Title:
CANCER METASTASIS INHIBITOR HAVING PYRROLE-IMIDAZOLE POLYAMIDE COMPOUND AS EFFECTIVE COMPONENT THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/215622
Kind Code:
A1
Abstract:
The present invention pertains to: a pyrrole-imidazole polyamide compound that has a specific structure, or a salt thereof; a membrane protein gene expression inhibitor that includes the compound or a salt thereof; and a cancer metastasis inhibitor that includes the compound or a salt thereof as an effective component thereof.
Inventors:
MURATA TAKUYA (JP)
SHIMOYA KOICHIRO (JP)
SUGIYAMA HIROSHI (JP)
IKEDA SHUJI (JP)
SHIMOYA KOICHIRO (JP)
SUGIYAMA HIROSHI (JP)
IKEDA SHUJI (JP)
Application Number:
PCT/JP2022/015956
Publication Date:
October 13, 2022
Filing Date:
March 30, 2022
Export Citation:
Assignee:
KAWASAKI GAKUEN EDUCATIONAL FOUND (JP)
International Classes:
C07D403/14; A61K31/4178; A61P35/04; A61P43/00
Domestic Patent References:
| WO1998049142A1 | 1998-11-05 | |||
| WO2018021200A1 | 2018-02-01 |
Other References:
GANESH N. PANDIAN, YUSUKE NAKANO, SHINSUKE SATO, HIRONOBU MORINAGA, TOSHIKAZU BANDO, HIROKI NAGASE, HIROSHI SUGIYAMA: "A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts", SCIENTIFIC REPORTS, vol. 2, no. 1, 1 December 2012 (2012-12-01), XP055484116, DOI: 10.1038/srep00544
RINA MAEDA, SHINSUKE SATO, SHUNSUKE OBATA, TOMO OHNO, KAORI HASHIYA, TOSHIKAZU BANDO, HIROSHI SUGIYAMA: "Molecular Characteristics of DNA-Alkylating PI Polyamides Targeting RUNX Transcription Factors", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 10, 13 March 2019 (2019-03-13), pages 4257 - 4263, XP055677312, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08813
GAO CAIYUN, YAO HONGYU, LIU HUIMIN, FENG YANYING, YANG ZHIJUN: "TM4SF1 is a potential target for anti-invasion and metastasis in ovarian cancer", BMC CANCER, vol. 19, no. 1, 1 December 2019 (2019-12-01), XP055976460, DOI: 10.1186/s12885-019-5417-7
RINA MAEDA, SHINSUKE SATO, SHUNSUKE OBATA, TOMO OHNO, KAORI HASHIYA, TOSHIKAZU BANDO, HIROSHI SUGIYAMA: "Molecular Characteristics of DNA-Alkylating PI Polyamides Targeting RUNX Transcription Factors", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 141, no. 10, 13 March 2019 (2019-03-13), pages 4257 - 4263, XP055677312, ISSN: 0002-7863, DOI: 10.1021/jacs.8b08813
GAO CAIYUN, YAO HONGYU, LIU HUIMIN, FENG YANYING, YANG ZHIJUN: "TM4SF1 is a potential target for anti-invasion and metastasis in ovarian cancer", BMC CANCER, vol. 19, no. 1, 1 December 2019 (2019-12-01), XP055976460, DOI: 10.1186/s12885-019-5417-7
Attorney, Agent or Firm:
SHOJI Takashi et al. (JP)
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