Title:
COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ICAM-1
Document Type and Number:
WIPO Patent Application WO2004065546
Kind Code:
A3
Abstract:
RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
Inventors:
REICH SAMUEL JOTHAM (US)
TOLENTINO MICHAEL J (US)
TOLENTINO MICHAEL J (US)
Application Number:
PCT/US2004/001166
Publication Date:
March 23, 2006
Filing Date:
January 16, 2004
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
REICH SAMUEL JOTHAM (US)
TOLENTINO MICHAEL J (US)
REICH SAMUEL JOTHAM (US)
TOLENTINO MICHAEL J (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C12Q1/68; A01N43/04; C07H21/04; A61K31/07
Foreign References:
| US6015894A | 2000-01-18 |
Other References:
KATZ S M ET AL: "ICAM-1 antisense oligodeoxynucleotide improves islet allograft survival and function.", CELL TRANSPLANTATION., vol. 9, 2000, pages 817 - 828, XP008062495
DRAGUN D ET AL: "ICAM-1 antisense oligodeoxynucleotide prevent reperfusion injury and enhance immediate graft function in renal transplantation.", KIDNEY INTERNATIONAL., vol. 54, 1998, pages 590 - 602, XP002996069
ELBASHIR S M ET AL: "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.", NATURE., vol. 411, 2001, pages 494 - 498, XP002206451
AGRAWAL S ET AL: "Antisense therapeutics: is it as simple as complementary base recognition?", MOLECULAR MEDICINE TODAY., vol. 6, 2000, pages 72 - 81, XP002952062
JEN K Y ET AL: "Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies.", STEM CELLS., vol. 18, 2000, pages 307 - 319, XP002181426
COBURN G A ET AL: "siRNAs: a new wave of RNA-based therapeutics.", J ANTIMICROB CHEMOTHER., vol. 51, 2003, pages 753 - 756, XP002992788
CAPLEN N J ET AL: "Gene therapy: RNAi as a gene therapy approach.", EXPERT OPIN BIOL THER., vol. 3, 2003, pages 575 - 586, XP008055014
AGAMI R ET AL: "RNAi and related mechanisms and their potential use for therapy.", CURR OPIN CHEM BIOL., vol. 6, 2002, pages 829 - 834, XP002239988
DRAGUN D ET AL: "ICAM-1 antisense oligodeoxynucleotide prevent reperfusion injury and enhance immediate graft function in renal transplantation.", KIDNEY INTERNATIONAL., vol. 54, 1998, pages 590 - 602, XP002996069
ELBASHIR S M ET AL: "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.", NATURE., vol. 411, 2001, pages 494 - 498, XP002206451
AGRAWAL S ET AL: "Antisense therapeutics: is it as simple as complementary base recognition?", MOLECULAR MEDICINE TODAY., vol. 6, 2000, pages 72 - 81, XP002952062
JEN K Y ET AL: "Suppression of gene expression by targeted disruption of messenger RNA: Available options and current strategies.", STEM CELLS., vol. 18, 2000, pages 307 - 319, XP002181426
COBURN G A ET AL: "siRNAs: a new wave of RNA-based therapeutics.", J ANTIMICROB CHEMOTHER., vol. 51, 2003, pages 753 - 756, XP002992788
CAPLEN N J ET AL: "Gene therapy: RNAi as a gene therapy approach.", EXPERT OPIN BIOL THER., vol. 3, 2003, pages 575 - 586, XP008055014
AGAMI R ET AL: "RNAi and related mechanisms and their potential use for therapy.", CURR OPIN CHEM BIOL., vol. 6, 2002, pages 829 - 834, XP002239988
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