Title:
BUAGAFURAN ACTIVE PHARMACEUTICAL INGREDIENT AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/214676
Kind Code:
A1
Abstract:
The present invention provides a method suitable for mass-producing a buagafuran active pharmaceutical ingredient. A buagafuran active pharmaceutical ingredient with high purity can be prepared by the method and can be applied to a new drug development process, such as clinical research, pharmaceutical research, and quality control research.
Inventors:
SONG BO (CN)
Application Number:
PCT/CN2018/083526
Publication Date:
November 29, 2018
Filing Date:
April 18, 2018
Export Citation:
Assignee:
BEI JING YUAN QI ZHI YAO TECH CO LTD (CN)
International Classes:
C07D307/00; A61K31/34
Foreign References:
| CN1254713A | 2000-05-31 | |||
| CN1322525A | 2001-11-21 |
Other References:
XIA, XUEJUN ET AL.: "Preparation and in vitro Study of Buagafuran Solid Dispersions", ACTA PHARMACEUTICA SINICA, vol. 43, no. 5, 31 May 2008 (2008-05-31), pages 548 - 552
LIU, QIAN ET AL.: "Synthesis and CNS Activities of alpha-agarofuran Derivatives", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 13, no. 3, 30 June 2003 (2003-06-30), pages 125 - 130
XIA, XUEJUN ET AL.: "Analysis and Identification of Degradation Products of Buagafuran by High Performance Liquid Chromatography-diode Array Detection-tandem Mass Spectrometry", ACTA PHARMACEUTICA SINICA, vol. 48, no. 8, 31 August 2013 (2013-08-31), pages 1292 - 1296
LIU, QIAN ET AL.: "Synthesis and CNS Activities of alpha-agarofuran Derivatives", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, vol. 13, no. 3, 30 June 2003 (2003-06-30), pages 125 - 130
XIA, XUEJUN ET AL.: "Analysis and Identification of Degradation Products of Buagafuran by High Performance Liquid Chromatography-diode Array Detection-tandem Mass Spectrometry", ACTA PHARMACEUTICA SINICA, vol. 48, no. 8, 31 August 2013 (2013-08-31), pages 1292 - 1296
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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