Title:
CANCER STEM CELL DIFFERENTIATION INDUCER
Document Type and Number:
WIPO Patent Application WO/2012/014936
Kind Code:
A1
Abstract:
Provided is an inducer of the differentiation of a cancer stem cell having resistance to existing therapy methods, which can be effective for the treatment of cancer through the induction of the differentiation of the cancer stem cell. Specifically provided are an inducer of the differentiation of a cancer stem cell which comprises an acetaminophen derivative as an active ingredient and an anti-cancer activity enhancer which comprises an acetaminophen derivative as an active ingredient and can enhance the anti-cancer activity of an anti-cancer agent when used in combination with the anti-cancer agent, wherein the acetaminophen derivative is acetaminophen (p-hydroxyacetamide) or o-hydroxyacetamide.
Inventors:
MIZUSHIMA TORU (JP)
Application Number:
PCT/JP2011/067098
Publication Date:
February 02, 2012
Filing Date:
July 27, 2011
Export Citation:
Assignee:
LTT BIO PHARMA CO LTD (JP)
MIZUSHIMA TORU (JP)
MIZUSHIMA TORU (JP)
International Classes:
A61K31/167; A61P35/00; A61P43/00; C12N5/095
Other References:
BILIR, A. ET AL.: "Acetaminophen and DMSO modulate growth and gemcitabine cytotoxicity in FM3A breast cancer cells in vitro", NEOPLASMA, vol. 51, no. 6, 2004, pages 460 - 464
TEICHER, B.A. ET AL.: "Cyclooxygenase inhibitors: in vitro and invivo effects on antitumor alkylating agents in the EMT-6 murine mammary carcinoma", INT J ONCOL, vol. 2, no. 2, 1993, pages 145 - 153
POSADAS, I. ET AL.: "Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line", BR J PHARMACOL, vol. 150, no. 5, 2007, pages 577 - 585
BASU, G.D. ET AL.: "Mechanisms underlying the growth inhibitory effects of the cyclo- oxygenase-2 inhibitor celecoxib in human breast cancer cells", BREAST CANCER RES, vol. 7, no. 4, 2005, pages R422 - R435, XP021011837, DOI: doi:10.1186/bcr1019
HINZ, B. ET AL.: "Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man", FASEB J, vol. 22, no. 2, 2008, pages 383 - 390
BAUMANN, J. ET AL.: "Inhibition of prostaglandin synthetases derived from neuronal and glial cells and rat renal medulla by ortho-, meta- and para-substituted aminophenolic compounds", PROSTAGLANDINS LEUKOT MED, vol. 10, no. 3, 1983, pages 319 - 329, XP023093057, DOI: doi:10.1016/0262-1746(82)90087-7
TEICHER, B.A. ET AL.: "Cyclooxygenase inhibitors: in vitro and invivo effects on antitumor alkylating agents in the EMT-6 murine mammary carcinoma", INT J ONCOL, vol. 2, no. 2, 1993, pages 145 - 153
POSADAS, I. ET AL.: "Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line", BR J PHARMACOL, vol. 150, no. 5, 2007, pages 577 - 585
BASU, G.D. ET AL.: "Mechanisms underlying the growth inhibitory effects of the cyclo- oxygenase-2 inhibitor celecoxib in human breast cancer cells", BREAST CANCER RES, vol. 7, no. 4, 2005, pages R422 - R435, XP021011837, DOI: doi:10.1186/bcr1019
HINZ, B. ET AL.: "Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man", FASEB J, vol. 22, no. 2, 2008, pages 383 - 390
BAUMANN, J. ET AL.: "Inhibition of prostaglandin synthetases derived from neuronal and glial cells and rat renal medulla by ortho-, meta- and para-substituted aminophenolic compounds", PROSTAGLANDINS LEUKOT MED, vol. 10, no. 3, 1983, pages 319 - 329, XP023093057, DOI: doi:10.1016/0262-1746(82)90087-7
Attorney, Agent or Firm:
KUSAMA, OSAMU (JP)
Osamu Kusama (JP)
Osamu Kusama (JP)
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