Title:
COMBINATION OF TAFIa INHIBITOR WITH PLASMINOGEN ACTIVATOR
Document Type and Number:
WIPO Patent Application WO/2016/204239
Kind Code:
A1
Abstract:
A medicinal composition for treating or preventing thrombosis, embolism and aftereffects thereof, characterized by comprising a specific TAFIa inhibitor and a plasminogen activator that are to be administered in combination. A method for treating or preventing thrombosis, embolism and aftereffects thereof, characterized by comprising administering a specific TAFIa inhibitor and a plasminogen activator in combination to a warm-blooded animal.
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Inventors:
NOGUCHI KENGO (JP)
ITO YUSUKE (JP)
EDO NAOKO (JP)
ITO YUSUKE (JP)
EDO NAOKO (JP)
Application Number:
PCT/JP2016/067963
Publication Date:
December 22, 2016
Filing Date:
June 16, 2016
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K31/4172; A61K31/4178; A61K38/48; A61P7/02; A61P43/00
Domestic Patent References:
| WO2011115064A1 | 2011-09-22 |
Other References:
MUTCH, N.J. ET AL.: "Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI", J. THROMB. HAEMOST., vol. 1, no. 9, 2003, pages 2000 - 2007, XP055338777, ISSN: 1538-7933
SUZUKI, K. ET AL.: "Enhancement of fibrinolysis by EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1- (3-phenylpropanoylamino)propyl] hydroxyphosphinoyl]methyl]heptanoic acid], a specific inhibitor of plasma carboxypeptidase B", J. PHARMACOL. EXP. THER., vol. 309, no. 2, 2004, pages 607 - 615, XP055338778, ISSN: 0022-3565
BIRD, E. ET AL.: "Is exogenous tissue plasminogen activator necessary for antithrombotic efficacy of an inhibitor of thrombin activatable fibrinolysis inhibitor (TAFI) in rats?", THROMB. RES., vol. 120, no. 4, 2007, pages 549 - 558, XP022170426, ISSN: 0049-3848
WANG Y.X. ET AL.: "A novel inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) - part II: enhancement of both exogenous and endogenous fibrinolysis in animal models of thrombosis", THROMB. HAEMOST., vol. 97, no. 1, 2007, pages 54 - 61, XP055338780, ISSN: 0340-6245
ISLAM, I. ET AL.: "3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa", BIOORG. MED. CHEM. LETT., vol. 17, no. 5, 2007, pages 1349 - 1354, XP005888478, ISSN: 0960-894X
OSHIBUCHI, R. ET AL.: "Use of rt-PA(Alteplase) for Acute Cerebral Infarction", J. JPN. SOC. CLIN. ANETH., vol. 28, no. 5, 2008, pages 807 - 813, XP055338782, ISSN: 0285-4945
See also references of EP 3311812A4
SUZUKI, K. ET AL.: "Enhancement of fibrinolysis by EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1- (3-phenylpropanoylamino)propyl] hydroxyphosphinoyl]methyl]heptanoic acid], a specific inhibitor of plasma carboxypeptidase B", J. PHARMACOL. EXP. THER., vol. 309, no. 2, 2004, pages 607 - 615, XP055338778, ISSN: 0022-3565
BIRD, E. ET AL.: "Is exogenous tissue plasminogen activator necessary for antithrombotic efficacy of an inhibitor of thrombin activatable fibrinolysis inhibitor (TAFI) in rats?", THROMB. RES., vol. 120, no. 4, 2007, pages 549 - 558, XP022170426, ISSN: 0049-3848
WANG Y.X. ET AL.: "A novel inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) - part II: enhancement of both exogenous and endogenous fibrinolysis in animal models of thrombosis", THROMB. HAEMOST., vol. 97, no. 1, 2007, pages 54 - 61, XP055338780, ISSN: 0340-6245
ISLAM, I. ET AL.: "3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa", BIOORG. MED. CHEM. LETT., vol. 17, no. 5, 2007, pages 1349 - 1354, XP005888478, ISSN: 0960-894X
OSHIBUCHI, R. ET AL.: "Use of rt-PA(Alteplase) for Acute Cerebral Infarction", J. JPN. SOC. CLIN. ANETH., vol. 28, no. 5, 2008, pages 807 - 813, XP055338782, ISSN: 0285-4945
See also references of EP 3311812A4
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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