Title:
C DIFF PROTEASE
Document Type and Number:
WIPO Patent Application WO/2014/193237
Kind Code:
A3
Abstract:
The invention relates to a peptide comprising the amino acid sequence A/P- A/P-V/P/I/C/T-P as a substrate for the protease CD2830 of Clostridium difficile. The invention further relates to kit or device comprising the peptide for determining the presence of Clostridium difficile in a sample and for identifying an agent that is capable of modulating protease activity of CD2830. The invention further relates to a composition, preferably a pharmaceutical composition, comprising an inhibitor of the protease activity of CD2830.
Inventors:
VAN LEEUWEN HANS CHRISTIAAN (NL)
HENSBERGEN PAUL JACOB (NL)
DRIJFHOUT JAN WOUTER (NL)
KUIJPER EDUARD (NL)
CORVER JEROEN (NL)
HENSBERGEN PAUL JACOB (NL)
DRIJFHOUT JAN WOUTER (NL)
KUIJPER EDUARD (NL)
CORVER JEROEN (NL)
Application Number:
PCT/NL2014/050349
Publication Date:
March 19, 2015
Filing Date:
May 30, 2014
Export Citation:
Assignee:
ACADEMISCH ZIEKENHUIS LEIDEN (NL)
International Classes:
C07K5/087; C07K5/107
Domestic Patent References:
| WO2009010765A2 | 2009-01-22 |
Foreign References:
| US20060121544A1 | 2006-06-08 | |||
| US20100291100A1 | 2010-11-18 |
Other References:
M. VIDAL ET AL: "Design of Peptoid Analogue Dimers and Measure of Their Affinity for Grb2 SH3 Domains +", BIOCHEMISTRY, vol. 43, no. 23, 1 June 2004 (2004-06-01), pages 7336 - 7344, XP055087222, ISSN: 0006-2960, DOI: 10.1021/bi030252n
JACQUOT ET AL: "High affinity Grb2-SH3 domain ligand incorporating Ceta-substituted prolines in a Sos-derived decapeptide", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 15, no. 3, 19 January 2007 (2007-01-19), pages 1439 - 1447, XP005823084, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2006.11.002
JACQUOT ET AL: "High affinity Grb2-SH3 domain ligand incorporating Ceta-substituted prolines in a Sos-derived decapeptide", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 15, no. 3, 19 January 2007 (2007-01-19), pages 1439 - 1447, XP005823084, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2006.11.002
Attorney, Agent or Firm:
JANSEN, C.M. (Johan de Wittlaan 7, JR Den Haag, NL)
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