CANCER RISK EVALUATION METHOD AND CANCER RISK EVALUATION SYSTEM

Title:

CANCER RISK EVALUATION METHOD AND CANCER RISK EVALUATION SYSTEM

Document Type and Number:

WIPO Patent Application WO/2019/065854

Kind Code:

A1

Abstract:

Provided is a cancer risk evaluation method which makes it possible to estimate, with high accuracy, a subject's risk of developing cancer, is not affected by drawbacks such as rapid amino acid degeneration and high costs that accompany methods using amino acid concentrations in blood, and can also estimate the site of origin of the cancer.　This method includes: a step S1 for measuring the concentration of an evaluation-use element group in a blood serum sample 2 collected from a subject; a step S2 for performing computation by applying the measured element group concentration data and age data for the subject to a discriminant function for identifying whether the subject belongs to a control group or a case group; and a step S3 for obtaining, on the basis of correlation among the evaluation-use element group obtained in step S2, an indicator for whether the subject is afflicted by any type of cancer. A combination of the 17 elements Na, Mg, P, S, K, Ca, Fe, Cu, Zn, Se, Rb, Sr, As, Mo, Cs, Co, and Ag is used as the evaluation-use element group.

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Inventors:

INAGAKI SEIICHI (JP)
OKAMOTO NAOYUKI (JP)
MIKAMI HARUO (JP)
MIYAGI YOHEI (JP)

Application Number:

PCT/JP2018/035978

Publication Date:

April 04, 2019

Filing Date:

September 27, 2018

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Assignee:

RENATECH CO LTD (JP)

International Classes:

G01N33/49

Domestic Patent References:

WO2016042805A1

2016-03-24

Foreign References:

JP2011047715A	2011-03-10
JP2013221866A	2013-10-28
JP5470848B2	2014-04-16
JP6082478B2	2017-02-15

Other References:

GUPTA SK ET AL.: "Serum trace elements and Cu/Zn ratio in breast cancer patients", JOURNAL OF SURGICAL ONCOLOGY, vol. 46, no. 3, March 1991 (1991-03-01), pages 178 - 181, XP055393817, DOI: 10.1002/jso.2930460311
NECIP PIRINCCI ET AL.: "Levels of Serum Trace Elements in Renal Cell Carcinoma Cases", ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol. 14, no. 1, 2013, pages 499 - 502
See also references of EP 3690438A4

Attorney, Agent or Firm:

IZUMI, Katsufumi (JP)

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