Title:
CALCIUM RECEPTOR-ACTIVE COMPOUNDS CALCIUM RECEPTOR-ACTIVE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO1996012697
Kind Code:
A3
Abstract:
Inorganic ion receptor modulating cpds. of formulae (I), (II) and (III) and their salts and complexes in the case of (I) and (II) are new, in which Ar2 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X1 ; X1 = lower alkyl, halo, lower alkoxy, lower thioalkyl, methylenedioxy, lower haloalkyl, lower haloalkoxy, OH, CH2OH, CONH2, CN or acetoxy; Ar1 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X2 ; X2 = as for X1 or N(CH3)2, phenyl, phenoxy, benzyl, benzyloxy, ~a,~a-dimethylbenzyl, NO2, CHO, CH3CH(OH), acetyl or ethylenedioxy; Ar3 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X3 ; X3 = as for X1 or benzyl, benzyloxy, dimethylbenzyl, NO2, CHO, CH3CH(OH), N(CH3)2, acetyl or ethylenedioxy; Ar4 = as for Ar2; Ar5 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X4 ; X4 = as for X1 or benzyl, benzyloxy, ~a,~a-dimethylbenzyl, NO2, CHO, CH3CH(OH), acetyl, ethylenedioxy or -CH=CH-phenyl; Ar6= naphthyl or phenyl which are opt. substd. with 0-5 substits. X5 ; X5 = as for X1 or acetyl, carbomethoxy or OCH2C(O)C2H5; q = 0-3; R = H or lower alkyl; R9, R11, R12 = H or CH3; R8 = H or phenyl; R10 = H, CH3 or phenyl.
Inventors:
VAN WAGENEN BRADFORD C
MOE SCOTT T
BALANDRIN MANUEL F
DELMAR ERIC G
NEMETH EDWARD F
MOE SCOTT T
BALANDRIN MANUEL F
DELMAR ERIC G
NEMETH EDWARD F
Application Number:
PCT/US1995/013704
Publication Date:
June 13, 1996
Filing Date:
October 23, 1995
Export Citation:
Assignee:
NPS PHARMA INC (US)
International Classes:
C07C211/27; A61K31/135; A61K31/137; A61K31/165; A61K31/215; A61K31/34; A61K31/343; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/40; A61K31/445; A61K31/4468; A61P3/00; A61P3/14; A61P9/08; A61P9/12; A61P13/12; A61P19/00; A61P19/08; A61P19/10; A61P35/00; A61P43/00; C07C211/28; C07C211/29; C07C211/30; C07C211/31; C07C211/35; C07C211/38; C07C211/42; C07C215/08; C07C215/48; C07C217/16; C07C217/54; C07C217/56; C07C217/58; C07C217/60; C07C217/62; C07C219/28; C07C223/02; C07C225/16; C07C229/38; C07C255/58; C07C317/32; C07C323/32; C07D207/08; C07D207/323; C07D211/58; C07D215/14; C07D307/79; C07D317/58; C07D317/64; C07D319/18; C07D333/54; G01N33/566; G01N33/68; (IPC1-7): C07C211/27; C07C211/30; C07C217/58; C07C211/28; A61K31/135
Domestic Patent References:
| WO1994018959A1 | 1994-09-01 | |||
| WO1993004373A1 | 1993-03-04 | |||
| WO1995011221A1 | 1995-04-27 | |||
| WO1995021815A1 | 1995-08-17 | |||
| WO1995018134A1 | 1995-07-06 |
Foreign References:
| EP0508307A2 | 1992-10-14 | |||
| DE2541184A1 | 1976-04-15 | |||
| US4000197A | 1976-12-28 | |||
| DE1231690B | 1967-01-05 |
Other References:
CHEMICAL ABSTRACTS, vol. 121, no. 19, 7 November 1994, Columbus, Ohio, US; abstract no. 230462, KOMEYOSHI, YUKIO ET AL: "Optically active amines and their manufacture, intermediates, and uses"
J. E. CLIFTON ET AL.: "Arylethanolamines derived from Salicylamide with .alpha. and .beta.-adrenoceptor blocking activity.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 25, no. 6, WASHINGTON US, pages 670 - 679
G.-Z. WANG ET AL.: "Ruthenium-catalysed transfer hydrogenation of imines by propan-2-ol", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, LETCHWORTH GB, pages 980 - 2
S. G. DAVIES ET AL.: "Asymmetric synthesis of R-.beta.-amino butanoic acid and S-.beta.tyrosine", TETRAHEDRON: ASYMMETRY, vol. 2, no. 3, OXFORD GB, pages 183 - 186
MAJEWSKI, MAREK ET AL.: "Enantioselective deprotonation of protected 4-hydroxycyclohexanones", CAN. J. CHEM. (1994), 72(7), 1699-704
J. C. G. VAN NIEL ET AL.: "NADH models XXI. Stereoselective reduction of chireal imines with hantzsch ester", TETRAHEDRON, vol. 41, no. 24, OXFORD GB, pages 6005 - 11
YUKIHIKO HASHIMOTO ET AL.: "Highly diastereoselective addition of organometallic reagents to chiral imines derived from 1-(2-methoxyphenyl)ethylamine", SYNLETT, no. 9, STUTTGART DE, pages 961 - 2
J. E. CLIFTON ET AL.: "Arylethanolamines derived from Salicylamide with .alpha. and .beta.-adrenoceptor blocking activity.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 25, no. 6, WASHINGTON US, pages 670 - 679
G.-Z. WANG ET AL.: "Ruthenium-catalysed transfer hydrogenation of imines by propan-2-ol", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, LETCHWORTH GB, pages 980 - 2
S. G. DAVIES ET AL.: "Asymmetric synthesis of R-.beta.-amino butanoic acid and S-.beta.tyrosine", TETRAHEDRON: ASYMMETRY, vol. 2, no. 3, OXFORD GB, pages 183 - 186
MAJEWSKI, MAREK ET AL.: "Enantioselective deprotonation of protected 4-hydroxycyclohexanones", CAN. J. CHEM. (1994), 72(7), 1699-704
J. C. G. VAN NIEL ET AL.: "NADH models XXI. Stereoselective reduction of chireal imines with hantzsch ester", TETRAHEDRON, vol. 41, no. 24, OXFORD GB, pages 6005 - 11
YUKIHIKO HASHIMOTO ET AL.: "Highly diastereoselective addition of organometallic reagents to chiral imines derived from 1-(2-methoxyphenyl)ethylamine", SYNLETT, no. 9, STUTTGART DE, pages 961 - 2
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