Title:
CALCIUM PHOSPHATE CARRYING PROTEIN, PROCESS FOR PRODUCING THE SAME AND SUSTAINED RELEASE PROTEIN PREPARATION, ARTIFICIAL BONE AND TISSUE ENGINERRING SCAFFOLD USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/047881
Kind Code:
A1
Abstract:
It is intended to provide sintered calcium phosphate carrying a protein which has a high biocompatibility with a drug to be used, by which the protein can be strongly carried in an increased amount owing to enhanced calcium phosphate deposition and which can sustainedly release the protein over a prolonged period of time. Sintered calcium phosphate wherein, using a persaturated solution of unstable calcium phosphate containing a protein capable of undergoing spontaneous nucleation, the period of time until the spontaneous nucleation is artificially controlled so that coprecipitation/deposition on a calcium phosphate substrate is completed before the spontaneous nucleation of the whole solution, or the spontaneous nucleation is effected exclusively around the substrate to thereby increase the amount of the deposited calcium phosphate, thereby increasing the amount of the protein carried thereon.
Inventors:
ITO ATSUO (JP)
SOGO YU (JP)
ONUMA KAZUO (JP)
ICHINOSE NOBORU (JP)
FUKAZAWA KOSHIRO (JP)
YAMAZAKI ATSUSHI (JP)
KONDO NAO (JP)
SOGO YU (JP)
ONUMA KAZUO (JP)
ICHINOSE NOBORU (JP)
FUKAZAWA KOSHIRO (JP)
YAMAZAKI ATSUSHI (JP)
KONDO NAO (JP)
Application Number:
PCT/JP2003/015040
Publication Date:
June 10, 2004
Filing Date:
November 25, 2003
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
UNIV WASEDA (JP)
ITO ATSUO (JP)
SOGO YU (JP)
ONUMA KAZUO (JP)
ICHINOSE NOBORU (JP)
FUKAZAWA KOSHIRO (JP)
YAMAZAKI ATSUSHI (JP)
KONDO NAO (JP)
UNIV WASEDA (JP)
ITO ATSUO (JP)
SOGO YU (JP)
ONUMA KAZUO (JP)
ICHINOSE NOBORU (JP)
FUKAZAWA KOSHIRO (JP)
YAMAZAKI ATSUSHI (JP)
KONDO NAO (JP)
International Classes:
A61F2/28; A61K9/14; A61K38/00; A61K47/04; A61L27/00; C04B35/447; C04B41/82; (IPC1-7): A61L27/44; A61K38/00; A61K47/04; A61L27/50
Domestic Patent References:
| WO1995013101A1 | 1995-05-18 | |||
| WO2001056628A1 | 2001-08-09 | |||
| WO1997041273A1 | 1997-11-06 |
Foreign References:
| EP0987031A1 | 2000-03-22 | |||
| EP0806212A1 | 1997-11-12 | |||
| GB2045083A | 1980-10-29 |
Attorney, Agent or Firm:
Hiraki, Yusuke (17-1 Toranomon 1-chom, Minato-ku Tokyo, JP)
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