Title:
CARBAPENEM COMPOUNDS, USE THEREOF, AND INTERMEDIATE COMPOUNDS OF THE SAME
Document Type and Number:
WIPO Patent Application WO/1998/034936
Kind Code:
A1
Abstract:
Carbapenem compounds represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein each symbol has the meaning as defined in the specification. Because of being excellent in absorbability in the digestive tract when administered orally and showing sufficient antimicrobial activities over a broad scope of microorganisms, these compounds (I) or pharmaceutically acceptable salts thereof are highly useful as preventives and remedies for infectious diseases, in particular, microbisms. These preventives and remedies are usable in preventing and treating diseases caused by bacteria such as purulent diseases, respiratory infection, biliary infection, and urinary tract infection in warm-blooded animals including human being, dog, cat, cow, horse, rat and mouse.
Inventors:
MATSUI HIROSHI (JP)
KASAI MASAYASU (JP)
KASAI MASAYASU (JP)
Application Number:
PCT/JP1998/000446
Publication Date:
August 13, 1998
Filing Date:
February 02, 1998
Export Citation:
Assignee:
KYOTO PHARMA IND (JP)
MATSUI HIROSHI (JP)
KASAI MASAYASU (JP)
MATSUI HIROSHI (JP)
KASAI MASAYASU (JP)
International Classes:
A61K31/4025; A61K31/407; A61P31/04; C07D207/16; C07D477/20; (IPC1-7): C07D487/04; A61K31/40
Foreign References:
| JPS6434986A | 1989-02-06 |
Other References:
SUNAGAWA M., ET AL.: "SYNTHESIS AND BIOLOGICAL PROPERTIES OF 1BETA-METHYLCARBAPENEMS WITH N-METHYLPYRROLIDINYLTHIO GROUP AT C-2 POSITION.", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP, GB, vol. 45., no. 06., 1 January 1992 (1992-01-01), GB, pages 971 - 976., XP002912926, ISSN: 0021-8820
"SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL CARBAPENEMS WITH A CATECHOL OR HYDROXYPYRIDONE MOIETY.", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP, GB, vol. 47., no. 11., 1 November 1994 (1994-11-01), GB, pages 1354 - 1358., XP002912927, ISSN: 0021-8820
SUNAGAWA M., ET AL.: "A NOVEL CARBAPENEM ANTIBIOTIC, SM-7338 STRUCTURE-ACTIVITY RELATIONSHIPS.", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP, GB, vol. 43., no. 05., 1 May 1990 (1990-05-01), GB, pages 519 - 532., XP002912928, ISSN: 0021-8820
See also references of EP 0987267A4
"SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL CARBAPENEMS WITH A CATECHOL OR HYDROXYPYRIDONE MOIETY.", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP, GB, vol. 47., no. 11., 1 November 1994 (1994-11-01), GB, pages 1354 - 1358., XP002912927, ISSN: 0021-8820
SUNAGAWA M., ET AL.: "A NOVEL CARBAPENEM ANTIBIOTIC, SM-7338 STRUCTURE-ACTIVITY RELATIONSHIPS.", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP, GB, vol. 43., no. 05., 1 May 1990 (1990-05-01), GB, pages 519 - 532., XP002912928, ISSN: 0021-8820
See also references of EP 0987267A4
Attorney, Agent or Firm:
Takashima, Hajime (3-9 Hiranomachi 3-chome, Chuo-k, Osaka-shi Osaka, JP)
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