Title:
BUTYLPHTHALIDE COMPOSITION DELIVERED VIA ORAL MUCOSA, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143631
Kind Code:
A1
Abstract:
A butylphthalide composition delivered via oral mucosa, and a use thereof. The composition comprises 100 parts by weight of butylphthalide, 50-1000 parts by weight of a first surfactant, and 0.2-300 parts by weight of a water-soluble polymer. The composition can significantly improve the dissolution stability of butylphthalide in saliva, and increases oral mucosa absorption of butylphthalide. The provided butylphthalide composition delivered via oral mucosa may be used to prevent or treat a histopathological damage or nerve cell damage type disease caused by ischemia and hypoxia.
Inventors:
GAN YONG (CN)
ZHU QUANLEI (CN)
GUO SHIYAN (CN)
ZHU QUANLEI (CN)
GUO SHIYAN (CN)
Application Number:
PCT/CN2021/141977
Publication Date:
July 07, 2022
Filing Date:
December 28, 2021
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K9/00; A61K31/365; A61K47/10; A61K47/14; A61K47/36; A61K47/44; A61P9/10; A61P21/00; A61P25/00
Foreign References:
| CN103169676A | 2013-06-26 | |||
| CN105688220A | 2016-06-22 | |||
| CN103505414A | 2014-01-15 | |||
| CN1726909A | 2006-02-01 | |||
| CN105434426A | 2016-03-30 | |||
| CN105999279A | 2016-10-12 |
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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