Title:
A CONVERGENT SYNTHESIS OF alpha -ARYL- beta -KETONITRILES
Document Type and Number:
WIPO Patent Application WO1999051568
Kind Code:
A3
Abstract:
The present invention relates to processes for the production of alpha -aryl- beta -ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
Inventors:
ZHOU JICHENG
OH LYNETTE MAY
MA PHILIP
OH LYNETTE MAY
MA PHILIP
Application Number:
PCT/US1999/006822
Publication Date:
November 18, 1999
Filing Date:
March 29, 1999
Export Citation:
Assignee:
DU PONT PHARM CO (US)
International Classes:
C07B61/00; C07C253/00; C07D261/08; C07C255/40; C07D201/08; C07C255/17; (IPC1-7): C07C253/00; C07C255/40; C07D261/08
Other References:
CHEMICAL ABSTRACTS, vol. 53, no. 22, 25 November 1959, Columbus, Ohio, US; HIROYUKI YASADU: "Synthesis of 4,5-disubstitutes isoxazoles and their cleavage reaction with sodium ethoxide. II. Application to the determination of attack point of ethyl formate on unsymmetrical ketones." column 21885; XP002116052
DE MUNNO A ET AL: "On the base catalyzed ring opening of 3-unsubstituted isoxazoles. Derivatives of 4- and 5-phenylisoxazole", J. CHEM. SOC., PERKIN TRANS. 2 (JCPKBH);1977; (9); PP.1121-4, Fac. Sci. MFN;Ist. Chim. Org.; Pisa; Italy, XP002116049
G.A.OLAH ET AL.: "Iodination of deactivated aromatics with N-Iodosuccinimide in trifluoromethanesulfonic acid (NIS-CF3SO3H) via in situ generated superelectrophilic Iodine(I) trifluoromezthanesulfonate", JOURNAL OF ORGANIC CHEMISTRY, vol. 58, 1993, EASTON US, pages 3194 - 3195, XP002116050
R.C. LAROCK: "Comprehensive organic transformations", VCH, XP002116051
DE MUNNO A ET AL: "On the base catalyzed ring opening of 3-unsubstituted isoxazoles. Derivatives of 4- and 5-phenylisoxazole", J. CHEM. SOC., PERKIN TRANS. 2 (JCPKBH);1977; (9); PP.1121-4, Fac. Sci. MFN;Ist. Chim. Org.; Pisa; Italy, XP002116049
G.A.OLAH ET AL.: "Iodination of deactivated aromatics with N-Iodosuccinimide in trifluoromethanesulfonic acid (NIS-CF3SO3H) via in situ generated superelectrophilic Iodine(I) trifluoromezthanesulfonate", JOURNAL OF ORGANIC CHEMISTRY, vol. 58, 1993, EASTON US, pages 3194 - 3195, XP002116050
R.C. LAROCK: "Comprehensive organic transformations", VCH, XP002116051
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