Title:
CAMPTOTHECIN DERIVATIVE INTERMEDIATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/072143
Kind Code:
A1
Abstract:
Disclosed in the present invention are a camptothecin derivative intermediate, and a preparation method therefor and the use thereof. The structural formula of the camptothecin derivative intermediate of the present invention is as shown in formula (I), and the definition of each substituent is as described in the description and claims. The intermediate (I) of the present invention can be used for preparing an intermediate (III), and can be further used for preparing exatecan and a derivative thereof. The preparation method of the present invention has the advantages of cheap and easily available raw materials, a novel method and simple route, mild conditions, a high yield, few by-products, suitability for scale-up synthesis and industrial production, etc.
Inventors:
ZHANG FUYAO (CN)
CHEN XIANJIE (CN)
CHEN XIANJIE (CN)
Application Number:
PCT/CN2022/127677
Publication Date:
May 04, 2023
Filing Date:
October 26, 2022
Export Citation:
Assignee:
SHANGHAI BEST LINK BIOSCIENCE LLC (CN)
International Classes:
C07C233/54; C07C269/06; C07C271/20; C07C271/22; C07D263/04; C07D263/10; C07D263/18; C07D263/44; C07D263/52; C07D491/22
Domestic Patent References:
| WO2022166762A1 | 2022-08-11 |
Foreign References:
| CN111470998A | 2020-07-31 | |||
| CN111065621A | 2020-04-24 | |||
| CN1175943A | 1998-03-11 | |||
| EP0495432A1 | 1992-07-22 | |||
| JPH0687746A | 1994-03-29 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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