Title:
CANINE PANCREATIC LIPSE
Document Type and Number:
WIPO Patent Application WO2006022882
Kind Code:
A3
Abstract:
Isolated nucleic acid molecules having a nucleotide sequence encoding canine pancreatic lipase polypeptides, allelic variants and fragments thereof. Vectors and host cells containing the polynucleotide sequences and methods for expressing the polypeptides. Monoclonal antibodies that specifically binds to the canine pancreatic lipase polypeptides. Cell lines secreting the monoclonal antibodies. Methods for determining the presence or amount of canine pancreatic lipase in a biological sample. The methods include using the monoclonal antibodies to specifically bind to canine pancreatic lipase polypeptides. The method includes using standards of recombinant canine pancreatic lipase. Devices and kits for performing methods for detecting canine pancreatic lipase in biological samples.
Inventors:
BEALL MELISSA (US)
HUTH STACEY PAZAR (US)
KRAH EUGENE REGIS (US)
HUTH STACEY PAZAR (US)
KRAH EUGENE REGIS (US)
Application Number:
PCT/US2005/012645
Publication Date:
October 26, 2006
Filing Date:
April 15, 2005
Export Citation:
Assignee:
IDEXX LAB INC (US)
BEALL MELISSA (US)
HUTH STACEY PAZAR (US)
KRAH EUGENE REGIS (US)
BEALL MELISSA (US)
HUTH STACEY PAZAR (US)
KRAH EUGENE REGIS (US)
International Classes:
C12N9/20; C07H21/04; C07K16/40; C12N1/18; C12N9/32; C12N15/55; C12Q1/68; G01N33/573; G01N33/577
Foreign References:
| US5750333A | 1998-05-12 |
Other References:
STEINER JORG M ET AL: "Purification of classical pancreatic lipase from dog pancreas.", BIOCHIMIE (PARIS), vol. 84, no. 12, December 2002 (2002-12-01), pages 1243 - 1251, XP007900681, ISSN: 0300-9084
DE CARO J ET AL: "Pancreatic lipase-related protein 1 (PLRP1) is present in the pancreatic juice of several species", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1387, no. 1-2, 8 September 1998 (1998-09-08), pages 331 - 341, XP004278488, ISSN: 0167-4838
STEINER JORG M ET AL: "Development and analytic validation of an enzyme-linked immunosorbent assay for the measurement of canine pancreatic lipase immunoreactivity in serum.", CANADIAN JOURNAL OF VETERINARY RESEARCH, vol. 67, no. 3, July 2003 (2003-07-01), pages 175 - 182, XP007900682, ISSN: 0830-9000
STEINER JORG M ET AL: "Development and validation of a radioimmunoassay for the measurement of canine pancreatic lipase immunoreactivity in serum of dogs.", AMERICAN JOURNAL OF VETERINARY RESEARCH, vol. 64, no. 10, October 2003 (2003-10-01), pages 1237 - 1241, XP008064998, ISSN: 0002-9645
QUIGLEY KELLEY A ET AL: "Hyperlipasemia in 6 dogs with pancreatic or hepatic neoplasia: Evidence for tumor lipase production", VETERINARY CLINICAL PATHOLOGY, vol. 30, no. 3, 2001, pages 114 - 120, XP007900687, ISSN: 0275-6382
DATABASE EMBL [online] 24 April 1990 (1990-04-24), "Human triglyceride lipase mRNA, complete cds.", XP002384143, retrieved from EBI accession no. EM_PRO:J05125 Database accession no. J05125
TAN S W ET AL: "Production and characterization of murine monoclonal antibodies to Blastocystis hominis", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 26, no. 4, 1996, pages 375 - 381, XP007900688, ISSN: 0020-7519
VISAI LIVIA ET AL: "Identification and characterization of a new ligand-binding site in FnbB, a fibronectin-binding adhesin from Streptococcus dysgalactiae.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1646, no. 1-2, 21 March 2003 (2003-03-21), pages 173 - 183, XP004413499, ISSN: 0006-3002
AOUBALA MUSTAPHA ET AL: "Human pancreatic lipase: Importance of the hinge region between the two domains, as revealed by monoclonal antibodies", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 8, 1995, pages 3932 - 3937, XP007900686, ISSN: 0021-9258
DE CARO J ET AL: "Pancreatic lipase-related protein 1 (PLRP1) is present in the pancreatic juice of several species", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1387, no. 1-2, 8 September 1998 (1998-09-08), pages 331 - 341, XP004278488, ISSN: 0167-4838
STEINER JORG M ET AL: "Development and analytic validation of an enzyme-linked immunosorbent assay for the measurement of canine pancreatic lipase immunoreactivity in serum.", CANADIAN JOURNAL OF VETERINARY RESEARCH, vol. 67, no. 3, July 2003 (2003-07-01), pages 175 - 182, XP007900682, ISSN: 0830-9000
STEINER JORG M ET AL: "Development and validation of a radioimmunoassay for the measurement of canine pancreatic lipase immunoreactivity in serum of dogs.", AMERICAN JOURNAL OF VETERINARY RESEARCH, vol. 64, no. 10, October 2003 (2003-10-01), pages 1237 - 1241, XP008064998, ISSN: 0002-9645
QUIGLEY KELLEY A ET AL: "Hyperlipasemia in 6 dogs with pancreatic or hepatic neoplasia: Evidence for tumor lipase production", VETERINARY CLINICAL PATHOLOGY, vol. 30, no. 3, 2001, pages 114 - 120, XP007900687, ISSN: 0275-6382
DATABASE EMBL [online] 24 April 1990 (1990-04-24), "Human triglyceride lipase mRNA, complete cds.", XP002384143, retrieved from EBI accession no. EM_PRO:J05125 Database accession no. J05125
TAN S W ET AL: "Production and characterization of murine monoclonal antibodies to Blastocystis hominis", INTERNATIONAL JOURNAL FOR PARASITOLOGY, vol. 26, no. 4, 1996, pages 375 - 381, XP007900688, ISSN: 0020-7519
VISAI LIVIA ET AL: "Identification and characterization of a new ligand-binding site in FnbB, a fibronectin-binding adhesin from Streptococcus dysgalactiae.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1646, no. 1-2, 21 March 2003 (2003-03-21), pages 173 - 183, XP004413499, ISSN: 0006-3002
AOUBALA MUSTAPHA ET AL: "Human pancreatic lipase: Importance of the hinge region between the two domains, as revealed by monoclonal antibodies", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 8, 1995, pages 3932 - 3937, XP007900686, ISSN: 0021-9258
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