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Title:
BRIDGED POLYETHYLENE GLYCOL-ALIPHATIC POLYESTER BLOCK COPOLYMER, PREPARATION METHOD FOR SAME, INTERMEDIATE OF SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/075760
Kind Code:
A1
Abstract:
The present invention relates to a bridged polyethylene glycol-aliphatic polyester block copolymer, applicable in preparing a delivery carrier for a small molecule chemotherapy medicament or a nucleic acid medicament. A nano-medicament carrier prepared with the bridged block copolymer produces specific degradation under the pH environment in a tumor tissue or tumor cells, thus changing the structure of nanoparticles, enhancing cellular uptake or intracellular medicament release, and increasing the sensitivity of tumor cells with respect to the medicament.

Inventors:
WANG, Jun (96 Jinzhai Road, Baohe DistrictHefei, Anhui 6, 230026, CN)
SUN, Chunyang (96 Jinzhai Road, Baohe DistrictHefei, Anhui 6, 230026, CN)
XU, Congfei (96 Jinzhai Road, Baohe DistrictHefei, Anhui 6, 230026, CN)
CAO, Zhiting (96 Jinzhai Road, Baohe DistrictHefei, Anhui 6, 230026, CN)
LI, Hongjun (96 Jinzhai Road, Baohe DistrictHefei, Anhui 6, 230026, CN)
Application Number:
CN2015/093676
Publication Date:
May 11, 2017
Filing Date:
November 03, 2015
Export Citation:
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Assignee:
UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA (96 Jinzhai Road, Baohe DistrictHefei, Anhui 6, 230026, CN)
International Classes:
A61K47/34; C08G63/08; C08G63/685; C08G81/00
Domestic Patent References:
WO2008124634A12008-10-16
Foreign References:
CN101768276A2010-07-07
CN101474408A2009-07-08
CN1629150A2005-06-22
CN101766817A2010-07-07
CN103193900A2013-07-10
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (Suite 4-1105, No. 87 West 3rd Ring North Rd.,Haidian District, Beijing 9, 100089, CN)
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