Title:
CANCER THERAPEUTIC AGENT COMPRISING LIGAND FOR NEUROMEDIN U RECEPTOR 2 (FM4) MOLECULE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2008/029601
Kind Code:
A1
Abstract:
It is found that a neuromedin U receptor 2 (FM4) molecule is expressed at a high level in a cancer cell such as a pancreatic cancer cell. When a ligand for the molecule is examined on its cancer cell proliferation inhibition effect, it is found that the ligand can inhibit the proliferation of a cancer cell. It is also found that the effect can be produced by a signal via an FM4 molecule. These findings reveal that a ligand for a neuromedin U receptor 2 (FM4) molecule is effective for the treatment of or prevention of the metastasis of cancer having enhanced expression of the neuromedin U receptor 2 (FM4) molecule such as pancreatic cancer.
Inventors:
KIMURA, Naoki (2-16, Komaba 4-chome, Meguro-k, Tokyo 41, 1530041, JP)
Application Number:
JP2007/065904
Publication Date:
March 13, 2008
Filing Date:
August 15, 2007
Export Citation:
Assignee:
FORERUNNER PHARMA RESEARCH CO., LTD. (2-16, Komaba 4-chome Meguro-k, Tokyo 41, 1530041, JP)
株式会社未来創薬研究所 (〒41 東京都目黒区駒場四丁目２番１６号 Tokyo, 1530041, JP)
株式会社未来創薬研究所 (〒41 東京都目黒区駒場四丁目２番１６号 Tokyo, 1530041, JP)
International Classes:
A61K45/00; A61K38/00; A61P35/00; A61P35/04; G01N33/15; G01N33/50; G01N33/53; G01N33/574
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (Kantetsu Tsukuba Bldg. 6F, 1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 47, 3000847, JP)
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