCAT

ATGAGGATCTTAGTCAAAAATACAAAGCAGCACAGGAAAAGAATTCTA

AATTAGAATGCTTGCTAAATGAATGCACTAGTCTTTGTGAAAATAGGAA

AAATGAGTTGGAACAGCTAAAGGAAGCATTTGCAAAGGAACACCAAGA

ATTCTTAACAAAATTAGCATTTGCTGAAGAAAGAAATCAGAATCTGATG

CTAGAGTTGGAGACAGTGCAGCAAGCTCTGAGATCTGAGATGACAGAT

AACCAAAACAATTCTAAGAGCGAGGCTGGTGGTTTAAAGCAAGAAATC

ATGACTTTAAAGGAAGAACAAAACAAAATGCAAAAGGAAGTTAATGAC

TTATTACAAGAGAATGAACAGCTGATGAAGGTAATGAAGACTAAACAT

GAATGTCAAAATCTAGAATCAGAACCAATTAGGAACTCTGTGAAAGAA

AGAGAGAGTGAGAGAAATCAATGTAATTTTAAACCTCAGATGGATCTT

GAAGTTAAAGAAATTTCTCTAGATAGTTATAATGCGCAGTTGGTGCAAT

TAGAAGCTATGCTAAGAAATAAGGAATTAAAACTTCAGGAAAGTGAGA

AGGAGAAGGAGTGCCTGCAGCATGAATTACAGACAATTAGAGGAGATC

TTGAAACCAGCAATTTGCAAGACATGCAGTCACAAGAAATTAGTGGCC

TTAAAGACTGTGAAATAGATGCGGAAGAAAAGTATATTTCAGGGCCTC

ATGAGTTGTCAACAAGTCAAAACGACAATGCACACCTTCAGTGCTCTCT

GCAAACAACAATGAACAAGCTGAATGAGCTAGAGAAAATATGTGAAAT

ACTGCAGGCTGAAAAGTATGAACTCGTAACTGAGCTGAATGATTCAAG

GTCAGAATGTATCACAGCAACTAGGAAAATGGCAGAAGAGGTAGGGAA

ACTACTAAATGAAGTTAAAATATTAAATGATGACAGTGGTCTTCTCCAT

GGTGAGTTAGTGGAAGACATACCAGGAGGTGAATTTGGTGAACAACCA

AATGAACAGCACCCTGTGTCTTTGGCTCCATTGGACGAGAGTAATTCCT

ACGAGCACTTGACATTGTCAGACAAAGAAGTTCAAATGCACTTTGCCGA

ATTGCAAGAGAAATTCTTATCTTTACAAAGTGAACACAAAATTTTACAT

GATCAGCACTGTCAGATGAGCTCTAAAATGTCAGAGCTGCAGACCTATG

TTGACTCATTAAAGGCCGAAAATTTGGTCTTGTCAACGAATCTGAGAAA

CTTTCAAGGTGACTTGGTGAAGGAGATGCAGCTGGGCTTGGAGGAGGG

GCTCGTTCCATCCCTGTCATCCTCTTGTGTGCCTGACAGCTCTAGTCTTA

GCAGTTTGGGAGACTCCTCCTTTTACAGAGCTCTTTTAGAACAGACAGG

AGATATGTCTCTTTTGAGTAATTTAGAAGGGGCTGTTTCAGCAAACCAG

TGCAGTGTAGATGAAGTATTTTGCAGCAGTCTGCAGGAGGAGAATCTG

ACCAGGAAAGAAACCCCTTCGGCCCCAGCGAAGGGTGTTGAAGAGCTT

GAGTCCCTCTGTGAGGTGTACCGGCAGTCCCTCGAGAAGCTAGAAGAG

AAAATGGAAAGTCAAGGGATTATGAAAAATAAGGAAATTCAAGAGCTC

GAGCAGTTATTAAGTTCTGAAAGGCAAGAGCTTGACTGCCTTAGGAAG

CAGTATTTGTCAGAAAATGAACAGTGGCAACAGAAGCTGACAAGCGTG

ACTCTGGAGATGGAGTCCAAGTTGGCGGCAGAAAAGAAACAGACGGAA

CAACTGTCACTTGAGCTGGAAGTAGCACGACTCCAGCTACAAGGTCTGG

ACTTAAGTTCTCGGTCTTTGCTTGGCATCGACACAGAAGATGCTATTCA

AGGCCGAAATGAGAGCTGTGACATATCAAAAGAACATACTTCAGAAAC

TACAGAAAGAACACCAAAGCATGATGTTCATCAGATTTGTGATAAAGA

TGCTCAGCAGGACCTCAATCTAGACATTGAGAAAATAACTGAGACTGG

TGCAGTGAAACCCACAGGAGAGTGCTCTGGGGAACAGTCCCCAGATAC

CAATTATGAGCCTCCAGGGGAAGATAAAACCCAGGGCTCTTCAGAATG

CATTTCTGAATTGTCATTTTCTGGTCCTAATGCTTTGGTACCTATGGATT

TCCTGGGGAATCAGGAAGATATCCATAATCTTCAACTGCGGGTAAAAG

AGACATCAAATGAGAATTTGAGATTACTTCATGTGATAGAGGACCGTG ACAGAAAAGTTGAAAGTTTGCTAAATGAAATGAAAGAATTAGACTCAA

AACTCCATTTACAGGAGGTACAACTAATGACCAAAATTGAAGCATGCA

TAGAATTGGAAAAAATAGTTGGGGAACTTAAGAAAGAAAACTCAGATT

TAAGTGAAAAATTGGAATATTTTTCTTGTGATCACCAGGAGTTACTCCA

GAGAGTAGAAACTTCTGAAGGCCTCAATTCTGATTTAGAAATGCATGCA

GATAAATCATCACGTGAAGATATTGGAGATAATGTGGCCAAGGTGAAT

GACAGCTGGAAGGAGAGATTTCTTGATGTGGAAAATGAGCTGAGTAGG

ATCAGATCGGAGAAAGCTAGCATTGAGCATGAAGCCCTCTACCTGGAG

GCTGACTTAGAGGTAGTTCAAACAGAGAAGCTATGTTTAGAAAAAGAC

AATGAAAATAAGCAGAAGGTTATTGTCTGCCTTGAAGAAGAACTCTCA

GTGGTCACAAGTGAGAGAAACCAGCTTCGTGGAGAATTAGATACTATG

TCAAAAAAAACCACGGCACTGGATCAGTTGTCTGAAAAAATGAAGGAG

AAAACACAAGAGCTTGAGTCTCATCAAAGTGAGTGTCTCCATTGCATTC

AGGTGGCAGAGGCAGAGGTGAAGGAAAAGACGGAACTCCTTCAGACTT

TGTCCTCTGATGTGAGTGAGCTGTTAAAAGACAAAACTCATCTCCAGGA

AAAGCTGCAGAGTTTGGAAAAGGACTCACAGGCACTGTCTTTGACAAA

ATGTGAGCTGGAAAACCAAATTGCACAACTGAATAAAGAGAAAGAATT

GCTTGTCAAGGAATCTGAAAGCCTGCAGGCCAGACTGAGTGAATCAGA

TTATGAAAAGCTGAATGTCTCCAAGGCCTTGGAGGCCGCACTGGTGGA

GAAAGGTGAGTTCGCATTGAGGCTGAGCTCAACACAGGAGGAAGTGCA

TCAGCTGAGAAGAGGCATCGAGAAACTGAGAGTTCGCATTGAGGCCGA

TGAAAAGAAGCAGCTGCACATCGCAGAGAAACTGAAAGAACGCGAGC

GGGAGAATGATTCACTTAAGGATAAAGTTGAGAACCTTGAAAGGGAAT

TGCAGATGTCAGAAGAAAACCAGGAGCTAGTGATTCTTGATGCCGAGA

ATTCCAAAGCAGAAGTAGAGACTCTAAAAACACAAATAGAAGAGATGG

CCAGAAGCCTGAAAGTTTTTGAATTAGACCTTGTCACGTTAAGGTCTGA

AAAAGAAAATCTGACAAAACAAATACAAGAAAAACAAGGTCAGTTGTC

AGAACTAGACAAGTTACTCTCTTCATTTAAAAGTCTGTTAGAAGAAAAG

GAGCAAGCAGAGATACAGATCAAAGAAGAATCTAAAACTGCAGTGGA

GATGCTTCAGAATCAGTTAAAGGAGCTAAATGAGGCAGTAGCAGCCTT

GTGTGGTGACCAAGAAATTATGAAGGCCACAGAACAGAGTCTAGACCC

ACCAATAGAGGAAGAGCATCAGCTGAGAAATAGCATTGAAAAGCTGAG

AGCCCGCCTAGAAGCTGATGAAAAGAAGCAGCTCTGTGTCTTACAACA

ACTGAAGGAAAGTGAGCATCATGCAGATTTACTTAAGGGTAGAGTGGA

GAACCTTGAAAGAGAGCTAGAGATAGCCAGGACAAACCAAGAGCATGC

AGCTCTTGAGGCAGAGAATTCCAAAGGAGAGGTAGAGACCCTAAAAGC

AAAAATAGAAGGGATGACCCAAAGTCTGAGAGGTCTGGAATTAGATGT

TGTTACTATAAGGTCAGAAAAAGAAAATCTGACAAATGAATTACAAAA

AGAGCAAGAGCGAATATCTGAATTAGAAATAATAAATTCATCATTTGA

AAATATTTTGCAAGAAAAAGAGCAAGAGAAAGTACAGATGAAAGAAA

AATCAAGCACTGCCATGGAGATGCTTCAAACACAATTAAAAGAGCTCA

ATGAGAGAGTGGCAGCCCTGCATAATGACCAAGAAGCCTGTAAGGCCA

AAGAGCAGAATCTTAGTAGTCAAGTAGAGTGTCTTGAACTTGAGAAGG

CTCAGTTGCTACAAGGCCTTGATGAGGCCAAAAATAATTATATTGTTTT

GCAATCTTCAGTGAATGGCCTCATTCAAGAAGTAGAAGATGGCAAGCA

GAAACTGGAGAAGAAGGATGAAGAAATCAGTAGACTGAAAAATCAAA

TTCAAGACCAAGAGCAGCTTGTCTCTAAACTGTCCCAGGTGGAAGGAG

AGCACCAACTTTGGAAGGAGCAAAACTTAGAACTGAGAAATCTGACAG

TGGAATTGGAGCAGAAGATCCAAGTGCTACAATCCAAAAATGCCTCTTT

GCAGGACACATTAGAAGTGCTGCAGAGTTCTTACAAGAATCTAGAGAA

TGAGCTTGAATTGACAAAAATGGACAAAATGTCCTTTGTTGAAAAAGTA

AACAAAATGACTGCAAAGGAAACTGAGCTGCAGAGGGAAATGCATGA

GATGGCACAGAAAACAGCAGAGCTGCAAGAAGAACTCAGTGGAGAGA

AAAATAGGCTAGCTGGAGAGTTGCAGTTACTGTTGGAAGAAATAAAGA

GCAGCAAAGATCAATTGAAGGAGCTCACACTAGAAAATAGTGAATTGA

AGAAGAGCCTAGATTGCATGCACAAAGACCAGGTGGAAAAGGAAGGG AAAGTGAGAGAGGAAATAGCTGAATATCAGCTACGGCTTCATGAAGCT

GAAAAGAAACACCAGGCTTTGCTTTTGGACACAAACAAACAGTATGAA

GTAGAAATCCAGACATACCGAGAGAAATTGACTTCTAAAGAAGAATGT

CTCAGTTCACAGAAGCTGGAGATAGACCTTTTAAAGTCTAGTAAAGAA

GAGCTCAATAATTCATTGAAAGCTACTACTCAGATTTTGGAAGAATTGA

AGAAAACCAAGATGGACAATCTAAAATATGTAAATCAGTTGAAGAAGG

AAAATGAACGTGCCCAGGGGAAAATGAAGTTGTTGATCAAATCCTGTA

AACAGCTGGAAGAGGAAAAGGAGATACTGCAGAAAGAACTCTCTCAAC

TTCAAGCTGCACAGGAGAAGCAGAAAACAGGTACTGTTATGGATACCA

AGGTCGATGAATTAACAACTGAGATCAAAGAACTGAAAGAAACTCTTG

AAGAAAAAACCAAGGAGGCAGATGAATACTTGGATAAGTACTGTTCCT

TGCTTATAAGCCATGAAAAGTTAGAGAAAGCTAAAGAGATGTTAGAGA

CACAAGTGGCCCATCTGTGTTCACAGCAATCTAAACAAGATTCCCGAGG

GTCTCCTTTGCTAGGTCCAGTTGTTCCAGGACCATCTCCAATCCCTTCTG

TTACTGAAAAGAGGTTATCATCTGGCCAAAATAAAGCTTCAGGCAAGA

GGCAAAGATCCAGTGGAATATGGGAGAATGGTAGAGGACCAACACCTG

CTACCCCAGAGAGCTTTTCTAAAAAAAGCAAGAAAGCAGTCATGAGTG

GTATTCACCCTGCAGAAGACACGGAAGGTACTGAGTTTGAGCCAGAGG

GACTTCCAGAAGTTGTAAAGAAAGGGTTTGCTGACATCCCGACAGGAA

AGACTAGCCCATATATCCTGCGAAGAACAACCATGGCAACTCGGACCA

GCCCCCGCCTGGCTGCACAGAAGTTAGCGCTATCCCCACTGAGTCTCGG

CAAAGAAAATCTTGCAGAGTCCTCCAAACCAACAGCTGGTGGCAGCAG

ATCACAAAAGGTCAAAGTTGCTCAGCGGAGCCCAGTAGATTCAGGCAC

CATCCTCCGAGAACCCACCACGAAATCCGTCCCAGTCAATAATCTTCCT

GAGAGAAGTCCGACTGACAGCCCCAGAGAGGGCCTGAGGGTCAAGCGA

GGCCGACTTGTCCCCAGCCCCAAAGCTGGACTGGAGTCCAACGGCAGT

GAGAACTGTAAGGTCCAGTGAAGGCACTTTGTGTGTCAGTACCCCTGGG

AGGTGCCAGTCATTGAATAGATAAGGCTGTGCCTACAGGACTTCTCTTT

AGTCAGGGCATGCTTTATTAGTGAGGAGAAAACAATTCCTTAGAAGTCT

TAAATATATTGTACTCTTTAGATCTCCCATGTGTAGGTATTGAAAAAGTT

TGGAAGCACTGATCACCTGTTAGCATTGCCATTCCTCTACTGCAATGTA

AATAGTATAAAGCTATGTATATAAAGCTTTTTGGTAATATGTTACAATT

AAAATGACAAGCACTATATCACAATCTCTGTTTGTATGTGGGTTTTACA

CTAAAAAAATGCAAAACACATTTTATTCTTCTAATTAACAGCTCCTAGG

AAAATGTAGACTTTTGCTTTATGATATTCTATCTGTAGTATGAGGCATG

GAATAGTTTTGTATCGGGAATTTCTCAGAGCTGAGTAAAATGAAGGAA

AAGCATGTTATGTGTTTTTAAGGAAAATGTGCACACATATACATGTAGG

AGTGTTTATCTTTCTCTTACAATCTGTTTTAGACATCTTTGCTTATGAAA

CCTGTACATATGTGTGTGTGGGTATGTGTTTATTTCCAGTGAGGGCTGC

AGGCTTCCTAGAGGTGTGCTATACCATGCGTCTGTCGTTGTGCTTTTTTC

TGTTTTTAGACCAATTTTTTACAGTTCTTTGGTAAGCATTGTCGTATCTG

GTGATGGATTAACATATAGCCTTTGTTTTCTAATAAAATAGTCGCCTTCG

TTTTCTGTAAAAAAAAAAAAAAAAAAAAAA

GGCACGAGGGGCCGACGCGAGCGCCGCGCTTCGCTTCAGCTGCTAGCT 161

GGCCCAAGGGAGGCGACCGCGGAGGGTGGCGAGGGGCGGCCAGGACC

CGCAGCCCCGGGGCCGGGCCGGTCCGGACCGCCAGGGAGGGCAGGTCA

GTGGGCAGATCGCGTCCGCGGGATTCAATCTCTGCCCGCTCTGATAACA

GTCCTTTTCCCTGGCGCTCACTTCGTGCCTGGCACCCGGCTGGGCGCCTC

AAGACCGTTGTCTCTTCGATCGCTTCTTTGGACTTGGCGACCATTTCAGA

GATGTCTTCCAGAAGTACCAAAGATTTAATTAAAAGTAAGTGGGGATC

GAAGCCTAGTAACTCCAAATCCGAAACTACATTAGAAAAATTAAAGGG

AGAAATTGCACACTTAAAGACATCAGTGGATGAAATCACAAGTGGGAA

AGGAAAGCTGACTGATAAAGAGAGACACAGACTTTTGGAGAAAATTCG

AGTCCTTGAGGCTGAGAAGGAGAAGAATGCTTATCAACTCACAGAGAA

GGACAAAGAAATACAGCGACTGAGAGACCAACTGAAGGCCAGATATA

GTACTACCGCATTGCTTGAACAGCTGGAAGAGACAACGAGAGAAGGAG AAAGGAGGGAGCAGGTGTTGAAAGCCTTATCTGAAGAGAAAGACGTAT

TGAAACAACAGTTGTCTGCTGCAACCTCACGAATTGCTGAACTTGAAAG

CAAAACCAATACACTCCGTTTATCACAGACTGTGGCTCCAAACTGCTTC

AACTCATCAATAAATAATATTCATGAAATGGAAATACAGCTGAAAGAT

GCTCTGGAGAAAAATCAGCAGTGGCTCGTGTATGATCAGCAGCGGGAA

GTCTATGTAAAAGGACTTTTAGCAAAGATCTTTGAGTTGGAAAAGAAA

ACGGAAACAGCTGCTCATTCACTCCCACAGCAGACAAAAAAGCCTGAA

TCAGAAGGTTATCTTCAAGAAGAGAAGCAGAAATGTTACAACGATCTC

TTGGCAAGTGCAAAAAAAGATCTTGAGGTTGAACGACAAACCATAACT

CAGCTGAGTTTTGAACTGAGTGAATTTCGAAGAAAATATGAAGAAACC

CAAAAAGAAGTTCACAATTTAAATCAGCTGTTGTATTCACAAAGAAGG

GCAGATGTGCAACATCTGGAAGATGATAGGCATAAAACAGAGAAGATA

CAAAAACTCAGGGAAGAGAATGATATTGCTAGGGGAAAACTTGAAGAA

GAGAAGAAGAGATCCGAAGAGCTCTTATCTCAGGTCCAGTTTCTTTACA

CATCTCTGCTAAAGCAGCAAGAAGAACAAACAAGGGTAGCTCTGTTGG

AACAACAGATGCAGGCATGTACTTTAGACTTTGAAAATGAAAAACTCG

ACCGTCAACATGTGCAGCATCAATTGCATGTAATTCTTAAGGAGCTCCG

AAAAGCAAGAAATCAAATAACACAGTTGGAATCCTTGAAACAGCTTCA

TGAGTTTGCCATCACAGAGCCATTAGTCACTTTCCAAGGAGAGACTGAA

AACAGAGAAAAAGTTGCCGCCTCACCAAAAAGTCCCACTGCTGCACTC

AATGAAAGCCTGGTGGAATGTCCCAAGTGCAATATACAGTATCCAGCC

ACTGAGCATCGCGATCTGCTTGTCCATGTGGAATACTGTTCAAAGTAGC

AAAATAAGTATTTGTTTTGATATTAAAAGATTCAATACTGTATTTTCTGT

TAGCTTGTGGGCATTTTGAATTATATATTTCACATTTTGCATAAAACTGC

CTATCTACCTTTGACACTCCAGCATGCTAGTGAATCATGTATCTTTTAGG

CTGCTGTGCATTTCTCTTGGCAGTGATACCTCCCTGACATGGTTCATCAT

CAGGCTGCAATGACAGAATGTGGTGAGCAGCGTCTACTGAGACTACTA

ACATTTTGCACTGTCAAAATACTTGGTGAGGAAAAGATAGCTCAGGTTA

TTGCTAATGGGTTAATGCACCAGCAAGCAAAATATTTTATGTTTTGGGG

GTTTGAAAAATCAAAGATAATTAACCAAGGATCTTAACTGTGTTCGCAT

TTTTTATCCAAGCACTTAGAAAACCTACAATCCTAATTTTGATGTCCATT

GTTAAGAGGTGGTGATAGATACTATTTTTTTTTTCATATTGTATAGCGGT

TATTAGAAAAGTTGGGGATTTTCTTGATCTTTATTGCTGCTTACCATTGA

AACTTAACCCAGCTGTGTTCCCCAACTCTGTTCTGCGCACGAAACAGTA

TCTGTTTGAGGCATAATCTTAAGTGGCCACACACAATGTTTTCTCTTATG

TTATCTGGCAGTAACTGTAACTTGAATTACATTAGCACATTCTGCTTAGC

TAAAATTGTTAAAATAAACTTTAATAAACCCATGTAGCCCTCTCATTTG

ATTGACAGTATTTTAGTTATTTTTGGCATTCTTAAAGCTGGGCAATGTAA

TGATCAGATCTTTGTTTGTCTGAACAGGTATTTTTATACATGCTTTTTGT

AAACCAAAAACTTTTAAATTTCTTCAGGTTTTCTAACATGCTTACCACTG

GGCTACTGTAAATGAGAAAAGAATAAAATTATTTAATGTTTTAAAAAA

AAAAAAAAA

GGCGGCTGAGCCTGAGCGGGGATGTAGAGGCGGCGGCAGCAGAGGCG 162

GCACTGGCGGCAAGAGCAGACGCCCGAGCCGAGCGAGAAGAGCGGCA

GAGCCTTATCCCCTGAAGCCGGGCCCCGCGTCCCAGCCCTGCCCAGCCC

GCGCCCAGCCATGCGCGCCGCCTGCTGAGTCCGGGCGCCGCACGCTGA

GCCCTCCGCCCGCGAGCCGCGCTCAGCTCGGGGGTGATTAGTTGCTTTT

TGTTGTTTTTTAATTTGGGCCGCGGGGAGGGGGAGGAGGGGCAGGTGCT

GCAGGCTCCCCCCCCTCCCCGCCTCGGGCCAGCCGCGGCGGCGCGACTC

GGGCTCCGGACCCGGGCACTGCTGGCGGCTGGAGCGGAGCGCACCGCG

GCGGTGGTGCCCAGAGCGGAGCGCAGCTCCCTGCCCCGCCCCTCCCCCT

CGGCCTCGCGGCGACGGCGGCGGTGGCGGCTTGGACGACTCGGAGAGC

CGAGTGAAGACATTTCCACCTGGACACCTGACCATGTGCCTGCCCTGAG

CAGCGAGGCCCACCAGGCATCTCTGTTGTGGGCAGCAGGGCCAGGTCC

TGGTCTGTGGACCCTCGGCAGTTGGCAGGCTCCCTCTGCAGTGGGGTCT

GGGCCTCGGCCCCACCATGTCGAGCCTCGGCGGTGGCTCCCAGGATGCC GGCGGCAGTAGCAGCAGCAGCACCAATGGCAGCGGTGGCAGTGGCAGC

AGTGGCCCAAAGGCAGGAGCAGCAGACAAGAGTGCAGTGGTGGCTGCC

GCCGCACCAGCCTCAGTGGCAGATGACACACCACCCCCCGAGCGTCGG

AACAAGAGCGGTATCATCAGTGAGCCCCTCAACAAGAGCCTGCGCCGC

TCCCGCCCGCTCTCCCACTACTCTTCTTTTGGCAGCAGTGGTGGTAGTGG

CGGTGGCAGCATGATGGGCGGAGAGTCTGCTGACAAGGCCACTGCGGC

TGCAGCCGCTGCCTCCCTGTTGGCCAATGGGCATGACCTGGCGGCGGCC

ATGGCGGTGGACAAAAGCAACCCTACCTCAAAGCACAAAAGTGGTGCT

GTGGCCAGCCTGCTGAGCAAGGCAGAGCGGGCCACGGAGCTGGCAGCC

GAGGGACAGCTGACGCTGCAGCAGTTTGCGCAGTCCACAGAGATGCTG

AAGCGCGTGGTGCAGGAGCATCTCCCGCTGATGAGCGAGGCGGGTGCT

GGCCTGCCTGACATGGAGGCTGTGGCAGGTGCCGAAGCCCTCAATGGC

CAGTCCGACTTCCCCTACCTGGGCGCTTTCCCCATCAACCCAGGCCTCTT

CATTATGACCCCGGCAGGTGTGTTCCTGGCCGAGAGCGCGCTGCACATG

GCGGGCCTGGCTGAGTACCCCATGCAGGGAGAGCTGGCCTCTGCCATC

AGCTCCGGCAAGAAGAAGCGGAAACGCTGCGGCATGTGCGCGCCCTGC

CGGCGGCGCATCAACTGCGAGCAGTGCAGCAGTTGTAGGAATCGAAAG

ACTGGCCATCAGATTTGCAAATTCAGAAAATGTGAGGAACTCAAAAAG

AAGCCTTCCGCTGCTCTGGAGAAGGTGATGCTTCCGACGGGAGCCGCCT

TCCGGTGGTTTCAGTGACGGCGGCGGAACCCAAAGCTGCCCTCTCCGTG

CAATGTCACTGCTCGTGTGGTCTCCAGCAAGGGATTCGGGCGAAGACA

AACGGATGCACCCGTCTTTAGAACCAAAAATATTCTCTCACAGATTTCA

TTCCTGTTTTTATATATATATTTTTTGTTGTCGTTTTAACATCTCCACGTC

CCTAGCATAAAAAGAAAAAGAAAAAAATTTAAACTGCTTTTTCGGAAG

AACAACAACAAAAAAGAGGTAAAGACGAATCTATAAAGTACCGAGACT

TCCTGGGCAAAGAATGGACAATCAGTTTCCTTCCTGTGTCGATGTCGAT

GTTGTCTGTGCAGGAGATGCAGTTTTTGTGTAGAGAATGTAAATTTTCT

GTAACCTTTTGAAATCTAGTTACTAATAAGCACTACTGTAATTTAGCAC

AGTTTAACTCCACCCTCATTTAAACTTCCTTTGATTCTTTCCGACCATGA

AATAGTGCATAGTTTGCCTGGAGAATCCACTCACGTTCATAAAGAGAAT

GTTGATGGCGCCGTGTAGAAGCCGCTCTGTATCCATCCACGCGTGCAGA

GCTGCCAGCAGGGAGCTCACAGAAGGGGAGGGAGCACCAGGCCAGCT

GAGCTGCACCCACAGTCCCGAGACTGGGATCCCCCACCCCAACAGTGA

TTTTGGAAAAAAAAATGAAAGTTCTGTTCGTTTATCCATTGCGATCTGG

GGAGCCCCATCTCGATATTTCCAATCCTGGCTACTTTTCTTAGAGAAAA

TAAGTCCTTTTTTTCTGGCCTTGCTAATGGCAACAGAAGAAAGGGCTTC

TTTGCGTGGTCCCCTGCTGGTGGGGGTGGGTCCCCAGGGGGCCCCCTGC

GGCCTGGGCCCCCCTGCCCACGGCCAGCTTCCTGCTGATGAACATGCTG

TTTGTATTGTTTTAGGAAACCAGGCTGTTTTGTGAATAAAACGAATGCA

TGTTTGTGTCACGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAA

NM_005228 CCCCGGCGCAGCGCGGCCGCAGCAGCCTCCGCCCCCCGCACGGTGTGA 163

GCGCCCGACGCGGCCGAGGCGGCCGGAGTCCCGAGCTAGCCCCGGCGG

CCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCC

GAGTCCCCGCCTCGCCGCCAACGCCACAACCACCGCGCACGGCCCCCTG

ACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAG

CAGCGATGCGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGC

TGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTT

GCCAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATC

ATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTCCTTGG

GAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTA

AAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAG

TGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGT

ACTACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACTATGATGCAAA

TAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAAATCCT

GCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGA GAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACAT

GTCGATGGACTTCCAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCC

AAGCTGTCCCAATGGGAGCTGCTGGGGTGCAGGAGAGGAGAACTGCCA

GAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGT

GGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGCA

CAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACG

AAGCCACGTGCAAGGACACCTGCCCCCCACTCATGCTCTACAACCCCAC

CACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGC

CACCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGC

TCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGAC

GGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGT

AACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTA

CGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCA

CATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACACATACTCCTCCTC

TGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAG

GGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGC

CTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCA

GTTTTCTCTTGCAGTCGTCAGCCTGAACATAACATCCTTGGGATTACGCT

CCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAA

ATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTGTTTGGGACCTC

CGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAA

GGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGG

GGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGC

AGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAG

TTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGCCTGCCTC

AGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCC

AGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGC

AGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGC

CGGCCATGTGTGCCACCTGTGCCATCCAAACTGCACCTACGGATGCACT

GGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCC

ATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCCC

TGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCAC

GCTGCGGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACC

CAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAAC

TGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGT

GTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGT

CGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGA

AATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGT

GTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACG

CAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTCCGGGAACACAAAG

ACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAA

GGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGC

AGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGA

TTTTGGGCTGGCCAAACTGCTGGGTGCGGAAGAGAAAGAATACCATGC

AGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTT

ACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTACGGGGTGAC

CGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCT

GCCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAG

CCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGA

TGATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATT

CTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAGGGGGAT

GAAAGAATGCATTTGCCAAGTCCTACAGACTCCAACTTCTACCGTGCCC

TGATGGATGAAGAAGACATGGACGACGTGGTGGATGCCGACGAGTACC

TCATCCCACAGCAGGGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCC

CCTCCTGAGCTCTCTGAGTGCAACCAGCAACAATTCCACCGTGGCTTGC

ATTGATAGAAATGGGCTGCAAAGCTGTCCCATCAAGGAAGACAGCTTC TTGCAGCGATACAGCTCAGACCCCACAGGCGCCTTGACTGAGGACAGC

ATAGACGACACCTTCCTCCCAGTGCCTGAATACATAAACCAGTCCGTTC

CCAAAAGGCCCGCTGGCTCTGTGCAGAATCCTGTCTATCACAATCAGCC

TCTGAACCCCGCGCCCAGCAGAGACCCACACTACCAGGACCCCCACAG

CACTGCAGTGGGCAACCCCGAGTATCTCAACACTGTCCAGCCCACCTGT

GTCAACAGCACATTCGACAGCCCTGCCCACTGGGCCCAGAAAGGCAGC

CACCAAATTAGCCTGGACAACCCTGACTACCAGCAGGACTTCTTTCCCA

AGGAAGCCAAGCCAAATGGCATCTTTAAGGGCTCCACAGCTGAAAATG

CAGAATACCTAAGGGTCGCGCCACAAAGCAGTGAATTTATTGGAGCAT

GACCACGGAGGATAGTATGAGCCCTAAAAATCCAGACTCTTTCGATACC

CAGGACCAAGCCACAGCAGGTCCTCCATCCCAACAGCCATGCCCGCATT

AGCTCTTAGACCCACAGACTGGTTTTGCAACGTTTACACCGACTAGCCA

GGAAGTACTTCCACCTCGGGCACATTTTGGGAAGTTGCATTCCTTTGTCT

TCAAACTGTGAAGCATTTACAGAAACGCATCCAGCAAGAATATTGTCCC

TTTGAGCAGAAATTTATCTTTCAAAGAGGTATATTTGAAAAAAAAAAAA

AGTATATGTGAGGATTTTTATTGATTGGGGATCTTGGAGTTTTTCATTGT

CGCTATTGATTTTTACTTCAATGGGCTCTTCCAACAAGGAAGAAGCTTG

CTGGTAGCACTTGCTACCCTGAGTTCATCCAGGCCCAACTGTGAGCAAG

GAGCACAAGCCACAAGTCTTCCAGAGGATGCTTGATTCCAGTGGTTCTG

CTTCAAGGCTTCCACTGCAAAACACTAAAGATCCAAGAAGGCCTTCATG

GCCCCAGCAGGCCGGATCGGTACTGTATCAAGTCATGGCAGGTACAGT

AGGATAAGCCACTCTGTCCCTTCCTGGGCAAAGAAGAAACGGAGGGGA

TGGAATTCTTCCTTAGACTTACTTTTGTAAAAATGTCCCCACGGTACTTA

CTCCCCACTGATGGACCAGTGGTTTCCAGTCATGAGCGTTAGACTGACT

TGTTTGTCTTCCATTCCATTGTTTTGAAACTCAGTATGCTGCCCCTGTCTT

GCTGTCATGAAATCAGCAAGAGAGGATGACACATCAAATAATAACTCG

GATTCCAGCCCACATTGGATTCATCAGCATTTGGACCAATAGCCCACAG

CTGAGAATGTGGAATACCTAAGGATAGCACCGCTTTTGTTCTCGCAAAA

ACGTATCTCCTAATTTGAGGCTCAGATGAAATGCATCAGGTCCTTTGGG

GCATAGATCAGAAGACTACAAAAATGAAGCTGCTCTGAAATCTCCTTTA

GCCATCACCCCAACCCCCCAAAATTAGTTTGTGTTACTTATGGAAGATA

GTTTTCTCCTTTTACTTCACTTCAAAAGCTTTTTACTCAAAGAGTATATG

TTCCCTCCAGGTCAGCTGCCCCCAAACCCCCTCCTTACGCTTTGTCACAC

AAAAAGTGTCTCTGCCTTGAGTCATCTATTCAAGCACTTACAGCTCTGG

CCACAACAGGGCATTTTACAGGTGCGAATGACAGTAGCATTATGAGTA

GTGTGGAATTCAGGTAGTAAATATGAAACTAGGGTTTGAAATTGATAAT

GCTTTCACAACATTTGCAGATGTTTTAGAAGGAAAAAAGTTCCTTCCTA

AAATAATTTCTCTACAATTGGAAGATTGGAAGATTCAGCTAGTTAGGAG

CCCACCTTTTTTCCTAATCTGTGTGTGCCCTGTAACCTGACTGGTTAACA

GCAGTCCTTTGTAAACAGTGTTTTAAACTCTCCTAGTCAATATCCACCCC

ATCCAATTTATCAAGGAAGAAATGGTTCAGAAAATATTTTCAGCCTACA

GTTATGTTCAGTCACACACACATACAAAATGTTCCTTTTGCTTTTAAAGT

AATTTTTGACTCCCAGATCAGTCAGAGCCCCTACAGCATTGTTAAGAAA

GTATTTGATTTTTGTCTCAATGAAAATAAAACTATATTCATTTCCACTCT

AAAAAAAAAAAAAAAAA

NM_001005862 GTTCCCGGATTTTTGTGGGCGCCTGCCCCGCCCCTCGTCCCCCTGCTGTG 164

TCCATATATCGAGGCGATAGGGTTAAGGGAAGGCGGACGCCTGATGGG

TTAATGAGCAAACTGAAGTGTTTTCCATGATCTTTTTTGAGTCGCAATTG

AAGTACCACCTCCCGAGGGTGATTGCTTCCCCATGCGGGGTAGAACCTT

TGCTGTCCTGTTCACCACTCTACCTCCAGCACAGAATTTGGCTTATGCCT

ACTCAATGTGAAGATGATGAGGATGAAAACCTTTGTGATGATCCACTTC

CACTTAATGAATGGTGGCAAAGCAAAGCTATATTCAAGACCACATGCA

AAGCTACTCCCTGAGCAAAGAGTCACAGATAAAACGGGGGCACCAGTA

GAATGGCCAGGACAAACGCAGTGCAGCACAGAGACTCAGACCCTGGCA

GCCATGCCTGCGCAGGCAGTGATGAGAGTGACATGTACTGTTGTGGAC

ATGCACAAAAGTGAGTGTGCACCGGCACAGACATGAAGCTGCGGCTCC CTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCTCTACCAGGG

CTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAAT

GCCAGCCTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGC

TCATCGCTCACAACCAAGTGAGGCAGGTCCCACTGCAGAGGCTGCGGA

TTGTGCGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCT

AGACAATGGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTC

CCCAGGAGGCCTGCGGGAGCTGCAGCTTCGAAGCCTCACAGAGATCTT

GAAAGGAGGGGTCTTGATCCAGCGGAACCCCCAGCTCTGCTACCAGGA

CACGATTTTGTGGAAGGACATCTTCCACAAGAACAACCAGCTGGCTCTC

ACACTGATAGACACCAACCGCTCTCGGGCCTGCCACCCCTGTTCTCCGA

TGTGTAAGGGCTCCCGCTGCTGGGGAGAGAGTTCTGAGGATTGTCAGA

GCCTGACGCGCACTGTCTGTGCCGGTGGCTGTGCCCGCTGCAAGGGGCC

ACTGCCCACTGACTGCTGCCATGAGCAGTGTGCTGCCGGCTGCACGGGC

CCCAAGCACTCTGACTGCCTGGCCTGCCTCCACTTCAACCACAGTGGCA

TCTGTGAGCTGCACTGCCCAGCCCTGGTCACCTACAACACAGACACGTT

TGAGTCCATGCCCAATCCCGAGGGCCGGTATACATTCGGCGCCAGCTGT

GTGACTGCCTGTCCCTACAACTACCTTTCTACGGACGTGGGATCCTGCA

CCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCAGAGGATGGAA

CACAGCGGTGTGAGAAGTGCAGCAAGCCCTGTGCCCGAGTGTGCTATG

GTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCAGTGCCA

ATATCCAGGAGTTTGCTGGCTGCAAGAAGATCTTTGGGAGCCTGGCATT

TCTGCCGGAGAGCTTTGATGGGGACCCAGCCTCCAACACTGCCCCGCTC

CAGCCAGAGCAGCTCCAAGTGTTTGAGACTCTGGAAGAGATCACAGGT

TACCTATACATCTCAGCATGGCCGGACAGCCTGCCTGACCTCAGCGTCT

TCCAGAACCTGCAAGTAATCCGGGGACGAATTCTGCACAATGGCGCCT

ACTCGCTGACCCTGCAAGGGCTGGGCATCAGCTGGCTGGGGCTGCGCTC

ACTGAGGGAACTGGGCAGTGGACTGGCCCTCATCCACCATAACACCCA

CCTCTGCTTCGTGCACACGGTGCCCTGGGACCAGCTCTTTCGGAACCCG

CACCAAGCTCTGCTCCACACTGCCAACCGGCCAGAGGACGAGTGTGTG

GGCGAGGGCCTGGCCTGCCACCAGCTGTGCGCCCGAGGGCACTGCTGG

GGTCCAGGGCCCACCCAGTGTGTCAACTGCAGCCAGTTCCTTCGGGGCC

AGGAGTGCGTGGAGGAATGCCGAGTACTGCAGGGGCTCCCCAGGGAGT

ATGTGAATGCCAGGCACTGTTTGCCGTGCCACCCTGAGTGTCAGCCCCA

GAATGGCTCAGTGACCTGTTTTGGACCGGAGGCTGACCAGTGTGTGGCC

TGTGCCCACTATAAGGACCCTCCCTTCTGCGTGGCCCGCTGCCCCAGCG

GTGTGAAACCTGACCTCTCCTACATGCCCATCTGGAAGTTTCCAGATGA

GGAGGGCGCATGCCAGCCTTGCCCCATCAACTGCACCCACTCCTGTGTG

GACCTGGATGACAAGGGCTGCCCCGCCGAGCAGAGAGCCAGCCCTCTG

ACGTCCATCATCTCTGCGGTGGTTGGCATTCTGCTGGTCGTGGTCTTGGG

GGTGGTCTTTGGGATCCTCATCAAGCGACGGCAGCAGAAGATCCGGAA

GTACACGATGCGGAGACTGCTGCAGGAAACGGAGCTGGTGGAGCCGCT

GACACCTAGCGGAGCGATGCCCAACCAGGCGCAGATGCGGATCCTGAA

AGAGACGGAGCTGAGGAAGGTGAAGGTGCTTGGATCTGGCGCTTTTGG

CACAGTCTACAAGGGCATCTGGATCCCTGATGGGGAGAATGTGAAAAT

TCCAGTGGCCATCAAAGTGTTGAGGGAAAACACATCCCCCAAAGCCAA

CAAAGAAATCTTAGACGAAGCATACGTGATGGCTGGTGTGGGCTCCCC

ATATGTCTCCCGCCTTCTGGGCATCTGCCTGACATCCACGGTGCAGCTG

GTGACACAGCTTATGCCCTATGGCTGCCTCTTAGACCATGTCCGGGAAA

ACCGCGGACGCCTGGGCTCCCAGGACCTGCTGAACTGGTGTATGCAGAT

TGCCAAGGGGATGAGCTACCTGGAGGATGTGCGGCTCGTACACAGGGA

CTTGGCCGCTCGGAACGTGCTGGTCAAGAGTCCCAACCATGTCAAAATT

ACAGACTTCGGGCTGGCTCGGCTGCTGGACATTGACGAGACAGAGTAC

CATGCAGATGGGGGCAAGGTGCCCATCAAGTGGATGGCGCTGGAGTCC

ATTCTCCGCCGGCGGTTCACCCACCAGAGTGATGTGTGGAGTTATGGTG

TGACTGTGTGGGAGCTGATGACTTTTGGGGCCAAACCTTACGATGGGAT

CCCAGCCCGGGAGATCCCTGACCTGCTGGAAAAGGGGGAGCGGCTGCC CCAGCCCCCCATCTGCACCATTGATGTCTACATGATCATGGTCAAATGT

TGGATGATTGACTCTGAATGTCGGCCAAGATTCCGGGAGTTGGTGTCTG

AATTCTCCCGCATGGCCAGGGACCCCCAGCGCTTTGTGGTCATCCAGAA

TGAGGACTTGGGCCCAGCCAGTCCCTTGGACAGCACCTTCTACCGCTCA

CTGCTGGAGGACGATGACATGGGGGACCTGGTGGATGCTGAGGAGTAT

CTGGTACCCCAGCAGGGCTTCTTCTGTCCAGACCCTGCCCCGGGCGCTG

GGGGCATGGTCCACCACAGGCACCGCAGCTCATCTACCAGGAGTGGCG

GTGGGGACCTGACACTAGGGCTGGAGCCCTCTGAAGAGGAGGCCCCCA

GGTCTCCACTGGCACCCTCCGAAGGGGCTGGCTCCGATGTATTTGATGG

TGACCTGGGAATGGGGGCAGCCAAGGGGCTGCAAAGCCTCCCCACACA

TGACCCCAGCCCTCTACAGCGGTACAGTGAGGACCCCACAGTACCCCTG

CCCTCTGAGACTGATGGCTACGTTGCCCCCCTGACCTGCAGCCCCCAGC

CTGAATATGTGAACCAGCCAGATGTTCGGCCCCAGCCCCCTTCGCCCCG

AGAGGGCCCTCTGCCTGCTGCCCGACCTGCTGGTGCCACTCTGGAAAGG

CCCAAGACTCTCTCCCCAGGGAAGAATGGGGTCGTCAAAGACGTTTTTG

CCTTTGGGGGTGCCGTGGAGAACCCCGAGTACTTGACACCCCAGGGAG

GAGCTGCCCCTCAGCCCCACCCTCCTCCTGCCTTCAGCCCAGCCTTCGA

CAACCTCTATTACTGGGACCAGGACCCACCAGAGCGGGGGGCTCCACC

CAGCACCTTCAAAGGGACACCTACGGCAGAGAACCCAGAGTACCTGGG

TCTGGACGTGCCAGTGTGAACCAGAAGGCCAAGTCCGCAGAAGCCCTG

ATGTGTCCTCAGGGAGCAGGGAAGGCCTGACTTCTGCTGGCATCAAGA

GGTGGGAGGGCCCTCCGACCACTTCCAGGGGAACCTGCCATGCCAGGA

ACCTGTCCTAAGGAACCTTCCTTCCTGCTTGAGTTCCCAGATGGCTGGA

AGGGGTCCAGCCTCGTTGGAAGAGGAACAGCACTGGGGAGTCTTTGTG

GATTCTGAGGCCCTGCCCAATGAGACTCTAGGGTCCAGTGGATGCCACA

GCCCAGCTTGGCCCTTTCCTTCCAGATCCTGGGTACTGAAAGCCTTAGG

GAAGCTGGCCTGAGAGGGGAAGCGGCCCTAAGGGAGTGTCTAAGAACA

AAAGCGACCCATTCAGAGACTGTCCCTGAAACCTAGTACTGCCCCCCAT

GAGGAAGGAACAGCAATGGTGTCAGTATCCAGGCTTTGTACAGAGTGC

TTTTCTGTTTAGTTTTTACTTTTTTTGTTTTGTTTTTTTAAAGATGAAATA

AAGACCCAGGGGGAGAATGGGTGTTGTATGGGGAGGCAAGTGTGGGGG

GTCCTTCTCCACACCCACTTTGTCCATTTGCAAATATATTTTGGAAAACA

GCTA

ΝΜ_001122742 ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAA 165

ACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGGCTCGAAA

GGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTC

TGAGTGATAATCTTCTCTTCAAGAAGAAGAAAACTAGGAAGGAGTAAG

CACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCA

CAGCACTTCTTGAAAAAGGATGTAGATTTTAATCTGAACTTTGAACCAT

CACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACG

GTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACC

AAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTG

GAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGG

GCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCG

AGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGG

TCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGC

GTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCT

CCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCC

TGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCA

GCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAA

ATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCA

ATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACT

GTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTC

CTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAA

CGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAG

GAGGAAGAGCTGCCAGGCCTGCCGGCTCCGCAAATGCTACGAAGTGGG AATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGT

TGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTG

GGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCA

TGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGA

CCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCCATACTCTATTCC

GAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTAC

TGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGA

AGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCT

TCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGC

TCCATGGAGCACCCAGGGAAGCTACTGTTTGCTCCTAACTTGCTCTTGG

ACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACA

TGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGA

GGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACA

CATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCA

CCGAGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAG

GCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTCCTC

CTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATC

TGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTATGACCTGCTGCT

GGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGG

GGCATCCGTGGAGGAGACGGACCAAAGCCACTTGGCCACTGCGGGCTC

TACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAG

GGTTTCCCTGCCACGGTCTGAGAGCTCCCTGGCTCCCACACGGTTCAGA

TAATCCCTGCTGCATTTTACCCTCATCATGCACCACTTTAGCCAAATTCT

GTCTCCTGCATACACTCCGGCATGCATCCAACACCAATGGCTTTCTAGA

TGAGTGGCCATTCATTTGCTTGCTCAGTTCTTAGTGGCACATCTTCTGTC

TTCTGTTGGGAACAGCCAAAGGGATTCCAAGGCTAAATCTTTGTAACAG

CTCTCTTTCCCCCTTGCTATGTTACTAAGCGTGAGGATTCCCGTAGCTCT

TCACAGCTGAACTCAGTCTATGGGTTGGGGCTCAGATAACTCTGTGCAT

TTAAGCTACTTGTAGAGACCCAGGCCTGGAGAGTAGACATTTTGCCTCT

GATAAGCACTTTTTAAATGGCTCTAAGAATAAGCCACAGCAAAGAATTT

AAAGTGGCTCCTTTAATTGGTGACTTGGAGAAAGCTAGGTCAAGGGTTT

ATTATAGCACCCTCTTGTATTCCTATGGCAATGCATCCTTTTATGAAAGT

GGTACACCTTAAAGCTTTTATATGACTGTAGCAGAGTATCTGGTGATTG

TCAATTCATTCCCCCTATAGGAATACAAGGGGCACACAGGGAAGGCAG

ATCCCCTAGTTGGCAAGACTATTTTAACTTGATACACTGCAGATTCAGA

TGTGCTGAAAGCTCTGCCTCTGGCTTTCCGGTCATGGGTTCCAGTTAATT

CATGCCTCCCATGGACCTATGGAGAGCAGCAAGTTGATCTTAGTTAAGT

CTCCCTATATGAGGGATAAGTTCCTGATTTTTGTTTTTATTTTTGTGTTAC

AAAAGAAAGCCCTCCCTCCCTGAACTTGCAGTAAGGTCAGCTTCAGGAC

CTGTTCCAGTGGGCACTGTACTTGGATCTTCCCGGCGTGTGTGTGCCTTA

CACAGGGGTGAACTGTTCACTGTGGTGATGCATGATGAGGGTAAATGG

TAGTTGAAAGGAGCAGGGGCCCTGGTGTTGCATTTAGCCCTGGGGCATG

GAGCTGAACAGTACTTGTGCAGGATTGTTGTGGCTACTAGAGAACAAG

AGGGAAAGTAGGGCAGAAACTGGATACAGTTCTGAGGCACAGCCAGAC

TTGCTCAGGGTGGCCCTGCCACAGGCTGCAGCTACCTAGGAACATTCCT

TGCAGACCCCGCATTGCCCTTTGGGGGTGCCCTGGGATCCCTGGGGTAG

TCCAGCTCTTCTTCATTTCCCAGCGTGGCCCTGGTTGGAAGAAGCAGCT

GTCACAGCTGCTGTAGACAGCTGTGTTCCTACAATTGGCCCAGCACCCT

GGGGCACGGGAGAAGGGTGGGGACCGTTGCTGTCACTACTCAGGCTGA

CTGGGGCCTGGTCAGATTACGTATGCCCTTGGTGGTTTAGAGATAATCC

AAAATCAGGGTTTGGTTTGGGGAAGAAAATCCTCCCCCTTCCTCCCCCG

CCCCGTTCCCTACCGCCTCCACTCCTGCCAGCTCATTTCCTTCAATTTCC

TTTGACCTATAGGCTAAAAAAGAAAGGCTCATTCCAGCCACAGGGCAG

CCTTCCCTGGGCCTTTGCTTCTCTAGCACAATTATGGGTTACTTCCTTTTT

CTTAACAAAAAAGAATGTTTGATTTCCTCTGGGTGACCTTATTGTCTGTA

ATTGAAACCCTATTGAGAGGTGATGTCTGTGTTAGCCAATGACCCAGGT GAGCTGCTCGGGCTTCTCTTGGTATGTCTTGTTTGGAAAAGTGGATTTCA

TTCATTTCTGATTGTCCAGTTAAGTGATCACCAAAGGACTGAGAATCTG

GGAGGGCAAAAAAAAAAAAAAAGTTTTTATGTGCACTTAAATTTGGGG

ACAATTTTATGTATCTGTGTTAAGGATATGTTTAAGAACATAATTCTTTT

GTTGCTGTTTGTTTAAGAAGCACCTTAGTTTGTTTAAGAAGCACCTTATA

TAGTATAATATATATTTTTTTGAAATTACATTGCTTGTTTATCAGACAAT

TGAATGTAGTAATTCTGTTCTGGATTTAATTTGACTGGGTTAACATGCA

AAAACCAAGGAAAAATATTTAGTTTTTTTTTTTTTTTTTGTATACTTTTC

AAGCTACCTTGTCATGTATACAGTCATTTATGCCTAAAGCCTGGTGATT

ATTCATTTAAATGAAGATCACATTTCATATCAACTTTTGTATCCACAGTA

GACAAAATAGCACTAATCCAGATGCCTATTGTTGGATACTGAATGACAG

ACAATCTTATGTAGCAAAGATTATGCCTGAAAAGGAAAATTATTCAGG

GCAGCTAATTTTGCTTTTACCAAAATATCAGTAGTAATATTTTTGGACA

GTAGCTAATGGGTCAGTGGGTTCTTTTTAATGTTTATACTTAGATTTTCT

TTTAAAAAAATTAAAATAAAACAAAAAAAAATTTCTAGGACTAGACGA

TGTAATACCAGCTAAAGCCAAACAATTATACAGTGGAAGGTTTTACATT

ATTCATCCAATGTGTTTCTATTCATGTTAAGATACTACTACATTTGAAGT

GGGCAGAGAACATCAGATGATTGAAATGTTCGCCCAGGGGTCTCCAGC

AACTTTGGAAATCTCTTTGTATTTTTACTTGAAGTGCCACTAATGGACAG

CAGATATTTTCTGGCTGATGTTGGTATTGGGTGTAGGAACATGATTTAA

AAAAAAACTCTTGCCTCTGCTTTCCCCCACTCTGAGGCAAGTTAAAATG

TAAAAGATGTGATTTATCTGGGGGGCTCAGGTATGGTGGGGAAGTGGA

TTCAGGAATCTGGGGAATGGCAAATATATTAAGAAGAGTATTGAAAGT

ATTTGGAGGAAAATGGTTAATTCTGGGTGTGCACCAGGGTTCAGTAGAG

TCCACTTCTGCCCTGGAGACCACAAATCAACTAGCTCCATTTACAGCCA

TTTCTAAAATGGCAGCTTCAGTTCTAGAGAAGAAAGAACAACATCAGC

AGTAAAGTCCATGGAATAGCTAGTGGTCTGTGTTTCTTTTCGCCATTGCC

TAGCTTGCCGTAATGATTCTATAATGCCATCATGCAGCAATTATGAGAG

GCTAGGTCATCCAAAGAGAAGACCCTATCAATGTAGGTTGCAAAATCT

AACCCCTAAGGAAGTGCAGTCTTTGATTTGATTTCCCTAGTAACCTTGC

AGATATGTTTAACCAAGCCATAGCCCATGCCTTTTGAGGGCTGAACAAA

TAAGGGACTTACTGATAATTTACTTTTGATCACATTAAGGTGTTCTCACC

TTGAAATCTTATACACTGAAATGGCCATTGATTTAGGCCACTGGCTTAG

AGTACTCCTTCCCCTGCATGACACTGATTACAAATACTTTCCTATTCATA

CTTTCCAATTATGAGATGGACTGTGGGTACTGGGAGTGATCACTAACAC

CATAGTAATGTCTAATATTCACAGGCAGATCTGCTTGGGGAAGCTAGTT

ATGTGAAAGGCAAATAGAGTCATACAGTAGCTCAAAAGGCAACCATAA

TTCTCTTTGGTGCAGGTCTTGGGAGCGTGATCTAGATTACACTGCACCA

TTCCCAAGTTAATCCCCTGAAAACTTACTCTCAACTGGAGCAAATGAAC

TTTGGTCCCAAATATCCATCTTTTCAGTAGCGTTAATTATGCTCTGTTTC

CAACTGCATTTCCTTTCCAATTGAATTAAAGTGTGGCCTCGTTTTTAGTC

ATTTAAAATTGTTTTCTAAGTAATTGCTGCCTCTATTATGGCACTTCAAT

TTTGCACTGTCTTTTGAGATTCAAGAAAAATTTCTATTCTTTTTTTTGCAT

CCAATTGTGCCTGAACTTTTAAAATATGTAAATGCTGCCATGTTCCAAA

CCCATCGTCAGTGTGTGTGTTTAGAGCTGTGCACCCTAGAAACAACATA

TTGTCCCATGAGCAGGTGCCTGAGACACAGACCCCTTTGCATTCACAGA

GAGGTCATTGGTTATAGAGACTTGAATTAATAAGTGACATTATGCCAGT

TTCTGTTCTCTCACAGGTGATAAACAATGCTTTTTGTGCACTACATACTC

TTCAGTGTAGAGCTCTTGTTTTATGGGAAAAGGCTCAAATGCCAAATTG

TGTTTGATGGATTAATATGCCCTTTTGCCGATGCATACTATTACTGATGT

GACTCGGTTTTGTCGCAGCTTTGCTTTGTTTAATGAAACACACTTGTAAA

CCTCTTTTGCACTTTGAAAAAGAATCCAGCGGGATGCTCGAGCACCTGT

AAACAATTTTCTCAACCTATTTGATGTTCAAATAAAGAATTAAACTAAA

NM_130398 AAATTGAAAGGTCAGCCTTTCGCGCGCTGTGTAGGCAAGTTACCCGTGT 166

TCTGCGTTGCCGGCCGTGGGTGCTCTGGCCACAGTGAGTTAGGGGCGTC GGAGCGGGTTTCTCCAACCGCAATCGGCTCCGCTCAAGGGGAGGAGGA GAGTCCCTTCTCGGAAGGCCTAAGGAAACGTGTCGTCTGGAATGGGCTT

GGGGGCCACGCCTGCACATCTCCGCGAGACAGAGGGATAAAGTGAAGA

TGGTGCTGTTATTGTTACCTCGAGTGCCACATGCGACCTCTGAGATATG

TACACAGTCATTCTTACTATCGCACTCAGCCATTCTTACTACGCTAAAG

AAGAAATAATTATTCGAGGATATTTGCCTGGCCCAGAAGAAACTTATGT

AAATTTCATGAACTATTATATCCGTTTTCCTCGGAGTGAGAGAAAACTC

TTTTTAGATATCATCTGAGAGAACTAGTGAATCCCAGTCACTGAGTGGA

GTTGAGAGTCTAAGAACCTCTGAAATTTGAGAACTGCTGGACCAGAGC

CTTTAGAGCTCTGATAAGGTGTCAACAGGGTAGTTAATTTGGCACCATG

GGGATACAGGGATTGCTACAATTTATCAAAGAAGCTTCAGAACCCATCC

ATGTGAGGAAGTATAAAGGGCAGGTAGTAGCTGTGGATACATATTGCT

GGCTTCACAAAGGAGCTATTGCTTGTGCTGAAAAACTAGCCAAAGGTG

AACCTACTGATAGGTATGTAGGATTTTGTATGAAATTTGTAAATATGTT

ACTATCTCATGGGATCAAGCCTATTCTCGTATTTGATGGATGTACTTTAC

CTTCTAAAAAGGAAGTAGAGAGATCTAGAAGAGAAAGACGACAAGCC

AATCTTCTTAAGGGAAAGCAACTTCTTCGTGAGGGGAAAGTCTCGGAA

GCTCGAGAGTGTTTCACCCGGTCTATCAATATCACACATGCCATGGCCC

ACAAAGTAATTAAAGCTGCCCGGTCTCAGGGGGTAGATTGCCTCGTGGC

TCCCTATGAAGCTGATGCGCAGTTGGCCTATCTTAACAAAGCGGGAATT

GTGCAAGCCATAATTACAGAGGACTCGGATCTCCTAGCTTTTGGCTGTA

AAAAGGTAATTTTAAAGATGGACCAGTTTGGAAATGGACTTGAAATTG

ATCAAGCTCGGCTAGGAATGTGCAGACAGCTTGGGGATGTATTCACGG

AAGAGAAGTTTCGTTACATGTGTATTCTTTCAGGTTGTGACTACCTGTCA

TCACTGCGTGGGATTGGATTAGCAAAGGCATGCAAAGTCCTAAGACTA

GCCAATAATCCAGATATAGTAAAGGTTATCAAGAAAATTGGACATTATC

TCAAGATGAATATCACGGTACCAGAGGATTACATCAACGGGTTTATTCG

GGCCAACAATACCTTCCTCTATCAGCTAGTTTTTGATCCCATCAAAAGG

AAACTTATTCCTCTGAACGCCTATGAAGATGATGTTGATCCTGAAACAC

TAAGCTACGCTGGGCAATATGTTGATGATTCCATAGCTCTTCAAATAGC

ACTTGGAAATAAAGATATAAATACTTTTGAACAGATCGATGACTACAAT

CCAGACACTGCTATGCCTGCCCATTCAAGAAGTCATAGTTGGGATGACA

AAACATGTCAAAAGTCAGCTAATGTTAGCAGCATTTGGCATAGGAATTA

CTCTCCCAGACCAGAGTCGGGTACTGTTTCAGATGCCCCACAATTGAAG

GAAAATCCAAGTACTGTGGGAGTGGAACGAGTGATTAGTACTAAAGGG

TTAAATCTCCCAAGGAAATCATCCATTGTGAAAAGACCAAGAAGTGCA

GAGCTGTCAGAAGATGACCTGTTGAGTCAGTATTCTCTTTCATTTACGA

AGAAGACCAAGAAAAATAGCTCTGAAGGCAATAAATCATTGAGCTTTT

CTGAAGTGTTTGTGCCTGACCTGGTAAATGGACCTACTAACAAAAAGAG

TGTAAGCACTCCACCTAGGACGAGAAATAAATTTGCAACATTTTTACAA

AGGAAAAATGAAGAAAGTGGTGCAGTTGTGGTTCCAGGGACCAGAAGC

AGGTTTTTTTGCAGTTCAGATTCTACTGACTGTGTATCAAACAAAGTGA

GCATCCAGCCTCTGGATGAAACTGCTGTCACAGATAAAGAGAACAATC

TGCATGAATCAGAGTATGGAGACCAAGAAGGCAAGAGACTGGTTGACA

CAGATGTAGCACGTAATTCAAGTGATGACATTCCGAATAATCATATTCC

AGGTGATCATATTCCAGACAAGGCAACAGTGTTTACAGATGAAGAGTC

CTACTCTTTTGAGAGCAGCAAATTTACAAGGACCATTTCACCACCCACT

TTGGGAACACTAAGAAGTTGTTTTAGTTGGTCTGGAGGTCTTGGAGATT

TTTCAAGAACGCCGAGCCCCTCTCCAAGCACAGCATTGCAGCAGTTCCG

AAGAAAGAGCGATTCCCCCACCTCTTTGCCTGAGAATAATATGTCTGAT

GTGTCGCAGTTAAAGAGCGAGGAGTCCAGTGACGATGAGTCTCATCCCT

TACGAGAAGAGGCATGTTCTTCACAGTCCCAGGAAAGTGGAGAATTCT

CACTGCAGAGTTCAAATGCATCAAAGCTTTCTCAGTGCTCTAGTAAGGA

CTCTGATTCAGAGGAATCTGATTGCAATATTAAGTTACTTGACAGTCAA

AGTGACCAGACCTCCAAGCTACGTTTATCTCATTTCTCAAAAAAAGACA

CACCTCTAAGGAACAAGGTTCCTGGGCTATATAAGTCCAGTTCTGCAGA

CTCTCTTTCTACAACCAAGATCAAACCTCTAGGACCTGCCAGAGCCAGT GGGCTGAGCAAGAAGCCGGCAAGCATCCAGAAGAGAAAGCATCATAAT

GCCGAGAACAAGCCGGGGTTACAGATCAAACTCAATGAGCTCTGGAAA

AACTTTGGATTTAAAAAAGATTCTGAAAAGCTTCCTCCTTGTAAGAAAC

CCCTGTCCCCAGTCAGAGATAACATCCAACTAACTCCAGAAGCGGAAG

AGGATATATTTAACAAACCTGAATGTGGCCGTGTTCAAAGAGCAATATT

CCAGTAAATGCAGACTGCTGCAAAGCTTTTGCCTGCAAGAGAATCTGAT

CAATTTGAAGTCCCTGTTTGGGAATGAGGCACTTATCAGCATGAAGAAT

TTTTTCTCATTCTGTGCCATTTTAAAAATAGAATACATTTTGTATATTAA

CTTTATAATTGGGTTGTGGTTTTTTTGCTCAGCTTTTTATATTTTTATAAG

AAGCTAAATAGAAGAATAATTGTATCTCTGACAGGTTTTTGGAGGTTTT

AGTGTTAATTGGGAAAATCCTCTGGAGTTTATAAAAGTCTACTCTAAAT

ATTTCTGTAATGTTGTCAAGTAGAAAGATAGTAAATGGAGAAACTACA

AAAAAAAAAAAAAAAAA

CCATGACCTGCCTTGAGAAGGGGCAGGGGAAGCCAGATGGACTGGAAG 167

TGGAGTGGCAGTGACCAAGGAGGAGGAGGTGTGATAGGCTTCCCACGC

AGGGTAGATCCAGAGACACCAGTGCCACCCATAGGCCCCTAGGACTGC

AGTGGTCACCCGATTCCTTTGTCCCAGCTGAGACTCAGTTCTGAGTGTTC

TATTTTGGGGAACAGAGGCGTCCTTGGTAGCATTTGGAAGAGGATAGCC

AGCTGGGGTGTGTGTACATCACAGCCTGACAGTAACAGCATCCGAACC

AGAGGTGACTGGCTAAGGGCAGACCCAGGGCAACAGGTTAACCGTTCT

AGGGCCGGGCACAGGGAGGAGAACATTCCAACACTCTGTGTGCCCAGT

GCCGACGCACGTTCTCTCTTTTATCCTCAAAACAGTCCTATGAGGATAT

AAGCCAGAGAGAGACAGAGACAAGGAATTACAAGTTGGTGAGAGTCA

GGATTTGAACTTGGCTCTGGCAGATGGAAAATTAGGGTCTGTATTCTTT

ACAAAACCGTGTGTGCCTCAGATGGAGTTGGTGCATAACAAGCAGAGG

TATCCAGGGTCGCGGTCCTGCTTGCCACGGAAGGGGCCGCCTTGTCAGT

TGTGACCACCCAGCCCTGGAAATGTCAGTAATGCTGTAAGGAGTGGGG

ATCGGATCAGATGCCATCCAGATGCTGAAGTTTGACCTTGTGTCATTTTT

CACTTTCTTTTTTGGCTCTTCTGCAATCAATTCATTTATTTAGCAAAAAA

GAAATTATGTGTGCCGAGAGCATGCAGAAGATATGTCTCCGTTCTCTGC

TTCCCTCCAAAAAAGAATCCCAAAACTGCTTTCTGTGAACGTGTGCCAG

GGTCCCAGCAGGACTCAGGGAGAGCAGGAAGCCCAGCCCAGACCCCTT

GCACAACCTACCGTGGGGAGGCCTTAGGCTCTGGCTACTACAGAGCTG

GTTCCAGTCTGCACTGCCACAGCCTGGCCAGGGACTTGGACACATCTGC

TGGCCACTTCCTGTCTCAGTTTCCTTATCTGCAAAATAAGGGAAAAGCC

CCCACAAAGGTGCACGTGTAGCAGGAGCTCTTTTCCCTCCCTATTTTAG

GAAGGCAGTTGGTGGGAAGTCCAGCTTGGGTCCCTGAGAGCTGTGAGA

AGGAGATGCGGCTGCTGCTGGCCCTGTTGGGGGTCCTGCTGAGTGTGCC

TGGGCCTCCAGTCTTGTCCCTGGAGGCCTCTGAGGAAGTGGAGCTTGGT

ATGGCTTCTGAGGTGGGAGAGGGTGGCAGGGGTGGGAAGAGTGGGCAC

CAGGAGGGGGCTGCTGGGCTGAGCAAAGCTGGAAAGGATCCTTGCCCA

GGCCCTGAGAAGGTGGCGGCAGGGCAGGGCTCAACCACTGAGACTCAG

TCAGTGCCTGGCTTCCAGCAAGCATTCATCTATCACTGTGTCTGCGAGA

GAGGACTGGCCTTGCAGGGCGCAGGGCCCTAAGCTGGGCTGCAGAGCT

GGTGGTGAGCTCCTTGCCTGGGTGTGTGTGCGTGTGTGTGTGTGTTCTGT

GCACTGGGTGTGTGACCTAGGAGGTCCAGGCAGCATGTGTGGTATAAG

CATTATGAGGGTGATATGCCCCGGTGCAGCATGACCCTGTATGTGGCAC

CAACAGCATGTGCCTTGTGTGTGTGTGTGTCCGTATGTGTGTGTGTGTAT

GCGTGTGTGTGTGTGTGTGTGTGTGTCTTGGCCACTGTCATGTGCACTAA

ATGCTGTGTGTGTGACATGCCCCAAGAGTGTGGCATTTGCCCTGGGTGT

GGCATCCGCAGCATGTGGCTGTGTGGGTGTCAAGGAGTGGTGGCTCCTT

CAGCATGCGTTGCGAAGTGCTTGTGCCCTGCATGTGCGGTGTGTTCTCT

GTACACAGGAGGCTGCCTCAGATGGGGCTGCGGGGTCTGCTGACCTCTG

CCCTCTGCCCACAGAGCCCTGCCTGGCTCCCAGCCTGGAGCAGCAAGAG

CAGGAGCTGACAGTAGCCCTTGGGCAGCCTGTGCGGCTGTGCTGTGGGC

GGGCTGAGCGTGGTGGCCACTGGTACAAGGAGGGCAGTCGCCTGGCAC CTGCTGGCCGTGTACGGGGCTGGAGGGGCCGCCTAGAGATTGCCAGCTT

CCTACCTGAGGATGCTGGCCGCTACCTCTGCCTGGCACGAGGCTCCATG

ATCGTCCTGCAGAATCTCACCTTGATTACAGGTGACTCCTTGACCTCCA

GCAACGATGATGAGGACCCCAAGTCCCATAGGGACCTCTCGAATAGGC

ACAGTTACCCCCAGCAAGGTCAGTAGGTCTCCAAGGACTTGTGTCCCCG

CTGCTGCTCATCTGATCACTGAGAAGAGGAGGCCTGTGTGGGAACACA

CGGTCATTCTAGGGGCCTTCCCCTGCCCTCCAGCACCCTACTGGACACA

CCCCCAGCGCATGGAGAAGAAACTGCATGCAGTACCTGCGGGGAACAC

CGTCAAGTTCCGCTGTCCAGCTGCAGGCAACCCCACGCCCACCATCCGC

TGGCTTAAGGATGGACAGGCCTTTCATGGGGAGAACCGCATTGGAGGC

ATTCGGCTGCGCCATCAGCACTGGAGTCTCGTGATGGAGAGCGTGGTGC

CCTCGGACCGCGGCACATACACCTGCCTGGTAGAGAACGCTGTGGGCA

GCATCCGTTATAACTACCTGCTAGATGTGCTGGAGCGGTCCCCGCACCG

GCCCATCCTGCAGGCCGGGCTCCCGGCCAACACCACAGCCGTGGTGGG

CAGCGACGTGGAGCTGCTGTGCAAGGTGTACAGCGATGCCCAGCCCCA

CATCCAGTGGCTGAAGCACATCGTCATCAACGGCAGCAGCTTCGGAGC

CGACGGTTTCCCCTATGTGCAAGTCCTAAAGACTGCAGACATCAATAGC

TCAGAGGTGGAGGTCCTGTACCTGCGGAACGTGTCAGCCGAGGACGCA

GGCGAGTACACCTGCCTCGCAGGCAATTCCATCGGCCTCTCCTACCAGT

CTGCCTGGCTCACGGTGCTGCCAGGTGAGCACCTGAAGGGCCAGGAGA

TGCTGCGAGATGCCCCTCTGGGCCAGCAGTGGGGGCTGTGGCCTGTTGG

GTGGTCAGTCTCTGTTGGCCTGTGGGGTCTGGCCTGGGGGGCAGTGTGT

GGATTTGTGGGTTTGAGCTGTATGACAGCCCCTCTGTGCCTCTCCACAC

GTGGCCGTCCATGTGACCGTCTGCTGAGGTGTGGGTGCCTGGGACTGGG

CATAACTACAGCTTCCTCCGTGTGTGTCCCCACATATGTTGGGAGCTGG

GAGGGACTGAGTTAGGGTGCACGGGGCGGCCAGTCTCACCACTGACCA

GTTTGTCTGTCTGTGTGTGTCCATGTGCGAGGGCAGAGGAGGACCCCAC

ATGGACCGCAGCAGCGCCCGAGGCCAGGTATACGGACATCATCCTGTA

CGCGTCGGGCTCCCTGGCCTTGGCTGTGCTCCTGCTGCTGGCCAGGCTG

TATCGAGGGCAGGCGCTCCACGGCCGGCACCCCCGCCCGCCCGCCACT

GTGCAGAAGCTCTCCCGCTTCCCTCTGGCCCGACAGTTCTCCCTGGAGT

CAGGCTCTTCCGGCAAGTCAAGCTCATCCCTGGTACGAGGCGTGCGTCT

CTCCTCCAGCGGCCCCGCCTTGCTCGCCGGCCTCGTGAGTCTAGATCTA

CCTCTCGACCCACTATGGGAGTTCCCCCGGGACAGGCTGGTGCTTGGGA

AGCCCCTAGGCGAGGGCTGCTTTGGCCAGGTAGTACGTGCAGAGGCCTT

TGGCATGGACCCTGCCCGGCCTGACCAAGCCAGCACTGTGGCCGTCAA

GATGCTCAAAGACAACGCCTCTGACAAGGACCTGGCCGACCTGGTCTC

GGAGATGGAGGTGATGAAGCTGATCGGCCGACACAAGAACATCATCAA

CCTGCTTGGTGTCTGCACCCAGGAAGGGCCCCTGTACGTGATCGTGGAG

TGCGCCGCCAAGGGAAACCTGCGGGAGTTCCTGCGGGCCCGGCGCCCC

CCAGGCCCCGACCTCAGCCCCGACGGTCCTCGGAGCAGTGAGGGGCCG

CTCTCCTTCCCAGTCCTGGTCTCCTGCGCCTACCAGGTGGCCCGAGGCA

TGCAGTATCTGGAGTCCCGGAAGTGTATCCACCGGGACCTGGCTGCCCG

CAATGTGCTGGTGACTGAGGACAATGTGATGAAGATTGCTGACTTTGGG

CTGGCCCGCGGCGTCCACCACATTGACTACTATAAGAAAACCAGCAAC

GGCCGCCTGCCTGTGAAGTGGATGGCGCCCGAGGCCTTGTTTGACCGGG

TGTACACACACCAGAGTGACGTGTGGTCTTTTGGGATCCTGCTATGGGA

GATCTTCACCCTCGGGGGCTCCCCGTATCCTGGCATCCCGGTGGAGGAG

CTGTTCTCGCTGCTGCGGGAGGGACATCGGATGGACCGACCCCCACACT

GCCCCCCAGAGCTGTACGGGCTGATGCGTGAGTGCTGGCACGCAGCGC

CCTCCCAGAGGCCTACCTTCAAGCAGCTGGTGGAGGCGCTGGACAAGG

TCCTGCTGGCCGTCTCTGAGGAGTACCTCGACCTCCGCCTGACCTTCGG

ACCCTATTCCCCCTCTGGTGGGGACGCCAGCAGCACCTGCTCCTCCAGC

GATTCTGTCTTCAGCCACGACCCCCTGCCATTGGGATCCAGCTCCTTCCC

CTTCGGGTCTGGGGTGCAGACATGAGCAAGGCTCAAGGCTGTGCAGGC

ACATAGGCTGGTGGCCTTGGGCCTTGGGGCTCAGCCACAGCCTGACACA GTGCTCGACCTTGATAGCATGGGGCCCCTGGCCCAGAGTTGCTGTGCCG

TGTCCAAGGGCCGTGCCCTTGCCCTTGGAGCTGCCGTGCCTGTGTCCTG

ATGGCCCAAATGTCAGGGTTCTGCTCGGCTTCTTGGACCTTGGCGCTTA

GTCCCCATCCCGGGTTTGGCTGAGCCTGGCTGGAGAGCTGCTATGCTAA

ACCTCCTGCCTCCCAATACCAGCAGGAGGTTCTGGGCCTCTGAACCCCC

TTTCCCCACACCTCCCCCTGCTGCTGCTGCCCCAGCGTCTTGACGGGAG

CATTGGCCCCTGAGCCCAGAGAAGCTGGAAGCCTGCCGAAAACAGGAG

CAAATGGCGTTTTATAAATTATTTTTTTGAAAT

NM_004496 TAAGATCCACATCAGCTCAACTGCACTTGCCTCGCAGAGGCAGCCCGCT 168

CACTTCCCGCGGAGGCGCTCCCCGGCGCCGCGCTCCGCGGCAGCCGCCT

GCCCCCGGCGCTGCCCCCGCCCGCCGCGCCGCCGCCGCCGCCGCGCACG

CCGCGCCCCGCAGCTCTGGGCTTCCTCTTCGCCCGGGTGGCGTTGGGCC

CGCGCGGGCGCTCGGGTGACTGCAGCTGCTCAGCTCCCCTCCCCCGCCC

CGCGCCGCGCGGCCGCCCGTCGCTTCGCACAGGGCTGGATGGTTGTATT

GGGCAGGGTGGCTCCAGGATGTTAGGAACTGTGAAGATGGAAGGGCAT

GAAACCAGCGACTGGAACAGCTACTACGCAGACACGCAGGAGGCCTAC

TCCTCCGTCCCGGTCAGCAACATGAACTCAGGCCTGGGCTCCATGAACT

CCATGAACACCTACATGACCATGAACACCATGACTACGAGCGGCAACA

TGACCCCGGCGTCCTTCAACATGTCCTATGCCAACCCGGGCCTAGGGGC

CGGCCTGAGTCCCGGCGCAGTAGCCGGCATGCCGGGGGGCTCGGCGGG

CGCCATGAACAGCATGACTGCGGCCGGCGTGACGGCCATGGGTACGGC

GCTGAGCCCGAGCGGCATGGGCGCCATGGGTGCGCAGCAGGCGGCCTC

CATGAATGGCCTGGGCCCCTACGCGGCCGCCATGAACCCGTGCATGAG

CCCCATGGCGTACGCGCCGTCCAACCTGGGCCGCAGCCGCGCGGGCGG

CGGCGGCGACGCCAAGACGTTCAAGCGCAGCTACCCGCACGCCAAGCC

GCCCTACTCGTACATCTCGCTCATCACCATGGCCATCCAGCAGGCGCCC

AGCAAGATGCTCACGCTGAGCGAGATCTACCAGTGGATCATGGACCTCT

TCCCCTATTACCGGCAGAACCAGCAGCGCTGGCAGAACTCCATCCGCCA

CTCGCTGTCCTTCAATGACTGCTTCGTCAAGGTGGCACGCTCCCCGGAC

AAGCCGGGCAAGGGCTCCTACTGGACGCTGCACCCGGACTCCGGCAAC

ATGTTCGAGAACGGCTGCTACTTGCGCCGCCAGAAGCGCTTCAAGTGCG

AGAAGCAGCCGGGGGCCGGCGGCGGGGGCGGGAGCGGAAGCGGGGGC

AGCGGCGCCAAGGGCGGCCCTGAGAGCCGCAAGGACCCCTCTGGCGCC

TCTAACCCCAGCGCCGACTCGCCCCTCCATCGGGGTGTGCACGGGAAGA

CCGGCCAGCTAGAGGGCGCGCCGGCCCCCGGGCCCGCCGCCAGCCCCC

AGACTCTGGACCACAGTGGGGCGACGGCGACAGGGGGCGCCTCGGAGT

TGAAGACTCCAGCCTCCTCAACTGCGCCCCCCATAAGCTCCGGGCCCGG

GGCGCTGGCCTCTGTGCCCGCCTCTCACCCGGCACACGGCTTGGCACCC

CACGAGTCCCAGCTGCACCTGAAAGGGGACCCCCACTACTCCTTCAACC

ACCCGTTCTCCATCAACAACCTCATGTCCTCCTCGGAGCAGCAGCATAA

GCTGGACTTCAAGGCATACGAACAGGCACTGCAATACTCGCCTTACGGC

TCTACGTTGCCCGCCAGCCTGCCTCTAGGCAGCGCCTCGGTGACCACCA

GGAGCCCCATCGAGCCCTCAGCCCTGGAGCCGGCGTACTACCAAGGTG

TGTATTCCAGACCCGTCCTAAACACTTCCTAGCTCCCGGGACTGGGGGG

TTTGTCTGGCATAGCCATGCTGGTAGCAAGAGAGAAAAAATCAACAGC

AAACAAAACCACACAAACCAAACCGTCAACAGCATAATAAAATCCCAA

CAACTATTTTTATTTCATTTTTCATGCACAACCTTTCCCCCAGTGCAAAA

GACTGTTACTTTATTATTGTATTCAAAATTCATTGTGTATATTACTACAA

AGACAACCCCAAACCAATTTTTTTCCTGCGAAGTTTAATGATCCACAAG

TGTATATATGAAATTCTCCTCCTTCCTTGCCCCCCTCTCTTTCTTCCCTCT

TTCCCCTCCAGACATTCTAGTTTGTGGAGGGTTATTTAAAAAAACAAAA

AAGGAAGATGGTCAAGTTTGTAAAATATTTGTTTGTGCTTTTTCCCCCTC

CTTACCTGACCCCCTACGAGTTTACAGGTCTGTGGCAATACTCTTAACC

ATAAGAATTGAAATGGTGAAGAAACAAGTATACACTAGAGGCTCTTAA

AAGTATTGAAAGACAATACTGCTGTTATATAGCAAGACATAAACAGAT

TATAAACATCAGAGCCATTTGCTTCTCAGTTTACATTTCTGATACATGCA GATAGCAGATGTCTTTAAATGAAATACATGTATATTGTGTATGGACTTA

ATTATGCACATGCTCAGATGTGTAGACATCCTCCGTATATTTACATAAC

ATATAGAGGTAATAGATAGGTGATATACATGATACATTCTCAAGAGTTG

CTTGACCGAAAGTTACAAGGACCCCAACCCCTTTGTCCTCTCTACCCAC

AGATGGCCCTGGGAATCAATTCCTCAGGAATTGCCCTCAAGAACTCTGC

TTCTTGCTTTGCAGAGTGCCATGGTCATGTCATTCTGAGGTCACATAAC

ACATAAAATTAGTTTCTATGAGTGTATACCATTTAAAGAATTTTTTTTTC

AGTAAAAGGGAATATTACAATGTTGGAGGAGAGATAAGTTATAGGGAG

CTGGATTTCAAAACGTGGTCCAAGATTCAAAAATCCTATTGATAGTGGC

CATTTTAATCATTGCCATCGTGTGCTTGTTTCATCCAGTGTTATGCACTT

TCCACAGTTGGACATGGTGTTAGTATAGCCAGACGGGTTTCATTATTAT

TTCTCTTTGCTTTCTCAATGTTAATTTATTGCATGGTTTATTCTTTTTCTTT

ACAGCTGAAATTGCTTTAAATGATGGTTAAAATTACAAATTAAATTGTT

AATTTTTATCAATGTGATTGTAATTAAAAATATTTTGATTTAAATAACAA

AAATAATACCAGATTTTAAGCCGTGGAAAATGTTCTTGATCATTTGCAG

TTAAGGACTTTAAATAAATCAAATGTTAACAAAAAAAAAAAAAAAA

NM_001453 ATGCAGGCGCGCTACTCCGTGTCCAGCCCCAACTCCCTGGGAGTGGTGC 169

CCTACCTCGGCGGCGAGCAGAGCTACTACCGCGCGGCGGCCGCGGCGG

CCGGGGGCGGCTACACCGCCATGCCGGCCCCCATGAGCGTGTACTCGC

ACCCTGCGCACGCCGAGCAGTACCCGGGCGGCATGGCCCGCGCCTACG

GGCCCTACACGCCGCAGCCGCAGCCCAAGGACATGGTGAAGCCGCCCT

ATAGCTACATCGCGCTCATCACCATGGCCATCCAGAACGCCCCGGACAA

GAAGATCACCCTGAACGGCATCTACCAGTTCATCATGGACCGCTTCCCC

TTCTACCGGGACAACAAGCAGGGCTGGCAGAACAGCATCCGCCACAAC

CTCTCGCTCAACGAGTGCTTCGTCAAGGTGCCGCGCGACGACAAGAAG

CCGGGCAAGGGCAGCTACTGGACGCTGGACCCGGACTCCTACAACATG

TTCGAGAACGGCAGCTTCCTGCGGCGGCGGCGGCGCTTCAAGAAGAAG

GACGCGGTGAAGGACAAGGAGGAGAAGGACAGGCTGCACCTCAAGGA

GCCGCCCCCGCCCGGCCGCCAGCCCCCGCCCGCGCCGCCGGAGCAGGC

CGACGGCAACGCGCCCGGTCCGCAGCCGCCGCCCGTGCGCATCCAGGA

CATCAAGACCGAGAACGGTACGTGCCCCTCGCCGCCCCAGCCCCTGTCC

CCGGCCGCCGCCCTGGGCAGCGGCAGCGCCGCCGCGGTGCCCAAGATC

GAGAGCCCCGACAGCAGCAGCAGCAGCCTGTCCAGCGGGAGCAGCCCC

CCGGGCAGCCTGCCGTCGGCGCGGCCGCTCAGCCTGGACGGTGCGGAT

TCCGCGCCGCCGCCGCCCGCGCCCTCCGCCCCGCCGCCGCACCATAGCC

AGGGCTTCAGCGTGGACAACATCATGACGTCGCTGCGGGGGTCGCCGC

AGAGCGCGGCCGCGGAGCTCAGCTCCGGCCTTCTGGCCTCGGCGGCCG

CGTCCTCGCGCGCGGGGATCGCACCCCCGCTGGCGCTCGGCGCCTACTC

GCCCGGCCAGAGCTCCCTCTACAGCTCCCCCTGCAGCCAGACCTCCAGC

GCGGGCAGCTCGGGCGGCGGCGGCGGCGGCGCGGGGGCCGCGGGGGG

CGCGGGCGGCGCCGGGACCTACCACTGCAACCTGCAAGCCATGAGCCT

GTACGCGGCCGGCGAGCGCGGGGGCCACTTGCAGGGCGCGCCCGGGGG

CGCGGGCGGCTCGGCCGTGGACGACCCCCTGCCCGACTACTCTCTGCCT

CCGGTCACCAGCAGCAGCTCGTCGTCCCTGAGTCACGGCGGCGGCGGC

GGCGGCGGCGGGGGAGGCCAGGAGGCCGGCCACCACCCTGCGGCCCAC

CAAGGCCGCCTCACCTCGTGGTACCTGAACCAGGCGGGCGGAGACCTG

GGCCACTTGGCGAGCGCGGCGGCGGCGGCGGCGGCCGCAGGCTACCCG

GGCCAGCAGCAGAACTTCCACTCGGTGCGGGAGATGTTCGAGTCACAG

AGGATCGGCTTGAACAACTCTCCAGTGAACGGGAATAGTAGCTGTCAA

ATGGCCTTCCCTTCCAGCCAGTCTCTGTACCGCACGTCCGGAGCTTTCGT

CTACGACTGTAGCAAGTTTTGACACACCCTCAAAGCCGAACTAAATCGA

ACCCCAAAGCAGGAAAAGCTAAAGGAACCCATCAAGGCAAAATCGAA

ACTAAAAAAAAAAAATCCAATTAAAAAAAACCCCTGAGAATATTCACC

ACACCAGCGAACAGAATATCCCTCCAAAAATTCAGCTCACCAGCACCA

GCACGAAGAAAACTCTATTTTCTTAACCGATTAATTCAGAGCCACCTCC

ACTTTGCCTTGTCTAAATAAACAAACCCGTAAACTGTTTTATACAGAGA CAGCAAAATCTTGGTTTATTAAAGGACAGTGTTACTCCAGATAACACGT

AAGTTTCTTCTTGCTTTTCAGAGACCTGCTTTCCCCTCCTCCCGTCTCCCC

TCTCTTGCCTTCTTCCTTGCCTCTCACCTGTAAGATATTATTTTATCCTAT

GTTGAAGGGAGGGGGAAAGTCCCCGTTTATGAAAGTCGCTTTCTTTTTA

TTCATGGACTTGTTTTAAAATGTAAATTGCAACATAGTAATTTATTTTTA

ATTTGTAGTTGGATGTCGTGGACCAAACGCCAGAAAGTGTTCCCAAAAC

CTGACGTTAAATTGCCTGAAACTTTAAATTGTGCTTTTTTTCTCATTATA

AAAAGGGAAACTGTATTAATCTTATTCTATCCTCTTTTCTTTCTTTTTGTT

GAACATATTCATTGTTTGTTTATTAATAAATTACCATTCAGTTTGAATGA

GACCTATATGTCTGGATACTTTAATAGAGCTTTAATTATTACGAAAAAA

GATTTCAGAGATAAAACACTAGAAGTTACCTATTCTCCACCTAAATCTC

TGAAAAATGGAGAAACCCTCTGACTAGTCCATGTCAAATTTTACTAAAA

GTCTTTTTGTTTAGATTTATTTTCCTGCAGCATCTTCTGCAAAATGTACT

ATATAGTCAGCTTGCTTTGAGGCTAGTAAAAAGATATTTTTCTAAACAG

ATTGGAGTTGGCATATAAACAAATACGTTTTCTCACTAATGACAGTCCA

TGATTCGGAAATTTTAAGCCCATGAATCAGCCGCGGTCTTACCACGGTG

ATGCCTGTGTGCCGAGAGATGGGACTGTGCGGCCAGATATGCACAGAT

AAATATTTGGCTTGTGTATTCCATATAAAATTGCAGTGCATATTATACAT

CCCTGTGAGCCAGATGCTGAATAGATATTTTCCTATTATTTCAGTCCTTT

ATAAAAGGAAAAATAAACCAGTTTTTAAATGTATGTATATAATTCTCCC

CCATTTACAATCCTTCATGTATTACATAGAAGGATTGCTTTTTTAAAAAT

ATACTGCGGGTTGGAAAGGGATATTTAATCTTTGAGAAACTATTTTAGA

AAATATGTTTGTAGAACAATTATTTTTGAAAAAGATTTAAAGCAATAAC

AAGAAGGAAGGCGAGAGGAGCAGAACATTTTGGTCTAGGGTGGTTTCT

TTTTAAACCATTTTTTCTTGTTAATTTACAGTTAAACCTAGGGGACAATC

CGGATTGGCCCTCCCCCTTTTGTAAATAACCCAGGAAATGTAATAAATT

CATTATCTTAGGGTGATCTGCCCTGCCAATCAGACTTTGGGGAGATGGC

GATTTGATTACAGACGTTCGGGGGGGTGGGGGGCTTGCAGTTTGTTTTG

GAGATAATACAGTTTCCTGCTATCTGCCGCTCCTATCTAGAGGCAACAC

TTAAGCAGTAATTGCTGTTGCTTGTTGTCAAAATTTGATCATTGTTAAAG

GATTGCTGCAAATAAATACACTTTAATTTCAGTCAAAAA

GTGGCCTCGAGGTGGTGGCAGGGCCGCCCCCTGCAGTCCGGAGACGAA 170

CGCACGGACCGGGCCTCCGGAGGCAGGTTCGGCTGGAAGGAACCGCTC

TCGCTTCGTCCTACACTTGCGCAAATGTCTCCGAGCTTACTCACATAGC

ATATTGGTATATCAAAATGAAATGCAAGGAACCAAAAATAACATAATT

GAAGGCAGTAAAAGTGAAATTAAATAGGAAGATCATCAGTCAAGGAAG

ACCCACTGGAGAGGACAGAAAATGAAGCAGTGTTTTATCATGTGTATTT

CAGCAGGTCTTCTTGAAATTTAACTAAAAATATGACTGCTCTCTCTTCA

GAGAACTGCTCTTTTCAGTACCAGTTACGTCAAACAAACCAGCCCCTAG

ACGTTAACTATCTGCTATTCTTGATCATACTTGGGAAAATATTATTAAAT

ATCCTTACACTAGGAATGAGAAGAAAAAACACCTGTCAAAATTTTATG

GAATATTTTTGCATTTCACTAGCATTCGTTGATCTTTTACTTTTGGTAAA

CATTTCCATTATATTGTATTTCAGGGATTTTGTACTTTTAAGCATTAGGT

TCACTAAATACCACATCTGCCTATTTACTCAAATTATTTCCTTTACTTAT

GGCTTTTTGCATTATCCAGTTTTCCTGACAGCTTGTATAGATTATTGCCT

GAATTTCTCTAAAACAACCAAGCTTTCATTTAAGTGTCAAAAATTATTTT

ATTTCTTTACAGTAATTTTAATTTGGATTTCAGTCCTTGCTTATGTTTTGG

GAGACCCAGCCATCTACCAAAGCCTGAAGGCACAGAATGCTTATTCTCG

TCACTGTCCTTTCTATGTCAGCATTCAGAGTTACTGGCTGTCATTTTTCA

TGGTGATGATTTTATTTGTAGCTTTCATAACCTGTTGGGAAGAAGTTACT

ACTTTGGTACAGGCTATCAGGATAACTTCCTATATGAATGAAACTATCT

TATATTTTCCTTTTTCATCCCACTCCAGTTATACTGTGAGATCTAAAAAA

ATATTCTTATCCAAGCTCATTGTCTGTTTTCTCAGTACCTGGTTACCATT

TGTACTACTTCAGGTAATCATTGTTTTACTTAAAGTTCAGATTCCAGCAT

ATATTGAGATGAATATTCCCTGGTTATACTTTGTCAATAGTTTTCTCATT

GCTACAGTGTATTGGTTTAATTGTCACAAGCTTAATTTAAAAGACATTG GATTACCTTTGGATCCATTTGTCAACTGGAAGTGCTGCTTCATTCCACTT

ACAATTCCTAATCTTGAGCAAATTGAAAAGCCTATATCAATAATGATTT

GTTAATATTATTAATTAAAAGTTACAGCTGTCATAAGATCATAATTTTAT

GAACAGAAAGAACTCAGGACATATTAAAAAATAAACTGAACTAAAACA

ACTTTTGCCCCCTGACTGATAGCATTTCAGAATGTGTCTTTTGAAGGGCT

ATACCAGTTATTAAATAGTGTTTTATTTTAAAAACAAAATAATTCCAAG

AAGTTTTTATAGTTATTCAGGGACACTATATTACAAATATTACTTTGTTA

TTAACACAAAAAGTGATAAGAGTTAACATTTGGCTATACTGATGTTTGT

GTTACTCAAAAAAACTACTGGATGCAAACTGTTATGTAAATCTGAGATT

TCACTGACAACTTTAAGATATCAACCTAAACATTTTTATTAAATGTTCA

AATGTAAGCAAGAAAAAAAAAA

NM_005310 ACCCGCCCCCATCTGCCCAAGATAATTTTAGTTTCCTTGGGCCTGGAAT 171

CTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCG

GGACACCCTCCTACCACCTGTAGAGAAGCGGGAGTGGATCTGAAATAA

AATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGG

TGTCCTGCTACTCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTG

GTTCCGTTAAGCCCCTCTCTCGCTCAGACGCCATGGAGCTGGATCTGTC

TCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGG

ACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGG

TAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCG

AGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTC

CCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCT

CCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATGTAGT

AAAGGTGTACAGTGAGGATGGGGCCTGCAGGTCTGTGGAGGTGGCAGC

AGGTGCCACAGCTCGCCACGTGTGTGAAATGCTGGTGCAGCGAGCTCA

CGCCTTGAGCGACGAGACCTGGGGGCTGGTGGAGTGCCACCCCCACCT

AGCACTGGAGCGGGGTTTGGAGGACCACGAGTCCGTGGTGGAAGTGCA

GGCTGCCTGGCCCGTGGGCGGAGATAGCCGCTTCGTCTTCCGGAAAAAC

TTCGCCAAGTACGAACTGTTCAAGAGCTCCCCACACTCCCTGTTCCCAG

AAAAAATGGTCTCCAGCTGTCTCGATGCACACACTGGTATATCCCATGA

AGACCTCATCCAGAACTTCCTGAATGCTGGCAGCTTTCCTGAGATCCAG

GGCTTTCTGCAGCTGCGGGGTTCAGGACGGAAGCTTTGGAAACGCTTTT

TCTGCTTCTTGCGCCGATCTGGCCTCTATTACTCCACCAAGGGCACCTCT

AAGGATCCGAGGCACCTGCAGTACGTGGCAGATGTGAACGAGTCCAAC

GTGTACGTGGTGACGCAGGGCCGCAAGCTCTACGGGATGCCCACTGAC

TTCGGTTTCTGTGTCAAGCCCAACAAGCTTCGAAATGGCCACAAGGGGC

TTCGGATCTTCTGCAGTGAAGATGAGCAGAGCCGCACCTGCTGGCTGGC

TGCCTTCCGCCTCTTCAAGTACGGGGTGCAGCTGTACAAGAATTACCAG

CAGGCACAGTCTCGCCATCTGCATCCATCTTGTTTGGGCTCCCCACCCTT

GAGAAGTGCCTCAGATAATACCCTGGTGGCCATGGACTTCTCTGGCCAT

GCTGGGCGTGTCATTGAGAACCCCCGGGAGGCTCTGAGTGTGGCCCTGG

AGGAGGCCCAGGCCTGGAGGAAGAAGACAAACCACCGCCTCAGCCTGC

CCATGCCAGCCTCCGGCACGAGCCTCAGTGCAGCCATCCACCGCACCCA

ACTCTGGTTCCACGGGCGCATTTCCCGTGAGGAGAGCCAGCGGCTTATT

GGACAGCAGGGCTTGGTAGACGGCCTGTTCCTGGTCCGGGAGAGTCAG

CGGAACCCCCAGGGCTTTGTCCTCTCTTTGTGCCACCTGCAGAAAGTGA

AGCATTATCTCATCCTGCCGAGCGAGGAGGAGGGCCGCCTGTACTTCAG

CATGGATGATGGCCAGACCCGCTTCACTGACCTGCTGCAGCTCGTGGAG

TTCCACCAGCTGAACCGCGGCATCCTGCCGTGCTTGCTGCGCCATTGCT

GCACGCGGGTGGCCCTCTGACCAGGCCGTGGACTGGCTCATGCCTCAGC

CCGCCTTCAGGCTGCCCGCCGCCCCTCCACCCATCCAGTGGACTCTGGG

GCGCGGCCACAGGGGACGGGATGAGGAGCGGGAGGGTTCCGCCACTCC

AGTTTTCTCCTCTGCTTCTTTGCCTCCCTCAGATAGAAAACAGCCCCCAC

TCCAGTCCACTCCTGACCCCTCTCCTCAAGGGAAGGCCTTGGGTGGCCC

CCTCTCCTTCTCCTAGCTCTGGAGGTGCTGCTCTAGGGCAGGGAATTAT

GGGAGAAGTGGGGGCAGCCCAGGCGGTTTCACGCCCCACACTTTGTAC AGACCGAGAGGCCAGTTGATCTGCTCTGTTTTATACTAGTGACAATAAA GATTATTTTTTGATACAAAAAAAAAAAAAAAAAAAAAAAA

NM_014176 AGTCAGAGGTCGCGCAGGCGCTGGTACCCCGTTGGTCCGCGCGTTGCTG 172

CGTTGTGAGGGGTGTCAGCTCAGTGCATCCCAGGCAGCTCTTAGTGTGG

AGCAGTGAACTGTGTGTGGTTCCTTCTACTTGGGGATCATGCAGAGAGC

TTCACGTCTGAAGAGAGAGCTGCACATGTTAGCCACAGAGCCACCCCC

AGGCATCACATGTTGGCAAGATAAAGACCAAATGGATGACCTGCGAGC

TCAAATATTAGGTGGAGCCAACACACCTTATGAGAAAGGTGTTTTTAAG

CTAGAAGTTATCATTCCTGAGAGGTACCCATTTGAACCTCCTCAGATCC

GATTTCTCACTCCAATTTATCATCCAAACATTGATTCTGCTGGAAGGATT

TGTCTGGATGTTCTCAAATTGCCACCAAAAGGTGCTTGGAGACCATCCC

TCAACATCGCAACTGTGTTGACCTCTATTCAGCTGCTCATGTCAGAACC

CAACCCTGATGACCCGCTCATGGCTGACATATCCTCAGAATTTAAATAT

AATAAGCCAGCCTTCCTCAAGAATGCCAGACAGTGGACAGAGAAGCAT

GCAAGACAGAAACAAAAGGCTGATGAGGAAGAGATGCTTGATAATCTA

CCAGAGGCTGGTGACTCCAGAGTACACAACTCAACACAGAAAAGGAAG

GCCAGTCAGCTAGTAGGCATAGAAAAGAAATTTCATCCTGATGTTTAGG

GGACTTGTCCTGGTTCATCTTAGTTAATGTGTTCTTTGCCAAGGTGATCT

AAGTTGCCTACCTTGAATTTTTTTTTAAATATATTTGATGACATAATTTT

TGTGTAGTTTATTTATCTTGTACATATGTATTTTGAAATCTTTTAAACCT

GAAAAATAAATAGTCATTTAATGTTGAAAAAAAAAAAAAAAAAAAAA

AAAAAAA

NM_006845 ACGCTTGCGCGCGGGATTTAAACTGCGGCGGTTTACGCGGCGTTAAGAC 173

TTCGTAGGGTTAGCGAAATTGAGGTTTCTTGGTATTGCGCGTTTCTCTTC

CTTGCTGACTCTCCGAATGGCCATGGACTCGTCGCTTCAGGCCCGCCTG

TTTCCCGGTCTCGCTATCAAGATCCAACGCAGTAATGGTTTAATTCACA

GTGCCAATGTAAGGACTGTGAACTTGGAGAAATCCTGTGTTTCAGTGGA

ATGGGCAGAAGGAGGTGCCACAAAGGGCAAAGAGATTGATTTTGATGA

TGTGGCTGCAATAAACCCAGAACTCTTACAGCTTCTTCCCTTACATCCG

AAGGACAATCTGCCCTTGCAGGAAAATGTAACAATCCAGAAACAAAAA

CGGAGATCCGTCAACTCCAAAATTCCTGCTCCAAAAGAAAGTCTTCGAA

GCCGCTCCACTCGCATGTCCACTGTCTCAGAGCTTCGCATCACGGCTCA

GGAGAATGACATGGAGGTGGAGCTGCCTGCAGCTGCAAACTCCCGCAA

GCAGTTTTCAGTTCCTCCTGCCCCCACTAGGCCTTCCTGCCCTGCAGTGG

CTGAAATACCATTGAGGATGGTCAGCGAGGAGATGGAAGAGCAAGTCC

ATTCCATCCGAGGCAGCTCTTCTGCAAACCCTGTGAACTCAGTTCGGAG

GAAATCATGTCTTGTGAAGGAAGTGGAAAAAATGAAGAACAAGCGAGA

AGAGAAGAAGGCCCAGAACTCTGAAATGAGAATGAAGAGAGCTCAGG

AGTATGACAGTAGTTTTCCAAACTGGGAATTTGCCCGAATGATTAAAGA

ATTTCGGGCTACTTTGGAATGTCATCCACTTACTATGACTGATCCTATCG

AAGAGCACAGAATATGTGTCTGTGTTAGGAAACGCCCACTGAATAAGC

AAGAATTGGCCAAGAAAGAAATTGATGTGATTTCCATTCCTAGCAAGTG

TCTCCTCTTGGTACATGAACCCAAGTTGAAAGTGGACTTAACAAAGTAT

CTGGAGAACCAAGCATTCTGCTTTGACTTTGCATTTGATGAAACAGCTT

CGAATGAAGTTGTCTACAGGTTCACAGCAAGGCCACTGGTACAGACAA

TCTTTGAAGGTGGAAAAGCAACTTGTTTTGCATATGGCCAGACAGGAAG

TGGCAAGACACATACTATGGGCGGAGACCTCTCTGGGAAAGCCCAGAA

TGCATCCAAAGGGATCTATGCCATGGCCTCCCGGGACGTCTTCCTCCTG

AAGAATCAACCCTGCTACCGGAAGTTGGGCCTGGAAGTCTATGTGACAT

TCTTCGAGATCTACAATGGGAAGCTGTTTGACCTGCTCAACAAGAAGGC

CAAGCTGCGCGTGCTGGAGGACGGCAAGCAACAGGTGCAAGTGGTGGG

GCTGCAGGAGCATCTGGTTAACTCTGCTGATGATGTCATCAAGATGATC

GACATGGGCAGCGCCTGCAGAACCTCTGGGCAGACATTTGCCAACTCC

AATTCCTCCCGCTCCCACGCGTGCTTCCAAATTATTCTTCGAGCTAAAG

GGAGAATGCATGGCAAGTTCTCTTTGGTAGATCTGGCAGGGAATGAGC

GAGGCGCGGACACTTCCAGTGCTGACCGGCAGACCCGCATGGAGGGCG CAGAAATCAACAAGAGTCTCTTAGCCCTGAAGGAGTGCATCAGGGCCC

TGGGACAGAACAAGGCTCACACCCCGTTCCGTGAGAGCAAGCTGACAC

AGGTGCTGAGGGACTCCTTCATTGGGGAGAACTCTAGGACTTGCATGAT

TGCCACGATCTCACCAGGCATAAGCTCCTGTGAATATACTTTAAACACC

CTGAGATATGCAGACAGGGTCAAGGAGCTGAGCCCCCACAGTGGGCCC

AGTGGAGAGCAGTTGATTCAAATGGAAACAGAAGAGATGGAAGCCTGC

TCTAACGGGGCGCTGATTCCAGGCAATTTATCCAAGGAAGAGGAGGAA

CTGTCTTCCCAGATGTCCAGCTTTAACGAAGCCATGACTCAGATCAGGG

AGCTGGAGGAGAAGGCTATGGAAGAGCTCAAGGAGATCATACAGCAA

GGACCAGACTGGCTTGAGCTCTCTGAGATGACCGAGCAGCCAGACTAT

GACCTGGAGACCTTTGTGAACAAAGCGGAATCTGCTCTGGCCCAGCAA

GCCAAGCATTTCTCAGCCCTGCGAGATGTCATCAAGGCCTTGCGCCTGG

CCATGCAGCTGGAAGAGCAGGCTAGCAGACAAATAAGCAGCAAGAAA

CGGCCCCAGTGACGACTGCAAATAAAAATCTGTTTGGTTTGACACCCAG

CCTCTTCCCTGGCCCTCCCCAGAGAACTTTGGGTACCTGGTGGGTCTAG

GCAGGGTCTGAGCTGGGACAGGTTCTGGTAAATGCCAAGTATGGGGGC

ATCTGGGCCCAGGGCAGCTGGGGAGGGGGTCAGAGTGACATGGGACAC

TCCTTTTCTGTTCCTCAGTTGTCGCCCTCACGAGAGGAAGGAGCTCTTAG

TTACCCTTTTGTGTTGCCCTTCTTTCCATCAAGGGGAATGTTCTCAGCAT

AGAGCTTTCTCCGCAGCATCCTGCCTGCGTGGACTGGCTGCTAATGGAG

AGCTCCCTGGGGTTGTCCTGGCTCTGGGGAGAGAGACGGAGCCTTTAGT

ACAGCTATCTGCTGGCTCTAAACCTTCTACGCCTTTGGGCCGAGCACTG

AATGTCTTGTACTTTAAAAAAATGTTTCTGAGACCTCTTTCTACTTTACT

GTCTCCCTAGAGATCCTAGAGGATCCCTACTGTTTTCTGTTTTATGTGTT

TATACATTGTATGTAACAATAAAGAGAAAAAATAAATCAGCTGTTTAA

GTGTGTGGAAAAAAAAAAAAAAAAAA

NM_006101 ACTGCGCGCGTCGTGCGTAATGACGTCAGCGCCGGCGGAGAATTTCAA 174

ATTCGAACGGCTTTGGCGGGCCGAGGAAGGACCTGGTGTTTTGATGACC

GCTGTCCTGTCTAGCAGATACTTGCACGGTTTACAGAAATTCGGTCCCT

GGGTCGTGTCAGGAAACTGGAAAAAAGGTCATAAGCATGAAGCGCAGT

TCAGTTTCCAGCGGTGGTGCTGGCCGCCTCTCCATGCAGGAGTTAAGAT

CCCAGGATGTAAATAAACAAGGCCTCTATACCCCTCAAACCAAAGAGA

AACCAACCTTTGGAAAGTTGAGTATAAACAAACCGACATCTGAAAGAA

AAGTCTCGCTATTTGGCAAAAGAACTAGTGGACATGGATCCCGGAATA

GTCAACTTGGTATATTTTCCAGTTCTGAGAAAATCAAGGACCCGAGACC

ACTTAATGACAAAGCATTCATTCAGCAGTGTATTCGACAACTCTGTGAG

TTTCTTACAGAAAATGGTTATGCACATAATGTGTCCATGAAATCTCTAC

AAGCTCCCTCTGTTAAAGACTTCCTGAAGATCTTCACATTTCTTTATGGC

TTCCTGTGCCCCTCATACGAACTTCCTGACACAAAGTTTGAAGAAGAGG

TTCCAAGAATCTTTAAAGACCTTGGGTATCCTTTTGCACTATCCAAAAG

CTCCATGTACACAGTGGGGGCTCCTCATACATGGCCTCACATTGTGGCA

GCCTTAGTTTGGCTAATAGACTGCATCAAGATACATACTGCCATGAAAG

AAAGCTCACCTTTATTTGATGATGGGCAGCCTTGGGGAGAAGAAACTG

AAGATGGAATTATGCATAATAAGTTGTTTTTGGACTACACCATAAAATG

CTATGAGAGTTTTATGAGTGGTGCCGACAGCTTTGATGAGATGAATGCA

GAGCTGCAGTCAAAACTGAAGGATTTATTTAATGTGGATGCTTTTAAGC

TGGAATCATTAGAAGCAAAAAACAGAGCATTGAATGAACAGATTGCAA

GATTGGAACAAGAAAGAGAAAAAGAACCGAATCGTCTAGAGTCGTTGA

GAAAACTGAAGGCTTCCTTACAAGGAGATGTTCAAAAGTATCAGGCAT

ACATGAGCAATTTGGAGTCTCATTCAGCCATTCTTGACCAGAAATTAAA

TGGTCTCAATGAGGAAATTGCTAGAGTAGAACTAGAATGTGAAACAAT

AAAACAGGAGAACACTCGACTACAGAATATCATTGACAACCAGAAGTA

CTCAGTTGCAGACATTGAGCGAATAAATCATGAAAGAAATGAATTGCA

GCAGACTATTAATAAATTAACCAAGGACCTGGAAGCTGAACAACAGAA

GTTGTGGAATGAGGAGTTAAAATATGCCAGAGGCAAAGAAGCGATTGA

AACACAATTAGCAGAGTATCACAAATTGGCTAGAAAATTAAAACTTATT CCTAAAGGTGCTGAGAATTCCAAAGGTTATGACTTTGAAATTAAGTTTA

ATCCCGAGGCTGGTGCCAACTGCCTTGTCAAATACAGGGCTCAAGTTTA

TGTACCTCTTAAGGAACTCCTGAATGAAACTGAAGAAGAAATTAATAA

AGCCCTAAATAAAAAAATGGGTTTGGAGGATACTTTAGAACAATTGAA

TGCAATGATAACAGAAAGCAAGAGAAGTGTGAGAACTCTGAAAGAAG

AAGTTCAAAAGCTGGATGATCTTTACCAACAAAAAATTAAGGAAGCAG

AGGAAGAGGATGAAAAATGTGCCAGTGAGCTTGAGTCCTTGGAGAAAC

ACAAGCACCTGCTAGAAAGTACTGTTAACCAGGGGCTCAGTGAAGCTA

TGAATGAATTAGATGCTGTTCAGCGGGAATACCAACTAGTTGTGCAAAC

CACGACTGAAGAAAGACGAAAAGTGGGAAATAACTTGCAACGTCTGTT

AGAGATGGTTGCTACACATGTTGGGTCTGTAGAGAAACATCTTGAGGA

GCAGATTGCTAAAGTTGATAGAGAATATGAAGAATGCATGTCAGAAGA

TCTCTCGGAAAATATTAAAGAGATTAGAGATAAGTATGAGAAGAAAGC

TACTCTAATTAAGTCTTCTGAAGAATGAAGATAAAATGTTGATCATGTA

TATATATCCATAGTGAATAAAATTGTCTCAGTAAAGTGTAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

BC042437 CTCCCTCCTCTGCACCATGACTACCTGCAGCCGCCAGTTCACCTCCTCCA 175

GCTCCATGAAGGGCTCCTGCGGCATCGGGGGCGGCATCGGGGGCGGCT

CCAGCCGCATCTCCTCCGTCCTGGCCGGAGGGTCCTGCCGCGCCCCCAG

CACCTACGGGGGCGGCCTGTCTGTCTCATCCTCCCGCTTCTCCTCTGGGG

GAGCCTATGGGTTGGGGGGCGGCTATGGCGGTGGCTTCAGCAGCAGCA

GCAGCAGCTTTGGTAGTGGCTTTGGGGGAGGATATGGTGGTGGCCTTGG

TGCTGGCTTGGGTGGTGGCTTTGGTGGTGGCTTTGCTGGTGGTGATGGG

CTTCTGGTGGGCAGTGAGAAGGTGACCATGCAGAACCTCAACGACCGC

CTGGCCTCCTACCTGGACAAGGTGCGTGCTCTGGAGGAGGCCAACGCC

GACCTGGAAGTGAAGATCCGTGACTGGTACCAGAGGCAGCGGCCTGCT

GAGATCAAAGACTACAGTCCCTACTTCAAGACCATTGAGGACCTGAGG

AACAAGATTCTCACAGCCACAGTGGACAATGCCAATGTCCTTCTGCAGA

TTGACAATGCCCGTCTGGCCGCGGATGACTTCCGCACCAAGTATGAGAC

AGAGTTGAACCTGCGCATGAGTGTGGAAGCCGACATCAATGGCCTGCG

CAGGGTGCTGGACGAACTGACCCTGGCCAGAGCTGACCTGGAGATGCA

GATTGAGAGCCTGAAGGAGGAGCTGGCCTACCTGAAGAAGAACCACGA

GGAGGAGATGAATGCCCTGAGAGGCCAGGTGGGTGGAGATGTCAATGT

GGAGATGGACGCTGCACCTGGCGTGGACCTGAGCCGCATTCTGAACGA

GATGCGTGACCAGTATGAGAAGATGGCAGAGAAGAACCGCAAGGATGC

CGAGGAATGGTTCTTCACCAAGACAGAGGAGCTGAACCGCGAGGTGGC

CACCAACAGCGAGCTGGTGCAGAGCGGCAAGAGCGAGATCTCGGAGCT

CCGGCGCACCATGCAGAACCTGGAGATTGAGCTGCAGTCCCAGCTCAG

CATGAAAGCATCCCTGGAGAACAGCCTGGAGGAGACCAAAGGTCGCTA

CTGCATGCAGCTGGCCCAGATCCAGGAGATGATTGGCAGCGTGGAGGA

GCAGCTGGCCCAGCTCCGCTGCGAGATGGAGCAGCAGAACCAGGAGTA

CAAGATCCTGCTGGACGTGAAGACGCGGCTGGAGCAGGAGATCGCCAC

CTACCGCCGCCTGCTGGAGGGCGAGGACGCCCACCTCTCCTCCTCCCAG

TTCTCCTCTGGATCGCAGTCATCCAGAGATGTGACCTCCTCCAGCCGCC

AAATCCGCACCAAGGTCATGGATGTGCACGATGGCAAGGTGGTGTCCA

CCCACGAGCAGGTCCTTCGCACCAAGAACTGAGGCTGCCCAGCCCCGCT

CAGGCCTAGGAGGCCCCCCGTGTGGACACAGATCCCACTGGAAGATCC

CCTCTCCTGCCCAAGCACTTCACAGCTGGACCCTGCTTCACCCTCACCCC

CTCCTGGCAATCAATACAGCTTCATTATCTGAGTTGCATAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAA

AK095281 CTCTTTTGCAGGGGCCGTTCCTCGGGGCATGACGCTGGCTCCTGCACAG 176

ATCCTGCTCCTCTGTGGCCTTCCTGGGCTGCCCTCCCCTCCTCCGGGACT GCTCTGGACTGACACTGCTCAGGTTCGGATTCCCTCAAAGACTTTGGGA GACAAGACTTGGTCCCCCTTTTACAAACAAGGGAACGGAGGCTCTAGA

ACTGACTTCCTGAAAGGCTTGGATCCAAAGCTCCCTCAGTTCAGCGGCC

ACGTCTATTTCCCTCAGACACAGGGATCCTTGAACCTGTGGGCTGTATC

TCCCCGCGGACTTGGAAGAATCCCAAGAGAGTGGGGCTCCCACAGGCT

GGAGTGCAATGGTGTGATCTCGGCTCACTGCAACCTCCACCTCCCAGGT

TCAAGCTATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGATC

CTGGTGGCTGTGGTCGGTAATTCCAGCTTCGTGCTGGCTACAGGTGGAT

GATGCCCACCTGGCTGCCGATGACCTCTGCACCAAGTGAGGCTGGGTCT

CTGGAGCTGCCCCAGGGGCTGGACAAGCTGACCCTGGCCGGGGCCAAC

CTGGAGATGCAGATTGAGAACCTCAAGGAGGACCTGGTCTACCTGAAG

AAGAACCACAAGCAGGAAATGAACGTCCTTTGAGGTCAGGTGGATGAG

GATGTCAGTGTGAAGATGGACACTGTGCCTGGAGTGAACCTGAGCTGC

ATCCTGAATGAGATGCGTGACCAGGACAAGACATTGGTGGAGAAGAGC

TGCAAGGATGCCGAGGGCTGGTTCTTCAGCATGGTGGGTGGCCGTGCGT

AAGCAGGTGTGTACACGTGTGGGCACATGTGCTGCATGCTGGTGCAGCT

GGAGCACTGGCAGATCCACAGGCTGTCCCAGTTGGAAGGACTTTTGGA

AACCAGTTGGACCAGCCCCTCATGTTTTAGATGTAAAACGTGAGGCTCA

GAGAGGACTCAAGCTCACACAGCCCTTCACTGTGGCCTGCAAAATAGA

TCCAGGTCTCTACAAGTCTGGTCTTGGGTTTCCACCACAGCTGTTTACAG

GATGTGCGTATTTGAATACATATGTATACCCTTGGCAAGCACAGGCTGA

GTATCTCCGGTATCCTAGGGACAGCAACAGGCGCAAAAGAATAACACC

CAGTGCCTGTCTTTGAGGTGCTGCAGTTCAGTAGGAAAAAGAAATGCA

AATGACCGCAGAGCAGGCTGAATTCCTCCAAGTTCCAATGTGGGTGCA

GAGGCTCTCTGTGTGCAGAAAGAGGGGCTGAACTGCGAGGTGGCCACC

AACACAGAGGCCCTGCAGAGTGGCTGGATAGAGATATGGAGCTCTACG

TCTCTGTGCAGAACCTGAGCCGTCCCAGCTCAGCAAGAAAGCATCGCTG

GAGGGCAGCCTGGTGGAGATGGAGGTGTGTTACAGGACCCTGCCGGCC

CAGCTGCAGGGGCTTAACAGAAGCATGGAGCAGCAGCTGTGCGAGCTC

TGCTGCGACACGGAGCACCAGGACCACAAGCACAGGTCCTTCTGGACG

TGAAGACGTGGCTGGAGCAGGAGATCGCCACCTACCGCCGCTTGCTGG

AGGTTGAGGACGCCCAGAGGTGATACTGACGATGCAGGCTGGAGTCTG

GCTGAGGAGCCTTGAATGCCAAGTTAAAGCGTCTGGACTAGATCACGT

AGGCAATGGGGAGCCATGGAGGGATTTGGAGCAGGAGAGTGAAATGA

ACATCAAGAGATTTTAGAACATTCACTCTGGCTGCAGAGGGAGAAATG

GATCAGAGGGGTCAGGGCGGGGCCAGAGAGATGTGTCAGGGGGCTGG

AGCAGGGAGTCTGGCCAGAGAAGTCCCGTGCGGTGGTGGGTAGTGGGG

CAGGGGAAGGAAGGTGGTGCACGCAGAAGAGAGGTTATAGCTCAAAA

CAGCGGGACTGGATGCCTGGATCTCGGGGTAAGCATGGCTCACAGTCA

GGACTCAGTAAGTGTCGGGAGAACACATGAAGGAGCAGGCATTGATGG

CCCTGGGTTTCTGGTTCTGATGACTGTGTGAGTGGTGAAGAGCAAGGTG

GGTGGTGGTTGGGTTTGCAGTTGGGAAGGGTGATCAGGCCTTCAGCTGA

GAGTGTCCCGGAGTCTCCATGCTTAGTCACACGTTGCAGCTTTTTGCTCC

CCGGAAATGGTGAAGTCCATCTATAGTCTAACAACAGTCTCTCCTGCTT

TAATTGGGTCTATTTGTTGGGCCCTCTGGGTTATGGAAAAACCACTTGC

TCAGCTTCTCCTTGTAAATTCCTGGTGAGTAGCCACAGAGTGCCGCCAG

ACCTACTGCTGTGCTGTTTCTTTTTCTTCTTCCTGCTGTGCTGAACCCCTG

CCCTTTCATTCTTGGGCCTGCGCTAATTTCTGTGCATTCCCAACTGTGAT

TTTTCACCAATTTAGGGGAACCTCCTCTGCCAGGGCCTACTTCTCCCCAG

CAGTGCTTGCAGGTGCCTGGGCTGGCTGGCATCCCTGGGCTGATGGGTG

CTTCTCTCCCTGCAGGCTGGCCACTCAGTACTCCTTGTCCCTGGCCTCGC

AGCCCACCCGGGAAGCCACAGTGACCAGCCACCAGGTGTGCCATCGTG

GAGGAAGTCCAGGTTGGAGAGGTGGTCTTCTTCTGTGAGCAGGTCCACT

TCTCCACCCACTGAGACCCCTTTCTGTCTGCGACAGCCCCACCTCGAGG

GCCACGGCACAGCCATCAGCTCCAGCTCCCAGCATGCTACTGCCACGCC

CCGAGTGTCCGTCTGGGCCCCGGTGCATGGCCTGTTGTCTTTCTGTATCT

ACTTTCTGCAGCCCCTCACTGAGGAGGCCTCCTGGGTTTGTCCAGTGCC TACT ATT AAAGCTTTGCTCCAAGTTC

M21389 GCATCCTTTTTGGGCTGCTCACAGCCCCCAGCCTCTATGGTGAAGACAT 177

ACTTGCTAGCAGCGTCACCAACTTGCTGCCAAGAGATCAGTGCTGCAAG

GCAAGGTTATTTCTAACTGAGCAGAGCCTGCCAGGAAGAAAGCGTTTG

CACCCCACACCACTGTGCAGGTGTGACCGGTGAGCTCACAGCTGCCCCC

CAGGCATGCCCAGCCCACTTAATCATTCACAGCTCGACAGCTCTCTCGC

CCAGCCCAGTTCTGGAAGGGATAAAAAGGGGGCATCACCGTTCCTGGG

TAACAGAGCCACCTTCTGCGTCCTGCTGAGCTCTGTTCTCTCCAGCACCT

CCCAACCCACTAGTGCCTGGTTCTCTTGCTCCACCAGGAACAAGCCACC

ATGTCTCGCCAGTCAAGTGTGTCCTTCCGGAGCGGGGGCAGTCGTAGCT

TCAGCACCGCCTCTGCCATCACCCCGTCTGTCTCCCGCACCAGCTTCACC

TCCGTGTCCCGGTCCGGGGGTGGCGGTGGTGGTGGCTTCGGCAGGGTCA

GCCTTGCGGGTGCTTGTGGAGTGGGTGGCTATGGCAGCCGGAGCCTCTA

CAACCTGGGGGGCTCCAAGAGGATATCCATCAGCACTAGAGGAGGCAG

CTTCAGGAACCGGTTTGGTGCTGGTGCTGGAGGCGGCTATGGCTTTGGA

GGTGGTGCCGGTAGTGGATTTGGTTTCGGCGGTGGAGCTGGTGGTGGCT

TTGGGCTCGGTGGCGGAGCTGGCTTTGGAGGTGGCTTCGGTGGCCCTGG

CTTTCCTGTCTGCCCTCCTGGAGGTATCCAAGAGGTCACTGTCAACCAG

AGTCTCCTGACTCCCCTCAACCTGCAAATCGACCCCAGCATCCAGAGGG

TGAGGACCGAGGAGCGCGAGCAGATCAAGACCCTCAACAATAAGTTTG

CCTCCTTCATCGACAAGGTGCGGTTCCTGGAGCAGCAGAACAAGGTTCT

GGACACCAAGTGGACCCTGCTGCAGGAGCAGGGCACCAAGACTGTGAG

GCAGAACCTGGAGCCGTTGTTCGAGCAGTACATCAACAACCTCAGGAG

GCAGCTGGACAGCATCGTGGGGGAACGGGGCCGCCTGGACTCAGAGCT

GAGAAACATGCAGGACCTGGTGGAAGACTTCAAGAACAAGTATGAGGA

TGAAATCAACAAGCGTACCACTGCTGAGAATGAGTTTGTGATGCTGAA

GAAGGATGTAGATGCTGCCTACATGAACAAGGTGGAGCTGGAGGCCAA

GGTTGATGCACTGATGGATGAGATTAACTTCATGAAGATGTTCTTTGAT

GCGGAGCTGTCCCAGATGCAGACGCATGTCTCTGACACCTCAGTGGTCC

TCTCCATGGACAACAACCGCAACCTGGACCTGGATAGCATCATCGCTGA

GGTCAAGGCCCAGTATGAGGAGATTGCCAACCGCAGCCGGACAGAAGC

CGAGTCCTGGTATCAGACCAAGTATGAGGAGCTGCAGCAGACAGCTGG

CCGGCATGGCGATGACCTCCGCAACACCAAGCATGAGATCACAGAGAT

GAACCGGATGATCCAGAGGCTGAGAGCCGAGATTGACAATGTCAAGAA

ACAGTGCGCCAATCTGCAGAACGCCATTGCGGATGCCGAGCAGCGTGG

GGAGCTGGCCCTCAAGGATGCCAGGAACAAGCTGGCCGAGCTGGAGGA

GGCCCTGCAGAAGGCCAAGCAGGACATGGCCCGGCTGCTGCGTGAGTA

CCAGGAGCTCATGAACACCAAGCTGGCCCTGGACGTGGAGATCGCCAC

TTACCGCAAGCTGCTGGAGGGCGAGGAATGCAGACTCAGTGGAGAAGG

AGTTGGACCAGTCAACATCTCTGTTGTCACAAGCAGTGTTTCCTCTGGA

TATGGCAGTGGCAGTGGCTATGGCGGTGGCCTCGGTGGAGGTCTTGGCG

GCGGCCTCGGTGGAGGTCTTGCCGGAGGTAGCAGTGGAAGCTACTACT

CCAGCAGCAGTGGGGGTGTCGGCCTAGGTGGTGGGCTCAGTGTGGGGG

GCTCTGGCTTCAGTGCAAGCAGTGGCCGAGGGCTGGGGGTGGGCTTTG

GCAGTGGCGGGGGTAGCAGCTCCAGCGTCAAATTTGTCTCCACCACCTC

CTCCTCCCGGAAGAGCTTCAAGAGCTAAGAACCTGCTGCAAGTCACTGC

CTTCCAAGTGCAGCAACCCAGCCCATGGAGATTGCCTCTTCTAGGCAGT

TGCTCAAGCCATGTTTTATCCTTTTCTGGAGAGTAGTCTAGACCAAGCC

AATTGCAGAACCACATTCTTTGGTTCCCAGGAGAGCCCCATTCCCAGCC

CCTGGTCTCCCGTGCCGCAGTTCTATATTCTGCTTCAAATCAGCCTTCAG

GTTTCCCACAGCATGGCCCCTGCTGACACGAGAACCCAAAGTTTTCCCA

AATCTAAATCATCAAAACAGAATCCCCACCCCAATCCCAAATTTTGTTT

TGGTTCTAACTACCTCCAGAATGTGTTCAATAAAATGCTTTTATAATAT

NM_001 123066 GGACGGCCGAGCGGCAGGGCGCTCGCGCGCGCCCACTAGTGGCCGGAG 178

GAGAAGGCTCCCGCGGAGGCCGCGCTGCCCGCCCCCTCCCCTGGGGAG

GCTCGCGTTCCCGCTGCTCGCGCCTGCGCCGCCCGCCGGCCTCAGGAAC GCGCCCTCTTCGCCGGCGCGCGCCCTCGCAGTCACCGCCACCCACCAGC

TCCGGCACCAACAGCAGCGCCGCTGCCACCGCCCACCTTCTGCCGCCGC

CACCACAGCCACCTTCTCCTCCTCCGCTGTCCTCTCCCGTCCTCGCCTCT

GTCGACTATCAGGTGAACTTTGAACCAGGATGGCTGAGCCCCGCCAGG

AGTTCGAAGTGATGGAAGATCACGCTGGGACGTACGGGTTGGGGGACA

GGAAAGATCAGGGGGGCTACACCATGCACCAAGACCAAGAGGGTGAC

ACGGACGCTGGCCTGAAAGAATCTCCCCTGCAGACCCCCACTGAGGAC

GGATCTGAGGAACCGGGCTCTGAAACCTCTGATGCTAAGAGCACTCCA

ACAGCGGAAGATGTGACAGCACCCTTAGTGGATGAGGGAGCTCCCGGC

AAGCAGGCTGCCGCGCAGCCCCACACGGAGATCCCAGAAGGAACCACA

GCTGAAGAAGCAGGCATTGGAGACACCCCCAGCCTGGAAGACGAAGCT

GCTGGTCACGTGACCCAAGAGCCTGAAAGTGGTAAGGTGGTCCAGGAA

GGCTTCCTCCGAGAGCCAGGCCCCCCAGGTCTGAGCCACCAGCTCATGT

CCGGCATGCCTGGGGCTCCCCTCCTGCCTGAGGGCCCCAGAGAGGCCAC

ACGCCAACCTTCGGGGACAGGACCTGAGGACACAGAGGGCGGCCGCCA

CGCCCCTGAGCTGCTCAAGCACCAGCTTCTAGGAGACCTGCACCAGGA

GGGGCCGCCGCTGAAGGGGGCAGGGGGCAAAGAGAGGCCGGGGAGCA

AGGAGGAGGTGGATGAAGACCGCGACGTCGATGAGTCCTCCCCCCAAG

ACTCCCCTCCCTCCAAGGCCTCCCCAGCCCAAGATGGGCGGCCTCCCCA

GACAGCCGCCAGAGAAGCCACCAGCATCCCAGGCTTCCCAGCGGAGGG

TGCCATCCCCCTCCCTGTGGATTTCCTCTCCAAAGTTTCCACAGAGATCC

CAGCCTCAGAGCCCGACGGGCCCAGTGTAGGGCGGGCCAAAGGGCAGG

ATGCCCCCCTGGAGTTCACGTTTCACGTGGAAATCACACCCAACGTGCA

GAAGGAGCAGGCGCACTCGGAGGAGCATTTGGGAAGGGCTGCATTTCC

AGGGGCCCCTGGAGAGGGGCCAGAGGCCCGGGGCCCCTCTTTGGGAGA

GGACACAAAAGAGGCTGACCTTCCAGAGCCCTCTGAAAAGCAGCCTGC

TGCTGCTCCGCGGGGGAAGCCCGTCAGCCGGGTCCCTCAACTCAAAGCT

CGCATGGTCAGTAAAAGCAAAGACGGGACTGGAAGCGATGACAAAAA

AGCCAAGACATCCACACGTTCCTCTGCTAAAACCTTGAAAAATAGGCCT

TGCCTTAGCCCCAAACACCCCACTCCTGGTAGCTCAGACCCTCTGATCC

AACCCTCCAGCCCTGCTGTGTGCCCAGAGCCACCTTCCTCTCCTAAATA

CGTCTCTTCTGTCACTTCCCGAACTGGCAGTTCTGGAGCAAAGGAGATG

AAACTCAAGGGGGCTGATGGTAAAACGAAGATCGCCACACCGCGGGGA

GCAGCCCCTCCAGGCCAGAAGGGCCAGGCCAACGCCACCAGGATTCCA

GCAAAAACCCCGCCCGCTCCAAAGACACCACCCAGCTCTGCGACTAAG

CAAGTCCAGAGAAGACCACCCCCTGCAGGGCCCAGATCTGAGAGAGGT

GAACCTCCAAAATCAGGGGATCGCAGCGGCTACAGCAGCCCCGGCTCC

CCAGGCACTCCCGGCAGCCGCTCCCGCACCCCGTCCCTTCCAACCCCAC

CCACCCGGGAGCCCAAGAAGGTGGCAGTGGTCCGTACTCCACCCAAGT

CGCCGTCTTCCGCCAAGAGCCGCCTGCAGACAGCCCCCGTGCCCATGCC

AGACCTGAAGAATGTCAAGTCCAAGATCGGCTCCACTGAGAACCTGAA

GCACCAGCCGGGAGGCGGGAAGGTGCAGATAATTAATAAGAAGCTGGA

TCTTAGCAACGTCCAGTCCAAGTGTGGCTCAAAGGATAATATCAAACAC

GTCCCGGGAGGCGGCAGTGTGCAAATAGTCTACAAACCAGTTGACCTG

AGCAAGGTGACCTCCAAGTGTGGCTCATTAGGCAACATCCATCATAAAC

CAGGAGGTGGCCAGGTGGAAGTAAAATCTGAGAAGCTTGACTTCAAGG

ACAGAGTCCAGTCGAAGATTGGGTCCCTGGACAATATCACCCACGTCCC

TGGCGGAGGAAATAAAAAGATTGAAACCCACAAGCTGACCTTCCGCGA

GAACGCCAAAGCCAAGACAGACCACGGGGCGGAGATCGTGTACAAGTC

GCCAGTGGTGTCTGGGGACACGTCTCCACGGCATCTCAGCAATGTCTCC

TCCACCGGCAGCATCGACATGGTAGACTCGCCCCAGCTCGCCACGCTAG

CTGACGAGGTGTCTGCCTCCCTGGCCAAGCAGGGTTTGTGATCAGGCCC

CTGGGGCGGTCAATAATTGTGGAGAGGAGAGAATGAGAGAGTGTGGAA

AAAAAAAGAATAATGACCCGGCCCCCGCCCTCTGCCCCCAGCTGCTCCT

CGCAGTTCGGTTAATTGGTTAATCACTTAACCTGCTTTTGTCACTCGGCT

TTGGCTCGGGACTTCAAAATCAGTGATGGGAGTAAGAGCAAATTTCATC TTTCCAAATTGATGGGTGGGCTAGTAATAAAATATTTAAAAAAAAACAT

TCAAAAACATGGCCACATCCAACATTTCCTCAGGCAATTCCTTTTGATT

CTTTTTTCTTCCCCCTCCATGTAGAAGAGGGAGAAGGAGAGGCTCTGAA

AGCTGCTTCTGGGGGATTTCAAGGGACTGGGGGTGCCAACCACCTCTGG

CCCTGTTGTGGGGGTGTCACAGAGGCAGTGGCAGCAACAAAGGATTTG

AAACTTGGTGTGTTCGTGGAGCCACAGGCAGACGATGTCAACCTTGTGT

GAGTGTGACGGGGGTTGGGGTGGGGCGGGAGGCCACGGGGGAGGCCG

AGGCAGGGGCTGGGCAGAGGGGAGAGGAAGCACAAGAAGTGGGAGTG

GGAGAGGAAGCCACGTGCTGGAGAGTAGACATCCCCCTCCTTGCCGCT

GGGAGAGCCAAGGCCTATGCCACCTGCAGCGTCTGAGCGGCCGCCTGT

CCTTGGTGGCCGGGGGTGGGGGCCTGCTGTGGGTCAGTGTGCCACCCTC

TGCAGGGCAGCCTGTGGGAGAAGGGACAGCGGGTAAAAAGAGAAGGC

AAGCTGGCAGGAGGGTGGCACTTCGTGGATGACCTCCTTAGAAAAGAC

TGACCTTGATGTCTTGAGAGCGCTGGCCTCTTCCTCCCTCCCTGCAGGGT

AGGGGGCCTGAGTTGAGGGGCTTCCCTCTGCTCCACAGAAACCCTGTTT

TATTGAGTTCTGAAGGTTGGAACTGCTGCCATGATTTTGGCCACTTTGC

AGACCTGGGACTTTAGGGCTAACCAGTTCTCTTTGTAAGGACTTGTGCC

TCTTGGGAGACGTCCACCCGTTTCCAAGCCTGGGCCACTGGCATCTCTG

GAGTGTGTGGGGGTCTGGGAGGCAGGTCCCGAGCCCCCTGTCCTTCCCA

CGGCCACTGCAGTCACCCCGTCTGCGCCGCTGTGCTGTTGTCTGCCGTG

AGAGCCCAATCACTGCCTATACCCCTCATCACACGTCACAATGTCCCGA

ATTCCCAGCCTCACCACCCCTTCTCAGTAATGACCCTGGTTGGTTGCAG

GAGGTACCTACTCCATACTGAGGGTGAAATTAAGGGAAGGCAAAGTCC

AGGCACAAGAGTGGGACCCCAGCCTCTCACTCTCAGTTCCACTCATCCA

ACTGGGACCCTCACCACGAATCTCATGATCTGATTCGGTTCCCTGTCTCC

TCCTCCCGTCACAGATGTGAGCCAGGGCACTGCTCAGCTGTGACCCTAG

GTGTTTCTGCCTTGTTGACATGGAGAGAGCCCTTTCCCCTGAGAAGGCC

TGGCCCCTTCCTGTGCTGAGCCCACAGCAGCAGGCTGGGTGTCTTGGTT

GTCAGTGGTGGCACCAGGATGGAAGGGCAAGGCACCCAGGGCAGGCCC

ACAGTCCCGCTGTCCCCCACTTGCACCCTAGCTTGTAGCTGCCAACCTC

CCAGACAGCCCAGCCCGCTGCTCAGCTCCACATGCATAGTATCAGCCCT

CCACACCCGACAAAGGGGAACACACCCCCTTGGAAATGGTTCTTTTCCC

CCAGTCCCAGCTGGAAGCCATGCTGTCTGTTCTGCTGGAGCAGCTGAAC

ATATACATAGATGTTGCCCTGCCCTCCCCATCTGCACCCTGTTGAGTTGT

AGTTGGATTTGTCTGTTTATGCTTGGATTCACCAGAGTGACTATGATAGT

GAAAAGAAAAAAAAAAAAAAAAAAGGACGCATGTATCTTGAAATGCTT

GTAAAGAGGTTTCTAACCCACCCTCACGAGGTGTCTCTCACCCCCACAC

TGGGACTCGTGTGGCCTGTGTGGTGCCACCCTGCTGGGGCCTCCCAAGT

TTTGAAAGGCTTTCCTCAGCACCTGGGACCCAACAGAGACCAGCTTCTA

GCAGCTAAGGAGGCCGTTCAGCTGTGACGAAGGCCTGAAGCACAGGAT

TAGGACTGAAGCGATGATGTCCCCTTCCCTACTTCCCCTTGGGGCTCCCT

GTGTCAGGGCACAGACTAGGTCTTGTGGCTGGTCTGGCTTGCGGCGCGA

GGATGGTTCTCTCTGGTCATAGCCCGAAGTCTCATGGCAGTCCCAAAGG

AGGCTTACAACTCCTGCATCACAAGAAAAAGGAAGCCACTGCCAGCTG

GGGGGATCTGCAGCTCCCAGAAGCTCCGTGAGCCTCAGCCACCCCTCAG

ACTGGGTTCCTCTCCAAGCTCGCCCTCTGGAGGGGCAGCGCAGCCTCCC

ACCAAGGGCCCTGCGACCACAGCAGGGATTGGGATGAATTGCCTGTCC

TGGATCTGCTCTAGAGGCCCAAGCTGCCTGCCTGAGGAAGGATGACTTG

ACAAGTCAGGAGACACTGTTCCCAAAGCCTTGACCAGAGCACCTCAGC

CCGCTGACCTTGCACAAACTCCATCTGCTGCCATGAGAAAAGGGAAGC

CGCCTTTGCAAAACATTGCTGCCTAAAGAAACTCAGCAGCCTCAGGCCC

AATTCTGCCACTTCTGGTTTGGGTACAGTTAAAGGCAACCCTGAGGGAC

TTGGCAGTAGAAATCCAGGGCCTCCCCTGGGGCTGGCAGCTTCGTGTGC

AGCTAGAGCTTTACCTGAAAGGAAGTCTCTGGGCCCAGAACTCTCCACC

AAGAGCCTCCCTGCCGTTCGCTGAGTCCCAGCAATTCTCCTAAGTTGAA

GGGATCTGAGAAGGAGAAGGAAATGTGGGGTAGATTTGGTGGTGGTTA GAGATATGCCCCCCTCATTACTGCCAACAGTTTCGGCTGCATTTCTTCAC

GCACCTCGGTTCCTCTTCCTGAAGTTCTTGTGCCCTGCTCTTCAGCACCA

TGGGCCTTCTTATACGGAAGGCTCTGGGATCTCCCCCTTGTGGGGCAGG

CTCTTGGGGCCAGCCTAAGATCATGGTTTAGGGTGATCAGTGCTGGCAG

ATAAATTGAAAAGGCACGCTGGCTTGTGATCTTAAATGAGGACAATCCC

CCCAGGGCTGGGCACTCCTCCCCTCCCCTCACTTCTCCCACCTGCAGAG

CCAGTGTCCTTGGGTGGGCTAGATAGGATATACTGTATGCCGGCTCCTT

CAAGCTGCTGACTCACTTTATCAATAGTTCCATTTAAATTGACTTCAGTG

GTGAGACTGTATCCTGTTTGCTATTGCTTGTTGTGCTATGGGGGGAGGG

GGGAGGAATGTGTAAGATAGTTAACATGGGCAAAGGGAGATCTTGGGG

TGCAGCACTTAAACTGCCTCGTAACCCTTTTCATGATTTCAACCACATTT

GCTAGAGGGAGGGAGCAGCCACGGAGTTAGAGGCCCTTGGGGTTTCTC

TTTTCCACTGACAGGCTTTCCCAGGCAGCTGGCTAGTTCATTCCCTCCCC

AGCCAGGTGCAGGCGTAGGAATATGGACATCTGGTTGCTTTGGCCTGCT

GCCCTCTTTCAGGGGTCCTAAGCCCACAATCATGCCTCCCTAAGACCTT

GGCATCCTTCCCTCTAAGCCGTTGGCACCTCTGTGCCACCTCTCACACTG

GCTCCAGACACACAGCCTGTGCTTTTGGAGCTGAGATCACTCGCTTCAC

CCTCCTCATCTTTGTTCTCCAAGTAAAGCCACGAGGTCGGGGCGAGGGC

AGAGGTGATCACCTGCGTGTCCCATCTACAGACCTGCAGCTTCATAAAA

CTTCTGATTTCTCTTCAGCTTTGAAAAGGGTTACCCTGGGCACTGGCCTA

GAGCCTCACCTCCTAATAGACTTAGCCCCATGAGTTTGCCATGTTGAGC

AGGACTATTTCTGGCACTTGCAAGTCCCATGATTTCTTCGGTAATTCTGA

GGGTGGGGGGAGGGACATGAAATCATCTTAGCTTAGCTTTCTGTCTGTG

AATGTCTATATAGTGTATTGTGTGTTTTAACAAATGATTTACACTGACTG

TTGCTGTAAAAGTGAATTTGGAAATAAAGTTATTACTCTGATTAAA

GCACCGCGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCCCTGTGTGTC 179

GGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGCGACCCCT

CTGACCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCG

GATTAGTGCGTACGAGCGCCCAGTGCCCTGGCCCGGAGAGTGGAATGA

TCCCCGAGGCCCAGGGCGTCGTGCTTCCGCAGTAGTCAGTCCCCGTGAA

GGAAACTGGGGAGTCTTGAGGGACCCCCGACTCCAAGCGCGAAAACCC

CGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCT

ACTGATGGTGCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGA

CCCTGGTTAGACCAAAGCCATTGCTTTTGAAGTTATTAAAGTCTGTTGG

TGCACAAAAAGACACTTATACTATGAAAGAGGTTCTTTTTTATCTTGGC

CAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAACATATTG

TATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTC

TCTGTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTG

GTAGTAGTCAATCAGCAGGAATCATCGGACTCAGGTACATCTGTGAGTG

AGAACAGGTGTCACCTTGAAGGTGGGAGTGATCAAAAGGACCTTGTAC

AAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTGGTTTCTAGACC

ATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTC

AGATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAG

TATTTCCCTTTCCTTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAG

ATATGTTGTGAAAGAAGCAGTAGCAGTGAATCTACAGGGACGCCATCG

AATCCGGATCTTGATGCTGGTGTAAGTGAACATTCAGGTGATTGGTTGG

ATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAATC

TCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTC

AGATGAAGATGATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGA

GAGTGATACAGATTCATTTGAAGAAGATCCTGAAATTTCCTTAGCTGAC

TATTGGAAATGCACTTCATGCAATGAAATGAATCCCCCCCTTCCATCAC

ATTGCAACAGATGTTGGGCCCTTCGTGAGAATTGGCTTCCTGAAGATAA

AGGGAAAGATAAAGGGGAAATCTCTGAGAAAGCCAAACTGGAAAACT

CAACACAAGCTGAAGAGGGCTTTGATGTTCCTGATTGTAAAAAAACTAT

AGTGAATGATTCCAGAGAGTCATGTGTTGAGGAAAATGATGATAAAAT

TACACAAGCTTCACAATCACAAGAAAGTGAAGACTATTCTCAGCCATCA ACTTCTAGTAGCATTATTTATAGCAGCCAAGAAGATGTGAAAGAGTTTG

AAAGGGAAGAAACCCAAGACAAAGAAGAGAGTGTGGAATCTAGTTTGC

CCCTTAATGCCATTGAACCTTGTGTGATTTGTCAAGGTCGACCTAAAAA

TGGTTGCATTGTCCATGGCAAAACAGGACATCTTATGGCCTGCTTTACA

TGTGCAAAGAAGCTAAAGAAAAGGAATAAGCCCTGCCCAGTATGTAGA

CAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAGTTGACCTGTCT

ATAAGAGAATTATATATTTCTAACTATATAACCCTAGGAATTTAGACAA

CCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTCACA

TAGATTTCTTCTCTTTAGTATAATTGACCTACTTTGGTAGTGGAATAGTG

AATACTTACTATAATTTGACTTGAATATGTAGCTCATCCTTTACACCAAC

TCCTAATTTTAAATAATTTCTACTCTGTCTTAAATGAGAAGTACTTGGTT

TTTTTTTTCTTAAATATGTATATGACATTTAAATGTAACTTATTATTTTTT

TTGAGACCGAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGGTGAT

CTTGGCTCACTGCAAGCTCTGCCCTCCCCGGGTTCGCACCATTCTCCTGC

CTCAGCCTCCCAATTAGCTTGGCCTACAGTCATCTGCCACCACACCTGG

CTAATTTTTTGTACTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGG

ATGGTCTCGATCTCCTGACCTCGTGATCCGCCCACCTCGGCCTCCCAAA

GTGCTGGGATTACAGGCATGAGCCACCG

NM_014791 GAGATTTGATTCCCTTGGCGGGCGGAAGCGGCCACAACCCGGCGATCG 180

AAAAGATTCTTAGGAACGCCGTACCAGCCGCGTCTCTCAGGACAGCAG

GCCCCTGTCCTTCTGTCGGGCGCCGCTCAGCCGTGCCCTCCGCCCCTCA

GGTTCTTTTTCTAATTCCAAATAAACTTGCAAGAGGACTATGAAAGATT

ATGATGAACTTCTCAAATATTATGAATTACATGAAACTATTGGGACAGG

TGGCTTTGCAAAGGTCAAACTTGCCTGCCATATCCTTACTGGAGAGATG

GTAGCTATAAAAATCATGGATAAAAACACACTAGGGAGTGATTTGCCC

CGGATCAAAACGGAGATTGAGGCCTTGAAGAACCTGAGACATCAGCAT

ATATGTCAACTCTACCATGTGCTAGAGACAGCCAACAAAATATTCATGG

TTCTTGAGTACTGCCCTGGAGGAGAGCTGTTTGACTATATAATTTCCCA

GGATCGCCTGTCAGAAGAGGAGACCCGGGTTGTCTTCCGTCAGATAGTA

TCTGCTGTTGCTTATGTGCACAGCCAGGGCTATGCTCACAGGGACCTCA

AGCCAGAAAATTTGCTGTTTGATGAATATCATAAATTAAAGCTGATTGA

CTTTGGTCTCTGTGCAAAACCCAAGGGTAACAAGGATTACCATCTACAG

ACATGCTGTGGGAGTCTGGCTTATGCAGCACCTGAGTTAATACAAGGCA

AATCATATCTTGGATCAGAGGCAGATGTTTGGAGCATGGGCATACTGTT

ATATGTTCTTATGTGTGGATTTCTACCATTTGATGATGATAATGTAATGG

CTTTATACAAGAAGATTATGAGAGGAAAATATGATGTTCCCAAGTGGCT

CTCTCCCAGTAGCATTCTGCTTCTTCAACAAATGCTGCAGGTGGACCCA

AAGAAACGGATTTCTATGAAAAATCTATTGAACCATCCCTGGATCATGC

AAGATTACAACTATCCTGTTGAGTGGCAAAGCAAGAATCCTTTTATTCA

CCTCGATGATGATTGCGTAACAGAACTTTCTGTACATCACAGAAACAAC

AGGCAAACAATGGAGGATTTAATTTCACTGTGGCAGTATGATCACCTCA

CGGCTACCTATCTTCTGCTTCTAGCCAAGAAGGCTCGGGGAAAACCAGT

TCGTTTAAGGCTTTCTTCTTTCTCCTGTGGACAAGCCAGTGCTACCCCAT

TCACAGACATCAAGTCAAATAATTGGAGTCTGGAAGATGTGACCGCAA

GTGATAAAAATTATGTGGCGGGATTAATAGACTATGATTGGTGTGAAG

ATGATTTATCAACAGGTGCTGCTACTCCCCGAACATCACAGTTTACCAA

GTACTGGACAGAATCAAATGGGGTGGAATCTAAATCATTAACTCCAGC

CTTATGCAGAACACCTGCAAATAAATTAAAGAACAAAGAAAATGTATA

TACTCCTAAGTCTGCTGTAAAGAATGAAGAGTACTTTATGTTTCCTGAG

CCAAAGACTCCAGTTAATAAGAACCAGCATAAGAGAGAAATACTCACT

ACGCCAAATCGTTACACTACACCCTCAAAAGCTAGAAACCAGTGCCTG

AAAGAAACTCCAATTAAAATACCAGTAAATTCAACAGGAACAGACAAG

TTAATGACAGGTGTCATTAGCCCTGAGAGGCGGTGCCGCTCAGTGGAAT

TGGATCTCAACCAAGCACATATGGAGGAGACTCCAAAAAGAAAGGGAG

CCAAAGTGTTTGGGAGCCTTGAAAGGGGGTTGGATAAGGTTATCACTGT

GCTCACCAGGAGCAAAAGGAAGGGTTCTGCCAGAGACGGGCCCAGAAG ACTAAAGCTTCACTATAACGTGACTACAACTAGATTAGTGAATCCAGAT

CAACTGTTGAATGAAATAATGTCTATTCTTCCAAAGAAGCATGTTGACT

TTGTACAAAAGGGTTATACACTGAAGTGTCAAACACAGTCAGATTTTGG

GAAAGTGACAATGCAATTTGAATTAGAAGTGTGCCAGCTTCAAAAACC

CGATGTGGTGGGTATCAGGAGGCAGCGGCTTAAGGGCGATGCCTGGGT

TTACAAAAGATTAGTGGAAGACATCCTATCTAGCTGCAAGGTATAATTG

ATGGATTCTTCCATCCTGCCGGATGAGTGTGGGTGTGATACAGCCTACA

TAAAGACTGTTATGATCGCTTTGATTTTAAAGTTCATTGGAACTACCAA

CTTGTTTCTAAAGAGCTATCTTAAGACCAATATCTCTTTGTTTTTAAACA

AAAGATATTATTTTGTGTATGAATCTAAATCAAGCCCATCTGTCATTAT

GTTACTGTCTTTTTTAATCATGTGGTTTTGTATATTAATAATTGTTGACTT

TCTTAGATTCACTTCCATATGTGAATGTAAGCTCTTAACTATGTCTCTTT

GTAATGTGTAATTTCTTTCTGAAATAAAACCATTTGTGAATATAG

BG765502 GCAGCGGAGGAGCCCAGTCCACGATGGCCCGGTCCCTGGTGTGCCTTG 181

GTGTCATCATCTTGCTGTCTGCCTTCTCCGGACCTGGTGTCAGGGGTGGT

CCTATGCCCAAGCTGGCTGACCGGAAGCTGTGTGCGGACCAGGAGTGC

AGCCACCCTATCTCCATGGCTGTGGCCCTTCAGGACTACATGGCCCCCG

ACTGCCGATTCCTGACCATTCACCGGGGCCAAGTGGTGTATGTCTTCTC

CAAGCTGAAGGGCCGTGGGCGGCTCTTCTGGGGAGGCAGCGTTCAGGG

AGATTACTATGGAGATCTGGCTGCTCGCCTGGGCTATTTCCCCAGTAGC

ATTGTCCGAGAGGACCAGACCCTGAAACCTGGCAAAGTCGATGTGAAG

ACAGACAAATGGGATTTCTACTGCCAGTGAGCTCAGCCTACCGCTGGCC

CTGCCGTTTCCCCTCCTTGGGTTTATGCAAATACAATCAGCCCAGTGCA

AAAAAAAAAAAAAAAAAAAAAAACTTCGGAGAAGAGATAGCAACAAA

AGGCCGCTTGTGTGAAGGCGCCAAAAGTTTTCGCCCAAGAGACCTTCGG

CCTCCCCCAGGGCGCGCGCAAAGGCGCCTTGTTTTGACAACCTCTTGGA

CAACCGGAGGGGCTACCGCCCGGAGACCCCTGTGGTGGACCCCCCGGG

CAACCCGGTGTGACAGGGTACTCACCCCCACGGCTTTGTCGGGGGTCCC

ACCAAAGGCCCCAAAGAGGCTCTTTCAAGGCACTATTCCTTGTTGTAGA

CCTTGTGTGTGCCACAGGCGCCAAAGAAACCTCGGGGGGCTAACAAAC

GCACGTGCTTGGCAGCTCCGAGAAGGCTCTCTCCCACCCGAGGGGTGG

ACGCAACAGGGGGAATGGGCCATCATATTGTTGCCCCCGGTGGGCACC

AACTCTTTTTCCCCCATAGAGAGGCCTTAGCACACTATGTGGGGCACGT

TATTGCCGCCTAGAGAAACCGAGCGCCAGAAAATTTCGAAGGGGGGGG

CGCTTCTCATCATTTTGCGCAAAACCCCCTTGTGGGAGTATGCCCCGAA

CTCCTCTGGAACACACAAGCGACACTTGCGCGGGGTCTGCAAAAAACC

TCCTGTTGGGAAGCCGGCTTCACN

NM_002417 TACCGGGCGGAGGTGAGCGCGGCGCCGGCTCCTCCTGCGGCGGACTTT 182

GGGTGCGACTTGACGAGCGGTGGTTCGACAAGTGGCCTTGCGGGCCGG

ATCGTCCCAGTGGAAGAGTTGTAAATTTGCTTCTGGCCTTCCCCTACGG

ATTATACCTGGCCTTCCCCTACGGATTATACTCAACTTACTGTTTAGAAA

ATGTGGCCCACGAGACGCCTGGTTACTATCAAAAGGAGCGGGGTCGAC

GGTCCCCACTTTCCCCTGAGCCTCAGCACCTGCTTGTTTGGAAGGGGTA

TTGAATGTGACATCCGTATCCAGCTTCCTGTTGTGTCAAAACAACATTG

CAAAATTGAAATCCATGAGCAGGAGGCAATATTACATAATTTCAGTTCC

ACAAATCCAACACAAGTAAATGGGTCTGTTATTGATGAGCCTGTACGGC

TAAAACATGGAGATGTAATAACTATTATTGATCGTTCCTTCAGGTATGA

AAATGAAAGTCTTCAGAATGGAAGGAAGTCAACTGAATTTCCAAGAAA

AATACGTGAACAGGAGCCAGCACGTCGTGTCTCAAGATCTAGCTTCTCT

TCTGACCCTGATGAGAAAGCTCAAGATTCCAAGGCCTATTCAAAAATCA

CTGAAGGAAAAGTTTCAGGAAATCCTCAGGTACATATCAAGAATGTCA

AAGAAGACAGTACCGCAGATGACTCAAAAGACAGTGTTGCTCAGGGAA

CAACTAATGTTCATTCCTCAGAACATGCTGGACGTAATGGCAGAAATGC

AGCTGATCCCATTTCTGGGGATTTTAAAGAAATTTCCAGCGTTAAATTA

GTGAGCCGTTATGGAGAATTGAAGTCTGTTCCCACTACACAATGTCTTG

ACAATAGCAAAAAAAATGAATCTCCCTTTTGGAAGCTTTATGAGTCAGT GAAGAAAGAGTTGGATGTAAAATCACAAAAAGAAAATGTCCTACAGTA

TTGTAGAAAATCTGGATTACAAACTGATTACGCAACAGAGAAAGAAAG

TGCTGATGGTTTACAGGGGGAGACCCAACTGTTGGTCTCGCGTAAGTCA

AGACCAAAATCTGGTGGGAGCGGCCACGCTGTGGCAGAGCCTGCTTCA

CCTGAACAAGAGCTTGACCAGAACAAGGGGAAGGGAAGAGACGTGGA

GTCTGTTCAGACTCCCAGCAAGGCTGTGGGCGCCAGCTTTCCTCTCTAT

GAGCCGGCTAAAATGAAGACCCCTGTACAATATTCACAGCAACAAAAT

TCTCCACAAAAACATAAGAACAAAGACCTGTATACTACTGGTAGAAGA

GAATCTGTGAATCTGGGTAAAAGTGAAGGCTTCAAGGCTGGTGATAAA

ACTCTTACTCCCAGGAAGCTTTCAACTAGAAATCGAACACCAGCTAAAG

TTGAAGATGCAGCTGACTCTGCCACTAAGCCAGAAAATCTCTCTTCCAA

AACCAGAGGAAGTATTCCTACAGATGTGGAAGTTCTGCCTACGGAAAC

TGAAATTCACAATGAGCCATTTTTAACTCTGTGGCTCACTCAAGTTGAG

AGGAAGATCCAAAAGGATTCCCTCAGCAAGCCTGAGAAATTGGGCACT

ACAGCTGGACAGATGTGCTCTGGGTTACCTGGTCTTAGTTCAGTTGATA

TCAACAACTTTGGTGATTCCATTAATGAGAGTGAGGGAATACCTTTGAA

AAGAAGGCGTGTGTCCTTTGGTGGGCACCTAAGACCTGAACTATTTGAT

GAAAACTTGCCTCCTAATACGCCTCTCAAAAGGGGAGAAGCCCCAACC

AAAAGAAAGTCTCTGGTAATGCACACTCCACCTGTCCTGAAGAAAATC

ATCAAGGAACAGCCTCAACCATCAGGAAAACAAGAGTCAGGTTCAGAA

ATCCATGTGGAAGTGAAGGCACAAAGCTTGGTTATAAGCCCTCCAGCTC

CTAGTCCTAGGAAAACTCCAGTTGCCAGTGATCAACGCCGTAGGTCCTG

CAAAACAGCCCCTGCTTCCAGCAGCAAATCTCAGACAGAGGTTCCTAA

GAGAGGAGGGAGAAAGAGTGGCAACCTGCCTTCAAAGAGAGTGTCTAT

CAGCCGAAGTCAACATGATATTTTACAGATGATATGTTCCAAAAGAAG

AAGTGGTGCTTCGGAAGCAAATCTGATTGTTGCAAAATCATGGGCAGAT

GTAGTAAAACTTGGTGCAAAACAAACACAAACTAAAGTCATAAAACAT

GGTCCTCAAAGGTCAATGAACAAAAGGCAAAGAAGACCTGCTACTCCA

AAGAAGCCTGTGGGCGAAGTTCACAGTCAATTTAGTACAGGCCACGCA

AACTCTCCTTGTACCATAATAATAGGGAAAGCTCATACTGAAAAAGTAC

ATGTGCCTGCTCGACCCTACAGAGTGCTCAACAACTTCATTTCCAACCA

AAAAATGGACTTTAAGGAAGATCTTTCAGGAATAGCTGAAATGTTCAA

GACCCCAGTGAAGGAGCAACCGCAGTTGACAAGCACATGTCACATCGC

TATTTCAAATTCAGAGAATTTGCTTGGAAAACAGTTTCAAGGAACTGAT

TCAGGAGAAGAACCTCTGCTCCCCACCTCAGAGAGTTTTGGAGGAAAT

GTGTTCTTCAGTGCACAGAATGCAGCAAAACAGCCATCTGATAAATGCT

CTGCAAGCCCTCCCTTAAGACGGCAGTGTATTAGAGAAAATGGAAACG

TAGCAAAAACGCCCAGGAACACCTACAAAATGACTTCTCTGGAGACAA

AAACTTCAGATACTGAGACAGAGCCTTCAAAAACAGTATCCACTGCAA

ACAGGTCAGGAAGGTCTACAGAGTTCAGGAATATACAGAAGCTACCTG

TGGAAAGTAAGAGTGAAGAAACAAATACAGAAATTGTTGAGTGCATCC

TAAAAAGAGGTCAGAAGGCAACACTACTACAACAAAGGAGAGAAGGA

GAGATGAAGGAAATAGAAAGACCTTTTGAGACATATAAGGAAAATATT

GAATTAAAAGAAAACGATGAAAAGATGAAAGCAATGAAGAGATCAAG

AACTTGGGGGCAGAAATGTGCACCAATGTCTGACCTGACAGACCTCAA

GAGCTTGCCTGATACAGAACTCATGAAAGACACGGCACGTGGCCAGAA

TCTCCTCCAAACCCAAGATCATGCCAAGGCACCAAAGAGTGAGAAAGG

CAAAATCACTAAAATGCCCTGCCAGTCATTACAACCAGAACCAATAAA

CACCCCAACACACACAAAACAACAGTTGAAGGCATCCCTGGGGAAAGT

AGGTGTGAAAGAAGAGCTCCTAGCAGTCGGCAAGTTCACACGGACGTC

AGGGGAGACCACGCACACGCACAGAGAGCCAGCAGGAGATGGCAAGA

GCATCAGAACGTTTAAGGAGTCTCCAAAGCAGATCCTGGACCCAGCAG

CCCGTGTAACTGGAATGAAGAAGTGGCCAAGAACGCCTAAGGAAGAGG

CCCAGTCACTAGAAGACCTGGCTGGCTTCAAAGAGCTCTTCCAGACACC

AGGTCCCTCTGAGGAATCAATGACTGATGAGAAAACTACCAAAATAGC

CTGCAAATCTCCACCACCAGAATCAGTGGACACTCCAACAAGCACAAA GCAATGGCCTAAGAGAAGTCTCAGGAAAGCAGATGTAGAGGAAGAATT

CTTAGCACTCAGGAAACTAACACCATCAGCAGGGAAAGCCATGCTTAC

GCCCAAACCAGCAGGAGGTGATGAGAAAGACATTAAAGCATTTATGGG

AACTCCAGTGCAGAAACTGGACCTGGCAGGAACTTTACCTGGCAGCAA

AAGACAGCTACAGACTCCTAAGGAAAAGGCCCAGGCTCTAGAAGACCT

GGCTGGCTTTAAAGAGCTCTTCCAGACTCCTGGTCACACCGAGGAATTA

GTGGCTGCTGGTAAAACCACTAAAATACCCTGCGACTCTCCACAGTCAG

ACCCAGTGGACACCCCAACAAGCACAAAGCAACGACCCAAGAGAAGTA

TCAGGAAAGCAGATGTAGAGGGAGAACTCTTAGCGTGCAGGAATCTAA

TGCCATCAGCAGGCAAAGCCATGCACACGCCTAAACCATCAGTAGGTG

AAGAGAAAGACATCATCATATTTGTGGGAACTCCAGTGCAGAAACTGG

ACCTGACAGAGAACTTAACCGGCAGCAAGAGACGGCCACAAACTCCTA

AGGAAGAGGCCCAGGCTCTGGAAGACCTGACTGGCTTTAAAGAGCTCT

TCCAGACCCCTGGTCATACTGAAGAAGCAGTGGCTGCTGGCAAAACTA

CTAAAATGCCCTGCGAATCTTCTCCACCAGAATCAGCAGACACCCCAAC

AAGCACAAGAAGGCAGCCCAAGACACCTTTGGAGAAAAGGGACGTAC

AGAAGGAGCTCTCAGCCCTGAAGAAGCTCACACAGACATCAGGGGAAA

CCACACACACAGATAAAGTACCAGGAGGTGAGGATAAAAGCATCAACG

CGTTTAGGGAAACTGCAAAACAGAAACTGGACCCAGCAGCAAGTGTAA

CTGGTAGCAAGAGGCACCCAAAAACTAAGGAAAAGGCCCAACCCCTAG

AAGACCTGGCTGGCTTGAAAGAGCTCTTCCAGACACCAGTATGCACTGA

CAAGCCCACGACTCACGAGAAAACTACCAAAATAGCCTGCAGATCACA

ACCAGACCCAGTGGACACACCAACAAGCTCCAAGCCACAGTCCAAGAG

AAGTCTCAGGAAAGTGGACGTAGAAGAAGAATTCTTCGCACTCAGGAA

ACGAACACCATCAGCAGGCAAAGCCATGCACACACCCAAACCAGCAGT

AAGTGGTGAGAAAAACATCTACGCATTTATGGGAACTCCAGTGCAGAA

ACTGGACCTGACAGAGAACTTAACTGGCAGCAAGAGACGGCTACAAAC

TCCTAAGGAAAAGGCCCAGGCTCTAGAAGACCTGGCTGGCTTTAAAGA

GCTCTTCCAGACACGAGGTCACACTGAGGAATCAATGACTAACGATAA

AACTGCCAAAGTAGCCTGCAAATCTTCACAACCAGACCCAGACAAAAA

CCCAGCAAGCTCCAAGCGACGGCTCAAGACATCCCTGGGGAAAGTGGG

CGTGAAAGAAGAGCTCCTAGCAGTTGGCAAGCTCACACAGACATCAGG

AGAGACTACACACACACACACAGAGCCAACAGGAGATGGTAAGAGCAT

GAAAGCATTTATGGAGTCTCCAAAGCAGATCTTAGACTCAGCAGCAAG

TCTAACTGGCAGCAAGAGGCAGCTGAGAACTCCTAAGGGAAAGTCTGA

AGTCCCTGAAGACCTGGCCGGCTTCATCGAGCTCTTCCAGACACCAAGT

CACACTAAGGAATCAATGACTAACGAAAAAACTACCAAAGTATCCTAC

AGAGCTTCACAGCCAGACCTAGTGGACACCCCAACAAGCTCCAAGCCA

CAGCCCAAGAGAAGTCTCAGGAAAGCAGACACTGAAGAAGAATTTTTA

GCATTTAGGAAACAAACGCCATCAGCAGGCAAAGCCATGCACACACCC

AAACCAGCAGTAGGTGAAGAGAAAGACATCAACACGTTTTTGGGAACT

CCAGTGCAGAAACTGGACCAGCCAGGAAATTTACCTGGCAGCAATAGA

CGGCTACAAACTCGTAAGGAAAAGGCCCAGGCTCTAGAAGAACTGACT

GGCTTCAGAGAGCTTTTCCAGACACCATGCACTGATAACCCCACGACTG

ATGAGAAAACTACCAAAAAAATACTCTGCAAATCTCCGCAATCAGACC

CAGCGGACACCCCAACAAACACAAAGCAACGGCCCAAGAGAAGCCTCA

AGAAAGCAGACGTAGAGGAAGAATTTTTAGCATTCAGGAAACTAACAC

CATCAGCAGGCAAAGCCATGCACACGCCTAAAGCAGCAGTAGGTGAAG

AGAAAGACATCAACACATTTGTGGGGACTCCAGTGGAGAAACTGGACC

TGCTAGGAAATTTACCTGGCAGCAAGAGACGGCCACAAACTCCTAAAG

AAAAGGCCAAGGCTCTAGAAGATCTGGCTGGCTTCAAAGAGCTCTTCC

AGACACCAGGTCACACTGAGGAATCAATGACCGATGACAAAATCACAG

AAGTATCCTGCAAATCTCCACAACCAGACCCAGTCAAAACCCCAACAA

GCTCCAAGCAACGACTCAAGATATCCTTGGGGAAAGTAGGTGTGAAAG

AAGAGGTCCTACCAGTCGGCAAGCTCACACAGACGTCAGGGAAGACCA

CACAGACACACAGAGAGACAGCAGGAGATGGAAAGAGCATCAAAGCG TTTAAGGAATCTGCAAAGCAGATGCTGGACCCAGCAAACTATGGAACT

GGGATGGAGAGGTGGCCAAGAACACCTAAGGAAGAGGCCCAATCACTA

GAAGACCTGGCCGGCTTCAAAGAGCTCTTCCAGACACCAGACCACACT

GAGGAATCAACAACTGATGACAAAACTACCAAAATAGCCTGCAAATCT

CCACCACCAGAATCAATGGACACTCCAACAAGCACAAGGAGGCGGCCC

AAAACACCTTTGGGGAAAAGGGATATAGTGGAAGAGCTCTCAGCCCTG

AAGCAGCTCACACAGACCACACACACAGACAAAGTACCAGGAGATGAG

GATAAAGGCATCAACGTGTTCAGGGAAACTGCAAAACAGAAACTGGAC

CCAGCAGCAAGTGTAACTGGTAGCAAGAGGCAGCCAAGAACTCCTAAG

GGAAAAGCCCAACCCCTAGAAGACTTGGCTGGCTTGAAAGAGCTCTTC

CAGACACCAATATGCACTGACAAGCCCACGACTCATGAGAAAACTACC

AAAATAGCCTGCAGATCTCCACAACCAGACCCAGTGGGTACCCCAACA

ATCTTCAAGCCACAGTCCAAGAGAAGTCTCAGGAAAGCAGACGTAGAG

GAAGAATCCTTAGCACTCAGGAAACGAACACCATCAGTAGGGAAAGCT

ATGGACACACCCAAACCAGCAGGAGGTGATGAGAAAGACATGAAAGC

ATTTATGGGAACTCCAGTGCAGAAATTGGACCTGCCAGGAAATTTACCT

GGCAGCAAAAGATGGCCACAAACTCCTAAGGAAAAGGCCCAGGCTCTA

GAAGACCTGGCTGGCTTCAAAGAGCTCTTCCAGACACCAGGCACTGAC

AAGCCCACGACTGATGAGAAAACTACCAAAATAGCCTGCAAATCTCCA

CAACCAGACCCAGTGGACACCCCAGCAAGCACAAAGCAACGGCCCAAG

AGAAACCTCAGGAAAGCAGACGTAGAGGAAGAATTTTTAGCACTCAGG

AAACGAACACCATCAGCAGGCAAAGCCATGGACACACCAAAACCAGCA

GTAAGTGATGAGAAAAATATCAACACATTTGTGGAAACTCCAGTGCAG

AAACTGGACCTGCTAGGAAATTTACCTGGCAGCAAGAGACAGCCACAG

ACTCCTAAGGAAAAGGCTGAGGCTCTAGAGGACCTGGTTGGCTTCAAA

GAACTCTTCCAGACACCAGGTCACACTGAGGAATCAATGACTGATGAC

AAAATCACAGAAGTATCCTGTAAATCTCCACAGCCAGAGTCATTCAAA

ACCTCAAGAAGCTCCAAGCAAAGGCTCAAGATACCCCTGGTGAAAGTG

GACATGAAAGAAGAGCCCCTAGCAGTCAGCAAGCTCACACGGACATCA

GGGGAGACTACGCAAACACACACAGAGCCAACAGGAGATAGTAAGAG

CATCAAAGCGTTTAAGGAGTCTCCAAAGCAGATCCTGGACCCAGCAGC

AAGTGTAACTGGTAGCAGGAGGCAGCTGAGAACTCGTAAGGAAAAGGC

CCGTGCTCTAGAAGACCTGGTTGACTTCAAAGAGCTCTTCTCAGCACCA

GGTCACACTGAAGAGTCAATGACTATTGACAAAAACACAAAAATTCCC

TGCAAATCTCCCCCACCAGAACTAACAGACACTGCCACGAGCACAAAG

AGATGCCCCAAGACACGTCCCAGGAAAGAAGTAAAAGAGGAGCTCTCA

GCAGTTGAGAGGCTCACGCAAACATCAGGGCAAAGCACACACACACAC

AAAGAACCAGCAAGCGGTGATGAGGGCATCAAAGTATTGAAGCAACGT

GCAAAGAAGAAACCAAACCCAGTAGAAGAGGAACCCAGCAGGAGAAG

GCCAAGAGCACCTAAGGAAAAGGCCCAACCCCTGGAAGACCTGGCCGG

CTTCACAGAGCTCTCTGAAACATCAGGTCACACTCAGGAATCACTGACT

GCTGGCAAAGCCACTAAAATACCCTGCGAATCTCCCCCACTAGAAGTG

GTAGACACCACAGCAAGCACAAAGAGGCATCTCAGGACACGTGTGCAG

AAGGTACAAGTAAAAGAAGAGCCTTCAGCAGTCAAGTTCACACAAACA

TCAGGGGAAACCACGGATGCAGACAAAGAACCAGCAGGTGAAGATAA

AGGCATCAAAGCATTGAAGGAATCTGCAAAACAGACACCGGCTCCAGC

AGCAAGTGTAACTGGCAGCAGGAGACGGCCAAGAGCACCCAGGGAAA

GTGCCCAAGCCATAGAAGACCTAGCTGGCTTCAAAGACCCAGCAGCAG

GTCACACTGAAGAATCAATGACTGATGACAAAACCACTAAAATACCCT

GCAAATCATCACCAGAACTAGAAGACACCGCAACAAGCTCAAAGAGAC

GGCCCAGGACACGTGCCCAGAAAGTAGAAGTGAAGGAGGAGCTGTTAG

CAGTTGGCAAGCTCACACAAACCTCAGGGGAGACCACGCACACCGACA

AAGAGCCGGTAGGTGAGGGCAAAGGCACGAAAGCATTTAAGCAACCTG

CAAAGCGGAAGCTGGACGCAGAAGATGTAATTGGCAGCAGGAGACAG

CCAAGAGCACCTAAGGAAAAGGCCCAACCCCTGGAAGATCTGGCCAGC

TTCCAAGAGCTCTCTCAAACACCAGGCCACACTGAGGAACTGGCAAAT GGTGCTGCTGATAGCTTTACAAGCGCTCCAAAGCAAACACCTGACAGTG

GAAAACCTCTAAAAATATCCAGAAGAGTTCTTCGGGCCCCTAAAGTAG

AACCCGTGGGAGACGTGGTAAGCACCAGAGACCCTGTAAAATCACAAA

GCAAAAGCAACACTTCCCTGCCCCCACTGCCCTTCAAGAGGGGAGGTG

GCAAAGATGGAAGCGTCACGGGAACCAAGAGGCTGCGCTGCATGCCAG

CACCAGAGGAAATTGTGGAGGAGCTGCCAGCCAGCAAGAAGCAGAGG

GTTGCTCCCAGGGCAAGAGGCAAATCATCCGAACCCGTGGTCATCATG

AAGAGAAGTTTGAGGACTTCTGCAAAAAGAATTGAACCTGCGGAAGAG

CTGAACAGCAACGACATGAAAACCAACAAAGAGGAACACAAATTACA

AGACTCGGTCCCTGAAAATAAGGGAATATCCCTGCGCTCCAGACGCCA

AAATAAGACTGAGGCAGAACAGCAAATAACTGAGGTCTTTGTATTAGC

AGAAAGAATAGAAATAAACAGAAATGAAAAGAAGCCCATGAAGACCT

CCCCAGAGATGGACATTCAGAATCCAGATGATGGAGCCCGGAAACCCA

TACCTAGAGACAAAGTCACTGAGAACAAAAGGTGCTTGAGGTCTGCTA

GACAGAATGAGAGCTCCCAGCCTAAGGTGGCAGAGGAGAGCGGAGGG

CAGAAGAGTGCGAAGGTTCTCATGCAGAATCAGAAAGGGAAAGGAGA

AGCAGGAAATTCAGACTCCATGTGCCTGAGATCAAGAAAGACAAAAAG

CCAGCCTGCAGCAAGCACTTTGGAGAGCAAATCTGTGCAGAGAGTAAC

GCGGAGTGTCAAGAGGTGTGCAGAAAATCCAAAGAAGGCTGAGGACA

ATGTGTGTGTCAAGAAAATAAGAACCAGAAGTCATAGGGACAGTGAAG

ATATTTGACAGAAAAATCGAACTGGGAAAAATATAATAAAGTTAGTTTT

GTGATAAGTTCTAGTGCAGTTTTTGTCATAAATTACAAGTGAATTCTGT

AAGTAAGGCTGTCAGTCTGCTTAAGGGAAGAAAACTTTGGATTTGCTGG

GTCTGAATCGGCTTCATAAACTCCACTGGGAGCACTGCTGGGCTCCTGG

ACTGAGAATAGTTGAACACCGGGGGCTTTGTGAAGGAGTCTGGGCCAA

GGTTTGCCCTCAGCTTTGCAGAATGAAGCCTTGAGGTCTGTCACCACCC

ACAGCCACCCTACAGCAGCCTTAACTGTGACACTTGCCACACTGTGTCG

TCGTTTGTTTGCCTATGTCCTCCAGGGCACGGTGGCAGGAACAACTATC

CTCGTCTGTCCCAACACTGAGCAGGCACTCGGTAAACACGAATGAATG

GATGAGCGCACGGATGAATGGAGCTTACAAGATCTGTCTTTCCAATGGC

CGGGGGCATTTGGTCCCCAAATTAAGGCTATTGGACATCTGCACAGGAC

AGTCCTATTTTTGATGTCCTTTCCTTTCTGAAAATAAAGTTTTGTGCTTT

GGAGAATGACTCGTGAGCACATCTTTAGGGACCAAGAGTGACTTTCTGT

AAGGAGTGACTCGTGGCTTGCCTTGGTCTCTTGGGAATACTTTTCTAACT

AGGGTTGCTCTCACCTGAGACATTCTCCACCCGCGGAATCTCAGGGTCC

CAGGCTGTGGGCCATCACGACCTCAAACTGGCTCCTAATCTCCAGCTTT

CCTGTCATTGAAAGCTTCGGAAGTTTACTGGCTCTGCTCCCGCCTGTTTT

CTTTCTGACTCTATCTGGCAGCCCGATGCCACCCAGTACAGGAAGTGAC

ACCAGTACTCTGTAAAGCATCATCATCCTTGGAGAGACTGAGCACTCAG

CACCTTCAGCCACGATTTCAGGATCGCTTCCTTGTGAGCCGCTGCCTCC

GAAATCTCCTTTGAAGCCCAGACATCTTTCTCCAGCTTCAGACTTGTAG

ATATAACTCGTTCATCTTCATTTACTTTCCACTTTGCCCCCTGTCCTCTCT

GTGTTCCCCAAATCAGAGAATAGCCCGCCATCCCCCAGGTCACCTGTCT

GGATTCCTCCCCATTCACCCACCTTGCCAGGTGCAGGTGAGGATGGTGC

ACCAGACAGGGTAGCTGTCCCCCAAAATGTGCCCTGTGCGGGCAGTGC

CCTGTCTCCACGTTTGTTTCCCCAGTGTCTGGCGGGGAGCCAGGTGACA

TCATAAATACTTGCTGAATGAATGCAGAAATCAGCGGTACTGACTTGTA

CTATATTGGCTGCCATGATAGGGTTCTCACAGCGTCATCCATGATCGTA

AGGGAGAATGACATTCTGCTTGAGGGAGGGAATAGAAAGGGGCAGGG

AGGGGACATCTGAGGGCTTCACAGGGCTGCAAAGGGTACAGGGATTGC

ACCAGGGCAGAACAGGGGAGGGTGTTCAAGGAAGAGTGGCTCTTAGCA

GAGGCACTTTGGAAGGTGTGAGGCATAAATGCTTCCTTCTACGTAGGCC

AACCTCAAAACTTTCAGTAGGAATGTTGCTATGATCAAGTTGTTCTAAC

ACTTTAGACTTAGTAGTAATTATGAACCTCACATAGAAAAATTTCATCC

AGCCATATGCCTGTGGAGTGGAATATTCTGTTTAGTAGAAAAATCCTTT

AGAGTTCAGCTCTAACCAGAAATCTTGCTGAAGTATGTCAGCACCTTTT CTCACCCTGGTAAGTACAGTATTTCAAGAGCACGCTAAGGGTGGTTTTC

ATTTTACAGGGCTGTTGATGATGGGTTAAAAATGTTCATTTAAGGGCTA

CCCCCGTGTTTAATAGATGAACACCACTTCTACACAACCCTCCTTGGTA

CTGGGGGAGGGAGAGATCTGACAAATACTGCCCATTCCCCTAGGCTGA

CTGGATTTGAGAACAAATACCCACCCATTTCCACCATGGTATGGTAACT

TCTCTGAGCTTCAGTTTCCAAGTGAATTTCCATGTAATAGGACATTCCCA

TTAAATACAAGCTGTTTTTACTTTTTCGCCTCCCAGGGCCTGTGGGATCT

GGTCCCCCAGCCTCTCTTGGGCTTTCTTACACTAACTCTGTACCTACCAT

CTCCTGCCTCCCTTAGGCAGGCACCTCCAACCACCACACACTCCCTGCT

GTTTTCCCTGCCTGGAACTTTCCCTCCTGCCCCACCAAGATCATTTCATC

CAGTCCTGAGCTCAGCTTAAGGGAGGCTTCTTGCCTGTGGGTTCCCTCA

CCCCCATGCCTGTCCTCCAGGCTGGGGCAGGTTCTTAGTTTGCCTGGAA

TTGTTCTGTACCTCTTTGTAGCACGTAGTGTTGTGGAAACTAAGCCACTA

ATTGAGTTTCTGGCTCCCCTCCTGGGGTTGTAAGTTTTGTTCATTCATGA

GGGCCGACTGCATTTCCTGGTTACTCTATCCCAGTGACCAGCCACAGGA

GATGTCCAATAAAGTATGTGATGAAATGGTCTTAAAAAAAAAAAAAA

NM_024101 GCGCCGGGACGTGGCCAGTTGCCCGCCTGCCCCGGAGAGCCAGGCGCT 183

AACCAGCCGCTCTGCGCCCCGCGCCCTGCTTGCCCCCATTATCCAGCCT

TGCCCCGGCGCCCTGACCTGACGCCCTGGCCTGACGCCCTGCTTCGTCG

CCTCCTTTCTCTCCCAGGTGCTGGACCAGGGACTGAGCGTCCCCCGGAG

AGGGTCCGGTGTGACCCCGACAAGAAGCAGAAATGGGGAAGAAACTG

GATCTTTCCAAGCTCACTGATGAAGAGGCCCAGCATGTCTTGGAAGTTG

TTCAACGAGATTTTGACCTCCGAAGGAAAGAAGAGGAACGGCTAGAGG

CGTTGAAGGGCAAGATTAAGAAGGAAAGCTCCAAGAGGGAGCTGCTTT

CCGACACTGCCCATCTGAACGAGACCCACTGCGCCCGCTGCCTGCAGCC

CTACCAGCTGCTTGTGAATAGCAAAAGGCAGTGCCTGGAATGTGGCCTC

TTCACCTGCAAAAGCTGTGGCCGCGTCCACCCGGAGGAGCAGGGCTGG

ATCTGTGACCCCTGCCATCTGGCCAGAGTCGTGAAGATCGGCTCACTGG

AGTGGTACTATGAGCATGTGAAAGCCCGCTTCAAGAGGTTCGGAAGTG

CCAAGGTCATCCGGTCCCTCCACGGGCGGCTGCAGGGTGGAGCTGGGC

CTGAACTGATATCTGAAGAGAGAAGTGGAGACAGCGACCAGACAGATG

AGGATGGAGAACCTGGCTCAGAGGCCCAGGCCCAGGCCCAGCCCTTTG

GCAGCAAAAAAAAGCGCCTCCTCTCCGTCCACGACTTCGACTTCGAGGG

AGACTCAGATGACTCCACTCAGCCTCAAGGTCACTCCCTGCACCTGTCC

TCAGTCCCTGAGGCCAGGGACAGCCCACAGTCCCTCACAGATGAGTCCT

GCTCAGAGAAGGCAGCCCCTCACAAGGCTGAGGGCCTGGAGGAGGCTG

ATACTGGGGCCTCTGGGTGCCACTCCCATCCGGAAGAGCAGCCGACCA

GCATCTCACCTTCCAGACACGGCGCCCTGGCTGAGCTCTGCCCGCCTGG

AGGCTCCCACAGGATGGCCCTGGGGACTGCTGCTGCACTCGGGTCGAAT

GTCATCAGGAATGAGCAGCTGCCCCTGCAGTACTTGGCCGATGTGGACA

CCTCTGATGAGGAAAGCATCCGGGCTCACGTGATGGCCTCCCACCATTC

CAAGCGGAGAGGCCGGGCGTCTTCTGAGAGTCAGATCTTTGAGCTGAA

TAAGCATATTTCAGCTGTGGAATGCCTGCTGACCTACCTGGAGAACACA

GTTGTGCCTCCCTTGGCCAAGGGTCTAGGTGCTGGAGTGCGCACGGAGG

CCGATGTAGAGGAGGAGGCCCTGAGGAGGAAGCTGGAGGAGCTGACC

AGCAACGTCAGTGACCAGGAGACCTCGTCCGAGGAGGAGGAAGCCAAG

GACGAAAAGGCAGAGCCCAACAGGGACAAATCAGTTGGGCCTCTCCCC

CAGGCGGACCCGGAGGTGGGCACGGCTGCCCATCAAACCAACAGACAG

GAAAAAAGCCCCCAGGACCCTGGGGACCCCGTCCAGTACAACAGGACC

ACAGATGAGGAGCTGTCAGAGCTGGAGGACAGAGTGGCAGTGACGGCC

TCAGAAGTCCAGCAGGCAGAGAGCGAGGTTTCAGACATTGAATCCAGG

ATTGCAGCCCTGAGGGCCGCAGGGCTCACGGTGAAGCCCTCGGGAAAG

CCCCGGAGGAAGTCAAACCTCCCGATATTTCTCCCTCGAGTGGCTGGGA

AACTTGGCAAGAGACCAGAGGACCCAAATGCAGACCCTTCAAGTGAGG

CCAAGGCAATGGCTGTGCCCTATCTTCTGAGAAGAAAGTTCAGTAATTC

CCTGAAAAGTCAAGGTAAAGATGATGATTCTTTTGATCGGAAATCAGTG TACCGAGGCTCGCTGACACAGAGAAACCCCAACGCGAGGAAAGGAATG

GCCAGCCACACCTTCGCGAAACCTGTGGTGGCCCACCAGTCCTAACGGG

ACAGGACAGAGAGACAGAGCAGCCCTGCACTGTTTTCCCTCCACCACA

GCCATCCTGTCCCTCATTGGCTCTGTGCTTTCCACTATACACAGTCACCG

TCCCAATGAGAAACAAGAAGGAGCACCCTCCACATGGACTCCCACCTG

CAAGTGGACAGCGACATTCAGTCCTGCACTGCTCACCTGGGTTTACTGA

TGACTCCTGGCTGCCCCACCATCCTCTCTGATCTGTGAGAAACAGCTAA

GCTGCTGTGACTTCCCTTTAGGACAATGTTGTGTAAATCTTTGAAGGAC

ACACCGAAGACCTTTATACTGTGATCTTTTACCCCTTTCACTCTTGGCTT

TCTTATGTTGCTTTCATGAATGGAATGGAAAAAAGATGACTCAGTTAAG

GCACCAGCCATATGTGTATTCTTGATGGTCTATATCGGGGTGTGAGCAG

ATGTTTGCGTATTTCTTGTGGGTGTGACTGGATATTAGACATCCGGACA

AGTGACTGAACTAATGATCTGCTGAATAATGAAGGAGGAATAGACACC

CCAGTCCCCACCCTACGTGCACCCGCTCTGCAAGTTCCCATGTGATCTG

TAGACCAGGGGAAATTACACTGCGGTCAAGGGCAGAGCCTGCACATGA

CAGCAAGTGAGCATTTGATAGATGCTCAGATGCTAGTGCAGAGAGCCT

GCTGGGAGACGAAGAGACAGCAGGCAGAGCTCCAGATGGGCAAGGAA

GAGGCTTGGTTCTAGCCTGGCTCTGCCCCTCACTGCAGTGGATCCAGTG

GGGCAGAGGACAGAGGGTCACAACCAATGAGGGATGTCTGCCAAGGAT

GGGGGTGCAGAGGCCACAGGAGTCAGCTTGCCACTCGCCCATTGGTTA

CATAGATGATCTCTCAGACAGGCTGGGACTCAGAGTTATTTCCTAGTAT

CGGTGTGCCCCATCCAGTTTTAAGTGGAGCCCTCCAAGACTCTCCAGAG

CTGCCTTTGAACATCCTAACAGTAATCACATCTCACCCTCCCTGAGGTTC

ACTTTAGACAGGACCCAATGGCTGCACTGCCTTTGTCAGAGGGGGTGCT

GAGAGGAGTGGCTTCTTTTAGAATCAAACAGTAGAGACAAGAGTCAAG

CCTTGTGTCTTCAAGCATTGACCAAGTTAAGTGTTTCCTTCCCTCTCTCA

ATAAGACACTTCCAGGAGCTTTCCAATCTCTCACTTAAAACTAAGGTTT

GAATCTCAAAGTGTTGCTGGGAGGCTGATACTCCTGCAACTTCAGGAGA

CCTGTGAGCACACATTAGCAGCTGTTTCTCTGACTCCTTGTGGCATCAG

ATAAAAACGTGGGAGTTTTTCCATATAATTCCCAGCCTTACTTATAAAT

TCTATTCTTTGAAAAAATTATTCAGGCTAGGTAAGGTGGCTCATACCTA

TAATCCCAGCCCTTTGAGAGGCCAAGGTGGGAGAATTGCTTGAGGCCA

GGAGTTTGAGACCTCCTGGGCAACATAGTGAGATCCCATCTCTACAAAA

AACAAAACAAAAAAATTACCCAAGCATGATGGTATATGCCTGTAGTCG

TACCTACTTACTTAGGAGGCTGAGGCAGGAGGATCACTTGAGCCCTGGA

GGTTGGGGCTGCAGTGAGCCATGATCGCATCACTATACTCGAGCCTGGG

CAACAGAGTGAGACCTTGTCTCTTAAAAAAATTAATAATAAATAAATG

AAAATAATTCTTCAGAAAAAAAAAAAAAAAA

NM_005940 AAGCCCAGCAGCCCCGGGGCGGATGGCTCCGGCCGCCTGGCTCCGCAG 184

CGCGGCCGCGCGCGCCCTCCTGCCCCCGATGCTGCTGCTGCTGCTCCAG

CCGCCGCCGCTGCTGGCCCGGGCTCTGCCGCCGGACGCCCACCACCTCC

ATGCCGAGAGGAGGGGGCCACAGCCCTGGCATGCAGCCCTGCCCAGTA

GCCCGGCACCTGCCCCTGCCACGCAGGAAGCCCCCCGGCCTGCCAGCA

GCCTCAGGCCTCCCCGCTGTGGCGTGCCCGACCCATCTGATGGGCTGAG

TGCCCGCAACCGACAGAAGAGGTTCGTGCTTTCTGGCGGGCGCTGGGA

GAAGACGGACCTCACCTACAGGATCCTTCGGTTCCCATGGCAGTTGGTG

CAGGAGCAGGTGCGGCAGACGATGGCAGAGGCCCTAAAGGTATGGAGC

GATGTGACGCCACTCACCTTTACTGAGGTGCACGAGGGCCGTGCTGACA

TCATGATCGACTTCGCCAGGTACTGGCATGGGGACGACCTGCCGTTTGA

TGGGCCTGGGGGCATCCTGGCCCATGCCTTCTTCCCCAAGACTCACCGA

GAAGGGGATGTCCACTTCGACTATGATGAGACCTGGACTATCGGGGAT

GACCAGGGCACAGACCTGCTGCAGGTGGCAGCCCATGAATTTGGCCAC

GTGCTGGGGCTGCAGCACACAACAGCAGCCAAGGCCCTGATGTCCGCC

TTCTACACCTTTCGCTACCCACTGAGTCTCAGCCCAGATGACTGCAGGG

GCGTTCAACACCTATATGGCCAGCCCTGGCCCACTGTCACCTCCAGGAC

CCCAGCCCTGGGCCCCCAGGCTGGGATAGACACCAATGAGATTGCACC GCTGGAGCCAGACGCCCCGCCAGATGCCTGTGAGGCCTCCTTTGACGCG

GTCTCCACCATCCGAGGCGAGCTCTTTTTCTTCAAAGCGGGCTTTGTGTG

GCGCCTCCGTGGGGGCCAGCTGCAGCCCGGCTACCCAGCATTGGCCTCT

CGCCACTGGCAGGGACTGCCCAGCCCTGTGGACGCTGCCTTCGAGGATG

CCCAGGGCCACATTTGGTTCTTCCAAGGTGCTCAGTACTGGGTGTACGA

CGGTGAAAAGCCAGTCCTGGGCCCCGCACCCCTCACCGAGCTGGGCCT

GGTGAGGTTCCCGGTCCATGCTGCCTTGGTCTGGGGTCCCGAGAAGAAC

AAGATCTACTTCTTCCGAGGCAGGGACTACTGGCGTTTCCACCCCAGCA

CCCGGCGTGTAGACAGTCCCGTGCCCCGCAGGGCCACTGACTGGAGAG

GGGTGCCCTCTGAGATCGACGCTGCCTTCCAGGATGCTGATGGCTATGC

CTACTTCCTGCGCGGCCGCCTCTACTGGAAGTTTGACCCTGTGAAGGTG

AAGGCTCTGGAAGGCTTCCCCCGTCTCGTGGGTCCTGACTTCTTTGGCT

GTGCCGAGCCTGCCAACACTTTCCTCTGACCATGGCTTGGATGCCCTCA

GGGGTGCTGACCCCTGCCAGGCCACGAATATCAGGCTAGAGACCCATG

GCCATCTTTGTGGCTGTGGGCACCAGGCATGGGACTGAGCCCATGTCTC

CTCAGGGGGATGGGGTGGGGTACAACCACCATGACAACTGCCGGGAGG

GCCACGCAGGTCGTGGTCACCTGCCAGCGACTGTCTCAGACTGGGCAG

GGAGGCTTTGGCATGACTTAAGAGGAAGGGCAGTCTTGGGCCCGCTAT

GCAGGTCCTGGCAAACCTGGCTGCCCTGTCTCCATCCCTGTCCCTCAGG

GTAGCACCATGGCAGGACTGGGGGAACTGGAGTGTCCTTGCTGTATCCC

TGTTGTGAGGTTCCTTCCAGGGGCTGGCACTGAAGCAAGGGTGCTGGGG

CCCCATGGCCTTCAGCCCTGGCTGAGCAACTGGGCTGTAGGGCAGGGCC

ACTTCCTGAGGTCAGGTCTTGGTAGGTGCCTGCATCTGTCTGCCTTCTGG

CTGACAATCCTGGAAATCTGTTCTCCAGAATCCAGGCCAAAAAGTTCAC

AGTCAAATGGGGAGGGGTATTCTTCATGCAGGAGACCCCAGGCCCTGG

AGGCTGCAACATACCTCAATCCTGTCCCAGGCCGGATCCTCCTGAAGCC

CTTTTCGCAGCACTGCTATCCTCCAAAGCCATTGTAAATGTGTGTACAG

TGTGTATAAACCTTCTTCTTCTTTTTTTTTTTTTAAACTGAGGATTGTC

TAGCAGCACACAAGGGTTCGTGTTTGTGGAACCAGGTAGCTTCCTTCAG 185

AGCTGACATTTGCCCACAGCCAGCCTGGCCCAGCCCCATACCACCAGCC

CTGGCGCTCTGGGGCGTGAGGTGCCTTTTCTGCCCCCCTGCTCTAGGGC

AGGTGGAAATCACCCATGGTGGGTCTACATCTGATAGAAGCATCTTATA

GTTCTGCTTCTGGACCAGACCATCCTGGGTTTTTCTCTGTTCTGCTGAAG

GGTTCCCTCCACGTGTCCATCACCTCGGTGAACTCTTGGGAGACCTGGG

AAGATGCTGGCCTCACCTCTCGCCTCTCCTTTCCCTCATTGTGCTGCCAC

CATCCTTCTCACACAGGCTCTCCAGGGAGAGCTGGGCAGGATGGGATCT

TCCTGGGTTCCCACCTTGCTCCGTGCCCCCTCTCACTGTTCCTGAAGTGT

GGCCACGGACTGCCTTGTTTTCTGGAAAGTCCCAAGTCTGGACCATGAC

TGAGCAGCATTCTCGGCTATCTGCCACCTGTCTGGGGCTCCTGGCCCCT

CTTAGACTCCCCTCTCCCTTCTGTTTCCCCCGAGCCCCTGACTTGGACCT

GCAGGGTGGGGAGAGGGATGGGACGAGAACCTGTGCTGGGGCCAAAG

GTCGCACTGGGGGAAGGTGGAGCCAGGGCAGCAGAGTGCCTGGCGTCG

GCCCCTATCCTGTCACTAGTTCCCCCGTTCTGGCCCCTGGCAGGTTTGTA

ACCCCAGATCAGAAGTACTCCATGGACAACACTCCCCACACGCCAACC

CCGTTCAAGAACGCCCTGGAGAAGTACGGACCCCTGAAGCCCCTGGTA

CGTGGTGTGGTCACTGCCGTGGATCTCTGCACAGTGGGATCCCTTCGGT

TCATCCAACCATGTTCAGTCCACAGGACCCTTCCCTCTGAGGTCTCATTT

GATTCTTTCTCCTGAGAAGATGCAGAGATCCTGATAATATAAATGGGGA

AGCTGAGGCTGCTCTTTGTCACTTCCTCCGACTGCTCCTGAGCACCTGA

GTTTGCAAGCACGCGCCGGCTGGTGCTAGAGACATGGTGGTATCCCGTG

ACACTCAGCCTCAGGATGGGGGAGACTGATGTGAAATACAAATAACTT

AAACACTTTCAGGCAAAGATAAGCACTGGGCCTAGTTCAGAGAAGTGG

CAAATTGCTACTCTGGCCTGTCTCTGACCAACTCCCAGTTCTCTACAGA

GCACGGGAAAGCCCCTCGGGGACGTCTTTCCTGCAGTGTGCAGGCTGCC

CTTCTCCCCTGCTCTTCCCAGTTGATGGGATGGTTGTGTTTTCTCTATGA

AAAAAGGAGTTGGCACCTTGGGCTTTCTGAAACACACAGGTGTTTTAGA AATCAGTGGAGGGTGAGAGAAAGGCATGGTTGTGGAGGCACTGGACTG

TGAACAAGGTCTGCAGCGGGTCCCCCTGCTGTCTCTCTCTACTGCATGG

AGCCTCCTATGAAGCCCAAGGTGGCTGGGGGCTGAGGCTCCCTTGGGCC

TGCCATGGAACTGATTCTGAGTCAAGCAGACTTTCCACGGACCATGCTA

CATGAGCCGAGGTGAGGCACTAGTTAGTGCTCCTTTCCTGTTGCAGTGG

AGATTTGGCTCCTCTGTACTAAAATATCTGCATGCTCTCCAAACAGGTG

TGAGGGCAAATCACATGACCTTGGCAGCTGTAATTAAAGTTTGTGGGGG

CTTTTCGGATGACTTATGAGGAGTGGCTGTGATTCGCACCTTTCACTCTT

AGTAGCACTCGCCCTCCCCTGTTCTCTGTTGCCTGAAGCTGGAGAGGTC

CTTGGAACCCCGAGGCCTGAGAAAGGGAAATGGGTTTGAGAGCCCCCA

TTAGTGTGGAACAAAGGGTTGAGTGAGCCTGGGCTTTGAGCTGTCGGG

GTCCTAATTCAGCAGCTGTGTGACTGTGTGCCAGGCTGTTGATCTCTGA

GCTTCTGTTTCTACCTGCTTAAAATGACGGTTACTGCACAGGGCTGTGT

GAGGGTTACAGTGCGTCTCTGGGCTGCTCCCAGCCATGGCAGGCCCCTG

GGAATCAAGGTCATCAGCTGCTTGTCCAAGGCAGCAGTTAGTGGTTGTG

AATGGTGCGTGTGAGATCTGCATCCTGGCGTCAGGCCTCCTTCCTGCCT

TACCCAGGACAGCCCAGTTGCAGCTGGGTTGGTCCCACAGTCCCACACA

CACACAGCCCGAGTGTGGTGCCTCACGTGGGCTGCCCCGTGCCTACCCA

CAGCCACAGACCCCGCACCTGGAGGAGGACTTGAAGGAGGTGCTGCGT

TCTGAGGCTGGCATCGAACTCATCATCGAGGACGACATCAGGCCCGAG

AAGCAGAAGAGGAAGCCTGGGCTGCGGCGGAGCCCCATCAAGAAAGTC

CGGAAGTCTCTGGCTCTTGACATTGTGGATGAGGATGTGAAGCTGATGA

TGTCCACACTGCCCAAGTCTCTATCCTTGCCGACAACTGCCCCTTCAAA

CTCTTCCAGCCTCACCCTGTCAGGTATCAAAGAAGACAACAGCTTGCTC

AACCAGGGCTTCTTGCAGGCCAAGCCCGAGAAGGCAGCAGTGGCCCAG

AAGCCCCGAAGCCACTTCACGACACCTGCCCCTATGTCCAGTGCCTGGA

AGACGGTGGCCTGCGGGGGGACCAGGGACCAGCTTTTCATGCAGGAGA

AAGCCCGGCAGCTCCTGGGCCGCCTGAAGCCCAGCCACACATCTCGGA

CCCTCATCTTGTCCTGAGGTGTTGAGGGTGTCACGAGCCCATTCACATG

TTTACAGGGGTTGTGGGGGCAGAGGGGGTCTGTGAATCTGAGAGTCATT

CAGGTGACCTCCTGCAGGGAGCCTTCTGCCACCAGCCCCTCCCCAGACT

CTCAGGTGGAGGCAACAGGGCCATGTGCTGCCCTGTTGCCGAGCCCAG

CTGTGGGCGGCTCCTGGTGCTAACAACAAAGTTCCACTTCCAGGTCTGC

CTGGTTCCCCCCCCAAGGCCACAGGGAGCTCCGTCAGCTTCTCCCAAGC

CCACGTCAGGCCTGGCCTCATCTCAGACCCTGCTTAGGATGGGGGATGT

GGCCAGGGGTGCTCCTGTGCTCACCCTCTCTTGGTGCATTTTTTTGGAAG

AATAAAATTGCCTCTCTCTTTGAAAAAAAAAAAAAAAAA

NM_002467 GACCCCCGAGCTGTGCTGCTCGCGGCCGCCACCGCCGGGCCCCGGCCGT 186

CCCTGGCTCCCCTCCTGCCTCGAGAAGGGCAGGGCTTCTCAGAGGCTTG

GCGGGAAAAAGAACGGAGGGAGGGATCGCGCTGAGTATAAAAGCCGG

TTTTCGGGGCTTTATCTAACTCGCTGTAGTAATTCCAGCGAGAGGCAGA

GGGAGCGAGCGGGCGGCCGGCTAGGGTGGAAGAGCCGGGCGAGCAGA

GCTGCGCTGCGGGCGTCCTGGGAAGGGAGATCCGGAGCGAATAGGGGG

CTTCGCCTCTGGCCCAGCCCTCCCGCTGATCCCCCAGCCAGCGGTCCGC

AACCCTTGCCGCATCCACGAAACTTTGCCCATAGCAGCGGGCGGGCACT

TTGCACTGGAACTTACAACACCCGAGCAAGGACGCGACTCTCCCGACG

CGGGGAGGCTATTCTGCCCATTTGGGGACACTTCCCCGCCGCTGCCAGG

ACCCGCTTCTCTGAAAGGCTCTCCTTGCAGCTGCTTAGACGCTGGATTTT

TTTCGGGTAGTGGAAAACCAGCAGCCTCCCGCGACGATGCCCCTCAACG

TTAGCTTCACCAACAGGAACTATGACCTCGACTACGACTCGGTGCAGCC

GTATTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCAGCA

GAGCGAGCTGCAGCCCCCGGCGCCCAGCGAGGATATCTGGAAGAAATT

CGAGCTGCTGCCCACCCCGCCCCTGTCCCCTAGCCGCCGCTCCGGGCTC

TGCTCGCCCTCCTACGTTGCGGTCACACCCTTCTCCCTTCGGGGAGACA

ACGACGGCGGTGGCGGGAGCTTCTCCACGGCCGACCAGCTGGAGATGG

TGACCGAGCTGCTGGGAGGAGACATGGTGAACCAGAGTTTCATCTGCG ACCCGGACGACGAGACCTTCATCAAAAACATCATCATCCAGGACTGTAT

GTGGAGCGGCTTCTCGGCCGCCGCCAAGCTCGTCTCAGAGAAGCTGGCC

TCCTACCAGGCTGCGCGCAAAGACAGCGGCAGCCCGAACCCCGCCCGC

GGCCACAGCGTCTGCTCCACCTCCAGCTTGTACCTGCAGGATCTGAGCG

CCGCCGCCTCAGAGTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTC

AACGACAGCAGCTCGCCCAAGTCCTGCGCCTCGCAAGACTCCAGCGCCT

TCTCTCCGTCCTCGGATTCTCTGCTCTCCTCGACGGAGTCCTCCCCGCAG

GGCAGCCCCGAGCCCCTGGTGCTCCATGAGGAGACACCGCCCACCACC

AGCAGCGACTCTGAGGAGGAACAAGAAGATGAGGAAGAAATCGATGTT

GTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTCAGAGTCTGGA

TCACCTTCTGCTGGAGGCCACAGCAAACCTCCTCACAGCCCACTGGTCC

TCAAGAGGTGCCACGTCTCCACACATCAGCACAACTACGCAGCGCCTCC

CTCCACTCGGAAGGACTATCCTGCTGCCAAGAGGGTCAAGTTGGACAGT

GTCAGAGTCCTGAGACAGATCAGCAACAACCGAAAATGCACCAGCCCC

AGGTCCTCGGACACCGAGGAGAATGTCAAGAGGCGAACACACAACGTC

TTGGAGCGCCAGAGGAGGAACGAGCTAAAACGGAGCTTTTTTGCCCTG

CGTGACCAGATCCCGGAGTTGGAAAACAATGAAAAGGCCCCCAAGGTA

GTTATCCTTAAAAAAGCCACAGCATACATCCTGTCCGTCCAAGCAGAGG

AGCAAAAGCTCATTTCTGAAGAGGACTTGTTGCGGAAACGACGAGAAC

AGTTGAAACACAAACTTGAACAGCTACGGAACTCTTGTGCGTAAGGAA

AAGTAAGGAAAACGATTCCTTCTAACAGAAATGTCCTGAGCAATCACCT

ATGAACTTGTTTCAAATGCATGATCAAATGCAACCTCACAACCTTGGCT

GAGTCTTGAGACTGAAAGATTTAGCCATAATGTAAACTGCCTCAAATTG

GACTTTGGGCATAAAAGAACTTTTTTATGCTTACCATCTTTTTTTTTTCTT

TAACAGATTTGTATTTAAGAATTGTTTTTAAAAAATTTTAAGATTTACAC

AATGTTTCTCTGTAAATATTGCCATTAAATGTAAATAACTTTAATAAAA

CGTTTATAGCAGTTACACAGAATTTCAATCCTAGTATATAGTACCTAGT

ATTATAGGTACTATAAACCCTAATTTTTTTTATTTAAGTACATTTTGCTT

TTTAAAGTTGATTTTTTTCTATTGTTTTTAGAAAAAATAAAATAACTGGC

AAATATATCATTGAGCCAAATCTTAAAAAAAAAAAAAAA

GTGGGAGGATTGCATTCAGTCTAGTTCCTGGTTGCCGGCTGAAATAACC 187

TGCTCTCCAAAATGTCCACAAAAGTGACTTAAGTCAGGTTCCCCCAAAC

CAGACACCAAGACAAGAATCCATGTGTGTGTGACTGAAGGAAGTGCTG

GGAGAGCCCCAGCTGCAGCCTGGATGTGAACTGCAACTCCAAAGTGTG

TCCAGACTCAAGGCAAGGGCACTAGGCTTTCCAGACCTCCTACTAAGTC

ATTGATCCAGCACTGCCCTGCCAGGACATAAATCCCTGGCACCTCTTGC

TCTCTGCAAAGGAGGGCAAAGCAGCTTCAGGAGCCCTTGGGAGTCCTC

CAAAGAGAGTCTAGGGTACAGGTCCGAAAGTAGAAGAACACAGAAGG

CAGGCCAGGGGCACTGTGAGATGGTAAAAGAGATCTGAAGGGATCCAG

AATTCAAGCCAGGAAGAAGCAGCAATCTGTCTTCTGGATTAAAACTGA

AGATCAACCTACTTTCAACTTACTAAGAAAGGGGATCATGGACATTGAA

GCATATCTTGAAAGAATTGGCTATAAGAAGTCTAGGAACAAATTGGAC

TTGGAAACATTAACTGATATTCTTCAACACCAGATCCGAGCTGTTCCCT

TTGAGAACCTTAACATCCATTGTGGGGATGCCATGGACTTAGGCTTAGA

GGCCATTTTTGATCAAGTTGTGAGAAGAAATCGGGGTGGATGGTGTCTC

CAGGTCAATCATCTTCTGTACTGGGCTCTGACCACTATTGGTTTTGAGAC

CACGATGTTGGGAGGGTATGTTTACAGCACTCCAGCCAAAAAATACAG

CACTGGCATGATTCACCTTCTCCTGCAGGTGACCATTGATGGCAGGAAC

TACATTGTCGATGCTGGGTTTGGACGCTCATACCAGATGTGGCAGCCTC

TGGAGTTAATTTCTGGGAAGGATCAGCCTCAGGTGCCTTGTGTCTTCCG

TTTGACGGAAGAGAATGGATTCTGGTATCTAGACCAAATCAGAAGGGA

ACAGTACATTCCAAATGAAGAATTTCTTCATTCTGATCTCCTAGAAGAC

AGCAAATACCGAAAAATCTACTCCTTTACTCTTAAGCCTCGAACAATTG

AAGATTTTGAGTCTATGAATACATACCTGCAGACATCTCCATCATCTGT

GTTTACTAGTAAATCATTTTGTTCCTTGCAGACCCCAGATGGGGTTCACT

GTTTGGTGGGCTTCACCCTCACCCATAGGAGATTCAATTATAAGGACAA TACAGATCTAATAGAGTTCAAGACTCTGAGTGAGGAAGAAATAGAAAA

AGTGCTGAAAAATATATTTAATATTTCCTTGCAGAGAAAGCTTGTGCCC

AAACATGGTGATAGATTTTTTACTATTTAGAATAAGGAGTAAAACAATC

TTGTCTATTTGTCATCCAGCTCACCAGTTATCAACTGACGACCTATCATG

TATCTTCTGTACCCTTACCTTATTTTGAAGAAAATCCTAGACATCAAATC

ATTTCACCTATAAAAATGTCATCATATATAATTAAACAGCTTTTTAAAG

AAACATAACCACAAACCTTTTCAAATAATAATAATAATAATAATAATAA

ATGTCTTTTAAAGATGGCCTGTGGTTATCTTGGAAATTGGTGATTTATGC

TAGAAAGCTTTTAATGTTGGTTTATTGTTGAATTCCTAGAAAAGTTTTAT

GGGTAGATGAGTAAATAAAATATTGTAAAAAAACTTATTGTCTATAAA

GTATATTAAAACATTGTTGGCTAATATAAAAAAAAAAAAAA

NM_014321 GCGCGCGGGTTTCGTTGACCCGCGGCGTTCACGGGAATTGTTCGCTTTA 188

GTGCCGGCGCCATGGGGTCGGAGCTGATCGGGCGCCTAGCCCCGCGCC

TGGGCCTCGCCGAGCCCGACATGCTGAGGAAAGCAGAGGAGTACTTGC

GCCTGTCCCGGGTGAAGTGTGTCGGCCTCTCCGCACGCACCACGGAGAC

CAGCAGTGCAGTCATGTGCCTGGACCTTGCAGCTTCCTGGATGAAGTGC

CCCTTGGACAGGGCTTATTTAATTAAACTTTCTGGTTTGAACAAGGAGA

CATATCAGAGCTGTCTTAAATCTTTTGAGTGTTTACTGGGCCTGAATTCA

AATATTGGAATAAGAGACCTAGCTGTACAGTTTAGCTGTATAGAAGCA

GTGAACATGGCTTCAAAGATACTAAAAAGCTATGAGTCCAGTCTTCCCC

AGACACAGCAAGTGGATCTTGACTTATCCAGGCCACTTTTCACTTCTGC

TGCACTGCTTTCAGCATGCAAGATTCTAAAGCTGAAAGTGGATAAAAAC

AAAATGGTAGCCACATCCGGTGTAAAAAAAGCTATATTTGATCGACTGT

GTAAACAACTAGAGAAGATTGGACAGCAGGTCGACAGAGAACCTGGAG

ATGTAGCTACTCCACCACGGAAGAGAAAGAAGATAGTGGTTGAAGCCC

CAGCAAAGGAAATGGAGAAGGTAGAGGAGATGCCACATAAACCACAG

AAAGATGAAGATCTGACACAGGATTATGAAGAATGGAAAAGAAAAATT

TTGGAAAATGCTGCCAGTGCTCAAAAGGCTACAGCAGAGTGATTTCAG

CTTCCAAACTGGTATACATTCCAAACTGATAGTACATTGCCATCTCCAG

GAAGACTTGACGGCTTTGGGATTTTGTTTAAACTTTTATAATAAGGATC

CTAAGACTGTTGCCTTTAAATAGCAAAGCAGCCTACCTGGAGGCTAAGT

CTGGGCAGTGGGCTGGCCCCTGGTGTGAGCATTAGACCAGCCACAGTG

CCTGATTGGTATAGCCTTATGTGCTTTCCTACAAAATGGAATTGGAGGC

CGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAG

GTGGGTGGATCACCTGAGGTCAGGAGCTCGAGACCAGCCTGGCCAACA

TGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGAT

GGTGCATGCCTGTAATCCCAGCTCCTCAGTAGGCTGAGACAGGAGCATC

ACTTGAACGTGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCACCACC

GCACTCCAGCCTGGGTGACAGAGCGAGACTTATCTCATAAATAAATAG

ATAGATACTCCAGCCTGGGTGACAGAGCGAGACTTATAGATAGATAGA

TAGATAGATGGATAGATAGATAGATAGATAGATAGATAGATAAACGGA

ATTGGAGCCATTTTGCTTTAAGTGAATGGCAGTCCCTTGTCTTATTCAGA

ATATAAAATTCAGTCTGAATGGCATCTTACAGATTTTACTTCAATTTTTG

TGTACGGTATTTTTTATTTGACTAAATCAATATATTGTACAGCCTAAGTT

AATAAATGTTATTTATATATGCAAAAAAAAAAAAAAAAA

NM_000926 AGTCCACAGCTGTCACTAATCGGGGTAAGCCTTGTTGTATTTGTGCGTG 189

TGGGTGGCATTCTCAATGAGAACTAGCTTCACTTGTCATTTGAGTGAAA

TCTACAACCCGAGGCGGCTAGTGCTCCCGCACTACTGGGATCTGAGATC

TTCGGAGATGACTGTCGCCCGCAGTACGGAGCCAGCAGAAGTCCGACC

CTTCCTGGGAATGGGCTGTACCGAGAGGTCCGACTAGCCCCAGGGTTTT

AGTGAGGGGGCAGTGGAACTCAGCGAGGGACTGAGAGCTTCACAGCAT

GCACGAGTTTGATGCCAGAGAAAAAGTCGGGAGATAAAGGAGCCGCGT

GTCACTAAATTGCCGTCGCAGCCGCAGCCACTCAAGTGCCGGACTTGTG

AGTACTCTGCGTCTCCAGTCCTCGGACAGAAGTTGGAGAACTCTCTTGG

AGAACTCCCCGAGTTAGGAGACGAGATCTCCTAACAATTACTACTTTTT

CTTGCGCTCCCCACTTGCCGCTCGCTGGGACAAACGACAGCCACAGTTC CCCTGACGACAGGATGGAGGCCAAGGGCAGGAGCTGACCAGCGCCGCC

CTCCCCCGCCCCCGACCCAGGAGGTGGAGATCCCTCCGGTCCAGCCACA

TTCAACACCCACTTTCTCCTCCCTCTGCCCCTATATTCCCGAAACCCCCT

CCTCCTTCCCTTTTCCCTCCTCCTGGAGACGGGGGAGGAGAAAAGGGGA

GTCCAGTCGTCATGACTGAGCTGAAGGCAAAGGGTCCCCGGGCTCCCC

ACGTGGCGGGCGGCCCGCCCTCCCCCGAGGTCGGATCCCCACTGCTGTG

TCGCCCAGCCGCAGGTCCGTTCCCGGGGAGCCAGACCTCGGACACCTTG

CCTGAAGTTTCGGCCATACCTATCTCCCTGGACGGGCTACTCTTCCCTCG

GCCCTGCCAGGGACAGGACCCCTCCGACGAAAAGACGCAGGACCAGCA

GTCGCTGTCGGACGTGGAGGGCGCATATTCCAGAGCTGAAGCTACAAG

GGGTGCTGGAGGCAGCAGTTCTAGTCCCCCAGAAAAGGACAGCGGACT

GCTGGACAGTGTCTTGGACACTCTGTTGGCGCCCTCAGGTCCCGGGCAG

AGCCAACCCAGCCCTCCCGCCTGCGAGGTCACCAGCTCTTGGTGCCTGT

TTGGCCCCGAACTTCCCGAAGATCCACCGGCTGCCCCCGCCACCCAGCG

GGTGTTGTCCCCGCTCATGAGCCGGTCCGGGTGCAAGGTTGGAGACAGC

TCCGGGACGGCAGCTGCCCATAAAGTGCTGCCCCGGGGCCTGTCACCA

GCCCGGCAGCTGCTGCTCCCGGCCTCTGAGAGCCCTCACTGGTCCGGGG

CCCCAGTGAAGCCGTCTCCGCAGGCCGCTGCGGTGGAGGTTGAGGAGG

AGGATGGCTCTGAGTCCGAGGAGTCTGCGGGTCCGCTTCTGAAGGGCA

AACCTCGGGCTCTGGGTGGCGCGGCGGCTGGAGGAGGAGCCGCGGCTG

TCCCGCCGGGGGCGGCAGCAGGAGGCGTCGCCCTGGTCCCCAAGGAAG

ATTCCCGCTTCTCAGCGCCCAGGGTCGCCCTGGTGGAGCAGGACGCGCC

GATGGCGCCCGGGCGCTCCCCGCTGGCCACCACGGTGATGGATTTCATC

CACGTGCCTATCCTGCCTCTCAATCACGCCTTATTGGCAGCCCGCACTC

GGCAGCTGCTGGAAGACGAAAGTTACGACGGCGGGGCCGGGGCTGCCA

GCGCCTTTGCCCCGCCGCGGAGTTCACCCTGTGCCTCGTCCACCCCGGT

CGCTGTAGGCGACTTCCCCGACTGCGCGTACCCGCCCGACGCCGAGCCC

AAGGACGACGCGTACCCTCTCTATAGCGACTTCCAGCCGCCCGCTCTAA

AGATAAAGGAGGAGGAGGAAGGCGCGGAGGCCTCCGCGCGCTCCCCGC

GTTCCTACCTTGTGGCCGGTGCCAACCCCGCAGCCTTCCCGGATTTCCC

GTTGGGGCCACCGCCCCCGCTGCCGCCGCGAGCGACCCCATCCAGACCC

GGGGAAGCGGCGGTGACGGCCGCACCCGCCAGTGCCTCAGTCTCGTCT

GCGTCCTCCTCGGGGTCGACCCTGGAGTGCATCCTGTACAAAGCGGAGG

GCGCGCCGCCCCAGCAGGGCCCGTTCGCGCCGCCGCCCTGCAAGGCGC

CGGGCGCGAGCGGCTGCCTGCTCCCGCGGGACGGCCTGCCCTCCACCTC

CGCCTCTGCCGCCGCCGCCGGGGCGGCCCCCGCGCTCTACCCTGCACTC

GGCCTCAACGGGCTCCCGCAGCTCGGCTACCAGGCCGCCGTGCTCAAG

GAGGGCCTGCCGCAGGTCTACCCGCCCTATCTCAACTACCTGAGGCCGG

ATTCAGAAGCCAGCCAGAGCCCACAATACAGCTTCGAGTCATTACCTCA

GAAGATTTGTTTAATCTGTGGGGATGAAGCATCAGGCTGTCATTATGGT

GTCCTTACCTGTGGGAGCTGTAAGGTCTTCTTTAAGAGGGCAATGGAAG

GGCAGCACAACTACTTATGTGCTGGAAGAAATGACTGCATCGTTGATAA

AATCCGCAGAAAAAACTGCCCAGCATGTCGCCTTAGAAAGTGCTGTCA

GGCTGGCATGGTCCTTGGAGGTCGAAAATTTAAAAAGTTCAATAAAGTC

AGAGTTGTGAGAGCACTGGATGCTGTTGCTCTCCCACAGCCAGTGGGCG

TTCCAAATGAAAGCCAAGCCCTAAGCCAGAGATTCACTTTTTCACCAGG

TCAAGACATACAGTTGATTCCACCACTGATCAACCTGTTAATGAGCATT

GAACCAGATGTGATCTATGCAGGACATGACAACACAAAACCTGACACC

TCCAGTTCTTTGCTGACAAGTCTTAATCAACTAGGCGAGAGGCAACTTC

TTTCAGTAGTCAAGTGGTCTAAATCATTGCCAGGTTTTCGAAACTTACA

TATTGATGACCAGATAACTCTCATTCAGTATTCTTGGATGAGCTTAATG

GTGTTTGGTCTAGGATGGAGATCCTACAAACACGTCAGTGGGCAGATGC

TGTATTTTGCACCTGATCTAATACTAAATGAACAGCGGATGAAAGAATC

ATCATTCTATTCATTATGCCTTACCATGTGGCAGATCCCACAGGAGTTTG

TCAAGCTTCAAGTTAGCCAAGAAGAGTTCCTCTGTATGAAAGTATTGTT

ACTTCTTAATACAATTCCTTTGGAAGGGCTACGAAGTCAAACCCAGTTT GAGGAGATGAGGTCAAGCTACATTAGAGAGCTCATCAAGGCAATTGGT

TTGAGGCAAAAAGGAGTTGTGTCGAGCTCACAGCGTTTCTATCAACTTA

CAAAACTTCTTGATAACTTGCATGATCTTGTCAAACAACTTCATCTGTAC

TGCTTGAATACATTTATCCAGTCCCGGGCACTGAGTGTTGAATTTCCAG

AAATGATGTCTGAAGTTATTGCTGCACAATTACCCAAGATATTGGCAGG

GATGGTGAAACCCCTTCTCTTTCATAAAAAGTGAATGTCATCTTTTTCTT

TTAAAGAATTAAATTTTGTGGTATGTCTTTTTGTTTTGGTCAGGATTATG

AGGTCTTGAGTTTTTATAATGTTCTTCTGAAAGCCTTACATTTATAACAT

CATAGTGTGTAAATTTAAAAGAAAAATTGTGAGGTTCTAATTATTTTCT

TTTATAAAGTATAATTAGAATGTTTAACTGTTTTGTTTACCCATATTTTC

TTGAAGAATTTACAAGATTGAAAAAGTACTAAAATTGTTAAAGTAAACT

ATCTTATCCATATTATTTCATACCATGTAGGTGAGGATTTTTAACTTTTG

CATCTAACAAATCATCGACTTAAGAGAAAAAATCTTACATGTAATAACA

CAAAGCTATTATATGTTATTTCTAGGTAACTCCCTTTGTGTCAATTATAT

TTCCAAAAATGAACCTTTAAAATGGTATGCAAAATTTTGTCTATATATA

TTTGTGTGAGGAGGAAATTCATAACTTTCCTCAGATTTTCAAAAGTATTT

TTAATGCAAAAAATGTAGAAAGAGTTTAAAACCACTAAAATAGATTGA

TGTTCTTCAAACTAGGCAAAACAACTCATATGTTAAGACCATTTTCCAG

ATTGGAAACACAAATCTCTTAGGAAGTTAATAAGTAGATTCATATCATT

ATGCAAATAGTATTGTGGGTTTTGTAGGTTTTTAAAATAACCTTTTTTGG

GGAGAGAATTGTCCTCTAATGAGGTATTGCGAGTGGACATAAGAAATC

AGAAGATTATGGCCTAACTGTACTCCTTACCAACTGTGGCATGCTGAAA

GTTAGTCACTCTTACTGATTCTCAATTCTCTCACCTTTGAAAGTAGTAAA

ATATCTTTCCTGCCAATTGCTCCTTTGGGTCAGAGCTTATTAACATCTTT

TCAAATCAAAGGAAAGAAGAAAGGGAGAGGAGGAGGAGGGAGGTATC

AATTCACATACCTTTCTCCTCTTTATCCTCCACTATCATGAATTCATATT

ATGTTTCAGCCATGCAAATCTTTTTACCATGAAATTTCTTCCAGAATTTT

CCCCCTTTGACACAAATTCCATGCATGTTTCAACCTTCGAGACTCAGCC

AAATGTCATTTCTGTAAAATCTTCCCTGAGTCTTCCAAGCAGTAATTTGC

CTTCTCCTAGAGTTTACCTGCCATTTTGTGCACATTTGAGTTACAGTAGC

ATGTTATTTTACAATTGTGACTCTCCTGGGAGTCTGGGAGCCATATAAA

GTGGTCAATAGTGTTTGCTGACTGAGAGTTGAATGACATTTTCTCTCTGT

CTTGGTATTACTGTAGATTTCGATCATTCTTTGGTTACATTTCTGCATAT

TTCTGTACCCATGACTTTATCACTTTCTTCTCCCATGCTTTATCTCCATCA

ATTATCTTCATTACTTTTAAATTTTCCACCTTTGCTTCCTACTTTGTGAGA

TCTCTCCCTTTACTGACTATAACATAGAAGAATAGAAGTGTATTTTATGT

GTCTTAAGGACAATACTTTAGATTCCTTGTTCTAAGTTTTTAAACTGAAT

GAATGGAATATTATTTCTCTCCCTAAGCAAAATTCCACAAAACAATTAT

TTCTTATGTTTATGTAGCCTTAAATTGTTTTGTACTGTAAACCTCAGCAT

AAAAACTTTCTTCATTTCTAATTTCATTCAACAAATATTGATTGAATACC

TGGTATTAGCACAAGAAAAATGTGCTAATAAGCCTTATGAGAATTTGGA

GCTGAAGAAAGACATATAACTCAGGAAAGTTACAGTCCAGTAGTAGGT

ATAAATTACAGTGCCTGATAAATAGGCATTTTAATATTTGTACACTCAA

CGTATACTAGGTAGGTGCAAAACATTTACATATAATTTTACTGATACCC

ATGCAGCACAAAGGTACTAACTTTAAATATTAAATAACACCTTTATGTG

TCAGTAATTCATTTGCATTAAATCTTATTGAAAAGGCTTTCAATATATTT

TCCCCACAAATGTCATCCCAAGAAAAAAGTATTTTTAACATCTCCCAAA

TATAATAGTTACAGGAAATCTACCTCTGTGAGAGTGACACCTCTCAGAA

TGAACTGTGTGACACAAGAAAATGAATGTAGGTCTATCCAAAAAAAAC

CCCAAGAAACAAAAACAATATTATTAGCCCTTTATGCTTAAGTGATGGA

CTCAGGGAACAGTTGATGTTGTGATCATTTTATTATCTGATTCTTGTTAC

TTTGAATTAAACCAATATTTTGATGATATAAATCATTTCCACCAGCATAT

ATTTAATTTCCATAATAACTTTAAAATTTTCTAATTTCACTCAACTATGA

GGGAATAGAATGTGGTGGCCACAGGTTTGGCTTTTGTTAAAATGTTTGA

TATCTTCGATGTTGATCTCTGTCTGCAATGTAGATGTCTAAACACTAGG

ATTTAATATTTAAGGCTAAGCTTTAAAAATAAAGTACCTTTTTAAAAAG AATATGGCTTCACCAAATGGAAAATACCTAATTTCTAAATCTTTTTCTCT

ACAAAGTCCTATCTACTAATGTCTCCATTACTATTTAGTCATCATAACCA

TTATCTTCATTTTACATGTCGTGTTCTTTCTGGTAGCTCTAAAATGACAC

TAAATCATAAGAAGACAGGTTACATATCAGGAAATACTTGAAGGTTAC

TGAAATAGATTCTTGAGTTAATGAAAATATTTTCTGTAAAAAGGTTTGA

AAAGCCATTTGAGTCTAAAGCATTATACCTCCATTATCAGTAGTTATGT

GACAATTGTGTGTGTGTTTAATGTTTAAAGATGTGGCACTTTTTAATAA

GGCAATGCTATGCTATTTTTTCCCATTTAACATTAAGATAATTTATTGCT

ATACAGATGATATGGAAATATGATGAACAATATTTTTTTTGCCAAAACT

ATGCCTTGTAAGTAGCCATGGAATGTCAACCTGTAACTTAAATTATCCA

CAGATAGTCATGTGTTTGATGATGGGCACTGTGGAGATAACTGACATAG

GACTGTGCCCCCCTTCTCTGCCACTTACTAGCTGGATGAGATTAAGCAA

GTCATTTAACTGCTCTGATTAAACCTGCCTTTCCCAAGTGCTTTGTAATG

AATAGAAATGGAAACCAAAAAAAACGTATACAGGCCTTCAGAAATAGT

AATTGCTACTATTTTGTTTTCATTAAGCCATAGTTCTGGCTATAATTTTA

TCAAACTCACCAGCTATATTCTACAGTGAAAGCAGGATTCTAGAAAGTC

TCACTGTTTTATTTATGTCACCATGTGCTATGATATATTTGGTTGAATTC

ATTTGAAATTAGGGCTGGAAGTATTCAAGTAATTTCTTCTGCTGAAAAA

ATACAGTGTTTTGAGTTTAGGGCCTGTTTTATCAAAGTTCTAAAGAGCC

TATCACTCTTCCATTGTAGACATTTTAAAATAATGACACTGATTTTAACA

TTTTTAAGTGTCTTTTTAGAACAGAGAGCCTGACTAGAACACAGCCCCT

CCAAAAACCCATGCTCAAATTATTTTTACTATGGCAGCAATTCCACAAA

AGGGAACAATGGGTTTAGAAATTACAATGAAGTCATCAACCCAAAAAA

CATCCCTATCCCTAAGAAGGTTATGATATAAAATGCCCACAAGAAATCT

ATGTCTGCTTTAATCTGTCTTTTATTGCTTTGGAAGGATGGCTATTACAT

TTTTAGTTTTTGCTGTGAATACCTGAGCAGTTTCTCTCATCCATACTTAT

CCTTCACACATCAGAAGTCAGGATAGAATATGAATCATTTTAAAAACTT

TTACAACTCCAGAGCCATGTGCATAAGAAGCATTCAAAACTTGCCAAA

ACATACATTTTTTTTCAAATTTAAAGATACTCTATTTTTGTATTCAATAG

CTCAACAACTGTGGTCCCCACTGATAAAGTGAAGTGGACAAGGAGACA

AGTAATGGCATAAGTTTGTTTTTCCCAAAGTATGCCTGTTCAATAGCCA

TTGGATGTGGGAAATTTCTACATCTCTTAAAATTTTACAGAAAATACAT

AGCCAGATAGTCTAGCAAAAGTTCACCAAGTCCTAAATTGCTTATCCTT

ACTTCACTAAGTCATGAAATCATTTTAATGAAAAGAACATCACCTAGGT

TTTGTGGTTTCTTTTTTTCTTATTCATGGCTGAGTGAAAACAACAATCTC

TGTTTCTCCCTAGCATCTGTGGACTATTTAATGTACCATTATTCCACACT

CTATGGTCCTTACTAAATACAAAATTGAACAAAAAGCAGTAAAACAAC

TGACTCTTCACCCATATTATAAAATATAATCCAAGCCAGATTAGTCAAC

ATCCATAAGATGAATCCAAGCTGAACTGGGCCTAGATTATTGAGTTCAG

GTTGGATCACATCCCTATTTATTAATAAACTTAGGAAAGAAGGCCTTAC

AGACCATCAGTTAGCTGGAGCTAATAGAACCTACACTTCTAAAGTTCGG

CCTAGAATCAATGTGGCCTTAAAAGCTGAAAAGAAGCAGGAAAGAACA

GTTTTCTTCAATAATTTGTCCACCCTGTCACTGGAGAAAATTTAAGAATT

TGGGGGTGTTGGTAGTAAGTTAAACACAGCAGCTGTTCATGGCAGAAA

TTATTCAATACATACCTTCTCTGAATATCCTATAACCAAAGCAAAGAAA

AACACCAAGGGGTTTGTTCTCCTCCTTGGAGTTGACCTCATTCCAAGGC

AGAGCTCAGGTCACAGGCACAGGGGCTGCGCCCAAGCTTGTCCGCAGC

CTTATGCAGCTGTGGAGTCTGGAAGACTGTTGCAGGACTGCTGGCCTAG

TCCCAGAATGTCAGCCTCATTTTCGATTTACTGGCTCTTGTTGCTGTATG

TCATGCTGACCTTATTGTTAAACACAGGTTTGTTTGCTTTTTTTCCACTC

ATGGAGACATGGGAGAGGCATTATTTTTAAGCTGGTTGAAAGCTTTAAC

CGATAAAGCATTTTTAGAGAAATGTGAATCAGGCAGCTAAGAAAGCAT

ACTCTGTCCATTACGGTAAAGAAAATGCACAGATTATTAACTCTGCAGT

GTGGCATTAGTGTCCTGGTCAATATTCGGATAGATATGAATAAAATATT

TAAATGGTATTGTAAATAGTTTTCAGGACATATGCTATAGCTTATTTTTA

TTATCTTTTGAAATTGCTCTTAATACATCAAATCCTGATGTATTCAATTT ATCAGATATAAATTATTCTAAATGAAGCCCAGTTAAATGTTTTTGTCTTG

TCAGTTATATGTTAAGTTTCTGATCTCTTTGTCTATGACGTTTACTAATC

TGCATTTTTACTGTTATGAATTATTTTAGACAGCAGTGGTTTCAAGCTTT

TTGCCACTAAAAATACCTTTTATTTTCTCCTCCCCCAGAAAAGTCTATAC

CTTGAAGTATCTATCCACCAAACTGTACTTCTATTAAGAAATAGTTATT

GTGTTTTCTTAATGTTTTGTTATTCAAAGACATATCAATGAAAGCTGCTG

AGCAGCATGAATAACAATTATATCCACACAGATTTGATATATTTTGTGC

AGCCTTAACTTGATAGTATAAAATGTCATTGCTTTTTAAATAATAGTTA

GTCAATGGACTTCTATCATAGCTTTCCTAAACTAGGTTAAGATCCAGAG

CTTTGGGGTCATAATATATTACATACAATTAAGTTATCTTTTTCTAAGGG

CTTTAAAATTCATGAGAATAACCAAAAAAGGTATGTGGAGAGTTAATA

CAAACATACCATATTCTTGTTGAAACAGAGATGTGGCTCTGCTTGTTCT

CCATAAGGTAGAAATACTTTCCAGAATTTGCCTAAACTAGTAAGCCCTG

AATTTGCTATGATTAGGGATAGGAAGAGATTTTCACATGGCAGACTTTA

GAATTCTTCACTTTAGCCAGTAAAGTATCTCCTTTTGATCTTAGTATTCT

GTGTATTTTAACTTTTCTGAGTTGTGCATGTTTATAAGAAAAATCAGCAC

AAAGGGTTTAAGTTAAAGCCTTTTTACTGAAATTTGAAAGAAACAGAA

GAAAATATCAAAGTTCTTTGTATTTTGAGAGGATTAAATATGATTTACA

AAAGTTACATGGAGGGCTCTCTAAAACATTAAATTAATTATTTTTTGTT

GAAAAGTCTTACTTTAGGCATCATTTTATTCCTCAGCAACTAGCTGTGA

AGCCTTTACTGTGCTGTATGCCAGTCACTCTGCTAGATTGTGGAGATTA

CCAGTGTTCCCGTCTTCTCCGAGCTTAGAGTTGGATGGGGAATAAAGAC

AGGTAAACAGATAGCTACAATATTGTACTGTGAATGCTTATGCTGGAGG

AAGTACAGGGAACTATTGGAGCACCTAAGAGGAGCACCTACCTTGAAT

TTAGGGGTTAGCAGAGGCATCCTGAAAAAAGTCAAAGCTAAGCCACAA

TCTATAAGCAGTTTAGGAATTAGCAGAACGTGCGTGGTGAGGAGATGC

CAAAGGCAAGAAGAGAAGAGTATTCCAAACAGGAGGGATTCCAAAGA

GAGAAGAGTATCCCAAACAACATTTGCACAAACCTGATGGGGAGAGAG

AATGTGGGGTGGGGATGGATGATGAGACTGAAGAAGAAAGCCAGGTCT

AGATAATCAGTGGCCTTGTACACCATGTTAAAGAGTGTAGACTTGATTC

TGTTGTAAACAGGAAAGCAGCACAATTCATATGAATATTTTAGAAGACT

CCCACTGGAATATGGAGAATAAAGTTGGAGATGACTAATCCTGGAAGC

AGGGAGAACATTTTTGAGGAAGTTGCACTATTTTGGTGAAAATGATGAT

CATAAACATGAAGAATTGTAGGTGATCATGACCTCCTCTCTAATTTTCC

AGAAGGGTTTTGGAAGATATAACATAGGAACATTGACAGGACTGACGA

AAGGAGATGAAATACACCATATAAATTGTCAAACACAAGGCCAGATGT

CTAATTATTTTGCTTATGTGTTGAAATTACAAATTTTTCATCAGGAAACC

AAAAACTACAAAACTTAGTTTTCCCAAGTCCCAGAATTCTATCTGTCCA

AACAATCTGTACCACTCCACCTATATCCCTACCTTTGCATGTCTGTCCAA

CCTCAAAGTCCAGGTCTATACACACGGGTAAGACTAGAGCAGTTCAAG

TTTCAGAAAATGAGAAAGAGGAACTGAGTTGTGCTGAACCCATACAAA

ATAAACACATTCTTTGTATAGATTCTTGGAACCTCGAGAGGAATTCACC

TAACTCATAGGTATTTGATGGTATGAATCCATGGCTGGGCTCGGCTTTT

AAAAAGCCTTATCTGGGATTCCTTCTATGGAACCAAGTTCCATCAAAGC

CCATTTAAAAGCCTACATTAAAAACAAAATTCTTGCTGCATTGTATACA

AATAATGATGTCATGATCAAATAATCAGATGCCATTATCAAGTGGAATT

ACAAAATGGTATACCCACTCCAAAAAAAAAAAAAAAGCTAAATTCTCA

GTAGAACATTGTGACTTCATGAGCCCTCCACAGCCTTGGAGCTGAGGAG

GGAGCACTGGTGAGCAGTAGGTTGAAGAGAAAACTTGGCGCTTAATAA

TCTATCCATGTTTTTTCATCTAAAAGAGCCTTCTTTTTGGATTACCTTATT

CAATTTCCATCAAGGAAATTGTTAGTTCCACTAACCAGACAGCAGCTGG

GAAGGCAGAAGCTTACTGTATGTACATGGTAGCTGTGGGAAGGAGGTT

TCTTTCTCCAGGTCCTCACTGGCCATACACCAGTCCCTTGTTAGTTATGC

CTGGTCATAGACCCCCGTTGCTATCATCTCATATTTAAGTCTTTGGCTTG

TGAATTTATCTATTCTTTCAGCTTCAGCACTGCAGAGTGCTGGGACTTTG

CTAACTTCCATTTCTTGCTGGCTTAGCACATTCCTCATAGGCCCAGCTCT TTTCTCATCTGGCCCTGCTGTGGAGTCACCTTGCCCCTTCAGGAGAGCC

ATGGCTTACCACTGCCTGCTAAGCCTCCACTCAGCTGCCACCACACTAA

ATCCAAGCTTCTCTAAGATGTTGCAGACTTTACAGGCAAGCATAAAAGG

CTTGATCTTCCTGGACTTCCCTTTACTTGTCTGAATCTCACCTCCTTCAA

CTTTCAGTCTCAGAATGTAGGCATTTGTCCTCTTTGCCCTACATCTTCCT

TCTTCTGAATCATGAAAGCCTCTCACTTCCTCTTGCTATGTGCTGGAGGC

TTCTGTCAGGTTTTAGAATGAGTTCTCATCTAGTCCTAGTAGCTTTTGAT

GCTTAAGTCCACCTTTTAAGGATACCTTTGAGATTTAGACCATGTTTTTC

GCTTGAGAAAGCCCTAATCTCCAGACTTGCCTTTCTGTGGATTTCAAAG

ACCAACTGAGGAAGTCAAAAGCTGAATGTTGACTTTCTTTGAACATTTC

CGCTATAACAATTCCAATTCTCCTCAGAGCAATATGCCTGCCTCCAACT

GACCAGGAGAAAGGTCCAGTGCCAAAGAGAAAAACACAAAGATTAATT

ATTTCAGTTGAGCACATACTTTCAAAGTGGTTTGGGTATTCATATGAGG

TTTTCTGTCAAGAGGGTGAGACTCTTCATCTATCCATGTGTGCCTGACA

GTTCTCCTGGCACTGGCTGGTAACAGATGCAAAACTGTAAAAATTAAGT

GATCATGTATTTTAACGATATCATCACATACTTATTTTCTATGTAATGTT

TTAAATTTCCCCTAACATACTTTGACTGTTTTGCACATGGTAGATATTCA

CATTTTTTTGTGTTGAAGTTGATGCAATCTTCAAAGTTATCTACCCCGTT

GCTTATTAGTAAAACTAGTGTTAATACTTGGCAAGAGATGCAGGGAATC

TTTCTCATGACTCACGCCCTATTTAGTTATTAATGCTACTACCCTATTTT

GAGTAAGTAGTAGGTCCCTAAGTACATTGTCCAGAGTTATACTTTTAAA

GATATTTAGCCCCATATACTTCTTGAATCTAAAGTCATACACCTTGCTCC

TCATTTCTGAGTGGGAAAGACATTTGAGAGTATGTTGACAATTGTTCTG

AAGGTTTTTGCCAAGAAGGTGAAACTGTCCTTTCATCTGTGTATGCCTG

GGGCTGGGTCCCTGGCAGTGATGGGGTGACAATGCAAAGCTGTAAAAA

CTAGGTGCTAGTGGGCACCTAATATCATCATCATATACTTATTTTCAAG

CTAATATGCAAAATCCCATCTCTGTTTTTAAACTAAGTGTAGATTTCAG

AGAAAATATTTTGTGGTTCACATAAGAAAACAGTCTACTCAGCTTGACA

AGTGTTTTATGTTAAATTGGCTGGTGGTTTGAAATGAATCATCTTCACAT

AATGTTTTCTTTAAAAATATTGTGAATTTAACTCTAATTCTTGTTATTCT

GTGTGATAATAAAGAATAAACTAATTTCTA

ATTCTATGCTGCAGCCTAAGCATCATTCCTCTTCTCTTCTTAGTGGAGAT 190

AAAATTACCCACTGCTCTCCTTACATTTACTTTGTCCATATTTGCTCCTA

TGCTCTAGGCTCGTGCACAACAAACACAGTGTGGGCCCTTACCCTAGAA

GCCAACTTCTCATGACCTTTCTCTATCTCCAGAATCCATGCAGTGGGAA

TGAAGGTAAAAGAAGGTTTTCATGGGATCCAGCTGAGAGCTCTACGGG

GAAAATGGATCTGAGGAGCCATGTGCTCCATCTCTTTTATTTTACAGGT

AGAGACTAGGGGTATAGAGTGAGGTGAATTACCGCAGTGACCCACACA

TTGTTGGCAGACCTAGGATTAGAACTCTGTCTTCCTGGTTCCCAGCTTGG

TGCTTTTGAAAGCATACTTGCTGCTTTCTTACCGGCCTGGTGTCTGCCAC

TTTGGGACAGAGTGTGGACTTGCTCACCTGCCCCATTTCTTAGGGATTCT

CATTCTGTGTTTGAGCAAGAATATTCTTATTCTGGAAAGAACCACATAC

CACAGGATTCTGGGTGAGCATAAGGAAGATTGTCTTGGGGATCTGACTT

AGCTCACGTATAGTGGCTATGATGAATTCAGTGTCTTATTTTTTGCATAT

GTATATTTTTAGTCTAATATTGCCTGGGTGTCTGAGCAAGTCTAGATGA

ATTTAATTGCTCTCATTTTTCCCCTGCCCCTCTTCCTTTGGTCTCTCTTTT

AGGAAATGTTTTTCTTTCAACATTCGTTTCATTCATTATTTACTCATTCG

GCCAACCAACATTTATTGAGTGCCTTCCCTGTATCAGGGACAGGGGCTT

ACAAAGTAGAATTTGATCCCACCTCTGCCCTCAGTAGCTCAGTGTCTAA

TGGAGGTAGTGATGTTCATTAAGCGTCGCCAGATACTGTGCTAGGTGCT

GTGCCTGTTCTCTCTCGCTTGTTCCTCACACACTTGAGAAGGCCGAAGCT

GATTCATAGCTTGGAAGGCAGGGGCCTTGGATTTGAACCCAGGCCTGAC

CAATGGCAGAACCTATCAGATGTGTGGACAGATGACATTGCCTTTCTTT

CTTTGGATATATCAAAATCAGCCAGCAGGCAGGAACTCCCATTTTGAGC

AAGCAATGTGCAGGAATGATAGGGTATACAGAGAGGAACAGGAGATG

GCCCCTGACTTCCAGCATGTGTCTGATGGACATCCAGGCTGCAGGCATC ATGGTGCTGTCTAGAGAGATGAGCCAGGTGCCCAGAGCCCATGGGCCA

ATGCTGCCCTTTCTTGAGCATGCCAAACAAAGCGGTTGGTGTGTTAGAG

GCACAGTCTCCTCCACTCTAAGTAAAAATCAGCATGAGTCCTAGCCCAC

ATTTCCCTAGTGAGTACACCAAAGATATCTATGAACTGGCAGTCATCAG

TGACTTCCTAAGGTTCCGGAAATGCATCTCTTACTCAGGAGTAAGCAAT

GATGTGCCTGCGGCTTTACGAGTTCTCACAGAATGACTTTCTGGACCCA

AATGTTTTTTCTGCTTCAGGACTGTGAAGGCCTTATTGTTCGCTCTGCCA

CCAAGGTGACCGCTGATGTCATCAACGCAGCTGAGAAACTCCAGGTGG

TGGGCAGGGCTGGCACAGGTGTGGACAATGTGGATCTGGAGGCCGCAA

CAAGGAAGGGCATCTTGGTTATGAACACCCCCAATGGGAACAGCCTCA

GTGCCGCAGAACTCACTTGTGGAATGATCATGTGCCTGGCCAGGCAGAT

TCCCCAGGCGACGGCTTCGATGAAGGACGGCAAATGGGAGCGGAAGAA

GTTCATGGGAACAGAGCTGAATGGAAAGACCCTGGGAATTCTTGGCCT

GGGCAGGATTGGGAGAGAGGTAGCTACCCGGATGCAGTCCTTTGGGAT

GAAGACTATAGGGTATGACCCCATCATTTCCCCAGAGGTCTCGGCCTCC

TTTGGTGTTCAGCAGCTGCCCCTGGAGGAGATCTGGCCTCTCTGTGATTT

CATCACTGTGCACACTCCTCTCCTGCCCTCCACGACAGGCTTGCTGAAT

GACAACACCTTTGCCCAGTGCAAGAAGGGGGTGCGTGTGGTGAACTGT

GCCCGTGGAGGGATCGTGGACGAAGGCGCCCTGCTCCGGGCCCTGCAG

TCTGGCCAGTGTGCCGGGGCTGCACTGGACGTGTTTACGGAAGAGCCGC

CACGGGACCGGGCCTTGGTGGACCATGAGAATGTCATCAGCTGTCCCCA

CCTGGGTGCCAGCACCAAGGAGGCTCAGAGCCGCTGTGGGGAGGAAAT

TGCTGTTCAGTTCGTGGACATGGTGAAGGGGAAATCTCTCACGGGGGTT

GTGAATGCCCAGGCCCTTACCAGTGCCTTCTCTCCACACACCAAGCCTT

GGATTGGTCTGGCAGAAGCTCTGGGGACACTGATGCGAGCCTGGGCTG

GGTCCCCCAAAGGGACCATCCAGGTGATAACACAGGGAACATCCCTGA

AGAATGCTGGGAACTGCCTAAGCCCCGCAGTCATTGTCGGCCTCCTGAA

AGAGGCTTCCAAGCAGGCGGATGTGAACTTGGTGAACGCTAAGCTGCT

GGTGAAAGAGGCTGGCCTCAATGTCACCACCTCCCACAGCCCTGCTGCA

CCAGGGGGGCAAGGCTTCGGGGAATGCCTCCTGGCCGTGGCCCTGGCA

GGCGCCCCTTACCAGGCTGTGGGCTTGGTCCAAGGCACTACACCTGTAC

TGCAGGGGCTCAATGGAGCTGTCTTCAGGCCAGAAGTGCCTCTCCGCAG

GGACCTGCCCCTGCTCCTATTCCGGACTCAGACCTCTGACCCTGCAATG

CTGCCTACCATGATTGGCCTCCTGGCAGAGGCAGGCGTGCGGCTGCTGT

CCTACCAGACTTCACTGGTGTCAGATGGGGAGACCTGGCACGTCATGGG

CATCTCCTCCTTGCTGCCCAGCCTGGAAGCGTGGAAGCAGCATGTGACT

GAAGCCTTCCAGTTCCACTTCTAACCTTGGAGCTCACTGGTCCCTGCCTC

TGGGGCTTTTCTGAAGAAACCCACCCACTGTGATCAATAGGGAGAGAA

AATCCACATTCTTGGGCTGAACGCGAGCCTCTGACACTGCTTACACTGC

ACTCTGACCCTGTAGTACAGCAATAACCGTCTAATAAAGAGCCTACCCC

C

CAAACAAAAACAGCCAAGCTTTTCTGCCAAAAAGATGACTGAGAAGAC 191

TGTTAAAGCAAAAAGCTCTGTTCCTGCCTCAGATGATGCCTATCCAGAA

ATAGAAAAATTCTTTCCCTTCAATCCTCTAGACTTTGAGAGTTTTGACCT

GCCTGAAGAGCACCAGATTGCGCACCTCCCCTTGAGTGGAGTGCCTCTC

ATGATCCTTGACGAGGAGAGAGAGCTTGAAAAGCTGTTTCAGCTGGGC

CCCCCTTCACCTGTGAAGATGCCCTCTCCACCATGGGAATCCAATCTGT

TGCAGTCTCCTTCAAGCATTCTGTCGACCCTGGATGTTGAATTGCCACCT

GTTTGCTGTGACATAGATATTTAAATTTCTTAGTGCTTCAGAGTCTGTGT

GTATTTGTATTAATAAAGCATTCTTTAACAGAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGGGGGGGAGACACAA

AAAGAATTCCCCAAGAGGGGGCCACAAGATAATCAGAGGATATCACAC

AAGATCTCTCGGCGCACCAACGACGGGGGCCCCAAATAAGGGAGAGAC

CCAGAATCACAACAGCCAAGACACGGTGGACACGACGGAAACAAACA

CACAGCCCAGACACGGGGGCAAACACGCGCGCACACCGCGGACACCAT

GGGACAAAGCAGACACCACCCACAAAACAACACCGCGGAGGGGGAAG AACAACAAAACAAGTGCGCAAACAGAACACAACCACAGAAAGAGAAA

AATTAAAACGGCCCCCAAGACGGCGACAACACAACAAAACAACCACTA

CAGAGCGCTCAACAGCCGAGTAAAAACACAACAACGGACAACTAACAC

ACAAAGGAATGAAACAAAGCGGGGCCACACACCGACACCGGAAATCC

GGCGAACAACTCACACCGAGCGAGGGTCCCAGACAACAAATACACAGA

CAACGAAACCGAGAAACAAGACCAGCAAGACGAGCAGGCAAAAGACA

AACAAGACAGAGGAGACGACGACGAACGCAAAGGACAAGAGGACACA

ACGACGCGAGGAGCGAGAGCGAGAGGAAGAGACAACAAAAAGACACA

AAAGAACAACAAGCAAGCAGCGAAGAACGACACACAACCACACGAGA

CAGCAGGAGCAGAGGCGGAGAAAACACAACGAGCAAGCCAAGACCAA

GAGAGGAGAACAAAATAAAAAAATACGAGAGCAGGCGGACGAGAGCA

CGAGACGAACAGACAAACGGGAATCAGAAGCATAACGATCCGCGACG

CGAACAACN

GTGCACCCTGTCCCAGCCGTCCTGTCCTGGCTGCTCGCTCTGCTTCGCTG 192

CGCCTCCACTATGCTCTCCCTCCGTGTCCCGCTCGCGCCCATCACGGACC

CGCAGCAGCTGCAGCTCTCGCCGCTGAAGGGGCTCAGCTTGGTCGACA

AGGAGAACACGCCGCCGGCCCTGAGCGGGACCCGCGTCCTGGCCAGCA

AGACCGCGAGGAGGATCTTCCAGGAGAAAACCCCCGCCGCTTTGTCAT

CTTCCCCATCGAGTACCATGATATCTGGCAGATGTATAAGAAGGCAGAG

GCTTCCTTTTGGACCGCCGAGGAGGTGGACCTCTCCAAGGACATTCAGC

ACTGGGAATCCCTGAAACCCGAGGAGAGATATTTTATATCCCATGTTCT

GGCTTTCTTTGCAGCAAGCGATGGCATAGTAAATGAAAACTTGGTGGAG

CGATTTAGCCAAGAAGTTCAGATTACAGAAGCCCGCTGTTTCTATGGCT

TCCAAATTGCCATGGAAAACATACATTCTGAAATGTATAGTCTTCTTAT

TGACACTTACATAAAAGATCCCAAAGAAAGGGAATTTCTCTTCAATGCC

ATTGAAACGATGCCTTGTGTCAAGAAGAAGGCAGACTGGGCCTTGCGC

TGGATTGGGGACAAAGAGGCTACCTATGGTGAACGTGTTGTAGCCTTTG

CTGCAGTGGAAGGCATTTTCTTTTCCGGTTCTTTTGCGTCGATATTCTGG

CTCAAGAAACGAGGACTGATGCCTGGCCTCACATTTTCTAATGAACTTA

TTAGCAGAGATGAGGGTTTACACTGTGATTTTGCTTGCCTGATGTTCAA

ACACCTGGTACACAAACCATCGGAGGAGAGAGTAAGAGAAATAATTAT

CAATGCTGTTCGGATAGAACAGGAGTTCCTCACTGAGGCCTTGCCTGTG

AAGCTCATTGGGATGAATTGCACTCTAATGAAGCAATACATTGAGTTTG

TGGCAGACAGACTTATGCTGGAACTGGGTTTTAGCAAGGTTTTCAGAGT

AGAGAACCCATTTGACTTTATGGAGAATATTTCACTGGAAGGAAAGACT

AACTTCTTTGAGAAGAGAGTAGGCGAGTATCAGAGGATGGGAGTGATG

TCAAGTCCAACAGAGAATTCTTTTACCTTGGATGCTGACTTCTAAATGA

ACTGAAGATGTGCCCTTACTTGGCTGATTTTTTTTTTTCCATCTCATAAG

AAAAATCAGCTGAAGTGTTACCAACTAGCCACACCATGAATTGTCCGTA

ATGTTCATTAACAGCATCTTTAAAACTGTGTAGCTACCTCACAACCAGT

CCTGTCTGTTTATAGTGCTGGTAGTATCACCTTTTGCCAGAAGGCCTGGC

TGGCTGTGACTTACCATAGCAGTGACAATGGCAGTCTTGGCTTTAAAGT

GAGGGGTGACCCTTTAGTGAGCTTAGCACAGCGGGATTAAACAGTCCTT

TAACCAGCACAGCCAGTTAAAAGATGCAGCCTCACTGCTTCAACGCAG

ATTTTAATGTTTACTTAAATATAAACCTGGCACTTTACAAACAAATAAA

CATTGTTTGTACTCACAAGGCGATAATAGCTTGATTTATTTGGTTTCTAC

ACCAAATACATTCTCCTGACCACTAATGGGAGCCAATTCACAATTCACT

AAGTGACTAAAGTAAGTTAAACTTGTGTAGACTAAGCATGTAATTTTTA

AGTTTTATTTTAATGAATTAAAATATTTGTTAACCAACTTTAAAGTCAGT

CCTGTGTATACCTAGATATTAGTCAGTTGGTGCCAGATAGAAGACAGGT

TGTGTTTTTATCCTGTGGCTTGTGTAGTGTCCTGGGATTCTCTGCCCCCT

CTGAGTAGAGTGTTGTGGGATAAAGGAATCTCTCAGGGCAAGGAGCTT

CTTAAGTTAAATCACTAGAAATTTAGGGGTGATCTGGGCCTTCATATGT

GTGAGAAGCCGTTTCATTTTATTTCTCACTGTATTTTCCTCAACGTCTGG

TTGATGAGAAAAAATTCTTGAAGAGTTTTCATATGTGGGAGCTAAGGTA

GTATTGTAAAATTTCAAGTCATCCTTAAACAAAATGATCCACCTAAGAT CTTGCCCCTGTTAAGTGGTGAAATCAACTAGAGGTGGTTCCTACAAGTT

GTTCATTCTAGTTTTGTTTGGTGTAAGTAGGTTGTGTGAGTTAATTCATT

TATATTTACTATGTCTGTTAAATCAGAAATTTTTTATTATCTATGTTCTTC

TAGATTTTACCTGTAGTTCATACTTCAGTCACCCAGTGTCTTATTCTGGC

ATTGTCTAAATCTGAGCATTGTCTAGGGGGATCTTAAACTTTAGTAGGA

AACCATGAGCTGTTAATACAGTTTCCATTCAAATATTAATTTCAGAATG

AAACATAATTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCC

AGGCTGGAGTGCAGTGGCGCGATTTTGGCTCACTGTAACCTCCATCTCC

TGGGTTCAAGCAATTCTCCTGTCTCAGCCTCCCTAGTAGCTGGGACTGC

AGGTATGTGCTACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATG

GAGTTTCACCATATTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTG

ATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTGCAGGCGTGATAAA

CAAATATTCTTAATAGGGCTACTTTGAATTAATCTGCCTTTATGTTTGGG

AGAAGAAAGCTGAGACATTGCATGAAAGATGATGAGAGATAAATGTTG

ATCTTTTGGCCCCATTTGTTAATTGTATTCAGTATTTGAACGTCGTCCTG

TTTATTGTTAGTTTTCTTCATCATTTATTGTATAGACAATTTTTAAATCTC

TGTAATATGATACATTTTCCTATCTTTTAAGTTATTGTTACCTAAAGTTA

ATCCAGATTATATGGTCCTTATATGTGTACAACATTAAAATGAAAGGCT

TTGTCTTGCATTGTGAGGTACAGGCGGAAGTTGGAATCAGGTTTTAGGA

TTCTGTCTCTCATTAGCTGAATAATGTGAGGATTAACTTCTGCCAGCTCA

GACCATTTCCTAATCAGTTGAAAGGGAAACAAGTATTTCAGTCTCAAAA

TTGAATAATGCACAAGTCTTAAGTGATTAAAATAAAACTGTTCTTATGT

CAGTTT

AGCGGGGGCACTCCAGCCCTGCAGCCTCCGGAGTCAGTGCCGCGCGCC 193

CGCCGCCCCGCGCCTTCCTGCTCGCCGCACCTCCGGGAGCCGGGGCGCA

CCCAGCCCGCAGCGCCGCCTCCCCGCCCGCGCCGCCTCCGACCGCAGGC

CGAGGGCCGCCACTGGCCGGGGGGACCGGGCAGCAGCTTGCGGCCGCG

GAGCCGGGCAACGCTGGGGACTGCGCCTTTTGTCCCCGGAGGTCCCTGG

AAGTTTGCGGCAGGACGCGCGCGGGGAGGCGGCGGAGGCAGCCCCGAC

GTCGCGGAGAACAGGGCGCAGAGCCGGCATGGGCATCGGGCGCAGCG

AGGGGGGCCGCCGCGGGGCAGCCCTGGGCGTGCTGCTGGCGCTGGGCG

CGGCGCTTCTGGCCGTGGGCTCGGCCAGCGAGTACGACTACGTGAGCTT

CCAGTCGGACATCGGCCCGTACCAGAGCGGGCGCTTCTACACCAAGCC

ACCTCAGTGCGTGGACATCCCCGCGGACCTGCGGCTGTGCCACAACGTG

GGCTACAAGAAGATGGTGCTGCCCAACCTGCTGGAGCACGAGACCATG

GCGGAGGTGAAGCAGCAGGCCAGCAGCTGGGTGCCCCTGCTCAACAAG

AACTGCCACGCCGGCACCCAGGTCTTCCTCTGCTCGCTCTTCGCGCCCG

TCTGCCTGGACCGGCCCATCTACCCGTGTCGCTGGCTCTGCGAGGCCGT

GCGCGACTCGTGCGAGCCGGTCATGCAGTTCTTCGGCTTCTACTGGCCC

GAGATGCTTAAGTGTGACAAGTTCCCCGAGGGGGACGTCTGCATCGCC

ATGACGCCGCCCAATGCCACCGAAGCCTCCAAGCCCCAAGGCACAACG

GTGTGTCCTCCCTGTGACAACGAGTTGAAATCTGAGGCCATCATTGAAC

ATCTCTGTGCCAGCGAGTTTGCACTGAGGATGAAAATAAAAGAAGTGA

AAAAAGAAAATGGCGACAAGAAGATTGTCCCCAAGAAGAAGAAGCCC

CTGAAGTTGGGGCCCATCAAGAAGAAGGACCTGAAGAAGCTTGTGCTG

TACCTGAAGAATGGGGCTGACTGTCCCTGCCACCAGCTGGACAACCTCA

GCCACCACTTCCTCATCATGGGCCGCAAGGTGAAGAGCCAGTACTTGCT

GACGGCCATCCACAAGTGGGACAAGAAAAACAAGGAGTTCAAAAACTT

CATGAAGAAAATGAAAAACCATGAGTGCCCCACCTTTCAGTCCGTGTTT

AAGTGATTCTCCCGGGGGCAGGGTGGGGAGGGAGCCTCGGGTGGGGTG

GGAGCGGGGGGGACAGTGCCCCGGGAACCCGGTGGGTCACACACACGC

ACTGCGCCTGTCAGTAGTGGACATTTAATCCAGTCGGCTTGTTCTTGCA

GCATTCCCGCTCCCTTCCCTCCATAGCCACGCTCCAAACCCCAGGGTAG

CCATGGCCGGGTAAAGCAAGGGCCATTTAGATTAGGAAGGTTTTTAAG

ATCCGCAATGTGGAGCAGCAGCCACTGCACAGGAGGAGGTGACAAACC

ATTTCCAACAGCAACACAGCCACTAAAACACAAAAAGGGGGATTGGGC GGAAAGTGAGAGCCAGCAGCAAAAACTACATTTTGCAACTTGTTGGTG

TGGATCTATTGGCTGATCTATGCCTTTCAACTAGAAAATTCTAATGATTG

GCAAGTCACGTTGTTTTCAGGTCCAGAGTAGTTTCTTTCTGTCTGCTTTA

AATGGAAACAGACTCATACCACACTTACAATTAAGGTCAAGCCCAGAA

AGTGATAAGTGCAGGGAGGAAAAGTGCAAGTCCATTATGTAATAGTGA

CAGCAAAGGGACCAGGGGAGAGGCATTGCCTTCTCTGCCCACAGTCTTT

CCGTGTGATTGTCTTTGAATCTGAATCAGCCAGTCTCAGATGCCCCAAA

GTTTCGGTTCCTATGAGCCCGGGGCATGATCTGATCCCCAAGACATGTG

GAGGGGCAGCCTGTGCCTGCCTTTGTGTCAGAAAAAGGAAACCACAGT

GAGCCTGAGAGAGACGGCGATTTTCGGGCTGAGAAGGCAGTAGTTTTC

AAAACACATAGTTAAAAAAGAAACAAATGAAAAAAATTTTAGAACAGT

CCAGCAAATTGCTAGTCAGGGTGAATTGTGAAATTGGGTGAAGAGCTT

ACGATTCTAATCTCATGTTTTTTCCTTTTCACATTTTTAAAAGAACAATG

ACAAACACCCACTTATTTTTCAAGGTTTTAAAACAGTCTACATTGAGCA

TTTGAAAGGTGTGCTAGAACAAGGTCTCCTGATCCGTCCGAGGCTGCTT

CCCAGAGGAGCAGCTCTCCCCAGGCATTTGCCAAGGGAGGCGGATTTC

CCTGGTAGTGTAGCTGTGTGGCTTTCCTTCCTGAAGAGTCCGTGGTTGCC

CTAGAACCTAACACCCCCTAGCAAAACTCACAGAGCTTTCCGTTTTTTT

CTTTCCTGTAAAGAAACATTTCCTTTGAACTTGATTGCCTATGGATCAAA

GAAATTCAGAACAGCCTGCCTGTCCCCCCGCACTTTTTACATATATTTGT

TTCATTTCTGCAGATGGAAAGTTGACATGGGTGGGGTGTCCCCATCCAG

CGAGAGAGTTTAAAAAGCAAAACATCTCTGCAGTTTTTCCCAAGTGCCC

TGAGATACTTCCCAAAGCCCTTATGTTTAATCAGCGATGTATATAAGCC

AGTTCACTTAGACAACTTTACCCTTCTTGTCCAATGTACAGGAAGTAGT

TCTAAAAAAAATGCATATTAATTTCTTCCCCCAAAGCCGGATTCTTAAT

TCTCTGCAACACTTTGAGGACATTTATGATTGTCCCTCTGGGCCAATGCT

TATACCCAGTGAGGATGCTGCAGTGAGGCTGTAAAGTGGCCCCCTGCG

GCCCTAGCCTGACCCGGAGGAAAGGATGGTAGATTCTGTTAACTCTTGA

AGACTCCAGTATGAAAATCAGCATGCCCGCCTAGTTACCTACCGGAGA

GTTATCCTGATAAATTAACCTCTCACAGTTAGTGATCCTGTCCTTTTAAC

ACCTTTTTTGTGGGGTTCTCTCTGACCTTTCATCGTAAAGTGCTGGGGAC

CTTAAGTGATTTGCCTGTAATTTTGGATGATTAAAAAATGTGTATATAT

ATTAGCTAATTAGAAATATTCTACTTCTCTGTTGTCAAACTGAAATTCAG

AGCAAGTTCCTGAGTGCGTGGATCTGGGTCTTAGTTCTGGTTGATTCAC

TCAAGAGTTCAGTGCTCATACGTATCTGCTCATTTTGACAAAGTGCCTC

ATGCAACCGGGCCCTCTCTCTGCGGCAGAGTCCTTAGTGGAGGGGTTTA

CCTGGAACATTAGTAGTTACCACAGAATACGGAAGAGCAGGTGACTGT

GCTGTGCAGCTCTCTAAATGGGAATTCTCAGGTAGGAAGCAACAGCTTC

AGAAAGAGCTCAAAATAAATTGGAAATGTGAATCGCAGCTGTGGGTTT

TACCACCGTCTGTCTCAGAGTCCCAGGACCTTGAGTGTCATTAGTTACTT

TATTGAAGGTTTTAGACCCATAGCAGCTTTGTCTCTGTCACATCAGCAA

TTTCAGAACCAAAAGGGAGGCTCTCTGTAGGCACAGAGCTGCACTATC

ACGAGCCTTTGTTTTTCTCCACAAAGTATCTAACAAAACCAATGTGCAG

ACTGATTGGCCTGGTCATTGGTCTCCGAGAGAGGAGGTTTGCCTGTGAT

TTCCTAATTATCGCTAGGGCCAAGGTGGGATTTGTAAAGCTTTACAATA

ATCATTCTGGATAGAGTCCTGGGAGGTCCTTGGCAGAACTCAGTTAAAT

CTTTGAAGAATATTTGTAGTTATCTTAGAAGATAGCATGGGAGGTGAGG

ATTCCAAAAACATTTTATTTTTAAAATATCCTGTGTAACACTTGGCTCTT

GGTACCTGTGGGTTAGCATCAAGTTCTCCCCAGGGTAGAATTCAATCAG

AGCTCCAGTTTGCATTTGGATGTGTAAATTACAGTAATCCCATTTCCCA

AACCTAAAATCTGTTTTTCTCATCAGACTCTGAGTAACTGGTTGCTGTGT

CATAACTTCATAGATGCAGGAGGCTCAGGTGATCTGTTTGAGCAGAGCA

CCCTAGGCAGCCTGCAGGGAATAACATACTGGCCGTTCTGACCTGTTGC

CAGCAGATACACAGGACATGGATGAAATTCCCGTTTCCTCTAGTTTCTT

CCTGTAGTACTCCTCTTTTAGATCCTAAGTCTCTTACAAAAGCTTTGAAT

ACTGTGAAAATGTTTTACATTCCATTTCATTTGTGTTGTTTTTTTAACTGC ATTTTACCAGATGTTTTGATGTTATCGCTTATGTTAATAGTAATTCCCGT

ACGTGTTCATTTTATTTTCATGCTTTTTCAGCCATGTATCAATATTCACTT

GACTAAAATCACTCAATTAATCAAAAAAAAAAAAAAAA

NM_012319 AGTCCTGGGCGAAGGGGGCGGTGGTTCCCCGCGGCGCTGCGCGCGGCG 194

GTAATTAGTGATTGTCTTCCAGCTTCGCGAAGGCTAGGGGCGCGGCTGC

CGGGTGGCTGCGCGGCGCTGCCCCCGGACCGAGGGGCAGCCAACCCAA

TGAAACCACCGCGTGTTCGCGCCTGGTAGAGATTTCTCGAAGACACCAG

TGGGCCCGTTCCGAGCCCTCTGGACCGCCCGTGTGGAACCAAACCTGCG

CGCGTGGCCGGGCCGTGGGACAACGAGGCCGCGGAGACGAAGGCGCA

ATGGCGAGGAAGTTATCTGTAATCTTGATCCTGACCTTTGCCCTCTCTGT

CACAAATCCCCTTCATGAACTAAAAGCAGCTGCTTTCCCCCAGACCACT

GAGAAAATTAGTCCGAATTGGGAATCTGGCATTAATGTTGACTTGGCAA

TTTCCACACGGCAATATCATCTACAACAGCTTTTCTACCGCTATGGAGA

AAATAATTCTTTGTCAGTTGAAGGGTTCAGAAAATTACTTCAAAATATA

GGCATAGATAAGATTAAAAGAATCCATATACACCATGACCACGACCAT

CACTCAGACCACGAGCATCACTCAGACCATGAGCGTCACTCAGACCAT

GAGCATCACTCAGACCACGAGCATCACTCTGACCATGATCATCACTCTC

ACCATAATCATGCTGCTTCTGGTAAAAATAAGCGAAAAGCTCTTTGCCC

AGACCATGACTCAGATAGTTCAGGTAAAGATCCTAGAAACAGCCAGGG

GAAAGGAGCTCACCGACCAGAACATGCCAGTGGTAGAAGGAATGTCAA

GGACAGTGTTAGTGCTAGTGAAGTGACCTCAACTGTGTACAACACTGTC

TCTGAAGGAACTCACTTTCTAGAGACAATAGAGACTCCAAGACCTGGA

AAACTCTTCCCCAAAGATGTAAGCAGCTCCACTCCACCCAGTGTCACAT

CAAAGAGCCGGGTGAGCCGGCTGGCTGGTAGGAAAACAAATGAATCTG

TGAGTGAGCCCCGAAAAGGCTTTATGTATTCCAGAAACACAAATGAAA

ATCCTCAGGAGTGTTTCAATGCATCAAAGCTACTGACATCTCATGGCAT

GGGCATCCAGGTTCCGCTGAATGCAACAGAGTTCAACTATCTCTGTCCA

GCCATCATCAACCAAATTGATGCTAGATCTTGTCTGATTCATACAAGTG

AAAAGAAGGCTGAAATCCCTCCAAAGACCTATTCATTACAAATAGCCT

GGGTTGGTGGTTTTATAGCCATTTCCATCATCAGTTTCCTGTCTCTGCTG

GGGGTTATCTTAGTGCCTCTCATGAATCGGGTGTTTTTCAAATTTCTCCT

GAGTTTCCTTGTGGCACTGGCCGTTGGGACTTTGAGTGGTGATGCTTTTT

TACACCTTCTTCCACATTCTCATGCAAGTCACCACCATAGTCATAGCCAT

GAAGAACCAGCAATGGAAATGAAAAGAGGACCACTTTTCAGTCATCTG

TCTTCTCAAAACATAGAAGAAAGTGCCTATTTTGATTCCACGTGGAAGG

GTCTAACAGCTCTAGGAGGCCTGTATTTCATGTTTCTTGTTGAACATGTC

CTCACATTGATCAAACAATTTAAAGATAAGAAGAAAAAGAATCAGAAG

AAACCTGAAAATGATGATGATGTGGAGATTAAGAAGCAGTTGTCCAAG

TATGAATCTCAACTTTCAACAAATGAGGAGAAAGTAGATACAGATGAT

CGAACTGAAGGCTATTTACGAGCAGACTCACAAGAGCCCTCCCACTTTG

ATTCTCAGCAGCCTGCAGTCTTGGAAGAAGAAGAGGTCATGATAGCTC

ATGCTCATCCACAGGAAGTCTACAATGAATATGTACCCAGAGGGTGCA

AGAATAAATGCCATTCACATTTCCACGATACACTCGGCCAGTCAGACGA

TCTCATTCACCACCATCATGACTACCATCATATTCTCCATCATCACCACC

ACCAAAACCACCATCCTCACAGTCACAGCCAGCGCTACTCTCGGGAGG

AGCTGAAAGATGCCGGCGTCGCCACTCTGGCCTGGATGGTGATAATGG

GTGATGGCCTGCACAATTTCAGCGATGGCCTAGCAATTGGTGCTGCTTT

TACTGAAGGCTTATCAAGTGGTTTAAGTACTTCTGTTGCTGTGTTCTGTC

ATGAGTTGCCTCATGAATTAGGTGACTTTGCTGTTCTACTAAAGGCTGG

CATGACCGTTAAGCAGGCTGTCCTTTATAATGCATTGTCAGCCATGCTG

GCGTATCTTGGAATGGCAACAGGAATTTTCATTGGTCATTATGCTGAAA

ATGTTTCTATGTGGATATTTGCACTTACTGCTGGCTTATTCATGTATGTT

GCTCTGGTTGATATGGTACCTGAAATGCTGCACAATGATGCTAGTGACC

ATGGATGTAGCCGCTGGGGGTATTTCTTTTTACAGAATGCTGGGATGCT

TTTGGGTTTTGGAATTATGTTACTTATTTCCATATTTGAACATAAAATCG

TGTTTCGTATAAATTTCTAGTTAAGGTTTAAATGCTAGAGTAGCTTAAA AAGTTGTCATAGTTTCAGTAGGTCATAGGGAGATGAGTTTGTATGCTGT

ACTATGCAGCGTTTAAAGTTAGTGGGTTTTGTGATTTTTGTATTGAATAT

TGCTGTCTGTTACAAAGTCAGTTAAAGGTACGTTTTAATATTTAAGTTAT

TCTATCTTGGAGATAAAATCTGTATGTGCAATTCACCGGTATTACCAGT

TTATTATGTAAACAAGAGATTTGGCATGACATGTTCTGTATGTTTCAGG

GAAAAATGTCTTTAATGCTTTTTCAAGAACTAACACAGTTATTCCTATA

CTGGATTTTAGGTCTCTGAAGAACTGCTGGTGTTTAGGAATAAGAATGT

GCATGAAGCCTAAAATACCAAGAAAGCTTATACTGAATTTAAGCAAAG

AAATAAAGGAGAAAAGAGAAGAATCTGAGAATTGGGGAGGCATAGAT

TCTTATAAAAATCACAAAATTTGTTGTAAATTAGAGGGGAGAAATTTAG

AATTAAGTATAAAAAGGCAGAATTAGTATAGAGTACATTCATTAAACA

TTTTTGTCAGGATTATTTCCCGTAAAAACGTAGTGAGCACTTTTCATATA

CTAATTTAGTTGTACATTTAACTTTGTATAATACAGAAATCTAAATATAT

TTAATGAATTCAAGCAATATATCACTTGACCAAGAAATTGGAATTTCAA

AATGTTCGTGCGGGTATATACCAGATGAGTACAGTGAGTAGTTTTATGT

ATCACCAGACTGGGTTATTGCCAAGTTATATATCACCAAAAGCTGTATG

ACTGGATGTTCTGGTTACCTGGTTTACAAAATTATCAGAGTAGTAAAAC

TTTGATATATATGAGGATATTAAAACTACACTAAGTATCATTTGATTCG

ATTCAGAAAGTACTTTGATATCTCTCAGTGCTTCAGTGCTATCATTGTGA

GCAATTGTCTTTTATATACGGTACTGTAGCCATACTAGGCCTGTCTGTGG

CATTCTCTAGATGTTTCTTTTTTACACAATAAATTCCTTATATCAGCTTG

AAAAAAAAAAAAAAAAAA

AACGCACTTGGCGCGCGGCGCGGGCTGCAGACGGCTGCGAGGCGCTGG 195

GCACAGGTGTCCTGATGGCAAATTTCAAGGGCCACGCGCTTCCAGGGA

GTTTCTTCCTGATCATTGGGCTGTGTTGGTCAGTGAAGTACCCGCTGAA

GTACTTTAGCCACACGCGGAAGAACAGCCCACTACATTACTATCAGCGT

CTCGAGATCGTCGAAGCCGCAATTAGGACTTTGTTTTCCGTCACTGGGA

TCCTGGCAGAGCAGTTTGTTCCGGATGGGCCCCACCTGCACCTCTACCA

TGAGAACCACTGGATAAAGTTAATGAATTGGCAGCACAGCACCATGTA

CCTATTCTTTGCAGTCTCAGGAATTGTTGACATGCTCACCTATCTGGTCA

GCCACGTTCCCTTGGGGGTGGACAGACTGGTTATGGCTGTGGCAGTATT

CATGGAAGGTTTCCTCTTCTACTACCACGTCCACAACCGGCCTCCGCTG

GACCAGCACATCCACTCACTCCTGCTGTATGCTCTGTTCGGAGGGTGTG

TTAGTATCTCCCTAGAGGTGATCTTCCGGGACCACATTGTGCTGGAACT

TTTCCGAACCAGTCTCATCATTCTTCAGGGAACCTGGTTCTGGCAGATT

GGGTTTGTGCTGTTCCCACCTTTTGGAACACCCGAATGGGACCAGAAGG

ATGATGCCAACCTCATGTTCATCACCATGTGCTTCTGCTGGCACTACCTG

GCTGCCCTCAGCATTGTGGCCGTCAACTATTCTCTTGTTTACTGCCTTTT

GACTCGGATGAAGAGACACGGAAGGGGAGAAATCATTGGAATTCAGAA

GCTGAATTCAGATGACACTTACCAGACCGCCCTCTTGAGTGGCTCAGAT

GAGGAATGAGCCGAGATGCGGAGGGCGCAGATGTCCCACTGCACAGCT

GGAATGAATGGAGTTCATCCCCTCCACCTGAATGCCTGCTGTGGTCTGA

TCTTAAGGGTCTATATATTTGCACCTCCTCATTCAACACAGGGCTGGAG

GTTCTACAACAGGAAATCAGGCCTACAGCATCCTGTGTATCTTGCAGTT

GGGATTTTTAAACATACTATAAAGTCTGTGTTGGTATAGTACCCTTCAT

AAGGAAAAATGAAGTAATGCCTATAAGTAGCAGGCCTTTGTGCCTCAG

TGTCAAGAGAAATCAAGAGATGCTAAAAGCTTTACAATGGAAGTGGCC

TCATGGATGAATCCGGGGTATGAGCCCAGGAGAACGTGCTGCTTTTGGT

AACTTATCCCTTTTTCTCTTAAGAAAGCAGGTACTTTCTTATTAGAAATA

TGTTAGAATGTGTAAGCAAACGACAGTGCCTTTAGAATTACAATTCTAA

CTTACATATTTTTTGAAAGTAAAATAATTCACAAGCTTTGGTATTTTAAA

ATTATTGTTAAACATATCATAACTAATCATACCAGGGTACTGCAATACC

ACTGTTTATAAGTGACAAAATTAGGCCAAAGGTGATTTTTTTTTAAATC

AGGAAGCTGGTTACTGGCTCTACTGAGAGTTGGAGCCCTGATGTTCTGA

TTCTTCAAAGTCACCCTAAAAGAAGATCTGACAGGAAAGCTGTATAATG

AGATAGAAAAACGTCAGGTATGGAAGGCTTTCAGTTTTAATATGGCTGA AAGCAAAGGATAACGAATTCAGAATTAGTAATGTAAAATCTTGATACC

CTAATCTTGCTTCTGGATCTGTTCTTTTTTTAAAAAAACTTCCTTCACCG

CGCCTATAATCCTAGCACTTTGGGAGGCCGAGGCAGGCAGATCACGGG

GTCAGGAGATCAAGACCATCCTGGCTAACATGGTGAAACCCCGTCTCTA

CTGAAAATACAAAAAATTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTT

CCAGCTACTCGGGAGGCTGAGGCAAGAGAATGGCATGAACCCGGTAGG

GGAGCTTGCAGTGAGCCCAGATCATGCCACTGTACTCCAGCCTAGGTGA

CAGAGCAAGACTCTGTCTCAAAAACAAGCAAACAGACTTCCTTCAACA

AATATTTATTAAATATCCACTTTGCAACAGCACTGAAATGGCTGTAAGG

ACTCCTGAGATATGTGTCCAGCAAGGAGTTTACAGTCAAACAGGAGAG

ACATGCCTGTAGTTACATCCAGTGTGATGGGTGCTGAGAGGCAAGTACA

AACCACGATG

BQ056428 TCCCGCCGCGCCACTTCGCCTGCCTCCGTCCCCCGCCCGCCGCGCCATG 196

CCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCCCCCCGCCGCAC

AGGAGCGGGACGCCGAGCCGCGTCCGCCGCACGGGGAGCTGCAGTACC

TGGGGCAGATCCAACACATCCTCCGCTGCGGCGTCAGGAAGGACGCCC

GCCCGGGCACCGGTACCCTGCCGGTATTCGGCATGCAGGCGCGCTACA

GCCTGAGAGATGAATTCCCTCTGCTGACAACCAAACGTGTGTTCTGGAA

CGGTGCTTCGGAGGAGCTGCTGTGGCTTATCAAGGGATCCACAAACGCT

ATAGACCTGTCTTCCCCGGCAGCGAAAATCTCGGGATGCCACTGGATCC

CGACACTCTCTGGACACCCTGGGATTCTCCACCAGAGAAGAACGCGACT

TGGGCCCAGTTTGTGGCTCTCAGCGGAGGCCTCCTGTGGCAGAATACAT

ACATTTCCAATCAGATCACTTCCCGGACACGGACCNTGACCAGCCTGCC

AAAAAGTGGATTTCCCCCCACCCCAGAACCCANCCCCTGACGCACAGA

AACCAACCCATTCGTTGTTGCCGCCTTGCGAACCCCAACCAGAATCTCT

CCCCCCTGGCCGGCGCGCCTGCCGCTGCCAATGCCCCTATGGCGGCCTC

TTGGCCCGCACCTTCCAATTGGTCGCCCTGCGCAACCAGCGAGAAAACA

CTGGCCCGCCCGTCTCCCCCCCGCTCCGCCTACCCCACTTAATGCGCCTC

CGTGGCATGACGCACGCGTTTGGTGTCCGCCGCCGTCTCATGTCCGCGC

GGTGTGGACCCCCTTTTCTCTCGCGGCACATCCCCCCTATTCCCTTGCCC

TTTGGGGGGCACCCCCTCTAGACCCGCGCTTCTCTTCTCGTCCGGTGGG

GGACATTGGTTTGCCTGCCGCGGCGGGGGCGNTAAAAATAAAAACAGC

CTGTTAGCCCGGCCCAGTACCCCCCCCCGGCCGGGGCCGCCTTNCGTTT

GCATTTATACCCCAACCCATAAAGCCGCGCCCCTTTAGCNCCNTAACTT

TTGTGGTGTGGCCTCCCCCCTTTTTCCCGGGGAGCAGCAACGGACATCT

GTACACTAATGCTGGCCCCGACCTTTCCCAAAAACCCCCCGCCCGTGTC

CCGTATAAATTTGGTGCCAANCCTGACGNGTTCTCCCCCGCCCTCGCCC

CGTTGGCCGCCCGTTTAAAGCCCCCCCGGTGGTTGCGCCGCCCAACGAG

TCCACCTATAGTTAANTCCACCAACACCCCCACCTTTTCCTCCCCGCCGC

ATCTTCCCCACGTACCCCCTTTTGTCGCGAGATGGCCACTCCCCCCCCCC

TGTTTGTTTAAAACAACGAGAATGGTGCTGCCAACGCTGGTCTTTTCCC

CCCCCGGACCGCGACCGCCAGGGGGAATACGTACCATAAGCCCCCGCG

CCCNCCTTTTTTCCCCCCTCCCCGCCAATCAAGATCCGCCGTCCATTAGA

CGTATTATTTTTCCCGCGATACACGAAAAAACAGGGCCGCCCATTTATA

ACTAAATTCCCGTCGCCGCCGCGCGGATATGTTTCCCAAAATACCACCC

CCCCCCCCCCATTTTCTTTGCCCCCAACTCCTGCGCACCGGTGTTCACCA

GCCTCGCGCCGC

BC032677 GGACGCGTGGGTCGACCCACGCGTCCGGACCCACGCGTCCGGTCGTGTT 197

CTCCGAGTTCCTGTCTCTCTGCCAACGCCGCCCGGATGGCTTCCCAAAA

CCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCTGA

GCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCA

GGAGCTGATGACCCTCATGGTGAGTGATTAAGTGCCCAGAACCCCAGC

CTTCCATCCAATTTTCAGTAGCCTCCTTTTTTCCGTCAGCTTTTTTGCTAG

ACATAGGGGTAATGTAATTTGCTCCCTCCTGGGAAAGAAGTTCATACAC

CCCACCTACACCATTTCTTCCAGCAGTCCCTCCTCCCAATTCCATCCCCC

CACACGAAGTTATCTCGAACACTTCCCTGAAGTCATACAAGACCCTCCC TATCCAGTGTGTCCCTACTTCCTAGCCCCAACCAAGCTTTACCCACACCC

AACTCCCCGCCCTTCTTGGTATTTCTAGCCTATGAATTTGGTTGCTTTAT

TTTGGATCAGAGTGATGAGATTAAGGGGAGGCTGGGCGCGGTAGCTCA

CACCTTATAATCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCC

CGGCCAGCAACTAATATTCTAATTGAACTAAAGCACAGGATGCCAATTT

ACAATCCTTAGACCAAAGAGTCACTGATGTCTCCACCAGATAAGAGGA

AAGCATCAGGCTAGGCATAGTGGCTCACACCTGTAATCTCAGCACTTTG

GGAGGCTGAGGCAGGCAGATCACATGAGCCCAGGAGTTTGAGACTGGC

CTGGGCAACATGGTGAAACCCTGTCTCTAAAATAAAAACTAAACTAAA

AAAACTTTTTAAAAAGGCAGTGGGGAGCATCAGAACCAGCTCAACAGT

TTGTCTACTGTCCGGTCCCAGAGAAACTCAAGATTCTAGCAAGCCCCTT

GTGTGGGGCTTGGGTTGGGACATGAGGCTGCTGCTGGAGCTTACTCTGC

AACTGTTTCTCCAAATGCCAGGTATATGAAGACCTGAGGTATAAGCTCT

CGCTAGAGTTCCCCAGTGGCTACCCTTACAATGCGCCCACAGTGAAGTT

CCTCACGCCCTGCTATCACCCCAACGTGGACACCCAGGGTAACATATGC

CTGGACATCCTGAAGGAAAAGTGGTCTGCCCTGTATGATGTCAGGACCA

TTCTGCTCTCCATCCAGAGCCTTCTAGGAGAACCCAACATTGATAGTCC

CTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACAGCTTTTAAG

AAGTACCTGCAAGAAACCTACTCAAAGCAGGTCACCAGCCAGGAGCCC

TGACCCAGGCTGCCCAGCCTGTCCTTGTGTCGTCTTTTTAATTTTTCCTT

AGATGGTCTGTCCTTTTTGTGATTTCTGTATAGGACTCTTTATCTTGAGC

TGTGGTATTTTTGTTTTGTTTTTGTCTTTTAAATTAAGCCTCGGTTGAGCC

CTTGTATATTAAATAAATGCATTTTTGTCCTTTTTTAAAAAAAAAATAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

[52] The NAN046 gene expression assay, as described herein, is able to identify intrinsic subtype from standard formalin fixed paraffin embedded tumor tissue (also see, Parker et al. J. Clin Oncol, 27(8): 1 160-7 (2009) and U.S. Patent Application Publication No. 2013/0337444 The methods utilize a supervised algorithm to classify subject samples according to breast cancer intrinsic subtype. This algorithm, referred to herein as the "NAN046 classification model", is based on the gene expression profile of a defined subset of intrinsic genes that has been identified herein as superior for classifying breast cancer intrinsic subtypes; see, U.S. Patent Application Publication No. 2013/0337444. In particular, expression of 46 of the genes listed in Table 1 is determined (which is by determining the expression of all 50 genes in Table 1 with the exception of determining the expression of MYBL2, BIRC5, GRB7 and CCNB1), i.e., the "NAN046" set of genes. The skilled artisan can utilize any primer and/or target sequence- specific probe for detecting any of (or each of) the genes in Table 1.

[53] At least 10, at least 15, at least 20, at least 25, at least 40, at least 41 , at least 42, at least 43, at least 44, at least 46, at least 47, at least 48, at least 49 or all 50 of the genes in Table 1 can be utilized in the methods and kits of the present invention. Preferably, the expression of each of the 50 genes is determined in a biological sample. More preferably, the expression of each of the genes in the NAN046 set of genes is determined in a biological sample. The prototypical gene expression profiles (i.e., centroid) of the four intrinsic subtypes were pre-defined from a training set of formalin fixed paraffin embedded tissues (FFPE) breast tumor samples using hierarchical clustering analysis of gene expression data. Table 4 shows the actual values of the prototypical gene expression profiles (i.e., centroids) of these four subtypes and for a normal sample.

[54] Table 4. Subtype Centroids for Comparison to a Sample

[55] Table 4.

MDM2 -0.7498 -0.4855 -0.1788 0.2397 0.1097

MEL 1.0209 0.2678 -0.8016 0.1012 -1.6272

MIA 1.2408 -0.5475 0.3289 -0.6320 0.6975

MKI67 1.0446 0.4630 -0.6717 0.3161 -1.7680

MLPH -1.4150 0.4842 0.8829 0.8194 -0.2419

MMP11 -0.1295 0.5220 0.3402 0.5653 -1.7370

MYBL2 0.9571 0.5492 -0.7814 0.1548 -1.4404

MYC 0.5639 -0.9904 -0.3015 -0.2791 0.9833

NAT1 -0.971 1 -0.2708 1.2256 0.9576 -0.5287

ORC6L 1.0086 0.5152 -1.0385 -0.0336 -1.4084

PGR -0.9216 -0.5755 1.2061 0.9278 0.6220

PHGDH 0.9192 0.0322 -0.5194 -0.5371 0.5184

PTTG1 0.9541 0.2079 -1.1207 0.1052 -1.4067

RRM2 0.7895 0.6336 -0.8099 0.3228 -1.7630

SFRPl 0.7694 -0.8271 0.2617 -1.0846 1.3790

SLC39A6 -0.9992 -0.4573 0.6607 0.9222 -0.2463

TMEM45B -1.0721 0.7926 0.3190 0.2016 -0.2250

TYMS 0.9823 -0.0960 -0.8593 0.1827 -1.3192

UBE2C 0.8294 0.3358 -1.0141 0.0608 -1.7637

UBE2T 0.6258 0.0617 -0.8652 -0.0487 -1.8602

[56] Figure 7 outlines the assay processes associated with the Breast Cancer Intrinsic Subtyping test. Following RNA isolation, the test will simultaneously measure the expression levels of at least 40 target genes (e.g., 46 or 50) plus eight housekeeping genes. For example, the housekeeping genes described in U.S. Patent Publication 2008/0032293 can be used for normalization. Exemplary housekeeping genes include MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLP0, and TFRC. The housekeeping genes are used to normalize the expression of the tumor sample. Each assay run may also include a reference sample consisting of in vitro transcribed RNA's of the target genes and the housekeeping genes for normalization purposes.

[57] After performing the Breast Cancer Intrinsic Subtyping test with a test breast cancer tumor sample and the reference sample provided as part of a test kit or as used in a method, a computational algorithm based on a Pearson's correlation compares the normalized and scaled gene expression profile of the at least 40 genes or the PAM50 or NAN046 intrinsic gene sets of the test sample to the prototypical expression signatures of the four breast cancer intrinsic subtypes. See, U.S. Patent Application Publication Nos. 2011/0145176 and 2013/0337444. In embodiments, the intrinsic subtype analysis is determined by determining the expression of a PAM50 or NAN046 sets of genes and the risk of recurrence ("ROR") is determined using the NAN046 set of genes (which is determining the expression of all 50 genes in Table 1 with the exception of determining the expression of MYBL2, BIRC5, GRB7 and CCNB1). Specifically, the intrinsic subtype is identified by comparing the expression of the at least 40 genes or the PAM50 or NAN046 set of genes in the biological sample with the expected expression profiles for the four intrinsic subtypes. The subtype with the most similar expression profile is assigned to the biological sample. The ROR score is an integer value on a 0-100 scale that is related to an individual patient's probability of distant recurrence within 10 years for the defined intended use population. The ROR score is calculated by comparing the expression profiles of the at least 40 genes, e.g., the NAN046 genes, in the biological sample with the expected profiles for the four intrinsic subtypes, as described above, to calculate four different correlation values. These correlation values may then be combined with a proliferation score (and optionally one or more clinicopathological variables, such as tumor size) to calculate the ROR score. Preferably, the ROR score is calculated by comparing only the expression profiles of the NAN046 genes.

[58] A ROR score can be calculated using any method or formula known in the art.

Exemplary formulae include Equations 1 to 6, as described herein.

[59] Figure 8 provides a schematic of specific algorithm transformations. The tumor sample is assigned the subtype with the largest positive correlation to the sample. Kaplan Meier survival curves are generated from a training set of untreated breast cancer patients demonstrate that the intrinsic subtypes are a prognostic indicator of recurrence free survival (RFS).

[60] The training set of formalin fixed paraffin embedded tissues (FFPE) breast tumor samples, which had well defined clinical characteristics and clinical outcome data, were used to establish a continuous Risk of Recurrence (ROR) score. The score is calculated using coefficients from a Cox model that includes correlation to each intrinsic subtype, a proliferation score (mean gene expression of a subset of 18 of the 46 genes), and tumor size. See, Table 5.

[61] Table 5.

Luminal A Pearson's correlation (C) - 0.3172

Luminal B Pearson's correlation (D) 0.4894

Proliferation Score (E) 0.1981

Tumor Size (F) 0.1133

[62] The test variables in Table 5 are multiplied by the corresponding coefficients and summed to produce a risk score ("ROR-PT") as shown in the following equation (Equation 1):

[63] ROR-PT equation = -0.0067*A + 0.4317*B + -0.3172*C + 0.4894*D + 0.1981 *E + 0.1133*F.

[64] In previous studies, the ROR score provided a continuous estimate of the risk of recurrence for ER-positive, node -negative patients who were treated with tamoxifen for 5 years (Nielsen et al. Clin. Cancer Res., 16(21):5222-5232 (2009)). The ROR score also exhibited a statistically significant improvement over a clinical model based in determining relapse-free survival (RFS) within this test population providing further evidence of the improved accuracy of this decision making tool when compared to traditional clinicopathological measures (Nielsen et al. Clin. Cancer Res ., 16(21):5222-5232 (2009)). As used herein, the definition of relapse-free survival is "the length of time after primary treatment for a cancer ends that the patient survives without any signs or symptoms of that cancer. In a clinical trial, measuring the relapse-free survival is one way to see how well a new treatment works."

[65] The ROR score is an integer value on a 0-100 scale that is related to an individual patient's probability of distant recurrence within 10 years for the defined intended use population. The ROR score is calculated by comparing the expression profiles of 46 genes in an unknown sample with the expected profiles for the four intrinsic subtypes, as described above, to calculate four different correlation values. These correlation values are then combined with a proliferation score and the tumor size to calculate the ROR score. Risk classification is also provided to allow interpretation of the ROR score by using cutoffs related to clinical outcome in tested patient populations. See, Table 6.

[66] Table 6. Risk classification by ROR range and nodal status

Node-Negative 41 -60 Intermediate

61 -100 High

0-15 Low

Node-Positive (1 -3 nodes) 16-40 Intermediate

41 -100 High

[67] The gene set contains many genes that are known markers for proliferation. The methods of the present invention provide for the determination of subsets of genes that provide a proliferation signature. The methods of the present invention can include determining the expression of at least one proliferation gene. Preferably, the at least one proliferation gene is least 1 , at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, at least 20, or at least 21 genes listed in Table 1 or Table 2.

[68] The methods of the present invention can include determining the expression of at least one of, a combination of, or each of, a 21 -gene subset of the intrinsic genes selected from ANLN, BIRC5, CCNB1, CCNE1 , CDC20, CDC6, CDCA1, CENPF, CEP55, EXOl , KIF2C, KNTC2, MELK, MKI67, MYBL2, ORC6L, PTTG1, RRM2, TYMS, UBE2C and/or UBE2T. The methods of the present invention can include determining the expression of at least one of, a combination of, or each of, a 19-gene subset of the intrinsic genes selected from ANLN, CCNB1, CCNE1 , CDC20, CDC6, CDCA1 , CENPF, CEP55, EXOl , KIF2C, KNTC2, MELK, MKI67, ORC6L, PTTG1, RRM2, TYMS, UBE2C and/or UBE2T. The methods of the present invention can include determining the expression of at least one of, a combination of, or each of, a 18-gene subset of the intrinsic genes selected from ANLN, CCNE1 , CDC20, CDC6, CDCA1, CENPF, CEP55, EXOl, KIF2C, KNTC2, MELK, MKI67, ORC6L, PTTG1, RRM2, TYMS, UBE2C and/or UBE2T. The methods of the present invention can include determining the expression of at least one of, a combination of, or each of, a 11 -gene subset of the intrinsic genes selected from BIRC5, CCNB1, CDC20, CDCA1/NUF2, CEP55, KNTC2/NDC80, MKI67, PTTG1 , RRM2, TYMS and/or UBE2C. The methods of the present invention can include determining the expression of at least one of, a combination of, or each of, a 10-gene subset of the intrinsic genes selected from ANLN, CCNB1 , CDC20, CENPF, CEP55, KIF2C, MKI67, MYBL2, RRM2 and/or UBE2C. [69] Methods of determining a proliferation signature from a biological sample are as described in Nielsen et al. Clin. Cancer Res., 16(21):5222-5232 (2009) and supplemental online material and in Bastien et al. BMC Medical Genomics, 5:44 (2012) (published online) and supplemental online material (these documents are incorporated herein, by reference, in their entireties).

[70] The present invention provides methods for determining a proliferation signature (also referred to as proliferation score or p-score, these terms are utilized interchangeably herein) of a breast cancer sample from a subject. The expression of one or more of the genes listed in Table 1 may be determined using methods known in the art and described herein, and normalized to control housekeeping genes (i.e., MRPL19, PSMC4, SF3A1, PUM1, ACTB, GAPD, GUSB, RPLPO, and TFRC). Preferably, the one or more genes from Table 1 are a subset of genes known for proliferation {e.g., cell cycle regulated genes see Bastien et al., BMC Medical Genomics 5:44-, 2012), as described herein. Optionally, the gene expression can be also normalized to a control sample by determining the ratio of each gene between the sample and a control sample. While any control sample known in the art may be utilized, one exemplary control sample comprises in vitro transcribed RNA sequences of each gene at a known concentration. The mean of all the log ratios or normalized values of each proliferation gene can be calculated to determine the average proliferation gene expression of the sample. The proliferation signature can be determined by scaling the calculated average gene expression to a range of, for example 1 -10, wherein the scaling is determined by a reference sample set. The lowest value of the proliferation signature corresponds to the lowest proliferation signature in the reference sample set, and the highest value of the proliferation signature corresponds to the highest proliferation signature, and the proliferation signature of a sample can be determined through linear interpolation between the highest and lowest values of the reference sample set.

[71] The reference sample set is a population of breast cancer samples wherein the proliferation signature of each sample has been determined as described supra. The reference sample set must be of sufficient size such that the set can be used to assess various clinical variables, for example response to treatment regimen, estrogen receptor status, and tumor size and the like, with statistical significance. In some embodiments, the reference sample set comprises primary breast cancer tissue from subjects diagnosed with breast cancer and "normal" breast tissue samples from reduction mammoplasties or non-cancerous breast tissue. These samples can be classified to particular breast cancer intrinsic subtypes, for example Luminal A, Luminal B, Basal-like and Her2 using the PAM50 or NAN046 classification models described herein. For example, the reference sample set contains at least 100 samples, at least 200 samples, at least 300 samples, at least 400 samples, at least 500 samples, at least 600 samples, at least 700 samples, at least 800 samples, at least 900 samples, or at least 1000 samples.

Preferably, the reference sample set contains at least 500 samples.

[72] The proliferation signatures of each reference sample in the reference sample set can be arranged from lowest to highest, for example 1 to 10. Once arranged by proliferation signature, the reference sample set can then be divided into sub-ranges, wherein each sub-range is a non- overlapping fraction of the reference set. The proliferation signature of the sample can be compared to reference sample set. These sub-ranges are used to determine the cutoff threshold limits for a low proliferation signature. For example, the sub-range can be 50%, 33%, 30%, 25%, 20%, 15%, 10%, or 5% of the proliferation signatures of the arranged reference sample set. Irrespective of the number of sub-ranges, the proliferation signature of the sample is deemed to be a low proliferation signature if it is present within the lowest sub-range of the reference sample set. For example, if the reference sample set is divided into three sub-ranges, the classification of a low proliferation signature is assigned if the proliferation signature of the sample is present within the lowest 33% of proliferation scores of the arranged reference sample set.

[73] Breast Cancer

[74] Subjects with breast cancer tumors that fit in the non-Basal-like subtype, classified by gene expression analysis, were surprisingly found to have a significantly decreased rate of local recurrence and significantly increased rate of breast cancer specific survival and overall survival when treated with a breast cancer treatment that included a taxane or taxane derivative {See, the Example and Figures 1 to 6).

[75] Classifying breast cancer tumors by intrinsic subtype and treating patients with a taxane or taxane derivative only when this treatment provides increased therapeutic efficacy to offset the added cost and side effects can improve the clinical outcome and quality of life of thousands of patients.

[76] For the purposes of the present disclosure, "breast cancer" includes, for example, those conditions classified by biopsy or histology as malignant pathology. The clinical delineation of breast cancer diagnoses is well known in the medical arts. One of skill in the art will appreciate that breast cancer refers to any malignancy of the breast tissue, including, for example, carcinomas and sarcomas. Particular embodiments of breast cancer include ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS), or mucinous carcinoma. Breast cancer also refers to infiltrating ductal carcinoma (IDC), lobular neoplasia or infiltrating lobular carcinoma (ILC). In most embodiments of the disclosure, the subject of interest is a human patient suspected of or actually diagnosed with breast cancer.

[77] Breast cancer includes all forms of cancer of the breast. Breast cancer can include primary epithelial breast cancers. Breast cancer can include cancers in which the breast is involved by other tumors such as lymphoma, sarcoma or melanoma. Breast cancer can include carcinoma of the breast, ductal carcinoma of the breast, lobular carcinoma of the breast, undifferentiated carcinoma of the breast, cystosarcoma phyllodes of the breast, angiosarcoma of the breast, and primary lymphoma of the breast. Breast cancer can include Stage I, II, IIIA, IIIB, IIIC and IV breast cancer. Ductal carcinoma of the breast can include invasive carcinoma, invasive carcinoma in situ with predominant intraductal component, inflammatory breast cancer, and a ductal carcinoma of the breast with a histologic type selected from the group consisting of comedo, mucinous (colloid), medullary, medullary with lymphcytic infiltrate, papillary, scirrhous, and tubular. Lobular carcinoma of the breast can include invasive lobular carcinoma with predominant in situ component, invasive lobular carcinoma, and infiltrating lobular carcinoma. Breast cancer can include Paget's disease, Paget's disease with intraductal carcinoma, and Paget's disease with invasive ductal carcinoma. Breast cancer can include breast neoplasms having histologic and ultrastructual heterogeneity (e.g., mixed cell types).

[78] A breast cancer that is to be treated can include familial breast cancer. A breast cancer that is to be treated can include sporadic breast cancer. A breast cancer that is to be treated can arise in a male subject. A breast cancer that is to be treated can arise in a female subject. A breast cancer that is to be treated can arise in a premenopausal female subject or a

postmenopausal female subject. A breast cancer that is to be treated can be in a pre-mastectomy female subject or a post-mastectomy female patient.

[79] A breast cancer that is to be treated can include a localized tumor of the breast. A breast cancer that is to be treated can include a tumor of the breast that is associated with a negative sentinel lymph node (SLN) biopsy. A breast cancer that is to be treated can include a tumor of the breast that is associated with a positive sentinel lymph node (SLN) biopsy. A breast cancer that is to be treated can include a tumor of the breast that is associated with one or more positive axillary lymph nodes, where the axillary lymph nodes have been staged by any applicable method. A breast cancer that is to be treated can include a tumor of the breast that has been typed as having nodal negative status (e.g., node-negative) or nodal positive status (e.g., node- positive). A breast cancer that is to be treated can include a tumor of the breast that has been typed as being hormone receptor negative (e.g., estrogen receptor-negative) or hormone receptor positive status (e.g., estrogen receptor-positive). A breast cancer that is to be treated can include a tumor of the breast that has metastasized to other locations in the body. A breast cancer that is to be treated can be classified as having metastasized to a location selected from the group consisting of bone, lung, liver, lymph nodes, and brain. A breast cancer that is to be treated can be classified according to a characteristic selected from the group consisting of metastatic, localized, regional, local-regional, locally advanced, distant, multicentric, bilateral, ipsilateral, contralateral, newly diagnosed, recurrent, and inoperable.

[80] For the purposes of the present disclosure, "taxane or taxane derivatives" are diterpenes, a class of drugs used in cancer chemotherapy produced by the plants of the genus Taxus (yews). These drugs are used to treat a wide variety of cancers including breast cancer. However, this class of drugs is extremely toxic and produces significant deleterious side effects. Taxanes and taxane derivatives include paclitaxel (Taxol®) or docetaxel (Taxotere®).

[81] For the purposes of the present disclosure, "a breast cancer treatment comprising taxane or a taxane derivative" is a breast cancer treatment that includes a taxane or a taxane derivative. These treatments can also include other cancer or chemotherapeutic agents.

[82] By "prolong" is meant an increase in time relative to a reference, standard, or control condition. Time may be increased anywhere from 0.01% to 10,000%, e.g., 0.01 %, 0.05%, 0.1 %, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90%, 100%, 200%, 300%, 400%, 500%, 600%, 700%, 800%, 900%, 1 ,000%, 2,000%, 3,000%, 4,000%, 5,000%, 6,000%, 7,000%, 8,000%, 9,000%, and 10,000%.

[83] Preferably taxanes and taxane derivatives are administered intravenously, but can be administered by any method known in the art. Taxanes or taxane derivatives can be

administered at dosages from about 75 mg/m ² to about 300 mg/m ² , preferably from about 75

2 2 2

mg/m to about 175 mg/m , and most preferably about 100 mg/m . It is preferred that dosages be administered over a time period of about 1 to about 24 hours or weekly (5-7 days). Dosages can be repeated from 1 to about 4 weeks or more, preferably from about 2 to about 3 weeks.

Preferably, the dosage schedule is eight 1-week courses of paclitaxel administered via a 60- minute intravenous infusion. Methods, schedules and dosages for administering taxanes or taxane derivatives are described in Martin et al., J Natl Cancer Inst. 100(11):805-14, 2008, which is incorporated herein, by reference, in its entirety.

[84] Classes of anti-cancer or chemotherapeutic agents as secondary agents can include anthracycline agents, alkylating agents, nucleoside analogs, platinum agents, vinca agents, anti- estrogen drugs, aromatase inhibitors, ovarian suppression agents, endocrine/hormonal agents, bisphophonate therapy agents and targeted biological therapy agents.

[85] Specific anti-cancer or chemotherapeutic agents can include cyclophosphamide, fluorouracil (or 5-fluorouracil or 5-FU), methotrexate, thiotepa, carboplatin, cisplatin, anthracyclines, gemcitabine, paclitaxel, protein-bound paclitaxel, docetaxel, vinorelbine, tamoxifen, raloxifene, toremifene, fulvestrant, irinotecan, ixabepilone, temozolmide, topotecan, vincristine, vinblastine, eribulin, mutamycin, capecitabine, capecitabine, anastrozole,

exemestane, letrozole, leuprolide, abarelix, buserlin, goserelin, megestrol acetate, risedronate, pamidronate, ibandronate, alendronate, denosumab, zoledronate, trastuzumab, tykerb or bevacizumab, or combinations thereof; one such combination is CMF which includes

cyclophosphamide, methotrexate, and fluorouracil.

[86] Description of Intrinsic Subtype Biology

[87] Luminal subtypes: The most common subtypes of breast cancer are the luminal subtypes, Luminal A and Luminal B. Prior studies suggest that Luminal A comprises approximately 30% to 40% and Luminal B approximately 20% of all breast cancers, but they represent over 90 % of hormone receptor positive breast cancers (Nielsen et al. Clin. Cancer Res., 16(21):5222-5232 (2009)). The gene expression pattern of these subtypes resembles the luminal epithelial component of the breast. These tumors are characterized by high expression of estrogen receptor (ER), progesterone receptor (PR), and genes associated with ER activation, such as LIV1, GATA3, and cyclin Dl, as well as expression of luminal cytokeratins 8 and 18 (Lisa Carey & Charles Perou (2009). "Gene Arrays, Prognosis, and Therapeutic Interventions". Jay R. Harris et al. (4th ed.), "Diseases of the breast" (pp. 458-472). Philadelphia, PA: Lippincott Williams & Wilkins). [88] Luminal A: Luminal A (LumA) breast cancers exhibit low expression of genes associated with cell cycle activation and the ERBB2 cluster resulting in a better prognosis than Luminal B. The Luminal A subgroup has the most favorable prognosis of all subtypes and is enriched for endocrine therapy-responsive tumors.

[89] Luminal B: Luminal B (LumB) breast cancers also express ER and ER-associated genes. Genes associated with cell cycle activation are highly expressed and this tumor type can be HER2(+) (-20%) or HER2(-). The prognosis is unfavorable (despite ER expression) and endocrine therapy responsiveness is generally diminished relative to LumA.

[90] HER2 -enriched: The HER2-enriched subtype is generally ER-negative and is HER2- positive in the majority of cases with high expression of the ERBB2 cluster, including ERBB2 and GRB7. Genes associated with cell cycle activation are highly expressed and these tumors have a poor outcome.

[91] Basal-like: The Basal-like subtype is generally ER-negative, is almost always clinically HER2 -negative and expresses a suite of "Basal" biomarkers including the basal epithelial cytokeratins (CK) and epidermal growth factor receptor (EGFR). Genes associated with cell cycle activation are highly expressed.

[92] Clinical variables

[93] The methods described herein, e.g., the PAM50 or AN046 classification models, may be further combined with information on clinical variables (also referred to herein as

"clinicopathological variables") to generate a continuous risk of recurrence (ROR) predictor. As described herein, a number of clinical and prognostic breast cancer factors are known in the art and are used to predict treatment outcome and the likelihood of disease recurrence. Such factors include, for example, lymph node involvement, tumor size, histologic grade, estrogen and progesterone hormone receptor status, HER2 levels, and tumor ploidy. In one embodiment, risk of recurrence (ROR) score is provided for a subject diagnosed with or suspected of having breast cancer. This score uses an above-described classification model, e.g., the PAM50 or NAN046 classification models, in combination with clinical factors of lymph node status (N) and tumor size Γ). Assessment of clinical variables is based on the American Joint Committee on Cancer (AJCC) standardized system for breast cancer staging. In this system, primary tumor size is categorized on a scale of 0-4 (TO: no evidence of primary tumor; Tl: < 2 cm; T2: > 2 cm to < 5 cm; T3: > 5 cm; T4: tumor of any size with direct spread to chest wall or skin). Lymph node status is classified as N0-N3 (NO: regional lymph nodes are free of metastasis; Nl : metastasis to movable, same-side axillary lymph node(s); N2: metastasis to same-side lymph node(s) fixed to one another or to other structures; N3: metastasis to same-side lymph nodes beneath the breastbone). Methods of identifying breast cancer patients and staging the disease are well known and may include manual examination, biopsy, review of patient's and/or family history, and imaging techniques, such as mammography, magnetic resonance imaging (MRI), and positron emission tomography (PET).

[94] Sample Source

[95] In one embodiment of the present disclosure, breast cancer subtype is assessed through the evaluation of expression patterns, or profiles, of the intrinsic genes listed in Table 1 in one or more subject samples and/or fluorescence in situ hybridization (FISH) analysis or

immunohistochemistry (IHC) performed to ascertain the ER, PgR and/or HER2 status of the cancer. As used herein, the term "subject" or "subject sample" refers to an individual regardless of health and/or disease status. A subject can be a subject, a study participant, a control subject, a screening subject, or any other class of individual from whom a sample is obtained and assessed in the context of the disclosure. Accordingly, a subject can be diagnosed with breast cancer, can present with one or more symptoms of breast cancer, or a predisposing factor, such as a family (genetic) or medical history (medical) factor, for breast cancer, can be undergoing treatment or therapy for breast cancer, or the like. As such, the subject is a subject in need of treatment for breast cancer, detection of breast cancer, classification of a cancer, screening of likelihood of effectiveness of a treatment, and prediction of local-regional relapse free or breast cancer specific survival in response to a treatment. Alternatively, a subject can be healthy with respect to any of the aforementioned factors or criteria. It will be appreciated that the term "healthy" as used herein, is relative to breast cancer status, as the term "healthy" cannot be defined to correspond to any absolute evaluation or status. Thus, an individual defined as healthy with reference to any specified disease or disease criterion, can in fact be diagnosed with any other one or more diseases, or exhibit any other one or more disease criterion, including one or more cancers other than breast cancer. However, the healthy controls are preferably free of any cancer. As used herein, the definition of effectiveness is "the ability of an intervention (for example, a drug or surgery) to produce the desired beneficial effect." [96] As used herein, a "subject in need thereof is a subject having breast cancer or presenting with one or more symptoms of breast cancer, or a subject having an increased risk of developing breast cancer relative to the population at large. Preferably, a subject in need thereof has breast cancer. The breast cancer can be primary breast cancer, locally advanced breast cancer or metastatic breast cancer. A "subject" includes a mammal. The mammal can be any mammal, e.g., a human, a primate, a bird, a mouse, a rat, a fowl, a dog, a cat, a cow, a horse, a goat, a camel, a sheep and a pig. Preferably, the mammal is a human. The subject can be a male or a female.

[97] In particular embodiments, the methods and kits for predicting breast cancer intrinsic subtypes, or ER, PgR and/or HER2 status (e.g., for predicting local-regional relapse free or breast cancer specific survival in a subject, for predicting the likelihood of the effectiveness of a breast cancer treatment including a taxane or taxane derivative, and for treating breast cancer in a subject with a taxane or taxane derivative) include collecting a biological sample comprising a cancer cell or tissue, such as a breast tissue sample or a primary breast tumor tissue sample. By "biological sample" is intended any sampling of cells, tissues, or bodily fluids in which expression of an intrinsic gene can be detected. Examples of such biological samples include, but are not limited to, biopsies and smears. Bodily fluids useful in the present disclosure include blood, lymph, urine, saliva, nipple aspirates, gynecological fluids, or any other bodily secretion or derivative thereof. Blood can include whole blood, plasma, serum, or any derivative of blood. In some embodiments, the biological sample includes breast cells, particularly breast tissue from a biopsy, such as a breast tumor tissue sample. Biological samples may be obtained from a subject by a variety of techniques including, for example, by scraping or swabbing an area, by using a needle to aspirate cells or bodily fluids, or by removing a tissue sample (i.e., biopsy). Methods for collecting various biological samples are well known in the art. In some embodiments, a breast tissue sample is obtained by, for example, fine needle aspiration biopsy, core needle biopsy, or excisional biopsy. Fixative and staining solutions may be applied to the cells or tissues for preserving the specimen and for facilitating examination. Biological samples, particularly breast tissue samples, may be transferred to a glass slide for viewing under magnification. In one embodiment, the biological sample is a formalin fixed paraffin embedded (FFPE) breast tissue sample, particularly a primary breast tumor sample. In various

embodiments, the tissue sample is obtained from a pathologist-guided tissue core sample. [98] Expression Profiling

[99] In various embodiments, the present disclosure provides methods for classifying, prognosticating, or monitoring breast cancer in subjects. In this embodiment, data obtained from analysis of intrinsic gene expression is evaluated using one or more pattern recognition algorithms. See, as examples, U.S. Patent Application Publication Nos. 201 1/0145176 and 2013/0337444. Such analysis methods may be used to form a predictive model, which can be used to classify test data. For example, one convenient and particularly effective method of classification employs multivariate statistical analysis modeling, first to form a model (a "predictive mathematical model") using data ("modeling data") from samples of known subtype (e.g., from subjects known to have a particular breast cancer intrinsic subtype: LumA, LumB, Basal-like, HER2 -enriched, or normal-like), and second to classify an unknown sample (e.g., "test sample") according to subtype. Pattern recognition methods have been used widely to characterize many different types of problems ranging, for example, over linguistics, fingerprinting, chemistry and psychology. In the context of the methods described herein, pattern recognition is the use of multivariate statistics, both parametric and non-parametric, to analyze data, and hence to classify samples and to predict the value of some dependent variable based on a range of observed measurements. There are two main approaches. One set of methods is termed "unsupervised" and these simply reduce data complexity in a rational way and also produce display plots which can be interpreted by the human eye. However, this type of approach may not be suitable for developing a clinical assay that can be used to classify samples derived from subjects independent of the initial sample population used to train the prediction algorithm.

[100] The other approach is termed "supervised" whereby a training set of samples with known class or outcome is used to produce a mathematical model which is then evaluated with independent validation data sets. Here, a "training set" of intrinsic gene expression data is used to construct a statistical model that predicts correctly the "subtype" of each sample. This training set is then tested with independent data (referred to as a test or validation set) to determine the robustness of the computer-based model. These models are sometimes termed "expert systems," but may be based on a range of different mathematical procedures. Supervised methods can use a data set with reduced dimensionality (for example, the first few principal components), but typically use unreduced data, with all dimensionality. In all cases the methods allow the quantitative description of the multivariate boundaries that characterize and separate each subtype in terms of its intrinsic gene expression profile. It is also possible to obtain confidence limits on any predictions, for example, a level of probability to be placed on the goodness of fit. The robustness of the predictive models can also be checked using cross-validation, by leaving out selected samples from the analysis.

[101] The PAM50 or NAN046 classification models described herein (and as described in U.S. Patent Application Publication Nos. 2011/0145176 and 2013/0337444) is based on the gene expression profile for a plurality of subject samples using the 50 or 46, respectively, intrinsic genes listed in Table 1. The plurality of samples includes a sufficient number of samples derived from subjects belonging to each subtype class. By "sufficient samples" or "representative number" in this context is intended a quantity of samples derived from each subtype that is sufficient for building a classification model that can reliably distinguish each subtype from all others in the group. A supervised prediction algorithm is developed based on the profiles of objectively-selected prototype samples for "training" the algorithm. The samples are selected and subtyped using an expanded intrinsic gene set according to the methods disclosed in International Patent Publication WO 2007/061876 and U.S. Patent Publication No.

2009/0299640. Alternatively, the samples can be subtyped according to any known assay for classifying breast cancer subtypes. After stratifying the training samples according to subtype, a centroid-based prediction algorithm is used to construct centroids based on the expression profile of all or some of the intrinsic gene set described in Table 1.

[102] In one embodiment, the prediction algorithm is the nearest centroid methodology related to that described in Narashiman and Chu (2002) PNAS 99:6567-6572. In the present disclosure, the method computes a standardized centroid for each subtype. This centroid is the average gene expression for each gene in each subtype (or "class") divided by the within-class standard deviation for that gene. Nearest centroid classification takes the gene expression profile of a new sample, and compares it to each of these class centroids. Subtype prediction is done by calculating the Spearman's rank correlation of each test case to the five centroids, and assigning a sample to a subtype based on the nearest centroid.

[103] Detection of intrinsic gene expression

[104] Any methods available in the art for detecting expression of the intrinsic genes listed in Table 1 are encompassed herein. By "detecting expression" is intended determining the quantity or presence of an RNA transcript or its expression product of an intrinsic gene. Methods for detecting expression of the intrinsic genes of the disclosure, that is, gene expression profiling, include methods based on hybridization analysis of polynucleotides, methods based on sequencing of polynucleotides, immunohistochemistry methods, and proteomics-based methods. The methods generally detect expression products (e.g., mRNA) of the intrinsic genes listed in Table 1. In preferred embodiments, PCR-based methods, such as reverse transcription PCR (RT-PCR) (Weis et al, TIG 8:263- 64, 1992), and array-based methods such as microarray (Schena et al, Science 270:467- 70, 1995) are used. By "microarray" is intended an ordered arrangement of hybridizable array elements, such as, for example, polynucleotide probes, on a substrate. The term "probe" refers to any molecule that is capable of selectively binding to a specifically intended target biomolecule, for example, a nucleotide transcript or a protein encoded by or corresponding to an intrinsic gene. Probes can be synthesized by one of skill in the art, or derived from appropriate biological preparations. Probes may be specifically designed to be labeled. Examples of molecules that can be utilized as probes include, but are not limited to, RNA, DNA, proteins, antibodies, and organic molecules.

[105] Many expression detection methods use isolated RNA. The starting material is typically total RNA isolated from a biological sample, such as a tumor or tumor cell line, and

corresponding normal tissue or cell line, respectively. If the source of RNA is a primary tumor, RNA {e.g., mRNA) can be extracted, for example, from frozen or archived paraffin-embedded and fixed (e.g., formalin-fixed) tissue samples (e.g., pathologist-guided tissue core samples).

[106] General methods for RNA extraction are well known in the art and are disclosed in standard textbooks of molecular biology, including Ausubel et al, ed., "Current Protocols in Molecular Biology", John Wiley & Sons, New York 1987-1999. Methods for RNA extraction from paraffin embedded tissues are disclosed, for example, in Rupp and Locker, Lab Invest. 56:A67, (1987); and De Andres et al. Biotechniques 18:42-44, (1995). In particular, RNA isolation can be performed using a purification kit, a buffer set and protease from commercial manufacturers, such as Qiagen (Valencia, CA), according to the manufacturer's instructions. For example, total RNA from cells in culture can be isolated using Qiagen RNeasy mini-columns. Other commercially available RNA isolation kits include Masterpure™ Complete DNA and RNA Purification Kit (Epicentre®, Madison, WI.) and Paraffin Block RNA Isolation Kit (Ambion®, Austin, TX). Total RNA from tissue samples can be isolated, for example, using RNA Stat-60 (Tel-Test, Friendswood, TX). RNA prepared from a tumor can be isolated, for example, by cesium chloride density gradient centrifugation. Additionally, large numbers of tissue samples can readily be processed using techniques well known to those of skill in the art, such as, for example, the single-step RNA isolation process of Chomczynski (U.S. Pat. No. 4,843,155).

[107] Isolated RNA can be used in hybridization or amplification assays that include, but are not limited to, PCR analyses and probe arrays. One method for the detection of RNA levels involves contacting the isolated RNA with a nucleic acid molecule (probe) that can hybridize to the mRNA encoded by the gene being detected. The nucleic acid probe can be, for example, a full-length cDNA, or a portion thereof, such as an oligonucleotide of at least 7, 15, 30, 60, 100, 250, or 500 nucleotides in length and sufficient to specifically hybridize under stringent conditions to an intrinsic gene of the present disclosure, or any derivative DNA or RNA.

Hybridization of an mRNA with the probe indicates that the intrinsic gene in question is being expressed. The term "stringent conditions" is as well-known in the art and as described, at least, in books, publications and patent documents listed herein.

[108] In one embodiment, the mRNA is immobilized on a solid surface and contacted with a probe, for example by running the isolated mRNA on an agarose gel and transferring the mRNA from the gel to a membrane, such as nitrocellulose. In an alternative embodiment, the probes are immobilized on a solid surface and the mRNA is contacted with the probes, for example, in an Agilent (Santa Clara, CA) gene chip array. A skilled artisan can readily adapt known mRNA detection methods for use in detecting the level of expression of the intrinsic genes of the present disclosure.

[109] An alternative method for determining the level of intrinsic gene expression product in a sample involves the process of nucleic acid amplification, for example, by RT-PCR (U.S. Pat. No. 4,683,202), ligase chain reaction (Barany, PNAS USA 88: 189-93, (1991)), self-sustained sequence replication (Guatelli et al., PNAS USA 87: 1874-78, (1990)), transcriptional amplification system (Kwoh et al., PNAS USA 86: 1 173-77, (1989)), Q-Beta Replicase (Lizardi et al, Bio/Technology 6:1197, (1988)), rolling circle replication (U.S. Pat. No. 5,854,033), or any other nucleic acid amplification method, followed by the detection of the amplified molecules using techniques well known to those of skill in the art. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers.

[110] In particular aspects of the disclosure, intrinsic gene expression can be assessed by quantitative RT-PCR. Numerous different PCR or quantitative real-time PCR (qPCR) protocols are known in the art and exemplified herein and can be directly applied or adapted for use using the presently-described methods and kits for the detection and/or quantification of the intrinsic genes listed in Table 1. Generally, in PCR, a target polynucleotide sequence is amplified by reaction with at least one oligonucleotide primer or a pair of oligonucleotide primers. The primer(s) hybridize to a complementary region of the target nucleic acid and a DNA polymerase extends the primer(s) to amplify the target sequence. Under conditions sufficient to provide polymerase-based nucleic acid amplification products, a nucleic acid fragment of one size dominates the reaction products (the target polynucleotide sequence which is the amplification product). The amplification cycle is repeated to increase the concentration of the single target polynucleotide sequence. The reaction can be performed in any thermocycler commonly used for PCR. However, preferred are cyclers with real time fluorescence measurement capabilities, for example, Smartcycler® (Cepheid, Sunnyvale, CA), ABI Prism 7700® (Applied

Biosystems®, Foster City, CA.), Rotor- Gene™ (Corbett Research, Sydney, Australia), Lightcycler® (Roche Diagnostics Corp, Indianapolis, IN.), iCycler® (Biorad Laboratories, Hercules, CA.) and MX4000® (Stratagene, La Jo 11a, CA.).

[Ill] In another embodiment of the disclosure, microarrays are used for expression profiling. Microarrays are particularly well suited for this purpose because of the reproducibility between different experiments. DNA microarrays provide one method for the simultaneous measurement of the expression levels of large numbers of genes. Each array consists of a reproducible pattern of capture probes attached to a solid support. Labeled RNA or DNA is hybridized to complementary probes on the array and then detected by laser scanning. Hybridization intensities for each probe on the array are determined and converted to a quantitative value representing relative gene expression levels. See, for example, U.S. Pat. Nos. 6,040,138, 5,800,992 and 6,020,135, 6,033,860, and 6,344,316. High-density oligonucleotide arrays are particularly useful for determining the gene expression profile for a large number of RNAs in a sample.

[112] In a preferred embodiment, the nCounter® Analysis System (NanoString Technologies, Seattle, WA) is used to detect intrinsic gene expression. The basis of the nCounter® Analysis System is the unique code assigned to each nucleic acid target to be assayed (International Patent Application Publication No. WO 08/124847, U.S. Patent No. 8,415,102 and Geiss et al. Nature Biotechnology. 2008. 26(3): 317-325). The code is composed of an ordered series of colored fluorescent spots which create a unique barcode for each target to be assayed. A pair of probes is designed for each DNA or RNA target, a biotinylated capture probe and a reporter probe carrying the fluorescent barcode. This system is also referred to, herein, as the nanoreporter code system.

[113] Specific reporter and capture probes are synthesized for each target. The reporter probe can comprise at a least a first label attachment region to which are attached one or more label monomers that emit light constituting a first signal; at least a second label attachment region, which is non-over-lapping with the first label attachment region, to which are attached one or more label monomers that emit light constituting a second signal; and a first target-specific sequence. Preferably, each sequence specific reporter probe comprises a target specific sequence capable of hybridizing to no more than one gene of Table 1 and optionally comprises at least three, or at least four label attachment regions, said attachment regions comprising one or more label monomers that emit light, constituting at least a third signal, or at least a fourth signal, respectively. The capture probe can comprise a second target-specific sequence; and a first affinity tag. In some embodiments, the capture probe can also comprise one or more label attachment regions. Preferably, the first target-specific sequence of the reporter probe and the second target-specific sequence of the capture probe hybridize to different regions of the same gene of Table 1 to be detected. Reporter and capture probes are all pooled into a single hybridization mixture, the "probe library". Preferably, the probe library comprises a probe pair (a capture probe and reporter) for each of the genes in Table 1. Preferably, the probe library comprises a probe pair (a capture probe and reporter) for each of the NAN046 genes as described above. Preferably, the probe library comprises a probe pair (a capture probe and reporter) for each of the housekeeping genes and other genes described herein, e.g., Her2.

[114] The relative abundance of each target is measured in a single multiplexed hybridization reaction. The method comprises contacting a biological sample with a probe library, the library comprising a probe pair for each of the at least 40 genes in Table 1 , e.g., each of the NAN046 or PAM50 genes, and/or the housekeeping genes and other genes described herein, such that the presence of each target in the sample creates a probe pair - target complex. The complex is then purified. More specifically, the sample is combined with the probe library, and hybridization occurs in solution. After hybridization, the tripartite hybridized complexes (probe pairs and target) are purified in a two-step procedure using magnetic beads linked to oligonucleotides complementary to universal sequences present on the capture and reporter probes. This dual purification process allows the hybridization reaction to be driven to completion with a large excess of target-specific probes, as they are ultimately removed, and, thus, do not interfere with binding and imaging of the sample. All post hybridization steps are handled robotically on a custom liquid-handling robot (Prep Station, Nano String Technologies).

[115] Purified reactions are deposited by the Prep Station into individual flow cells of a sample cartridge, bound to a streptavi din-coated surface via the capture probe, electrophoresed to elongate the reporter probes, and immobilized. After processing, the sample cartridge is transferred to a fully automated imaging and data collection device (Digital Analyzer,

NanoString Technologies). The expression level of a target is measured by imaging each sample and counting the number of times the code for that target is detected. For each sample, typically 600 fields-of-view (FOV) are imaged (1376 X 1024 pixels) representing approximately 10 mm of the binding surface. Typical imaging density is 100-1200 counted reporters per field of view depending on the degree of multiplexing, the amount of sample input, and overall target abundance. Data is output in simple spreadsheet format listing the number of counts per target, per sample.

[116] This system can be used along with nanoreporters. Additional disclosure regarding nanoreporters can be found in International Publication No. WO 07/076129 and WO 07/076132, and US Patent Publication No. 2010/0015607 and 2010/0261026. Further, the term nucleic acid probes and nanoreporters can include the rationally designed (e.g., synthetic sequences) described in International Publication No. WO 2010/019826 and US Patent Publication No.

2010/0047924.

[117] Data processing

[118] It is often useful to pre-process gene expression data, for example, by addressing missing data, translation, scaling, normalization, and weighting. Multivariate projection methods, such as principal component analysis (PCA) and partial least squares analysis (PLS), are so-called scaling sensitive methods. By using prior knowledge and experience about the type of data studied, the quality of the data prior to multivariate modeling can be enhanced by scaling and/or weighting. Adequate scaling and/or weighting can reveal important and interesting variation hidden within the data, and therefore make subsequent multivariate modeling more efficient. Scaling and weighting may be used to place the data in the correct metric, based on knowledge and experience of the studied system, and therefore reveal patterns already inherently present in the data.

[119] If possible, missing data, for example gaps in column values, should be avoided.

However, if necessary, such missing data may be replaced or "filled" with, for example, the mean value of a column ("mean fill"); a random value ("random fill"); or a value based on a principal component analysis ("principal component fill").

[120] "Translation" of the descriptor coordinate axes can be useful. Examples of such translation include normalization and mean centering. "Normalization" may be used to remove sample-to -sample variation. For microarray data, the process of normalization aims to remove systematic errors by balancing the fluorescence intensities of the two labeling dyes. The dye bias can come from various sources including differences in dye labeling efficiencies, heat and light sensitivities, as well as scanner settings for scanning two channels. Some commonly used methods for calculating normalization factor include: (i) global normalization that uses all genes on the array; (ii) housekeeping genes normalization that uses constantly expressed

housekeeping/invariant genes; and (iii) internal controls normalization that uses known amount of exogenous control genes added during hybridization (Quackenbush, Nat. Genet. 32 (Suppl.), 496-501 (2002)). In one embodiment, the intrinsic genes disclosed herein can be normalized to control housekeeping genes. For example, the housekeeping genes described in U.S. Patent Publication 2008/0032293 can be used for normalization. Exemplary housekeeping genes include MRPL19, PSMC4, SF3A1, PUMI, ACTB, GAPD, GUSB, RPLPO, and TFRC. It will be understood by one of skill in the art that the methods disclosed herein are not bound by normalization to any particular housekeeping genes, and that any suitable housekeeping gene(s) known in the art can be used.

[121] Many normalization approaches are possible, and they can often be applied at any of several points in the analysis. In one embodiment, microarray data is normalized using the LOWESS method, which is a global locally weighted scatterplot smoothing normalization function. In another embodiment, qPCR data is normalized to the geometric mean of set of multiple housekeeping genes. [122] "Mean centering" may also be used to simplify interpretation. Usually, for each descriptor, the average value of that descriptor for all samples is subtracted. In this way, the mean of a descriptor coincides with the origin, and all descriptors are "centered" at zero. In "unit variance scaling," data can be scaled to equal variance. Usually, the value of each descriptor is scaled by 1/StDev, where StDev is the standard deviation for that descriptor for all samples. "Pareto scaling" is, in some sense, intermediate between mean centering and unit variance scaling. In Pareto scaling, the value of each descriptor is scaled by l/sqrt(StDev), where StDev is the standard deviation for that descriptor for all samples. In this way, each descriptor has a variance numerically equal to its initial standard deviation. The Pareto scaling may be performed, for example, on raw data or mean centered data.

[123] "Logarithmic scaling" may be used to assist interpretation when data have a positive skew and/or when data spans a large range, e.g., several orders of magnitude. Usually, for each descriptor, the value is replaced by the logarithm of that value. In "equal range scaling," each descriptor is divided by the range of that descriptor for all samples. In this way, all descriptors have the same range, that is, 1. However, this method is sensitive to presence of outlier points. In "autoscaling," each data vector is mean centered and unit variance scaled. This technique is very useful because each descriptor is then weighted equally, and large and small values are treated with equal emphasis. This can be important for genes expressed at very low, but still detectable, levels.

[124] In one embodiment, data is collected for one or more test samples and classified using the at least 40 genes of Table 1 as described herein, e.g., the PAM50 or NAN046 classification models. When comparing data from multiple analyses (e.g., comparing expression profiles for one or more test samples to the centra ids constructed from samples collected and analyzed in an independent study), it will be necessary to normalize data across these data sets. In one embodiment, Distance Weighted Discrimination (DWD) is used to combine these data sets together (Benito et al. (2004) Bioinformatics 20(1): 105-114). DWD is a multivariate analysis tool that is able to identify systematic biases present in separate data sets and then make a global adjustment to compensate for these biases; in essence, each separate data set is a multidimensional cloud of data points, and DWD takes two points clouds and shifts one such that it more optimally overlaps the other.

[125] The methods described herein may be implemented and/or the results recorded using any device capable of implementing the methods and/or recording the results. Examples of devices that may be used include but are not limited to electronic computational devices, including computers of all types. When the methods described herein are implemented and/or recorded in a computer, the computer program that may be used to configure the computer to carry out the steps of the methods may be contained in any computer readable medium capable of containing the computer program. Examples of computer readable medium that may be used include but are not limited to diskettes, CD-ROMs, DVDs, ROM, RAM, non-transitory computer-readable media, and other memory and computer storage devices. The computer program that may be used to configure the computer to carry out the steps of the methods and/or record the results may also be provided over an electronic network, for example, over the internet, an intranet, or other network.

[126] Calculation of risk of recurrence

[127] Provided herein are methods for predicting breast cancer outcome within the context of the intrinsic subtype and optionally other clinical variables. Outcome may refer to overall or disease-specific survival, event- free survival, or outcome in response to a particular treatment or therapy. In particular, the methods may be used to predict the likelihood of long-term, disease- free survival. "Predicting the likelihood of survival of a breast cancer patient" is intended to assess the risk that a patient will die as a result of the underlying breast cancer. "Long-term, disease-free survival" is intended to mean that the patient does not die from or suffer a recurrence of the underlying breast cancer within a period of at least five years, or at least ten or more years, following initial diagnosis or treatment.

[128] In embodiments, outcome is predicted based on classification of a subject according to cancer subtype. This classification is based on expression profiling using the at least 40 intrinsic genes listed in Table 1. In addition to providing a subtype assignment, the at least 40 intrinsic genes listed in Table 1 , e.g., the PAM50 or AN046 genes, provide measurements of the similarity of a test sample to all four subtypes which is translated into a Risk of Recurrence (ROR) score that can be used in any patient population regardless of disease status and treatment options. The intrinsic subtypes and ROR also have value in the prediction of pathological complete response in women treated with, for example, neoadjuvant taxane and anthracycline chemotherapy (Rouzier et al., J Clin Oncol 23:8331-9 (2005)). Thus, in various embodiments of the present disclosure, a risk of recurrence (ROR) model is used to predict outcome. Using these risk models, subjects can be stratified into low, medium, and high risk of recurrence groups. Calculation of ROR can provide prognostic information to guide treatment decisions and/or monitor response to therapy.

[129] In some embodiments described herein, the prognostic performance of the intrinsic subtypes defied by expression profiles of the at least 40 genes listed in Table 1, e.g., the PAM50- or NAN046-defined intrinsic subtypes, and/or other clinical parameters is assessed utilizing a Cox Proportional Hazards Model Analysis, which is a regression method for survival data that provides an estimate of the hazard ratio and its confidence interval. The Cox model is a well- recognized statistical technique for exploring the relationship between the survival of a patient and particular variables. This statistical method permits estimation of the hazard (i.e., risk) of individuals given their prognostic variables (e.g., intrinsic gene expression profile with or without additional clinical factors, as described herein). The "hazard ratio" is the risk of death at any given time point for patients displaying particular prognostic variables. See generally Spruance et al., Antimicrob. Agents & Chemo. 48:2787-92 (2004).

[130] The classification models described herein, e.g., the PAM50 or AN046 classification models, can be trained for risk of recurrence using subtype distances (or correlations) alone, or using subtype distances with clinical variables as discussed supra. In one embodiment, the risk score for a test sample is calculated using intrinsic subtype distances alone using the following equation (Equation 2):

[131] ROR = 0.05*Basal + 0.1 1*HER2 + -0.25*LumA + 0.07*LumB + -0.1 l*Normal,

where the variables "Basal," "HER2," "LumA," "LumB," and "Normal" are the distances to the centroid for each respective classifier when the expression profile from a test sample is compared to centroids constructed using the gene expression data deposited with the National Center for Biotechnology Information Gene Expression Omnibus (GEO); as examples with accession number GSE2845 or GSE10886.

[132] Risk score can also be calculated using a combination of breast cancer subtype and the clinical variables tumor size (T) and lymph nodes status (N) using the following equation (Equation 3):

[133] ROR (full) = 0.05*Basal + 0.1 *HER2 + -0.19*LumA + 0.05*LumB + - 0.09*Normal + 0.16*T + 0.08*N,

where the variables "Basal," "HER2," "LumA," and "LumB" are as described supra and when comparing test expression profiles to centroids constructed using the gene expression data deposited with GEO; as examples with accession number GSE2845 or GSE10886.

[134] In yet another embodiment, risk score for a test sample is calculated using intrinsic subtype distances alone using the following equation (Equation 4):

[135] ROR-S = 0.05*Basal + 0.12*HER2 + -0.34*LumA + 0.0.23*LumB,

where the variables "Basal," "HER2," "LumA," and "LumB" are as described supra and the test expression profiles are compared to centroids constructed using the gene expression data deposited with GEO; as examples with accession number GSE2845 or GSE 10886.

[136] In yet another embodiment, risk score can also be calculated using a combination of breast cancer subtype and the clinical variable tumor size (T) using the following equation (Equation 5):

[137] ROR-C = 0.05*Basal + 0.1 1*HER2 + -0.23*LumA + 0.09*LumB + 0.17*T,

where the variables "Basal," "HER2," "LumA," and "LumB" are as described supra and the test expression profiles are compared to centroids constructed using the gene expression data deposited with GEO; as examples with accession number GSE2845 or GSE10886.

[138] In yet another embodiment, risk score for a test sample is calculated using intrinsic subtype distances in combination with the proliferation signature ("Prolif ') using the following equation (Equation 6):

[139] ROR-P = -0.001 *Basal + 0.7*HER2 + -0.95*LumA + 0.49*LumB + 0.34*Prolif,

where the variables "Basal," "HER2," "LumA," "LumB" and "Prolif are as described supra and the test expression profiles are compared to centroids constructed using the gene expression data deposited with GEO; as examples with accession number GSE2845 or

GSE10886.

[140] In yet another embodiment, risk score can also be calculated using a combination of breast cancer subtype, proliferation signature and the clinical variable tumor size (T) using the ROR-PT described in conjunction with Table 5.

[141] Detection of Subtypes

[142] Immunohistochemistry (IHC) for estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki67 can be performed concurrently on serial sections with the standard streptavidin- biotin complex method with 3,3'-diaminobenzidine as the chromogen. Staining for ER, PR, and HER2 interpretation can be performed as described previously (Cheang et ai, Clin Cancer Res. 2008; 14(5): 1368-1376.), however any method known in the art may be used.

[143] For example, a Ki67 antibody (clone SP6; ThermoScientific™, Fremont, CA) can be applied at a 1 :200 dilution for 32 minutes, by following the Ventana Benchmark automated immunostainer (Ventana®, Tucson, AZ) standard Cell Conditioner 1 (CC1 , a proprietary buffer) protocol at 98°C for 30 minutes. An ER antibody (clone SP1; ThermoFisher Scientific™) can be used at 1 :250 dilution with 10-minute incubation, after an 8-minute microwave antigen retrieval in 10 mM sodium citrate (pH 6.0). Ready-to-use PR antibody (clone 1E2; Ventana®) can be used by following the CC1 protocol as above. HER2 staining can be done with a SP3 antibody (ThermoFisher Scientific™) at a 1 :100 dilution after antigen retrieval in 0.05 M Tris buffer (pH 10.0) with heating to 95°C in a steamer for 30 minutes. For HER2 fluorescent in situ

hybridization (FISH) assay, slides can be hybridized with probes to LSI (locus-specific identifier) HER2/neu and to centromere 17 by use of the PathVysion HER-2 DNA Probe kit (Abbott Molecular, Abbott Park, IL) according to manufacturer's instructions, with

modifications to pretreatment and hybridization as previously described (Brown LA, Irving J, Parker R, et al. "Amplification of EMSY, a novel oncogene on 1 1 ql 3, in high grade ovarian surface epithelial carcinomas". Gynecol Oncol. 2006; 100(2):264-270). Slides can then be counterstained with 4',6-diamidino-2-phenylindole. Stained material can be visualized on a Zeiss Axioplan epifluorescent microscope, and signals analyzed with a Metafer image acquisition system (Metasystems, Altlussheim, Germany). Biomarker expression from immunohistochemistry assays can then be scored by two pathologists, who are blinded to the clinicopathological characteristics and outcome and who used previously established and published criteria for biomarker expression levels that had been developed on other breast cancer cohorts.

[144] Tumors are considered positive for ER or PR if immuno staining is observed in more than 1% of tumor nuclei, as described previously. Tumors are considered positive for HER2 if immuno staining is scored as 3+ according to HercepTest™ (Dako, Carpinteria, CA) criteria, with an amplification ratio for fluorescent in situ hybridization of 2.0 or more being the cut point that can be used to segregate immunohistochemistry equivocal tumors (scored as 2+) (Yaziji, et al., JAMA, 291(16):1972-1977 (2004)). Ki67 can be visually scored for percentage of tumor cell nuclei with positive immunostaining above the background level.

[145] Other methods can also be used to detect subtype. These techniques include enzyme - linked immunosorbent assay (ELISA), Western blots, Northern blots, or fluorescence-activated cell sorting (FACS) analysis.

[146] Kits

[147] The present disclosure also describes kits useful for classifying breast cancer intrinsic subtypes and/or providing prognostic information to identify breast cancers that are more or less responsive to a taxanes or taxanes derivative therapy. These kits comprise a set of

reporter/capture probes and/or primers specific for the genes listed in Table 1 , and/or

housekeeping genes, and/or other genes described herein. The kits can further include instructions for detecting the aforementioned genes and classifying breast cancer intrinsic subtypes and/or providing prognostic information to identify breast cancers that are more responsive to a taxanes or taxanes derivative therapy. The kits may include instructions for recommended treatments based on a classified breast cancer intrinsic subtype. Preferably, the kit comprises a set of reporter/capture probes and/or primers specific for at least 10, at least 15, at least 20, at least 25, at least 40, 41 , 42, 43, 44, 45, 46, 47, 48, 49 or all 50 genes listed in Table 1. The kit may further comprise a non-transitory computer readable medium.

[148] In embodiments of the present disclosure, the capture probes are immobilized on an array. By "array" is intended a solid support or a substrate with peptide or nucleic acid probes attached to the support or substrate. Arrays typically comprise a plurality of different capture probes that are coupled to a surface of a substrate in different, known locations. The arrays of the disclosure comprise a substrate having a plurality of capture probes that can specifically bind an intrinsic gene expression product. The number of capture probes on the substrate varies with the purpose for which the array is intended. The arrays may be low-density arrays or high- density arrays and may contain 4 or more, 8 or more, 12 or more, 16 or more, 32 or more addresses, but will minimally comprise capture probes for at least 10, at least 15, at least 20, at least 25, or at least 46 of the intrinsic genes or all 50 intrinsic genes listed in Table 1. The array may include capture probes for the housekeeping genes and/or other genes listed herein.

[149] Techniques for the synthesis of these arrays using mechanical synthesis methods are described in, e.g., U.S. Patent No. 5,384,261. The array may be fabricated on a surface of virtually any shape or even a multiplicity of surfaces. Arrays may be probes (e.g., nucleic-acid binding probes) on beads, gels, polymeric surfaces, fibers such as fiber optics, glass or any other appropriate substrate, see U.S. Pat. Nos. 5,770,358, 5,789,162, 5,708,153, 6,040,193 and 5,800,992. Arrays may be packaged in such a manner as to allow for diagnostics or other manipulation on the device. See, for example, U.S. Pat. Nos. 5,856,174 and 5,922,591.

[150] In embodiments, the kit comprises a set of oligonucleotide primers sufficient for the detection and/or quantitation of each of the intrinsic genes listed in Table 1. Preferably, the kit comprises a set of oligonucleotide primers sufficient for the detection and/or quantitation of at least 10, at least 15, at least 20, at least 25, at least 46 of the intrinsic genes or all 50 intrinsic genes listed in Table 1 and/or for the detection and/or quantitation of the housekeeping genes and/or other genes listed herein. The oligonucleotide primers may be provided in a lyophilized or reconstituted form, or may be provided as a set of nucleotide sequences. In certain embodiments, the primers are provided in a microplate format, where each primer set occupies a well (or multiple wells, as in the case of replicates) in the microplate. The microplate may further comprise primers sufficient for the detection of one or more housekeeping genes (e.g., eight) as discussed herein. The kit may further comprise reagents and instructions sufficient for the amplification of expression products from the genes listed in Table 1 and/or for the amplification of expression products from the housekeeping genes and/or other genes listed herein.

[151] In order to facilitate ready access, e.g., for comparison, review, recovery, and/or modification, the molecular signatures/expression profiles are typically recorded in a database. Most typically, the database is a relational database accessible by a computational device, although other formats, e.g., manually accessible indexed files of expression profiles as photographs, analogue or digital imaging readouts, and spreadsheets can be used. Regardless of whether the expression patterns initially recorded are analog or digital in nature, the expression patterns, expression profiles (collective expression patterns), and molecular signatures

(correlated expression patterns) are stored digitally and accessed via a database. Typically, the database is compiled and maintained at a central facility, with access being available locally and/or remotely.

[152] Example

[153] Figure 1 illustrates the design of clinical trial of the present Example. The clinical trial included 376 patients among 74 UK centers between August 2008 & March 2014. An intention to treat population size of 370 patients was selected as sufficient to detect a 15% improvement in objective response rate (ORR) with Carboplatin compared with Docetaxel (power=90%, 2-sided alpha=0.05). The ORR related to the proportion of patients with complete response or partial response at cycle 3 or 6 of randomized treatment. Fisher's exact test was used for comparisons and Logistic regression allowed adjustment for baseline factors. Secondary endpoints include progression-free survival (PFS), overall survival (OS), response to crossover treatment, frequency of cerebral metastases, and toxicity. Pre-planned biological subgroup analyses included Germline BRCAl/2, Homologous Recombination Deficiency (HRD) score, and Basal- like (IHC and PAM50).

[154] Baseline characteristics of study population are shown below in Table 7

[155] Table 4.

Carboplatin Docetaxel

(N=188) (N=188)

Patient status at TN - no known mutation 166 88.3 171 910 baseline, n (%) Known BRCA1/2 mutation 17 9.0 12 6.4

Not-TN & not known B RCA 1/2* 5 2.7 5 2.7

Stage, n (%) Locally advanced 15 8.0 20 10.6 t _o_

o Metastatic 173 92.0 168 89.4 cc ECOG PS, n (%) 0 or 1 174 92.6 176 93.6

^■ 2 14 7.5 12 6.4

Taxane in adjuvant setting, n (%) 65 34.6 61 32.5

Liver or parenchymal lung metastases, n (%) 98 52. 1 100 53.2

' Local center subsequently declared , -neligible (but included in ITT analysis)

[156] Figure 2 illustrates intrinsic subtype by PAM50 or NAN046 for subjects in the trial with triple negative breast cancer (TNBC).

[157] Figure 3 illustrates the objective response rates observed for patients in the trial. Figure 4 discloses the response rates for patients with Basal-like subtype as determined by IHC. Figure 5 illustrates the response rates of patients with Basal-like subtype as determined by PAM50 or NAN046. Figure 6 illustrates waterfall plots of response rates for patients with Basal-like subtype as determined by PAM50 or NAN046.

[158] Subjects with breast cancer tumors that fit in the non-Basal-like subtype, classified by gene expression analysis, were surprisingly found to have a significantly decreased rate of local recurrence and significantly increased rate of breast cancer specific survival and overall survival when treated with a breast cancer treatment that included a taxane or taxane derivative.