Title:
CANCER THERAPEUTIC COMBINATION COMPRISING CANCER-TARGETING TRANS-SPLICING RIBOZYME AND IMMUNE CHECKPOINT INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/128048
Kind Code:
A1
Abstract:
The present invention relates to a cancer therapeutic combination comprising a cancer-targeting trans-splicing ribozyme and an immune checkpoint inhibitor. The ribozyme of the present invention exhibits cancer cell-specific expression, is superb in terms of expression efficiency at a posttranscriptional level, anticancer activity against heterogeneous cancers, and stability in normal liver tissues, has a synergistic therapeutic effect on cancer when administered in combination with an immune checkpoint inhibitor, and can be used as a therapeutic modality for cancer resistant to an immune checkpoint inhibitor.
Inventors:
LEE SEONG-WOOK (KR)
CHO EUN YI (KR)
HAN SEUNG RYUL (KR)
PARK HYE RIM (KR)
CHO EUN YI (KR)
HAN SEUNG RYUL (KR)
PARK HYE RIM (KR)
Application Number:
PCT/KR2022/001106
Publication Date:
July 06, 2023
Filing Date:
January 21, 2022
Export Citation:
Assignee:
RZNOMICS INC (KR)
International Classes:
A61K48/00; A61K31/7105; A61K45/06; A61P35/00; C12N15/113
Foreign References:
| KR102252423B1 | 2021-05-13 | |||
| KR20160038674A | 2016-04-07 | |||
| KR20150021839A | 2015-03-03 |
Other References:
SEUNG-PIL SHIN, SEO HYE-HYUN, SHIN JAE-HUN, PARK HYUNG-BAE, LIM DONG-PYO, EOM HYEON-SEOK, BAE YONG-SOO, KIM IN-HOO, CHOI KYUNGHO, : "Adenovirus Expressing Both Thymidine Kinase and Soluble PD1 Enhances Antitumor Immunity by Strengthening CD8 T-cell Response", MOLECULAR THERAPY, vol. 21, no. 3, 1 March 2013 (2013-03-01), pages 688 - 695, XP055179835, ISSN: 15250016, DOI: 10.1038/mt.2012.252
JUHYUN KIM, RANHUI WON, GUYEE BAN, MI HA JU, KYUNG SOOK CHO, SANG YOUNG HAN, JIN-SOOK JEONG, SEONG-WOOK LEE: "Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation", SCIENTIFIC REPORTS, vol. 5, pages 12315, XP055275537, DOI: 10.1038/srep12315
KIM, JU-HYUN: "Development of liver cancer gene therapy based on the cancer-specific RNA replacement through microRNA regulation", PH.D. THESIS, GRADUATE SCHOOL DANKOOK UNIVERSITY, 2014, pages 1 - 79, XP009547540
LEE, SEONG-WOOK: "Development of cancer gene therapy based on the cancer-specific RNA replacement through microRNA regulation", FINAL REPORT OF GOVERNMENT PROJECT, 2012, pages 1 - 12, XP009547543
JUHYUN KIM, RANHUI WON, GUYEE BAN, MI HA JU, KYUNG SOOK CHO, SANG YOUNG HAN, JIN-SOOK JEONG, SEONG-WOOK LEE: "Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation", SCIENTIFIC REPORTS, vol. 5, pages 12315, XP055275537, DOI: 10.1038/srep12315
KIM, JU-HYUN: "Development of liver cancer gene therapy based on the cancer-specific RNA replacement through microRNA regulation", PH.D. THESIS, GRADUATE SCHOOL DANKOOK UNIVERSITY, 2014, pages 1 - 79, XP009547540
LEE, SEONG-WOOK: "Development of cancer gene therapy based on the cancer-specific RNA replacement through microRNA regulation", FINAL REPORT OF GOVERNMENT PROJECT, 2012, pages 1 - 12, XP009547543
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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