Title:
C2-SYMMETRICAL RUTHENOCENE DIPHOSPHINE LIGANDS ONLY WITH SURFACE CHIRALITY AND THEIR MANUFACTURE.
Document Type and Number:
WIPO Patent Application WO/2007/140717
Kind Code:
A1
Abstract:
The invention affords C2-symmetrical ruthenocene diphosphine ligands with
surface chirality and their manufacture. The present invention uses (S)- (S)-
1, 1' - 2 (biphenyl phosphino)-2, 2'-2[(S)- 4- isopropyl oxazolinyl] ruthenocene
as raw material and the product is prepared through two or three steps of reaction.
At the action of trifluoroacetic acid, (S)- (S)- 1, 1' - 2 (biphenyl phosphino)-2,
2'-2[(S)- 4- isopropyl oxazolinyl] ruthenocene first removes oxazoline
and gets esteramides compound which then carrys out ester exchange or reduction
alkylation and gets the product of ruthenocene diphosphine ligand with surface
chirality.The ligand with the structure as follows from the invention can be
used in all kinds of metallic catalysis asymmetric reaction and has good reaction
activity and stereoselectivity. Wherein, R is methyl or ethyl, R1
is lined or branched chain alkyl, cycloalkyl, alkyloxyl, aryl, arylalkyl and
alkylamino.
Inventors:
ZHANG WANBIN (CN)
XIE FANG (CN)
LIU DELONG (CN)
LUO LI (CN)
HUA GENGHONG (CN)
SHANG JIAN (CN)
XIE FANG (CN)
LIU DELONG (CN)
LUO LI (CN)
HUA GENGHONG (CN)
SHANG JIAN (CN)
Application Number:
PCT/CN2007/001824
Publication Date:
December 13, 2007
Filing Date:
June 08, 2007
Export Citation:
Assignee:
UNIV SHANGHAI JIAOTONG (CN)
ZHANG WANBIN (CN)
XIE FANG (CN)
LIU DELONG (CN)
LUO LI (CN)
HUA GENGHONG (CN)
SHANG JIAN (CN)
ZHANG WANBIN (CN)
XIE FANG (CN)
LIU DELONG (CN)
LUO LI (CN)
HUA GENGHONG (CN)
SHANG JIAN (CN)
International Classes:
C07F17/02; C07F9/50
Domestic Patent References:
| WO2004099226A1 | 2004-11-18 |
Foreign References:
| CN1876668A | 2006-12-13 | |||
| CN1876667A | 2006-12-13 | |||
| CN1876666A | 2006-12-13 | |||
| CN1166835A | 1997-12-03 | |||
| JP2000256384A | 2000-09-19 | |||
| JP2005047883A | 2005-02-24 |
Attorney, Agent or Firm:
JEEKAI & PARTNERS (Jinyu TowerA129 West Xuan Wu Men Street, Xicheng, Beijing 1, CN)
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