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Title:
CANCER STEM CELL TARGETING PEPTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/103064
Kind Code:
A1
Abstract:
A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15. Also provided is a composition comprising said synthetic peptide with a therapeutic agent fused thereto, and a pharmaceutically acceptable carrier or diluent. Further provided is a method of screening a peptide specifically targeting to a cancer stem cell. The method comprises the steps of establishing an oligopeptide library by using a phage expression system, contacting the library with a culture of bulk tumor cells of a cancer cell line, contacting the phages which do not bind to the bulk tumor cells with a culture of cancer stem cells of said cancer cell line, and screening a peptide specifically targeting to a cancer stem cell from the phages which bind to the cancer stem cells.

Inventors:
CHUANG CHIN-KAI (CN)
SU YU-HSYU (CN)
LIN TAI-YUN (CN)
Application Number:
PCT/CN2016/109163
Publication Date:
June 14, 2018
Filing Date:
December 09, 2016
Export Citation:
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Assignee:
AGRICULTURAL TECH RES INST (CN)
International Classes:
C07K7/06; C07K1/04; G01N33/50; G01N33/574
Domestic Patent References:
WO2012118778A12012-09-07
WO2013040142A22013-03-21
Foreign References:
US20150259380A12015-09-17
US20100076175A12010-03-25
CN105039333A2015-11-11
US20120208770A12012-08-16
TW200833844A2008-08-16
TW200833355A2008-08-16
Other References:
CHE YU-JUI ET AL.: "An Integrated Microfluidic System for Screening of Peptides Specific to Colon Cancer Cells and Colon Cancer Stem Cells Using the Phage Display Technology", PROCEEDINGS OF THE 9TH IEEE INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS, 16 April 2014 (2014-04-16), pages 440 - 443, XP032647884
SAMUEL BECK ET AL.: "Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells", BIOMATERIALS, vol. 32, no. 33, 30 August 2011 (2011-08-30), pages 8518 - 8528, XP028295853
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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