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Title:
BRIDGE LINKERS FOR CONJUGATION OF CELL-BINDING MOLECULES
Document Type and Number:
WIPO Patent Application WO/2015/151081
Kind Code:
A3
Abstract:
Provided are linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule, methods of making such linkers, and methods of using such linkers in making homogeneous conjugates, as well as application of the conjugates in the treatment of cancers, infections and autoimmune disorders.

Inventors:
ZHAO ROBERT YONGXIN (US)
Application Number:
IB2015/055264
Publication Date:
June 02, 2016
Filing Date:
July 12, 2015
Export Citation:
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Assignee:
SUZHOU M CONJ BIOTECH CO LTD (CN)
ZHAO ROBERT YONGXIN (US)
International Classes:
C07C243/28; A61K45/06; A61K47/48; A61P31/00; A61P35/00; C07C275/50; C07C311/55; C07D207/452; C07D213/71; C07D403/14; C07K5/065
Domestic Patent References:
WO2014080251A12014-05-30
WO2015028850A12015-03-05
Foreign References:
US5316888A1994-05-31
Other References:
DLRR, S. ET AL.: "Neue Synthesen und Reaktionen unges├ąttigter Heterotitanacyclen", JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 458, no. 1-2, 5 October 1993 (1993-10-05), pages 89 - 96, XP055451777, ISSN: 0022-328X
BARTON, D. H. R. ET AL.: "An unusual reaction between the esters of N-hydroxy-2- thiopyridone and activated azo compounds", TETRAHEDRON, vol. 44, no. 24, 31 December 1988 (1988-12-31), pages 7385 - 7392, XP026596495, ISSN: 0040-4020
SUNDERMEYER, W. ET AL.: "Perfluoralkyl- und Fluorcarbonyl-Hydrazine", JOURNAL OF FLUORINE CHEMISTRY, vol. 34, no. 2, 31 December 1986 (1986-12-31), pages 251 - 254, XP026730936, ISSN: 0022-1139
SPRENGER, G. H. ET AL.: "Photochemistry of perfluoroalkyl and perfluoroacyl N- chloramines. Reactions of N-chloramines and N-chlorimines in the presence of mercury", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 96, no. 6, 20 March 1974 (1974-03-20), pages 1770 - 1775, XP055451778, ISSN: 0002-7863
See also references of EP 3319936A4
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