Title:
CADM1 V9-RECOGNIZING ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2019/177173
Kind Code:
A1
Abstract:
The present invention provides an antibody that recognizes the v9 fragment of the CADM1 cell adhesion molecule.
Inventors:
MURAKAMI YOSHINORI (JP)
ITO TAKESHI (JP)
HAMAKUBO TAKAO (JP)
IWANARI HIROKO (JP)
ITO TAKESHI (JP)
HAMAKUBO TAKAO (JP)
IWANARI HIROKO (JP)
Application Number:
PCT/JP2019/011201
Publication Date:
September 19, 2019
Filing Date:
March 18, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C07K16/18; G01N33/574; C12P21/08
Other References:
KIKUCHI, SHINJI ET AL.: "Expression of a splicing variant of the CADM1 specific to small cell lung cancer", CANCER SCIENCE, vol. 103, no. 6, June 2012 (2012-06-01), pages 1051 - 1057, XP055176884, doi:10.1111/j.1349-7006.2012.02277.x
FUKAMI, TAKESHI ET AL.: "Identification of the Tslcl gene , a mouse orthologue of the human tumor suppressor TSLC1 gene", GENE, vol. 295, 2002, pages 7 - 12, XP004381365, doi:10.1016/S0378-1119(02)00835-1
HRABOVSKA, ANNA ET AL.: "A Novel System for the Efficient Generation of Antibodies Following Immunization of Unique Knockout Mouse Strains", PLOS ONE, vol. 5, no. 9, September 2010 (2010-09-01), pages 1 - 7, XP055131783, doi:10.1371/journal.pone.0012892
DECLERCK, PAUL J. ET AL.: "Generation of Monoclonal Antibodies against Autologous Proteins in Gene -inactivated Mice", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 15, April 1995 (1995-04-01), pages 8397 - 8400, XP002174630, doi:10.1074/jbc.270.15.8397
KIKUCHI ET AL., CANCER SCIENCE, vol. 103, no. 6, 2012, pages 1051 - 1057
SHIRAKABE ET AL., SCIENTIFIC REPORTS, vol. 7, 2017, pages 46714
NAGARA ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 417, no. 1, 2012, pages 462 - 467
SEO, H. ET AL., NAT. BIOTECHNOL., vol. 6, 2002, pages 731 - 736
ITOH, K. ET AL., JPN. J. CANCER RES., vol. 92, 2001, pages 1313 - 1321
KOIDE, A. ET AL., J. MOL. BIOL., vol. 284, 1998, pages 1141 - 1151
YAMADA D ET AL., MOL CELL BIOL, 2006
SAITOH R ET AL., J IMMUNOL METHODS, 2007
MASUDA K ET AL., J BIOL CHEM, 2003
MURAKAMI S ET AL., PLOS ONE, 2014
NAGARA ET AL., BIOCHEM BIOPHYS RES COMMUN, 2012
SHIRAKABE ET AL., SCI REP, 2017
See also references of EP 3766898A4
FUKAMI, TAKESHI ET AL.: "Identification of the Tslcl gene , a mouse orthologue of the human tumor suppressor TSLC1 gene", GENE, vol. 295, 2002, pages 7 - 12, XP004381365, doi:10.1016/S0378-1119(02)00835-1
HRABOVSKA, ANNA ET AL.: "A Novel System for the Efficient Generation of Antibodies Following Immunization of Unique Knockout Mouse Strains", PLOS ONE, vol. 5, no. 9, September 2010 (2010-09-01), pages 1 - 7, XP055131783, doi:10.1371/journal.pone.0012892
DECLERCK, PAUL J. ET AL.: "Generation of Monoclonal Antibodies against Autologous Proteins in Gene -inactivated Mice", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 15, April 1995 (1995-04-01), pages 8397 - 8400, XP002174630, doi:10.1074/jbc.270.15.8397
KIKUCHI ET AL., CANCER SCIENCE, vol. 103, no. 6, 2012, pages 1051 - 1057
SHIRAKABE ET AL., SCIENTIFIC REPORTS, vol. 7, 2017, pages 46714
NAGARA ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 417, no. 1, 2012, pages 462 - 467
SEO, H. ET AL., NAT. BIOTECHNOL., vol. 6, 2002, pages 731 - 736
ITOH, K. ET AL., JPN. J. CANCER RES., vol. 92, 2001, pages 1313 - 1321
KOIDE, A. ET AL., J. MOL. BIOL., vol. 284, 1998, pages 1141 - 1151
YAMADA D ET AL., MOL CELL BIOL, 2006
SAITOH R ET AL., J IMMUNOL METHODS, 2007
MASUDA K ET AL., J BIOL CHEM, 2003
MURAKAMI S ET AL., PLOS ONE, 2014
NAGARA ET AL., BIOCHEM BIOPHYS RES COMMUN, 2012
SHIRAKABE ET AL., SCI REP, 2017
See also references of EP 3766898A4
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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