Title:
CAPSULATING SYSTEM BINDING TO NUCLEOLIN
Document Type and Number:
WIPO Patent Application WO/2009/142525
Kind Code:
A3
Abstract:
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.
Inventors:
SERENO DE ALMEIDA MOREIRA JOAO NUNO (PT)
DANTAS NUNES CALDEIRA DE MOURA VERA LUCIA (PT)
DE MAGALHAES SIMOES SERGIO PAULO (PT)
MONTEIRO PEDROSO DE LIMA MARIA DA CONCEICAO (PT)
DANTAS NUNES CALDEIRA DE MOURA VERA LUCIA (PT)
DE MAGALHAES SIMOES SERGIO PAULO (PT)
MONTEIRO PEDROSO DE LIMA MARIA DA CONCEICAO (PT)
Application Number:
PCT/PT2009/000027
Publication Date:
December 09, 2010
Filing Date:
May 21, 2009
Export Citation:
Assignee:
UNIV DE COIMBRA (PT)
CT DE NEUROCIENCIAS E BIOLOG CELULAR (PT)
SERENO DE ALMEIDA MOREIRA JOAO NUNO (PT)
DANTAS NUNES CALDEIRA DE MOURA VERA LUCIA (PT)
DE MAGALHAES SIMOES SERGIO PAULO (PT)
MONTEIRO PEDROSO DE LIMA MARIA DA CONCEICAO (PT)
CT DE NEUROCIENCIAS E BIOLOG CELULAR (PT)
SERENO DE ALMEIDA MOREIRA JOAO NUNO (PT)
DANTAS NUNES CALDEIRA DE MOURA VERA LUCIA (PT)
DE MAGALHAES SIMOES SERGIO PAULO (PT)
MONTEIRO PEDROSO DE LIMA MARIA DA CONCEICAO (PT)
International Classes:
A61K47/48; A61K9/127; A61K49/00; A61P35/00; A61K31/704; C07K14/47
Domestic Patent References:
| WO2007055561A1 | 2007-05-18 | |||
| WO2003087124A2 | 2003-10-23 | |||
| WO2009005793A2 | 2009-01-08 | |||
| WO2010008876A2 | 2010-01-21 |
Foreign References:
| US20050287122A1 | 2005-12-29 | |||
| US20050196343A1 | 2005-09-08 | |||
| JP2008162981A | 2008-07-17 |
Other References:
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MAKELA ET AL: "Peptide-mediated interference with baculovirus transduction", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 134, no. 1-2, 18 January 2008 (2008-01-18), pages 20 - 32, XP022500123, ISSN: 0168-1656
HENKE E ET AL: "Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo", NATURE BIOTECHNOLOGY 200801 US LNKD- DOI:10.1038/NBT1366, vol. 26, no. 1, January 2008 (2008-01-01), pages 91 - 100, XP002604443
AKERMAN M E ET AL: "NANOCRYSTAL TARGETING IN VIVO", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.152463399, vol. 99, no. 20, 16 September 2002 (2002-09-16), pages 12617 - 12621, XP001182896, ISSN: 0027-8424
PARK JI-HO ET AL: "Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) 2008 LNKD- PUBMED:18696519, vol. 47, no. 38, 2008, pages 7284 - 7288, XP002604444, ISSN: 1521-3773
PARK JI-HO ET AL: "Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.", SMALL (WEINHEIM AN DER BERGSTRASSE, GERMANY) MAR 2009 LNKD- PUBMED:19263431, vol. 5, no. 6, March 2009 (2009-03-01), pages 694 - 700, XP002604445, ISSN: 1613-6829
MAKELA ET AL: "Peptide-mediated interference with baculovirus transduction", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 134, no. 1-2, 18 January 2008 (2008-01-18), pages 20 - 32, XP022500123, ISSN: 0168-1656
HENKE E ET AL: "Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo", NATURE BIOTECHNOLOGY 200801 US LNKD- DOI:10.1038/NBT1366, vol. 26, no. 1, January 2008 (2008-01-01), pages 91 - 100, XP002604443
AKERMAN M E ET AL: "NANOCRYSTAL TARGETING IN VIVO", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.152463399, vol. 99, no. 20, 16 September 2002 (2002-09-16), pages 12617 - 12621, XP001182896, ISSN: 0027-8424
PARK JI-HO ET AL: "Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery.", ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) 2008 LNKD- PUBMED:18696519, vol. 47, no. 38, 2008, pages 7284 - 7288, XP002604444, ISSN: 1521-3773
PARK JI-HO ET AL: "Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.", SMALL (WEINHEIM AN DER BERGSTRASSE, GERMANY) MAR 2009 LNKD- PUBMED:19263431, vol. 5, no. 6, March 2009 (2009-03-01), pages 694 - 700, XP002604445, ISSN: 1613-6829
Attorney, Agent or Firm:
VIEIRA PEREIRA FERREIRA, Maria Silvina (MODET & CoRua Castilho 5, 9ยบ Andar -163 Lisboa, PT)
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