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Title:
BROMO BENZYL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/202275
Kind Code:
A1
Abstract:
Disclosed in the present invention are a bromo benzyl ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to a bromo benzyl ether derivative represented by formula I, a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, and a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.

Inventors:
FENG, Zhiqiang (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
CHEN, Xiaoguang (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
ZHANG, Lijing (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
YANG, Yang (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
LAI, Fangfang (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
JI, Ming (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
ZHOU, Chuan (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
ZHEN, Yi (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
XUE, Nina (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
LI, Ling (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
Application Number:
CN2017/085419
Publication Date:
November 30, 2017
Filing Date:
May 23, 2017
Export Citation:
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Assignee:
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (ZHANG, XubinNo.A2, Nan Wei Road, Xicheng District, Beijing 0, 100050, CN)
International Classes:
C07D319/18; C07D405/12; C07D405/14; A61K31/4545; A61K31/455; A61P31/00; A61P35/00; A61P37/00
Domestic Patent References:
2015-03-12
Foreign References:
US20150291549A12015-10-15
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