Title:
CARBAZOLE, CARBOLINE AND INDOLE DERIVATIVES USEFUL IN THE INHIBITION OF VEGF PRODUCTION
Document Type and Number:
WIPO Patent Application WO2006058088
Kind Code:
A3
Abstract:
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds and compositions useful in the inhibition of BEGF production, and/or in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
Inventors:
CAO LIANGXIAN (US)
CHOI SOONGYU (US)
MOON YOUNG-CHOON (US)
TAMILARASU NADARAJAN (US)
QI HONGYAN (US)
LENNOX WILLIAM JOSEPH (US)
HWANG SEONGWOO (US)
CHOI SOONGYU (US)
MOON YOUNG-CHOON (US)
TAMILARASU NADARAJAN (US)
QI HONGYAN (US)
LENNOX WILLIAM JOSEPH (US)
HWANG SEONGWOO (US)
Application Number:
PCT/US2005/042484
Publication Date:
December 07, 2006
Filing Date:
November 23, 2005
Export Citation:
Assignee:
PTC THERAPEUTICS INC (US)
CAO LIANGXIAN (US)
CHOI SOONGYU (US)
MOON YOUNG-CHOON (US)
TAMILARASU NADARAJAN (US)
QI HONGYAN (US)
LENNOX WILLIAM JOSEPH (US)
HWANG SEONGWOO (US)
CAO LIANGXIAN (US)
CHOI SOONGYU (US)
MOON YOUNG-CHOON (US)
TAMILARASU NADARAJAN (US)
QI HONGYAN (US)
LENNOX WILLIAM JOSEPH (US)
HWANG SEONGWOO (US)
International Classes:
C07D209/88; C07D209/94; C07D213/82; C07D239/42; C07D261/14; C07D263/32; C07D271/10; C07D285/06; C07D307/68; C07D307/84; C07D317/66; C07D333/38; C07D487/22; C07D495/04; C07D498/22
Domestic Patent References:
WO2004069831A1 | 2004-08-19 | |||
WO2004096766A1 | 2004-11-11 |
Foreign References:
US4014890A | 1977-03-29 | |||
US6175015B1 | 2001-01-16 | |||
US5451600A | 1995-09-19 | |||
US5166204A | 1992-11-24 | |||
US6706750B1 | 2004-03-16 |
Other References:
K. SHANMUGASUNDARAM ET AL.: "Synthesis of 3-Phenylisooxazolo[3,4-a]carbazoles", ZEITSCHRIFT FÜR NATURFORSCHUNG, vol. 54b, 1999, pages 1202 - 1204, XP002378366
K. SHANMUGASUNDARAM ET AL.: "Synthesis and biological activity of pyrazino[3,2,1-j,k]carbazoles", INDIAN JOURNAL OF CHEMISTRY, vol. 37b, 1998, pages 1133 - 1136, XP008063392
K. SHANMUGASUNDARAM ET AL.: "Synthesis and biological activity of pyrazino[3,2,1-j,k]carbazoles", INDIAN JOURNAL OF CHEMISTRY, vol. 37b, 1998, pages 1133 - 1136, XP008063392
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