Title:
CANDIDA ANTI-FUNGAL COMPOSITION CONTAINING LIPOTEICHOIC ACID
Document Type and Number:
WIPO Patent Application WO/2024/029756
Kind Code:
A1
Abstract:
The present invention relates to an antifungal composition, a pharmaceutical composition for the prevention and treatment of candidiasis, and uses thereof, wherein the compositions each utilize the activity of lipoteichoic acid derived from various Gram-positive bacteria to inhibit the adhesion and aggregation of Candida fungi. When used, the compositions were identified to have the effect of inhibiting the adhesive and aggregative strength, which are key virulence factors for the infection of Candida fungi and candidiasis, and thus can be used for antifungal purposes against Candida fungi and for the prevention or treatment of candidiasis-related infections.
Inventors:
HAN SEUNG HYUN (KR)
PARK DONG HYUN (KR)
LEE DONGWOOK (KR)
PARK DONG HYUN (KR)
LEE DONGWOOK (KR)
Application Number:
PCT/KR2023/009382
Publication Date:
February 08, 2024
Filing Date:
July 04, 2023
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A01N63/20; A01P3/00; A23K10/16; A23L33/10; A61K31/70; A61K35/74; A61K35/744; A61P31/10; C09D5/14
Foreign References:
| KR20140082206A | 2014-07-02 | |||
| KR20200059871A | 2020-05-29 | |||
| KR20190017168A | 2019-02-20 |
Other References:
AHN KI BUM, BAIK JUNG EUN, YUN CHEOL-HEUI, HAN SEUNG HYUN: "Lipoteichoic Acid Inhibits Staphylococcus aureus Biofilm Formation", FRONTIERS IN MICROBIOLOGY, FRONTIERS MEDIA, LAUSANNE, vol. 9, 27 February 2018 (2018-02-27), Lausanne , XP093135775, ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.00327
LEE DONGWOOK, IM JINTAEK, PARK DONG HYUN, JEONG SUNGHO, PARK MIRI, YOON SEOKMIN, PARK JAEWOONG, HAN SEUNG HYUN: "Lactobacillus plantarum Lipoteichoic Acids Possess Strain-Specific Regulatory Effects on the Biofilm Formation of Dental Pathogenic Bacteria", FRONTIERS IN MICROBIOLOGY, FRONTIERS MEDIA, LAUSANNE, vol. 12, 15 November 2021 (2021-11-15), Lausanne , XP093135780, ISSN: 1664-302X, DOI: 10.3389/fmicb.2021.758161
CERESA C., TESSAROLO F., CAOLA I., NOLLO G., CAVALLO M., RINALDI M., FRACCHIA L.: "Inhibition of Candida albicans adhesion on medical-grade silicone by a Lactobacillus-derived biosurfactant", JOURNAL OF APPLIED MICROBIOLOGY, vol. 118, no. 5, 1 May 2015 (2015-05-01), GB , pages 1116 - 1125, XP009552784, ISSN: 1364-5072, DOI: 10.1111/jam.12760
ZEISE KAREN D., WOODS ROBERT J., HUFFNAGLE GARY B.: "Interplay between Candida albicans and Lactic Acid Bacteria in the Gastrointestinal Tract: Impact on Colonization Resistance, Microbial Carriage, Opportunistic Infection, and Host Immunity", CLINICAL MICROBIOLOGY REVIEW, WASHINGTON, DC., US, vol. 34, no. 4, 15 December 2021 (2021-12-15), US , XP093135786, ISSN: 0893-8512, DOI: 10.1128/CMR.00323-20
PROTEIN J, vol. 32, 2013, pages 15 - 26
"Goodman And Gilman's: The Pharmacological Bases of Therapeutics", 1990, MACK PUBLISHING COMPANY
COSTERTON JSTEWARD: "Battling Biofilms", SCIENTIFIC AMERICAN, 2001, pages 75 - 81
LEE DONGWOOK, IM JINTAEK, PARK DONG HYUN, JEONG SUNGHO, PARK MIRI, YOON SEOKMIN, PARK JAEWOONG, HAN SEUNG HYUN: "Lactobacillus plantarum Lipoteichoic Acids Possess Strain-Specific Regulatory Effects on the Biofilm Formation of Dental Pathogenic Bacteria", FRONTIERS IN MICROBIOLOGY, FRONTIERS MEDIA, LAUSANNE, vol. 12, 15 November 2021 (2021-11-15), Lausanne , XP093135780, ISSN: 1664-302X, DOI: 10.3389/fmicb.2021.758161
CERESA C., TESSAROLO F., CAOLA I., NOLLO G., CAVALLO M., RINALDI M., FRACCHIA L.: "Inhibition of Candida albicans adhesion on medical-grade silicone by a Lactobacillus-derived biosurfactant", JOURNAL OF APPLIED MICROBIOLOGY, vol. 118, no. 5, 1 May 2015 (2015-05-01), GB , pages 1116 - 1125, XP009552784, ISSN: 1364-5072, DOI: 10.1111/jam.12760
ZEISE KAREN D., WOODS ROBERT J., HUFFNAGLE GARY B.: "Interplay between Candida albicans and Lactic Acid Bacteria in the Gastrointestinal Tract: Impact on Colonization Resistance, Microbial Carriage, Opportunistic Infection, and Host Immunity", CLINICAL MICROBIOLOGY REVIEW, WASHINGTON, DC., US, vol. 34, no. 4, 15 December 2021 (2021-12-15), US , XP093135786, ISSN: 0893-8512, DOI: 10.1128/CMR.00323-20
PROTEIN J, vol. 32, 2013, pages 15 - 26
"Goodman And Gilman's: The Pharmacological Bases of Therapeutics", 1990, MACK PUBLISHING COMPANY
COSTERTON JSTEWARD: "Battling Biofilms", SCIENTIFIC AMERICAN, 2001, pages 75 - 81
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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