Title:
CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS
Document Type and Number:
WIPO Patent Application WO/2010/008736
Kind Code:
A3
Abstract:
A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.
Inventors:
WONG CHI-HUEY
WU CHUNG-YI
WANG CHENG-CHI
WU CHUNG-YI
WANG CHENG-CHI
Application Number:
PCT/US2009/047532
Publication Date:
March 11, 2010
Filing Date:
June 16, 2009
Export Citation:
Assignee:
ACADEMIA SINICA
WONG CHI-HUEY
WU CHUNG-YI
WANG CHENG-CHI
WONG CHI-HUEY
WU CHUNG-YI
WANG CHENG-CHI
International Classes:
G01N33/574; G01N33/53
Domestic Patent References:
| WO2006068758A2 | 2006-06-29 |
Foreign References:
| JP2002515060A | 2002-05-21 |
Other References:
SEVERINE VAN SLAMBROUCK ET AL.: "Clustering ofmonosialyl-Gb5 initiates downstream signaling events leading to invasion ofMCF-7 breast cancer cells.", THE BIOCHEMICAL JOURNAL, vol. 401, no. 3, February 2007 (2007-02-01), pages 689 - 699, XP008140655
REIJI KANNAGI ET AL.: "New globoseries glycosphingolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen, stage-specific embryonic antigen 3.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 14, July 2005 (2005-07-01), pages 8934 - 8942, XP008140760
CHENG-YUAN HUANG ET AL.: "Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 103, no. 1, January 2006 (2006-01-01), pages 15 - 20, XP008140715
CHENG-CHI WANG ET AL.: "Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 105, no. 33, 19 August 2008 (2008-08-19), pages 11661 - 11666, XP002613600
REIJI KANNAGI ET AL.: "New globoseries glycosphingolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen, stage-specific embryonic antigen 3.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 258, no. 14, July 2005 (2005-07-01), pages 8934 - 8942, XP008140760
CHENG-YUAN HUANG ET AL.: "Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 103, no. 1, January 2006 (2006-01-01), pages 15 - 20, XP008140715
CHENG-CHI WANG ET AL.: "Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 105, no. 33, 19 August 2008 (2008-08-19), pages 11661 - 11666, XP002613600
Attorney, Agent or Firm:
TSAO, Y., Rocky et al. (10 Fawcett StreetCambridge, Massachusetts, US)
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