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Title:
CARBAZOLAMIDE DERIVATIVE OR SALT THEREOF AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/007284
Kind Code:
A1
Abstract:
Disclosed are a new carbazolamide derivative as shown in general formula I and having the effect of regulating RORγt activity or a salt thereof and a preparation method therefor. Also disclosed is the use of the carbazolamide derivative or the salt thereof in the preparation of a drug for treating a disease associated with RORγt. Experimental results show that the carbazolamide derivative of the present invention or a salt thereof can effectively regulate RORγt protein receptor activity, thereby regulating the differentiation of Th17 cells and the production of IL-17, can further be used as a therapeutic drug for treating related diseases mediated by RORγt, and is especially applicable to the treatment of multiple sclerosis, rheumatoid arthritis, collagen-induced arthritis, psoriasis, inflammatory bowel disease, encephalomyelitis, Crohn's disease, asthma, various cancers and other related diseases.

Inventors:
WANG YONGHUI (CN)
HUANG YAFEI (CN)
YU MINGCHENG (CN)
XIE QIONG (CN)
Application Number:
PCT/CN2018/093715
Publication Date:
January 10, 2019
Filing Date:
June 29, 2018
Export Citation:
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Assignee:
UNIV FUDAN (CN)
International Classes:
C07D209/88; A61K31/403; A61K31/4439; A61P1/00; A61P17/06; A61P19/02; A61P25/28; A61P29/00; A61P31/12; A61P35/00; A61P37/02; C07D471/04
Domestic Patent References:
WO1994014773A11994-07-07
Foreign References:
CN106232582A2016-12-14
Other References:
HUANG, YAFEI ET AL.: "Discovery of Carbazole Carboxamides As Novel RORgt Inverse Agonists", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 148, 16 February 2018 (2018-02-16), pages 456 - 476, XP055564825
STNEXT REGISTRY (STNEXT REGISTRY, 14 September 2016 (2016-09-14), Retrieved from the Internet
Attorney, Agent or Firm:
SUNRAY INTELLECTUAL PROPERTY ATTORNEYS (CN)
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