Title:
CALYCINS
Document Type and Number:
WIPO Patent Application WO2002015939
Kind Code:
A3
Abstract:
The invention relates to the use of calycins, and in particular, the use of lipocalins in the transport and/or binding of ligands to a substrate wherein said substrate is not hair or skin; and also the modification of calycins to alter the specificity and/or affinity of said calycins for said substrate and/or ligands.
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Inventors:
FINDLAY JOHN (GB)
Application Number:
PCT/GB2001/003813
Publication Date:
August 22, 2002
Filing Date:
August 24, 2001
Export Citation:
Assignee:
UNIV LEEDS (GB)
FINDLAY JOHN (GB)
FINDLAY JOHN (GB)
International Classes:
A61K47/48; C12N15/09; C07K14/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; (IPC1-7): A61K47/48
Domestic Patent References:
| WO1999016873A1 | 1999-04-08 |
Foreign References:
| EP0335654A2 | 1989-10-04 |
Other References:
STEMMER, W. P. C.: "Rapid evolution of a protein in vitro by DNA shuffling", NATURE, no. 370, 1994, pages 389 - 391, XP002917680
FLOWER D: "Multiple molecular recognition properties of the lipocalin protein family", JOURNAL OF MOLECULAR RECOGNITION, HEYDEN & SON LTD., LONDON, GB, vol. 8, 1995, pages 185 - 195, XP002095125, ISSN: 0952-3499
FLOWER D: "The lipocalin protein family: structure and function", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 318, 1996, pages 1 - 14, XP002095126, ISSN: 0264-6021
LEE J M ET AL: "CROSSLINKING OF TISSUE-DERIVED BIOMATERIALS IN 1-ETHYL-3-(3-DIMETHYLAMINOPROPYL)-CARBODIIMIDE (EDC)", JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE, CHAPMAN AND HALL, LONDON, GB, vol. 7, no. 9, 1996, pages 531 - 541, XP000907368, ISSN: 0957-4530
LOEBEL D ET AL: "SUBTYPES OF ODORANT-BINDING PROTEINS HETEROLOGOUS EXPRESSION AND LIGAND BINDING", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 254, no. 2, June 1998 (1998-06-01), pages 318 - 324, XP000891882, ISSN: 0014-2956
FLOWER D: "Multiple molecular recognition properties of the lipocalin protein family", JOURNAL OF MOLECULAR RECOGNITION, HEYDEN & SON LTD., LONDON, GB, vol. 8, 1995, pages 185 - 195, XP002095125, ISSN: 0952-3499
FLOWER D: "The lipocalin protein family: structure and function", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 318, 1996, pages 1 - 14, XP002095126, ISSN: 0264-6021
LEE J M ET AL: "CROSSLINKING OF TISSUE-DERIVED BIOMATERIALS IN 1-ETHYL-3-(3-DIMETHYLAMINOPROPYL)-CARBODIIMIDE (EDC)", JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE, CHAPMAN AND HALL, LONDON, GB, vol. 7, no. 9, 1996, pages 531 - 541, XP000907368, ISSN: 0957-4530
LOEBEL D ET AL: "SUBTYPES OF ODORANT-BINDING PROTEINS HETEROLOGOUS EXPRESSION AND LIGAND BINDING", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 254, no. 2, June 1998 (1998-06-01), pages 318 - 324, XP000891882, ISSN: 0014-2956
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