Title:
CAPILLARY GEL ELECTROPHORESIS DETECTION KIT CONTAINING REDUCING AGENT
Document Type and Number:
WIPO Patent Application WO/2022/227362
Kind Code:
A1
Abstract:
The present invention relates to a capillary gel electrophoresis detection kit containing a reducing agent. The reducing agent is selected from a monothiol compound and a dithiol compound, wherein the monothiol compound is selected from 11-mercapto-1-undecanol, and the dithiol compound is selected from 2,2'-(1,2-ethylenedioxy)diethanethiol and glycol dimercaptoacetate. The kit of the present invention can reduce environmental pollution and harm to a human body during a process of reduced capillary gel electrophoresis analysis of biopharmaceuticals, such as monoclonal antibodies, and ensures the accuracy of purity under reduction conditions, wherein the biopharmaceuticals comprise recombinant anti-ricin humanized monoclonal antibodies, recombinant anti-HER2 humanized monoclonal antibodies, T-DM1, and recombinant human II-type tumor necrosis factor receptor-antibody fusion proteins for injection.
Inventors:
FANG WEIJIE (CN)
SHEN BINBIN (CN)
SHEN BINBIN (CN)
Application Number:
PCT/CN2021/115986
Publication Date:
November 03, 2022
Filing Date:
September 01, 2021
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
G01N27/447; G01N33/68
Foreign References:
| CN113189183A | 2021-07-30 | |||
| CN111316091A | 2020-06-19 | |||
| CN110225925A | 2019-09-10 | |||
| US6074837A | 2000-06-13 |
Other References:
TANG L H, AIZENMAN E: "The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro.", THE JOURNAL OF PHYSIOLOGY, vol. 465, no. 1, 1 June 1993 (1993-06-01), GB , pages 303 - 323, XP055981248, ISSN: 0022-3751, DOI: 10.1113/jphysiol.1993.sp019678
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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