CAP-GLY DOMAIN STRUCTURE AND USES THEREOF

WIPO Patent Application WO2003048341

A3

The present invention relates to a polypeptide that includes amino acid sequence of the CAP-Gly domain or a portion thereof and heterologous amino acid sequence, the structure of any such polypeptide and its use in designing, identifying or validating ligands to the CAP-Gly domain or homologous structure.

LUO MING (US)

PCT/US2002/041462

January 13, 2005

December 03, 2002

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UAB RESEARCH FOUNDATION (US)
LUO MING (US)

C07K14/47; (IPC1-7): G06F17/00

WATANABE T.K. ET AL.: "Cloning, expression and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain", CYTOGENICS AND CELL GENETICS, vol. 72, 1996, pages 208 - 211, XP008039972
DATABASE GENBANK [online] XP002903680, Database accession no. (AAQ20728)
HAMPTON RESEARCH CRYSTAL SCREEN, 1990, pages 1 - 4, XP008039982
BRUNGER A.T. ET AL.: "Crystallography & NMR system: A new software suite for macromolecular structure determination", ACTA CRYSTALLOGRAPHICA, vol. D54, 1998, pages 905 - 921, XP002903681
LI S. ET AL.: "Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-GLY) domain", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 50, 13 December 2002 (2002-12-13), pages 48596 - 48601, XP002903682

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