Title:
CANCER BIOMARKERS AND METHODS OF TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2014/150819
Kind Code:
A3
Abstract:
The present invention concerns cancer biomarkers. In particular, the invention concerns c-met as biomarkers for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.
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Inventors:
YAUCH ROBERT (US)
KOEPPEN HARTMUT (US)
KOEPPEN HARTMUT (US)
Application Number:
PCT/US2014/024316
Publication Date:
January 08, 2015
Filing Date:
March 12, 2014
Export Citation:
Assignee:
GENENTECH INC (US)
HOFFMANN LA ROCHE (CH)
HOFFMANN LA ROCHE (CH)
International Classes:
G01N33/574; G01N33/74
Domestic Patent References:
| WO2013036872A1 | 2013-03-14 | |||
| WO2012031027A1 | 2012-03-08 |
Other References:
WILLIAM E PIERCEALL ET AL: "Strategies for H-score normalization of preanalytical technical variables with potential utility to immunohistochemical-based biomarker quantitation in therapeutic response diagnostics", ANALYTICAL CELLULAR PATHOLOGY (AMSTERDAM), 1 January 2011 (2011-01-01), Netherlands, pages 159 - 168, XP055125690, Retrieved from the Internet [retrieved on 20140627], DOI: 10.3233/ACP-2011-0014
KNUDSEN BEATRICE S ET AL: "A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings", APPLIED IMMUNOHISTOCHEMSITRY AND MOLECULAR MORPHOLOGY, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 17, no. 1, 1 January 2009 (2009-01-01), pages 57 - 67, XP008100340, ISSN: 1541-2016, DOI: 10.1097/PAI.0B013E3181816AE2
FAORO LEONARDO ET AL: "MET/PKC.beta. expression correlate with metastasis and inhibition is synergistic in lung cancer", JOURNAL OF CARCINOGENESIS, BIOMED CENTRAL, LONDON, GB, vol. 8, no. 15, 1 January 2009 (2009-01-01), pages 1 - 6, XP008123497, ISSN: 1477-3163, [retrieved on 20091124], DOI: 10.4103/1477-3163.57857
"Guidance for Industry. Clinical Trial Endpoints for the Approval of Cancer. Drugs and Biologics.", 1 May 2007 (2007-05-01), pages 1 - 22, XP055033920, Retrieved from the Internet [retrieved on 20120726]
KNUDSEN BEATRICE S ET AL: "A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings", APPLIED IMMUNOHISTOCHEMSITRY AND MOLECULAR MORPHOLOGY, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 17, no. 1, 1 January 2009 (2009-01-01), pages 57 - 67, XP008100340, ISSN: 1541-2016, DOI: 10.1097/PAI.0B013E3181816AE2
FAORO LEONARDO ET AL: "MET/PKC.beta. expression correlate with metastasis and inhibition is synergistic in lung cancer", JOURNAL OF CARCINOGENESIS, BIOMED CENTRAL, LONDON, GB, vol. 8, no. 15, 1 January 2009 (2009-01-01), pages 1 - 6, XP008123497, ISSN: 1477-3163, [retrieved on 20091124], DOI: 10.4103/1477-3163.57857
"Guidance for Industry. Clinical Trial Endpoints for the Approval of Cancer. Drugs and Biologics.", 1 May 2007 (2007-05-01), pages 1 - 22, XP055033920, Retrieved from the Internet
Attorney, Agent or Firm:
COBURN, Cara, M. et al. (Inc.1 DNA Way, MS-4, South San Francisco CA, US)
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