CA-IX SPECIFIC RADIOPHARMACEUTICALS FOR THE TREATMENT AND IMAGING OF CANCER

Title:

CA-IX SPECIFIC RADIOPHARMACEUTICALS FOR THE TREATMENT AND IMAGING OF CANCER

Document Type and Number:

WIPO Patent Application WO/2010/065906

Kind Code:

A3

Abstract:

A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus, pharmaceutical compositions may be prepared with one or more of the compounds of Formula (I), (II), (III), or (IV).

Inventors:

BABICH JOHN W (US)
ZIMMERMAN CRAIG (US)
JOYAL JOHN (US)
MARESCA KEVIN P (US)
LU GENLIANG (US)
HILLIER SHAWN (US)

Application Number:

PCT/US2009/066842

Publication Date:

May 12, 2011

Filing Date:

December 04, 2009

Export Citation:

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Assignee:

MOLECULAR INSIGHT PHARM INC (US)
BABICH JOHN W (US)
ZIMMERMAN CRAIG (US)
JOYAL JOHN (US)
MARESCA KEVIN P (US)
LU GENLIANG (US)
HILLIER SHAWN (US)

International Classes:

C07D213/38; A61K51/04; A61K51/08; C07F13/00

Domestic Patent References:

WO2003077727A2	2003-09-25
WO2005079865A1	2005-09-01
WO2009089383A2	2009-07-16

Foreign References:

JPH04342560A

1992-11-30

Other References:

ROY BIDHAN C ET AL: "Two-prong inhibitors for human carbonic anhydrase II.", 20 October 2004, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 20 OCT 2004 LNKD- PUBMED:15479058, VOL. 126, NR. 41, PAGE(S) 13206 - 13207, ISSN: 0002-7863, XP002577772
KREBS H A: "Inhibition of carbonic anhydrase by sulphonamides.", 1948, THE BIOCHEMICAL JOURNAL 1948 LNKD- PUBMED:16748445, VOL. 43, NR. 4, PAGE(S) 525 - 528, ISSN: 0264-6021, XP002577773

Attorney, Agent or Firm:

VILLACORTA, Gilberto M et al. (Washington Harbour3000 K St., NW, Sixth Floo, Washington DC, US)

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