Title:
C-TYPE NATRIURETIC PEPTIDES AND METHODS THEREOF IN TREATING ACUTE LUNG INJURY
Document Type and Number:
WIPO Patent Application WO/2021/252910
Kind Code:
A3
Abstract:
The present disclosure relates to the treatment of lung, liver, and/or kidney injury, by administering to a subject in need thereof a therapeutically effective amount of a (very) long acting C-type natriuretic peptide (CNP), CNP derivative, (very) long acting CNP derivative, or (very) long acting CNP receptor (NPRB) agonist. The disclosure also relates to the treatment of non-cardiovascular causes of low blood oxygenation, elevated levels of inflammatory cells in the lung, pulmonary edema, sepsis, bacteremia, fibrosis in general, and/or interstitial lung disease using the same.
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Inventors:
TACHIBANA HIROFUMI (US)
KUMAZOE MOTOFUMI (US)
TANAKA YASUTAKE (US)
NOJIRI TAKASHI (US)
CASTILLO GERARDO (US)
NISHIMOTO-ASHFIELD AKIKO (US)
BOLOTIN ELIJAH (US)
YAO YAO (US)
KUMAZOE MOTOFUMI (US)
TANAKA YASUTAKE (US)
NOJIRI TAKASHI (US)
CASTILLO GERARDO (US)
NISHIMOTO-ASHFIELD AKIKO (US)
BOLOTIN ELIJAH (US)
YAO YAO (US)
Application Number:
PCT/US2021/037031
Publication Date:
March 10, 2022
Filing Date:
June 11, 2021
Export Citation:
Assignee:
PHARMAIN CORP (US)
TACHIBANA HIROFUMI (JP)
KUMAZOE MOTOFUMI (JP)
TANAKA YASUTAKE (JP)
NOJIRI TAKASHI (JP)
CASTILLO GERARDO (US)
NISHIMOTO ASHFIELD AKIKO (US)
BOLOTIN ELIJAH (US)
YAO YAO (US)
TACHIBANA HIROFUMI (JP)
KUMAZOE MOTOFUMI (JP)
TANAKA YASUTAKE (JP)
NOJIRI TAKASHI (JP)
CASTILLO GERARDO (US)
NISHIMOTO ASHFIELD AKIKO (US)
BOLOTIN ELIJAH (US)
YAO YAO (US)
International Classes:
A61K47/54; C07K14/58
Domestic Patent References:
| WO2012088608A1 | 2012-07-05 |
Foreign References:
| US20200017567A1 | 2020-01-16 | |||
| US20170196931A1 | 2017-07-13 | |||
| US20170368190A1 | 2017-12-28 | |||
| US20150125457A1 | 2015-05-07 |
Other References:
KIMURA TORU, NOJIRI TAKASHI, HINO JUN, HOSODA HIROSHI, MIURA KOICHI, SHINTANI YASUSHI, INOUE MASAYOSHI, ZENITANI MASAHIRO, TAKABAT: "C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice", RESPIRATORY RESEARCH, BIOMED CENTRAL LTD., LONDON, GB, vol. 17, no. 1, 19 February 2016 (2016-02-19), GB , pages 19, XP055915366, ISSN: 1465-9921, DOI: 10.1186/s12931-016-0335-6
CAROLYN M. HENDRICKSON, MICHAEL A. MATTHAY: "Viral Pathogens and Acute Lung Injury: Investigations Inspired by the SARS Epidemic and the 2009 H1N1 Influenza Pandemic", SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 34, no. 4, August 2013 (2013-08-01), pages 475 - 486, XP093010200, ISSN: 1069-3424, DOI: 10.1055/s-0033-1351122.
CAROLYN M. HENDRICKSON, MICHAEL A. MATTHAY: "Viral Pathogens and Acute Lung Injury: Investigations Inspired by the SARS Epidemic and the 2009 H1N1 Influenza Pandemic", SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 34, no. 4, August 2013 (2013-08-01), pages 475 - 486, XP093010200, ISSN: 1069-3424, DOI: 10.1055/s-0033-1351122.
Attorney, Agent or Firm:
ZHENG, Juan (US)
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