Title:
CANINE-DERIVED NATURAL KILLER CELLS, AND MASS PROLIFERATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/109055
Kind Code:
A3
Abstract:
The present invention relates to canine-derived natural killer cells, and a mass proliferation method thereof. The canine-derived natural killer cells of the present invention can be used as an agent for preventing or treating cancer or viral diseases, disorders or symptoms of canines. According to the present invention, the mass proliferation method of natural killer cells can enable the maximum proliferation of canine-derived natural killer cells while remarkably increasing the killing activity thereof, thereby allowing a great number of natural killer cells to be obtained with the collection of a small amount of blood, and thus the method would greatly contribute to commercialization as a cell therapeutic agent.
Inventors:
KIM SANG-KI (KR)
SHIN DONG-JUN (KR)
PARK JI-YUN (KR)
CHO DUCK (KR)
SHIN DONG-JUN (KR)
PARK JI-YUN (KR)
CHO DUCK (KR)
Application Number:
PCT/KR2013/000352
Publication Date:
August 29, 2013
Filing Date:
January 17, 2013
Export Citation:
Assignee:
NAT UNIV KONGJU IND ACAD COOP (KR)
International Classes:
C12N5/02; C12N5/0783
Foreign References:
| US20020068044A1 | 2002-06-06 |
Other References:
HUANG, YI CHUN ET AL.: "CD5 low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 84, no. 6, 15 August 2008 (2008-08-15), pages 1501 - 1510, XP055082424
CHO, DEOK ET AL.: "Selective Expansion of Natural Killer Cells from Peripheral Blood Mononuclear Cells by K562 Cell Line and IL-2", KOREAN JOURNAL OF HEMATOLOGY, vol. 41, no. 1, 31 March 2006 (2006-03-31), pages 8 - 15
LIN, YI-CHUN ET AL.: "Canine CD8 T cells showing NK cytotoxic activity express mRNAs for NK cell associated surface molecules", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 133, no. 2, 5 August 2009 (2009-08-05), pages 144 - 153, XP026816594
BONKOBARA, M. ET AL.: "Characterization of cDNA and the genomic sequence encoding canine neural cell adhesion molecule CD56 N CAM", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 107, no. 1, 15 August 2005 (2005-08-15), pages 171 - 176, XP004952309
CHO, DEOK ET AL.: "Selective Expansion of Natural Killer Cells from Peripheral Blood Mononuclear Cells by K562 Cell Line and IL-2", KOREAN JOURNAL OF HEMATOLOGY, vol. 41, no. 1, 31 March 2006 (2006-03-31), pages 8 - 15
LIN, YI-CHUN ET AL.: "Canine CD8 T cells showing NK cytotoxic activity express mRNAs for NK cell associated surface molecules", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 133, no. 2, 5 August 2009 (2009-08-05), pages 144 - 153, XP026816594
BONKOBARA, M. ET AL.: "Characterization of cDNA and the genomic sequence encoding canine neural cell adhesion molecule CD56 N CAM", VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 107, no. 1, 15 August 2005 (2005-08-15), pages 171 - 176, XP004952309
Attorney, Agent or Firm:
LEEON INTELLECTUAL PROPERTY LAW FIRM (811 Guro-dong, Guro-gu, Seoul 152-050, KR)
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Claims: