Title:
CANCER TREATMENT AGENT
Document Type and Number:
WIPO Patent Application WO/2023/013763
Kind Code:
A1
Abstract:
The present invention provides a novel and effective cancer immunotherapeutic agent exhibiting a therapeutic effect against refractory cancers, particularly against cancers for which immune checkpoint inhibitors used as a monotherapy or in combination with another drug are ineffective. Specifically, the present invention provides a cancer treatment agent obtained by combining an immune checkpoint inhibitor, interleukin-18 (IL-18), and a T-cell growth factor (e.g., interleukin-2 (IL-2)).
Inventors:
TANAKA YOSHIMASA (JP)
KIMURA KIMINORI (JP)
KIMURA KIMINORI (JP)
Application Number:
PCT/JP2022/030084
Publication Date:
February 09, 2023
Filing Date:
August 05, 2022
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
TOKYO METROPOLITAN GOVERNMENT (JP)
TOKYO METROPOLITAN GOVERNMENT (JP)
International Classes:
A61K38/20; A61K39/395; A61K45/00; A61P35/00; A61P43/00
Foreign References:
| JP4024366B2 | 2007-12-19 | |||
| JP4753867B2 | 2011-08-24 | |||
| JP2004530432A | 2004-10-07 | |||
| JP2020533301A | 2020-11-19 | |||
| JP2020033362A | 2020-03-05 | |||
| JP2021130294A | 2021-09-09 |
Other References:
DONG WENJUAN, WU XIAOJIN, MA SHOUBAO, WANG YUFENG, NALIN ANSEL P., ZHU ZHENG, ZHANG JIANYING, BENSON DON M., HE KAI, CALIGIURI MIC: "The Mechanism of Anti–PD-L1 Antibody Efficacy against PD-L1–Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 9, no. 10, 1 October 2019 (2019-10-01), US , pages 1422 - 1437, XP055958906, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-18-1259
SENJU HIROAKI, KUMAGAI ASUKA, NAKAMURA YOICHI, YAMAGUCHI HIROYUKI, NAKATOMI KATSUMI, FUKAMI SHOTA, SHIRAISHI KENGO, HARADA YUKA, N: "Effect of IL-18 on the Expansion and Phenotype of Human Natural Killer Cells: Application to Cancer Immunotherapy", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, vol. 14, no. 3, 1 January 2018 (2018-01-01), pages 331 - 340, XP055820133, ISSN: 1449-2288, DOI: 10.7150/ijbs.22809
RAHIMI KALATEH SHAH MOHAMMAD GHASEM, GHAHREMANLOO ATEFEH, SOLTANI ARASH, FATHI ESMAT, HASHEMY SEYED ISAAC: "Cytokines as potential combination agents with PD‐1/PD‐L1 blockade for cancer treatment", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 235, no. 7-8, 1 July 2020 (2020-07-01), US , pages 5449 - 5460, XP055930605, ISSN: 0021-9541, DOI: 10.1002/jcp.29491
MA, Z ET AL., CLIN. CANCER RES., vol. 22, no. 12, 2009, pages 2969 - 2980
EL-DARAWISH, Y ET AL., J. LEUKOC. BIOL., vol. 104, 2018, pages 253 - 264
FABBI, M ET AL., J. LEUKOC. BIOL., vol. 97, 2015, pages 665 - 675
ZHOU, T ET AL., NATURE, vol. 583, no. 7817, 2020, pages 609 - 614
"UniProtKB", Database accession no. P13232
SHINSAIBOKOGAKUJIKKEN: "Protocol", NEW CELL ENGINEERING EXPERIMENTAL PROTOCOL, vol. 263, 1995, pages 267
"Virology", vol. 52, 1973, SHUJUNSHA, pages: 456
KATZENELLENGOBEN ET AL., MOL. CANCER RES, vol. 5, no. 11, 2007, pages 1159 - 1170
SENJU HIROAKI, KUMAGAI ASUKA, NAKAMURA YOICHI, YAMAGUCHI HIROYUKI, NAKATOMI KATSUMI, FUKAMI SHOTA, SHIRAISHI KENGO, HARADA YUKA, N: "Effect of IL-18 on the Expansion and Phenotype of Human Natural Killer Cells: Application to Cancer Immunotherapy", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, vol. 14, no. 3, 1 January 2018 (2018-01-01), pages 331 - 340, XP055820133, ISSN: 1449-2288, DOI: 10.7150/ijbs.22809
RAHIMI KALATEH SHAH MOHAMMAD GHASEM, GHAHREMANLOO ATEFEH, SOLTANI ARASH, FATHI ESMAT, HASHEMY SEYED ISAAC: "Cytokines as potential combination agents with PD‐1/PD‐L1 blockade for cancer treatment", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 235, no. 7-8, 1 July 2020 (2020-07-01), US , pages 5449 - 5460, XP055930605, ISSN: 0021-9541, DOI: 10.1002/jcp.29491
MA, Z ET AL., CLIN. CANCER RES., vol. 22, no. 12, 2009, pages 2969 - 2980
EL-DARAWISH, Y ET AL., J. LEUKOC. BIOL., vol. 104, 2018, pages 253 - 264
FABBI, M ET AL., J. LEUKOC. BIOL., vol. 97, 2015, pages 665 - 675
ZHOU, T ET AL., NATURE, vol. 583, no. 7817, 2020, pages 609 - 614
"UniProtKB", Database accession no. P13232
SHINSAIBOKOGAKUJIKKEN: "Protocol", NEW CELL ENGINEERING EXPERIMENTAL PROTOCOL, vol. 263, 1995, pages 267
"Virology", vol. 52, 1973, SHUJUNSHA, pages: 456
KATZENELLENGOBEN ET AL., MOL. CANCER RES, vol. 5, no. 11, 2007, pages 1159 - 1170
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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