Title:
BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/129361
Kind Code:
A3
Abstract:
Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.
Inventors:
KECK GARY E (US)
KRAFT MATTHEW B (US)
TRUONG ANH P (US)
SANCHEZ CARINA C (US)
LI WEI (US)
COVEL JONATHAN A (US)
WELCH DENNIE (US)
POUDEL YAM (US)
KRAFT MATTHEW B (US)
TRUONG ANH P (US)
SANCHEZ CARINA C (US)
LI WEI (US)
COVEL JONATHAN A (US)
WELCH DENNIE (US)
POUDEL YAM (US)
Application Number:
PCT/US2009/040747
Publication Date:
July 08, 2010
Filing Date:
April 16, 2009
Export Citation:
Assignee:
UNIV UTAH RES FOUND (US)
KECK GARY E (US)
KRAFT MATTHEW B (US)
TRUONG ANH P (US)
SANCHEZ CARINA C (US)
LI WEI (US)
COVEL JONATHAN A (US)
WELCH DENNIE (US)
POUDEL YAM (US)
KECK GARY E (US)
KRAFT MATTHEW B (US)
TRUONG ANH P (US)
SANCHEZ CARINA C (US)
LI WEI (US)
COVEL JONATHAN A (US)
WELCH DENNIE (US)
POUDEL YAM (US)
International Classes:
C07D493/22; A61K31/365; A61P25/28; A61P35/00; C07F7/08
Other References:
WENDER P. A. ET AL.: "The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 95, 1998, pages 6624 - 6629, XP002542068
KECK, GARY E. ET AL: "Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 130(21), 6660-6661 CODEN: JACSAT; ISSN: 0002-7863, 2008, XP002542069
KECK, GARY E. ET AL: "Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 130(21), 6660-6661 CODEN: JACSAT; ISSN: 0002-7863, 2008, XP002542069
Attorney, Agent or Firm:
VILLANUEVA, Lawrence, A. (PC2018 Powers Ferry Road,Suite 80, Atlanta GA, US)
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